公开(公告)号：US20230279147A1

公开(公告)日：2023-09-07

申请号：US18054427

申请日：2022-11-10

Applicant: Aelan Cell Technologies, Inc.

Inventor： Victoria V. LUNYAK ,  James Robert TOLLERVEY

IPC: C07K16/44

CPC classification number: C07K16/44 ,  A61K2039/505

Abstract: Provided herein are antibodies that specifically bind a protein comprising an H1.0K180me2 antigen or a peptide thereof, methods of making such antibodies, and methods of using such antibodies for therapeutics and diagnostics.

公开(公告)号：US20190322729A1

公开(公告)日：2019-10-24

申请号：US16164676

申请日：2018-10-18

Applicant: Aelan Cell Technologies, Inc.

Inventor： Victoria LUNYAK ,  James Robert TOLLERVEY

IPC: C07K16/18 ,  C07K14/47 ,  G01N33/68

Abstract: Provided herein are H1.0K180me2 antibodies, H1.0K180me2 proteins, and H1.0K180me2 peptides and methods of use for diagnostics and therapeutics. These H1.0K180me2 antibodies, H1.0K180me2 proteins, and H1.0K180me2 peptides may be used in the treatment of methylated H1.0-related diseases or conditions in an individual. These H1.0K180me2 antibodies, H1.0K180me2 proteins, and H1.0K180me2 peptides may also be used for the detection and quantification of a histone H1.0 protein or fragment thereof, comprising a dimethylated lysine at lysine residue 180 (H1.0K180me2); such compositions and methods are useful for detecting replicative senescence, DNA damage, genotoxic stress, radiation exposure, Alzheimer's disease, are useful for monitoring therapeutic regimens, patient stratification, drug screening, and may serve as a marker of biological aging in a system.

公开(公告)号：US20190234948A1

公开(公告)日：2019-08-01

申请号：US16164701

申请日：2018-10-18

Applicant: Aelan Cell Technologies, Inc.

Inventor： Victoria LUNYAK ,  James Robert TOLLERVEY

IPC: G01N33/573 ,  C12N9/10 ,  G01N33/543

CPC classification number: G01N33/573 ,  C07K14/47 ,  C12N9/1007 ,  C12P21/02 ,  C12P21/06 ,  C12Y201/01 ,  C12Y201/01043 ,  G01N33/54306

Abstract: Provided herein are compositions and methods related to the production and detection of a histone H1.0 protein dimethylated at lysine residue 180 (K180) (H1.0K180me2 protein) or a histone H1.0 peptide dimethylated at a lysine residue corresponding to K180 (H1.0K180me2 peptides). The H1.0K180me2 protein and H1.0K180me2 peptides are useful for applications including, but not limited to, molecular diagnostics of DNA damage, genotoxic stress, radiation exposure, and Alzheimer's disease, therapeutics, monitoring of therapeutic regimens, patient stratification, and drug screening. Also provided herein are antibodies specific for the H1.0K180me2 protein and H1.0K180me2 peptides.

公开(公告)号：US20240255509A1

公开(公告)日：2024-08-01

申请号：US18506086

申请日：2023-11-09

Applicant: Aelan Cell Technologies, Inc.

Inventor： Victoria LUNYAK ,  James Robert TOLLERVEY

IPC: G01N33/573 ,  C07K14/47 ,  C07K16/18 ,  C12N9/10 ,  C12P21/02 ,  C12P21/06 ,  G01N33/543 ,  G01N33/68

CPC classification number: G01N33/573 ,  C07K14/47 ,  C07K16/18 ,  C12N9/1007 ,  C12P21/02 ,  C12P21/06 ,  C12Y201/01043 ,  G01N33/54306 ,  G01N33/6896 ,  C12Y201/01 ,  G01N2800/2821 ,  G01N2800/50

Abstract: Provided herein are H1.0K180me2 antibodies, H1.0K180me2 proteins, and H1.0K180me2 peptides and methods of use for diagnostics and therapeutics. These H1.0K180me2 antibodies, H1.0K180me2 proteins, and H1.0K180me2 peptides may be used in the treatment of methylated H1.0-related diseases or conditions in an individual. These H1.0K180me2 antibodies, H1.0K180me2 proteins, and H1.0K180me2 peptides may also be used for the detection and quantification of a histone H1.0 protein or fragment thereof, comprising a dimethylated lysine at lysine residue 180 (H1.0K180me2); such compositions and methods are useful for detecting replicative senescence, DNA damage, genotoxic stress, radiation exposure, Alzheimer's disease, are useful for monitoring therapeutic regimens, patient stratification, drug screening, and may serve as a marker of biological aging in a system.

公开(公告)号：US20210302429A1

公开(公告)日：2021-09-30

申请号：US17175540

申请日：2021-02-12

Applicant: Aelan Cell Technologies, Inc.

Inventor： Victoria LUNYAK ,  James Robert TOLLERVEY

IPC: G01N33/573 ,  C12N9/10 ,  C12P21/06 ,  C07K14/47 ,  C12P21/02 ,  C07K16/18 ,  G01N33/68 ,  G01N33/543

Abstract: Provided herein are compositions and methods related to the production and detection of a histone H1.0 protein dimethylated at lysine residue 180 (K180) (H1.0K180me2 protein) or a histone H1.0 peptide dimethylated at a lysine residue corresponding to K180 (H1.0K180me2 peptides). The H1.0K180me2 protein and H1.0K180me2 peptides are useful for applications including, but not limited to, molecular diagnostics of DNA damage, genotoxic stress, radiation exposure, and Alzheimer's disease, therapeutics, monitoring of therapeutic regimens, patient stratification, and drug screening. Also provided herein are antibodies specific for the H1.0K180me2 protein and H1.0K180me2 peptides.