公开(公告)号：US11639390B2

公开(公告)日：2023-05-02

申请号：US17378565

申请日：2021-07-16

Applicant: AbbVie Inc.

Inventor： Jing Min ,  Teresa (Iok-Chan) Ng ,  Lorenzo Benatuil ,  Jacqueline Bixby ,  Tatyana Dekhtyar ,  Feng Dong ,  Axel Hernandez, Jr. ,  Preethi Krishnan ,  Liangjun Lu ,  Federico Mensa ,  Renee Miller ,  Gautam Sahu

IPC: C12N5/02 ,  C12N5/20 ,  C12N1/20 ,  C12N15/00 ,  C07K16/46 ,  C07K16/00 ,  C07H21/04 ,  C07K16/28 ,  A61P31/18 ,  C12N15/63 ,  A61K39/00

Abstract: The present disclosure provides anti-α4β7 antibodies that bind human α4β7, their methods of making, and their uses to treat patients with HIV infection.

公开(公告)号：US20220017624A1

公开(公告)日：2022-01-20

申请号：US17378565

申请日：2021-07-16

Applicant: AbbVie Inc.

Inventor： Jing Min ,  Teresa (Iok-Chan) Ng ,  Lorenzo Benatuil ,  Jacqueline Bixby ,  Tatyana Dekhtyar ,  Feng Dong ,  Axel Hernandez, Jr. ,  Preethi Krishnan ,  Liangjun Lu ,  Federico Mensa ,  Renee Miller ,  Gautam Sahu

IPC: C07K16/28 ,  A61P31/18 ,  C12N15/63

Abstract: The present disclosure provides anti-α4β7 antibodies that bind human α4β7, their methods of making, and their uses to treat patients with HIV infection.

公开(公告)号：US09670276B2

公开(公告)日：2017-06-06

申请号：US13940506

申请日：2013-07-12

Applicant: AbbVie Inc.

Inventor： Susan E. Lacy ,  Lorenzo Benatuil ,  Meha Chhaya ,  Emma Fung ,  Renee Miller ,  Ravi Chari ,  Sarah J. Heighton ,  Jacqueline G. Bixby

IPC: C12P21/08 ,  A61K39/395 ,  C07K16/24 ,  A61K39/00

CPC classification number: C07K16/245 ,  A61K2039/505 ,  C07K2317/24 ,  C07K2317/33 ,  C07K2317/56 ,  C07K2317/60 ,  C07K2317/622 ,  C07K2317/76 ,  C07K2317/92

Abstract: The disclosure provides binding proteins that specifically bind to IL-1α and IL-1β. These binding proteins can be organized into DVD-Igs. These proteins can be used to modulate the activity of IL-1α and/or IL-1β and can be used for the treatment immunological diseases such as rheumatoid arthritis, osteoarthritis, psoriasis, multiple sclerosis, and other autoimmune diseases. In addition, their uses in the amelioration and/or treatment of pain in an individual suffering from a disease or disorder associated with IL-1 accumulation.