公开(公告)号：US11217437B2

公开(公告)日：2022-01-04

申请号：US16298654

申请日：2019-03-11

Applicant: Agilent Technologies, Inc.

Inventor： Kenneth R. Newton ,  Nigel P. Gore ,  Mark Denning

IPC: H01J49/00 ,  H01J49/06 ,  H01J49/08

Abstract: Electron capture dissociation (ECD) is performed by transmitting an electron beam through a cell along an electron beam axis, generating plasma in the cell by energizing a gas with the electron beam, and transmitting an ion beam through the interaction region along an ion beam axis to produce fragment ions. Generating the plasma forms an interaction region in the cell spaced from and not intersecting the electron beam, and including low-energy electrons effective for ECD. The ion beam axis may be at an angle to and offset from the ion beam axis, such that the electron beam does not intersect the ion beam.

公开(公告)号：US10388501B1

公开(公告)日：2019-08-20

申请号：US15959884

申请日：2018-04-23

Applicant: Agilent Technologies, Inc.

Inventor： Maozi Liu ,  Nigel P. Gore

IPC: H01J49/04 ,  H01J49/06 ,  H01J49/24

Abstract: An ion transfer device for transferring ions from a first chamber to a second, reduced-pressure chamber includes a tube and a bore selector. The tube includes a plurality of tube bores. The bore selector is positioned at an inlet end of the tube and includes an inlet port. The tube is movable relative to the bore selector, and/or the bore selector is movable relative to the tube, to align the inlet port with a selected one of the tube bores while blocking the other tube bores. Alignment of the inlet port with the selected tube bore defines an ion transfer path from the first chamber, through the selected tube bore, and to the second chamber. The ion transfer device may be utilized, for example, in an atmospheric-pressure interface of a mass spectrometer.

公开(公告)号：US20190287775A1

公开(公告)日：2019-09-19

申请号：US16298654

申请日：2019-03-11

Applicant: Agilent Technologies, Inc.

Inventor： Kenneth R. Newton ,  Nigel P. Gore ,  Mark Denning

IPC: H01J49/00 ,  H01J49/08 ,  H01J49/06

Abstract: Electron capture dissociation (ECD) is performed by transmitting an electron beam through a cell along an electron beam axis, generating plasma in the cell by energizing a gas with the electron beam, and transmitting an ion beam through the interaction region along an ion beam axis to produce fragment ions. Generating the plasma forms an interaction region in the cell spaced from and not intersecting the electron beam, and including low-energy electrons effective for ECD. The ion beam axis may be at an angle to and offset from the ion beam axis, such that the electron beam does not intersect the ion beam.

公开(公告)号：US09673032B1

公开(公告)日：2017-06-06

申请号：US15087312

申请日：2016-03-31

Applicant: Agilent Technologies, Inc.

Inventor： Arthur Schleifer ,  Nigel P. Gore

IPC: H01J49/10 ,  H01J49/04 ,  H01J49/14 ,  H01J49/34

CPC classification number: H01J49/045

Abstract: A sample sprayer includes a first conduit for conducting a liquid sample, a second conduit surrounding the first conduit to define an annular passage for conducting a gas, a sprayer tip in which a fluid interaction region receives the liquid sample and the gas. The sprayer tip is configured to produce a sample spray by contact between the liquid sample and the gas in the fluid interaction region and emit the sample spray from the orifice. An adjustable positioning device is configured to translate the first conduit along the longitudinal axis in response to adjustment of the positioning device, wherein an axial position of the first conduit is adjustable relative to the orifice.