公开(公告)号：US20090093870A1

公开(公告)日：2009-04-09

申请号：US11867790

申请日：2007-10-05

申请人： Adolfo Menendez ,  Paul W. Schmokel ,  Eilaz P. Babaev ,  Scott R. Banaszewski ,  Michael R. Afremov

发明人： Adolfo Menendez ,  Paul W. Schmokel ,  Eilaz P. Babaev ,  Scott R. Banaszewski ,  Michael R. Afremov

IPC分类号： A61F2/06 ,  B05D3/02

CPC分类号： B05D1/002 ,  A61F2/82 ,  A61M2025/1031 ,  B05B13/0228 ,  B05D1/02

摘要： The present invention is directed towards the holding of medical devices during manufacture to enable the application of therapeutic and/or protective coatings. More specifically, the present invention provides medical device holders that securely retain stents and other medical devices during the application of a coating while minimizing compressive and tensile forces applied to the stents. The invention avoids disruptions to coating quality due to holder blockage during coating deposition. The invention discloses an improved device containing a mandrel and frame that may improve coating uniformity by eliminating shadowing from the frame of the medical device holder when applying coatings to stents and other medical devices.

摘要翻译： 本发明涉及在制造过程中保持医疗装置以能够施用治疗和/或保护性涂层。 更具体地，本发明提供了在施加涂层期间可靠地保持支架和其他医疗装置的医疗装置保持器，同时最小化施加到支架的压缩和拉伸力。 本发明避免了在涂布沉积期间由于夹持器堵塞而导致的涂层质量的破坏。 本发明公开了一种包含心轴和框架的改进装置，当将支架和其它医疗装置涂覆时，可以通过消除从医疗装置支架的框架上的遮蔽来提高涂层的均匀性。

公开(公告)号：US20090090299A1

公开(公告)日：2009-04-09

申请号：US11867818

申请日：2007-10-05

申请人： Adolfo Menendez ,  Paul W. Schmokel ,  Eilaz P. Babaev ,  Scott R. Banaszewski ,  Michael R. Afremov

发明人： Adolfo Menendez ,  Paul W. Schmokel ,  Eilaz P. Babaev ,  Scott R. Banaszewski ,  Michael R. Afremov

IPC分类号： B05C13/02

CPC分类号： B05B13/0442 ,  B05D1/002 ,  B05D1/02

摘要： The present invention is directed towards the holding of medical devices during manufacture to enable the application of therapeutic and/or protective coatings. More specifically, the present invention provides medical device holders that securely retain stents and other medical devices during the application of a coating while minimizing compressive and tensile forces applied to the stents. The invention avoids disruptions to coating quality due to holder blockage during coating deposition. The invention discloses an improved device containing a mandrel and frame that may improve coating uniformity by eliminating shadowing from the frame of the medical device holder when applying coatings to stents and other medical devices.

摘要翻译： 本发明涉及在制造过程中保持医疗装置以能够施用治疗和/或保护性涂层。 更具体地，本发明提供了在施加涂层期间可靠地保持支架和其他医疗装置的医疗装置保持器，同时最小化施加到支架的压缩和拉伸力。 本发明避免了在涂布沉积期间由于夹持器堵塞而导致的涂层质量的破坏。 本发明公开了一种包含心轴和框架的改进装置，当将支架和其它医疗装置涂覆时，可以通过消除从医疗装置支架的框架上的遮蔽来提高涂层的均匀性。

公开(公告)号：US20080243048A1

公开(公告)日：2008-10-02

申请号：US11692001

申请日：2007-03-27

申请人： Eilaz P. Babaev

发明人： Eilaz P. Babaev

IPC分类号： A61M37/00

CPC分类号： A61N7/00 ,  A61B2017/00889 ,  A61L2/0011 ,  A61L2/025 ,  A61M37/0092

摘要： The present invention relates to a method of treating wounds by applying ultrasonic energy to a wound to inactivate, destroy, and/or remove infectious agents, and/or deliver a coupling medium to debride, cleanse, and/or sterilize the wound. The method of the present invention comprises the steps of placing the wound in front of the ultrasound emitting surface in near field, activating the ultrasound transducer, generating ultrasonic energy, emitting ultrasonic waves from ultrasound emitting surface, allowing ozone to be created in the near field, applying ozone to the wound, introducing a coupling medium to the ultrasound emitting surface of the wound device, sonicating the coupling medium, and applying the coupling medium to a wound.

摘要翻译： 本发明涉及一种通过向伤口施加超声波能量来灭活，破坏和/或去除感染剂和/或递送耦合介质来清创，清洁和/或消毒伤口来治疗伤口的方法。 本发明的方法包括以下步骤：将伤口放置在近场的超声波发射表面之前，激活超声换能器，产生超声能量，从超声发射表面发射超声波，允许在近场产生臭氧 向伤口施加臭氧，向绕线装置的超声波发射表面引入耦合介质，超声波耦合介质，以及将耦合介质施加到伤口上。

公开(公告)号：US07896539B2

公开(公告)日：2011-03-01

申请号：US11204872

申请日：2005-08-16

申请人： Eilaz P. Babaev

发明人： Eilaz P. Babaev

IPC分类号： B01F11/00 ,  B05B1/08

CPC分类号： B05B17/0623 ,  B05B17/063

摘要： Ultrasound methods and apparatus for mixing two or more different liquids are disclosed. The ultrasound methods and apparatus may mix varied components including drugs, polymers, and coatings for application to a variety of medical apparatus surfaces. The apparatus and technique can generate a proper mixture which is uninterruptedly/continuously delivered to the surface of the medical apparatus. The apparatus may include specific ultrasound transducer/tip configurations which may allow for the mixing of different liquids in a mixing camera located inside of the vibrating tip. The apparatus and methods of the present invention may mix different drugs, applying them to stent surface using different effects like ultrasound cavitation and radiation forces. Furthermore, the disclosed methods and apparatus may generate a mixture and may deliver a targeted, gentle, highly controllable dispensation of continuous liquid spray which can reduce the loss of expensive pharmaceuticals.

摘要翻译： 公开了用于混合两种或更多种不同液体的超声方法和装置。 超声方法和装置可以将各种组分（包括药物，聚合物和涂层）混合以应用于各种医疗装置表面。 该装置和技术可以产生不间断地/连续输送到医疗装置的表面的合适的混合物。 该装置可以包括特定的超声换能器/尖端配置，其可以允许在位于振动尖端内部的混合摄像机中混合不同的液体。 本发明的装置和方法可以混合不同的药物，使用诸如超声空化和辐射力的不同效果将它们应用于支架表面。 此外，所公开的方法和装置可以产生混合物并且可以递送靶向，温和，高度可控的连续液体喷雾分配，其可以减少昂贵药物的损失。

公开(公告)号：US07572268B2

公开(公告)日：2009-08-11

申请号：US11250870

申请日：2005-10-13

申请人： Eilaz P. Babaev

发明人： Eilaz P. Babaev

IPC分类号： A61B17/32 ,  A61B18/18

CPC分类号： A61B18/0206 ,  A61B17/22004 ,  A61B17/320068 ,  A61B18/0218 ,  A61B2018/0262

摘要： An ultrasonic apparatus and method is provided for the selective and targeted removal of unwanted tissues. The apparatus and methods may utilize combinations of ultrasonic and cryogenic energy for the selective removal tissue. The apparatus generates and delivers to the tissue cryogenic and ultrasonic energy either in combination or in sequence, provides resize ablation of unwanted tissue parts, and may be used on various body tissues including internal organs.

摘要翻译： 提供超声波装置和方法用于选择性和有目的地去除不想要的组织。 该装置和方法可以利用超声波和低温能量的组合来选择性去除组织。 该装置以组合或顺序产生并递送至组织低温和超声能量，提供不想要的组织部分的大小消融，并且可以用于包括内部器官在内的各种身体组织。

公开(公告)号：US07943352B2

公开(公告)日：2011-05-17

申请号：US11393180

申请日：2006-03-29

申请人： Eilaz P. Babaev

发明人： Eilaz P. Babaev

IPC分类号： C12N13/00

CPC分类号： C12N13/00 ,  A61K2039/521 ,  A61K2039/5252 ,  A61L2/0011 ,  C12M47/06 ,  C12N1/066

摘要： Method and device for the creation of vaccines using ultrasonic waves, comprised of an ultrasound generator and a transducer to produce ultrasonic waves, is disclosed. The transducer has a specific ultrasound tip depending upon the type of delivery method utilized and depending on the shape of the vial containing the solution of the virus, bacterium, or other infectious agent. The apparatus delivers ultrasonic waves to solution either directly through the insertion of the ultrasound tip into the solution, through a coupling medium adjacent to the vial or near the vial, or through an air or gas medium. The ultrasound waves have the effect of destroying the viable virus, bacterium, or other infectious agent and of releasing the appropriate antigens, thus resulting in a vaccine for that virus, bacterium, or other infectious agent.

摘要翻译： 公开了一种使用超声波产生疫苗的方法和装置，其包括超声发生器和换能器以产生超声波。 传感器具有特定的超声尖端，这取决于所使用的递送方式的类型，并且取决于包含病毒，细菌或其它感染因子的溶液的小瓶的形状。 该装置直接通过将超声尖端插入溶液中，通过邻近小瓶或靠近小瓶的耦合介质，或通过空气或气体介质将超声波提供给溶液。 超声波具有破坏活的病毒，细菌或其他感染因子并释放合适的抗原的效果，从而导致该病毒，细菌或其它感染因子的疫苗。

公开(公告)号：US20080243047A1

公开(公告)日：2008-10-02

申请号：US11691969

申请日：2007-03-27

申请人： Eilaz P. Babaev

发明人： Eilaz P. Babaev

IPC分类号： A61M37/00

CPC分类号： A61N7/00 ,  A61B2017/00889 ,  A61L2/0011 ,  A61L2/025

摘要： The present invention relates to a method of treating wounds by applying ultrasonic energy to a wound to inactivate, destroy, and/or remove infectious agents, and/or deliver a coupling medium to debride, cleanse, and/or sterilize the wound. The device of the present invention comprises an ultrasound generator, an ultrasound transducer, a transducer tip at the distal end of the ultrasound transducer, and a radiation surface tilted with respect to the longitudinal axis of the transducer tip. Ultrasonic waves emanating from the tilted radiation surface of the present invention may travel through the air directly to the wound, and/or may be applied to the wound through a coupling medium.

摘要翻译： 本发明涉及一种通过向伤口施加超声波能量来灭活，破坏和/或去除感染剂和/或递送耦合介质来清创，清洁和/或消毒伤口来治疗伤口的方法。 本发明的装置包括超声波发生器，超声波换能器，超声换能器的远端处的换能器尖端以及相对于换能器尖端的纵向轴线倾斜的辐射表面。 从本发明的倾斜辐射表面发出的超声波可以直接穿过空气直到伤口，和/或可通过耦合介质施加到伤口。