公开(公告)号：US20150110845A1

公开(公告)日：2015-04-23

申请号：US14511240

申请日：2014-10-10

Applicant: Agency for Science, Technology and Research

Inventor： Yen Nee Tan ,  Yuan Chong Jason Lim ,  Chao Wang ,  Lian Hui Zhang

IPC: A61K33/38 ,  A01N59/16 ,  A61K9/00 ,  A61K31/7088 ,  A61K31/713 ,  A61K9/14 ,  A01N43/90 ,  A01N25/26

CPC classification number: A61K9/0014 ,  A01N59/16 ,  A61K9/5153 ,  A61K31/7088 ,  A61K31/713 ,  A61K31/7135 ,  B82Y5/00 ,  A01N43/90

Abstract: There is provided a polynucleotide-templated metal nanocluster for use in therapy. There is also provided use of a polynucleotide-templated metal nanocluster in the manufacture of a medicament for prophylactically or therapeutically treating a microbial infection as well as a method of prophylactically or therapeutically treating a microbial infection comprising administering to a subject a polynucleotide-templated metal nanocluster. There is also provided an antimicrobial agent comprising a polynucleotide-templated metal nanocluster.

Abstract translation: 提供了用于治疗的多核苷酸模板化金属纳米团簇。 还提供了多核苷酸模板化的金属纳米簇在制备用于预防或治疗微生物感染的药物中的用途以及预防或治疗性治疗微生物感染的方法，包括向受试者施用多核苷酸模板化的金属纳米簇 。 还提供了包含多核苷酸模板化的金属纳米簇的抗微生物剂。

公开(公告)号：US10982138B2

公开(公告)日：2021-04-20

申请号：US15836784

申请日：2017-12-08

Applicant: Agency for Science, Technology and Research

Inventor： Yong Yu ,  Yen Nee Tan

IPC: C09K11/58 ,  C09K11/06

Abstract: The present invention relates to a method for forming a nanocomposite having a core-shell structure, the method comprising the steps of: forming a core comprising a first fluorophore capable of aggregation induced emission, and depositing a second fluorophore capable of aggregation caused quenching onto the surface of the core to form a shell at least partially surrounding the core. The present invention also relates to a nanocomposite obtained by said method, and a method of altering the fluorescence of said nanocomposite. The nanocomposite may exhibit dual emission colours and opposite aggregation fluorescent behaviours.

公开(公告)号：US11248088B2

公开(公告)日：2022-02-15

申请号：US16166017

申请日：2018-10-19

Applicant: Agency for Science, Technology and Research

Inventor： Xin Ting Zheng ,  Yen Nee Tan ,  Victor Hesheng Xu

IPC: A01N37/44 ,  A61K31/787 ,  A61K9/51 ,  B82Y15/00 ,  B82Y40/00 ,  C08G73/02 ,  G01N1/30 ,  B82Y5/00 ,  C08L101/00 ,  A01N37/50 ,  A61K9/14 ,  B82Y30/00

Abstract: The present invention relates to a hybrid nanodot made by a process comprising a step of reacting a mixture of an amino acid and a polymer selected from polycationic polymers or any copolymers or derivatives of these polymers under hydrothermal reaction conditions. The present invention also relates to a process for synthesizing said hybrid nanodots.

公开(公告)号：US20190161579A1

公开(公告)日：2019-05-30

申请号：US16166017

申请日：2018-10-19

Applicant: Agency for Science, Technology and Research

Inventor： Xin Ting Zheng ,  Yen Nee Tan ,  Victor Hesheng Xu

IPC: C08G73/02 ,  G01N1/30 ,  A01N37/44 ,  B82Y5/00 ,  B82Y40/00 ,  B82Y15/00 ,  A61K9/51 ,  A61K31/787

Abstract: The present invention relates to a hybrid nanodot made by a process comprising a step of reacting a mixture of an amino acid and a polymer selected from polycationic polymers or any copolymers or derivatives of these polymers under hydrothermal reaction conditions. The present invention also relates to a process for synthesizing said hybrid nanodots.

公开(公告)号：US20140134609A1

公开(公告)日：2014-05-15

申请号：US13968930

申请日：2013-08-16

Applicant: Agency for Science, Technology and Research

Inventor： Yen Nee Tan ,  Xiaodi Su

IPC: C12Q1/34

CPC classification number: G01N33/542 ,  C12Q1/6816 ,  G01N33/5308 ,  G01N33/54313 ,  C12Q2527/125 ,  C12Q2563/103 ,  C12Q2563/155

Abstract: The present invention provides a colorimetric method for detecting a polynucleotide strand binding molecule using one type of metal particles modified with a single type of interacting molecules. The interacting molecule is capable of specifically binding to nucleic and of protecting the metal particle from aggregation. Furthermore, the metal particles are capable of aggregation upon salt aggregation and/or cleavage of the interacting molecule, and colorimetric change changes upon aggregation.

Abstract translation: 本发明提供了使用一种类型的用单一相互作用分子修饰的金属颗粒检测多核苷酸链结合分子的比色法。 相互作用的分子能够特异性结合核酸并保护金属颗粒免受聚集。 此外，金属颗粒能够在相互作用的分子的盐聚集和/或裂解时聚集，并且在聚集时比色变化发生变化。