公开(公告)号：US09775930B2

公开(公告)日：2017-10-03

申请号：US14685474

申请日：2015-04-13

Applicant: Abbott Cardiovascular Systems Inc. ,  Medical University of South Carolina

Inventor： Eugene T. Michal ,  Shubhayu Basu ,  Alexander J. Sheehy ,  Francis G. Spinale ,  Rupak Mukherjee

IPC: C12P7/28 ,  A61L27/26 ,  A61L27/20 ,  A61L27/22 ,  A61L27/50 ,  A61L27/52 ,  A61L27/38

CPC classification number: A61L27/26 ,  A61L27/20 ,  A61L27/22 ,  A61L27/3834 ,  A61L27/50 ,  A61L27/52 ,  A61L2300/418 ,  A61L2300/64 ,  A61L2400/06 ,  A61L2430/20 ,  C08L5/04 ,  C08L89/00

Abstract: A bioscaffolding can be formed within a post-myocardial infarct region sufficient to cause attenuation of a rate of myocardial infarct expansion. A bioscaffolding may further be formed in the post-myocardial infarct region to cause an increase in posterior left ventricular wall thickness. The gel or bioscaffolding can be formed from a mixture of gel components of different gelation systems. For example, a bioscaffolding can be formed by mixing at least two different components of at least two different two-component gelation systems to form a first mixture and by mixing at least two different components (other than the components that make up the first mixture) of the at least two different two-component gelation systems to form a second mixture.

公开(公告)号：US20170258961A9

公开(公告)日：2017-09-14

申请号：US14685474

申请日：2015-04-13

Applicant: Abbott Cardiovascular Systems Inc. ,  Medical University of South Carolina

Inventor： Eugene T. Michal ,  Shubhayu Basu ,  Alexander J. Sheehy ,  Francis G. Spinale ,  Rupak Mukherjee

IPC: A61L27/26 ,  A61L27/38

CPC classification number: A61L27/26 ,  A61L27/20 ,  A61L27/22 ,  A61L27/3834 ,  A61L27/50 ,  A61L27/52 ,  A61L2300/418 ,  A61L2300/64 ,  A61L2400/06 ,  A61L2430/20 ,  C08L5/04 ,  C08L89/00

Abstract: A bioscaffolding can be formed within a post-myocardial infarct region sufficient to cause attenuation of a rate of myocardial infarct expansion. A bioscaffolding may further be formed in the post-myocardial infarct region to cause an increase in posterior left ventricular wall thickness. The gel or bioscaffolding can be formed from a mixture of gel components of different gelation systems. For example, a bioscaffolding can be formed by mixing at least two different components of at least two different two-component gelation systems to form a first mixture and by mixing at least two different components (other than the components that make up the first mixture) of the at least two different two-component gelation systems to form a second mixture.

公开(公告)号：US20150209473A1

公开(公告)日：2015-07-30

申请号：US14685474

申请日：2015-04-13

Applicant: Abbott Cardiovascular Systems Inc.

Inventor： Eugene T. Michal ,  Shubhayu Basu ,  Alexander J. Sheehy ,  Francis G. Spinale ,  Rupak Mukherjee

IPC: A61L27/26 ,  A61L27/38

CPC classification number: A61L27/26 ,  A61L27/20 ,  A61L27/22 ,  A61L27/3834 ,  A61L27/50 ,  A61L27/52 ,  A61L2300/418 ,  A61L2300/64 ,  A61L2400/06 ,  A61L2430/20 ,  C08L5/04 ,  C08L89/00

Abstract: A bioscaffolding can be formed within a post-myocardial infarct region sufficient to cause attenuation of a rate of myocardial infarct expansion. A bioscaffolding may further be formed in the post-myocardial infarct region to cause an increase in posterior left ventricular wall thickness. The gel or bioscaffolding can be formed from a mixture of gel components of different gelation systems. For example, a bioscaffolding can be formed by mixing at least two different components of at least two different two-component gelation systems to form a first mixture and by mixing at least two different components (other than the components that make up the first mixture) of the at least two different two-component gelation systems to form a second mixture.