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1.发明申请TREATMENT OF CARDIAC DISEASES THAT PROMOTE EPICARDIAL ARTERY ENLARGEMENT WITH BIORESORBABLE SCAFFOLDS 审中-公开治疗带有生物可持续性障碍的EPICARDIAR ARTERY扩展的心脏病公开(公告)号：US20160038315A1
公开(公告)日：2016-02-11
申请号：US14454595
申请日：2014-08-07
Applicant: Abbott Cardiovascular Systems Inc.
Inventor： Paul Consigny , Alexander J. Sheehy
IPC: A61F2/82
CPC classification number: A61F2/82 , A61F2/915 , A61F2210/0004 , A61F2230/0019 , A61F2230/0021 , A61L31/148 , A61L2430/20
Abstract: Methods of treating coronary artery disease (CAD) and a cardiac disease that stimulates enlargement of the epicardial artery with a bioresorbable scaffold in a patient in need thereof are disclosed. Methods of treating CAD and an event that precipitates enlargement of the epicardial artery with a bioresorbable scaffold in a patient in need thereof are disclosed.
Abstract translation: 公开了在有需要的患者中治疗冠状动脉疾病（CAD）和刺激心外膜动脉扩大的心脏疾病的方法。 公开了治疗CAD的方法和在有需要的患者中用生物可再吸收的支架沉淀心外膜动脉扩大的事件。
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公开(公告)号：US09474834B2
公开(公告)日：2016-10-25
申请号：US14251536
申请日：2014-04-11
Applicant: Abbott Cardiovascular Systems Inc.
Inventor： Stephen D. Pacetti , O. Mikael Trollsas , Alexander J. Sheehy
CPC classification number: A61L31/10 , A61L31/08 , A61L31/16 , A61L33/128 , A61L2300/252 , A61L2300/42 , A61L2420/02 , C08L89/00
Abstract: Coatings for medical devices, the coatings including albumin, the methods of forming the coatings, and the coated medical devices are disclosed. In preferred embodiments the medical device is a bioabsorbable stent. The albumin coating layer improves the thromboresistance of the device.
Abstract translation: 公开了用于医疗装置的涂层，包括白蛋白的涂层，形成涂层的方法和涂覆的医疗装置。 在优选实施例中，医疗装置是生物可吸收支架。 白蛋白涂层改善了该装置的血栓阻力。
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公开(公告)号：US09775930B2
公开(公告)日：2017-10-03
申请号：US14685474
申请日：2015-04-13
Inventor： Eugene T. Michal , Shubhayu Basu , Alexander J. Sheehy , Francis G. Spinale , Rupak Mukherjee
CPC classification number: A61L27/26 , A61L27/20 , A61L27/22 , A61L27/3834 , A61L27/50 , A61L27/52 , A61L2300/418 , A61L2300/64 , A61L2400/06 , A61L2430/20 , C08L5/04 , C08L89/00
Abstract: A bioscaffolding can be formed within a post-myocardial infarct region sufficient to cause attenuation of a rate of myocardial infarct expansion. A bioscaffolding may further be formed in the post-myocardial infarct region to cause an increase in posterior left ventricular wall thickness. The gel or bioscaffolding can be formed from a mixture of gel components of different gelation systems. For example, a bioscaffolding can be formed by mixing at least two different components of at least two different two-component gelation systems to form a first mixture and by mixing at least two different components (other than the components that make up the first mixture) of the at least two different two-component gelation systems to form a second mixture.
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Patent Agency Ranking
公开(公告)号：US20170258961A9
公开(公告)日：2017-09-14
申请号：US14685474
申请日：2015-04-13
Inventor： Eugene T. Michal , Shubhayu Basu , Alexander J. Sheehy , Francis G. Spinale , Rupak Mukherjee
CPC classification number: A61L27/26 , A61L27/20 , A61L27/22 , A61L27/3834 , A61L27/50 , A61L27/52 , A61L2300/418 , A61L2300/64 , A61L2400/06 , A61L2430/20 , C08L5/04 , C08L89/00
Abstract: A bioscaffolding can be formed within a post-myocardial infarct region sufficient to cause attenuation of a rate of myocardial infarct expansion. A bioscaffolding may further be formed in the post-myocardial infarct region to cause an increase in posterior left ventricular wall thickness. The gel or bioscaffolding can be formed from a mixture of gel components of different gelation systems. For example, a bioscaffolding can be formed by mixing at least two different components of at least two different two-component gelation systems to form a first mixture and by mixing at least two different components (other than the components that make up the first mixture) of the at least two different two-component gelation systems to form a second mixture.
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公开(公告)号：US20160374838A1
公开(公告)日：2016-12-29
申请号：US14754479
申请日：2015-06-29
Applicant: Abbott Cardiovascular Systems Inc.
Inventor： Stephen D. Pacetti , Alexander J. Sheehy , Chad J. Abunassar
IPC: A61F2/915
CPC classification number: A61F2/915 , A61F2002/91558 , A61F2002/91566 , A61F2210/0004 , A61F2210/0076 , A61F2250/0067 , A61L31/06 , A61L31/10 , A61L31/16 , A61L2300/416 , A61L2300/606 , A61L2300/608 , A61L2420/02 , A61L2420/08 , C08L67/04
Abstract: Stents including a poly(D,L-lactide)(PDLLA)-based scaffold and PDLLA based therapeutic layer are disclosed. The PDLLA based scaffold may be amorphous and may include a primer layer. Methods of applying the PDLLA-based coating to the scaffold are disclosed with solvent processing methods using a solvent blend are also disclosed. Methods of removing residual solvent from a PDLLA-base coating that also condition the scaffold are disclosed. Methods of treating restenosis that release drugs to prevent restenosis without interfering with the natural positive remodeling of a vessel are disclosed.
Abstract translation: 公开了包含基于聚（D，L-丙交酯）（PDLLA）的支架和基于PDLLA的治疗层的支架。 基于PDLLA的支架可以是无定形的，并且可以包括底漆层。 公开了使用溶剂共混物的溶剂处理方法将基于PDLLA的涂层施用于支架的方法。 公开了从处于支架状态的PDLLA基底涂层除去残余溶剂的方法。 公开了治疗释放药物以预防再狭窄而不干扰血管的天然阳性重塑的再狭窄的方法。
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公开(公告)号：US20150209473A1
公开(公告)日：2015-07-30
申请号：US14685474
申请日：2015-04-13
Applicant: Abbott Cardiovascular Systems Inc.
Inventor： Eugene T. Michal , Shubhayu Basu , Alexander J. Sheehy , Francis G. Spinale , Rupak Mukherjee
CPC classification number: A61L27/26 , A61L27/20 , A61L27/22 , A61L27/3834 , A61L27/50 , A61L27/52 , A61L2300/418 , A61L2300/64 , A61L2400/06 , A61L2430/20 , C08L5/04 , C08L89/00
Abstract: A bioscaffolding can be formed within a post-myocardial infarct region sufficient to cause attenuation of a rate of myocardial infarct expansion. A bioscaffolding may further be formed in the post-myocardial infarct region to cause an increase in posterior left ventricular wall thickness. The gel or bioscaffolding can be formed from a mixture of gel components of different gelation systems. For example, a bioscaffolding can be formed by mixing at least two different components of at least two different two-component gelation systems to form a first mixture and by mixing at least two different components (other than the components that make up the first mixture) of the at least two different two-component gelation systems to form a second mixture.
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公开(公告)号：US20150290363A1
公开(公告)日：2015-10-15
申请号：US14251536
申请日：2014-04-11
Applicant: Abbott Cardiovascular Systems Inc.
Inventor： Stephen D. Pacetti , O. Mikael Trollsas , Alexander J. Sheehy
CPC classification number: A61L31/10 , A61L31/08 , A61L31/16 , A61L33/128 , A61L2300/252 , A61L2300/42 , A61L2420/02 , C08L89/00
Abstract: Coatings for medical devices, the coatings including albumin, the methods of forming the coatings, and the coated medical devices are disclosed. In preferred embodiments the medical device is a bioabsorbable stent. The albumin coating layer improves the thromboresistance of the device.
Abstract translation: 公开了用于医疗装置的涂层，包括白蛋白的涂层，形成涂层的方法和涂覆的医疗装置。 在优选实施例中，医疗装置是生物可吸收支架。 白蛋白涂层改善了该装置的血栓阻力。
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8.发明申请Treatment of coronary artery lesions with a scaffold having vessel scaffold interactions that reduce or prevent angina 审中-公开用具有减少或预防心绞痛的血管支架相互作用的支架治疗冠状动脉病变公开(公告)号：US20150073535A1
公开(公告)日：2015-03-12
申请号：US14120555
申请日：2014-06-02
Applicant: Abbott Cardiovascular Systems Inc.
Inventor： Paul Consigny , Richard J. Rapoza , Syed Faiyaz Ahmed Hossainy , Chad J. Abunassar , Alexander J. Sheehy , Laura E. Perkins , Santosh V. Prabhu , Wai-Fung Cheong , Pooja A. Sadarangani , Stephen D. Pacetti
CPC classification number: A61L31/148 , A61F2/915 , A61F2002/91566 , A61L31/10 , A61L31/16 , A61L2300/402 , A61L2300/416
Abstract: Methods of treating coronary artery disease (CAD) with bioresorbable stents resulting in reduced angina or non-ischemic chest pain are described. Methods of treatment and devices for treatment of angina and post-procedural chest pain that include anti-angina agents incorporated into the device are disclosed.
Abstract translation: 描述了具有导致心绞痛或非缺血性胸痛减轻的生物可再吸收支架的冠状动脉疾病（CAD）的方法。 公开了治疗方法和治疗心绞痛和手术后胸痛的装置，其包括并入装置中的抗心绞痛药物。
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