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公开(公告)号：US20180068840A1
公开(公告)日：2018-03-08
申请号：US15256626
申请日：2016-09-05
Applicant: Agilent Technologies, Inc.
Inventor： Kenneth R. Newton
CPC classification number: H01J49/0404 , H01J49/145 , H01J49/24
Abstract: An ion transfer device for transferring ions from one chamber to another, reduced-pressure chamber includes an inlet section and a main capillary section. The inlet section has a lumen and the main capillary section has a bore communicating with the lumen. The inside diameter of the lumen is less than that of the bore. The inlet section may be removable from an installation site separately from the main capillary section. The ion transfer device may be utilized, for example, in an atmospheric-pressure interface of a mass spectrometer.
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2.发明授权Thin field terminator for linear quadrupole ion guides, and related systems and methods 有权用于线性四极离子导向器的薄场终止器，以及相关的系统和方法公开(公告)号：US09536723B1
公开(公告)日：2017-01-03
申请号：US14615889
申请日：2015-02-06
Applicant: Agilent Technologies, Inc.
Inventor： James L. Bertsch , Kenneth R. Newton
CPC classification number: H01J49/063 , H01J3/18 , H01J49/067 , H01J49/26 , H01J49/4215
Abstract: A field terminator includes a plurality of electrode plates positioned around a guide axis at a radial distance therefrom. The plates generate a quadrupole DC field such that a polarity on each plate is opposite to a polarity on the plates adjacent thereto. The plates may be positioned at an axial end of a quadrupole ion guide such as a mass filter. In addition to an RF field, the ion guide may generate a quadrupole DC field. The DC field of the plates may be opposite in polarity to that of the ion guide.
Abstract translation: 场终止器包括多个电极板，定位在引导轴线的径向距离处。 板产生四极DC场，使得每个板上的极性与相邻的板上的极性相反。 板可以位于四极离子导向器的轴向端部，例如质量过滤器。 除了RF场之外，离子导向器可以产生四极DC场。 板的DC场可能与离子导向器的极性相反。
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3.发明授权Plasma-based electron capture dissociation (ECD) apparatus and related systems and methods 有权基于等离子体的电子捕获解离（ECD）装置及相关系统和方法公开(公告)号：US09105454B2
公开(公告)日：2015-08-11
申请号：US14483462
申请日：2014-09-11
Applicant: Agilent Technologies, Inc.
Inventor： Trygve Ristroph , Mark Denning , Kenneth R. Newton , Guthrie Partridge
CPC classification number: H01J49/0054 , H05H1/24 , H05H1/2406 , H05H2001/4645 , H05H2001/481
Abstract: An electron capture dissociation (ECD) apparatus includes a plasma source for generating plasma. Analyte ions are exposed to the plasma in an ECD interaction region, either inside or outside the plasma source. The apparatus may include one or more devices for refining the plasma in preparation for interaction with the analyte ions. Refining may entail removing unwanted species from the plasma, such as photons, metastable particles, neutral particles, and/or high-energy electrons unsuitable for ECD, and/or controlling a density of low-energy electrons in the plasma.
Abstract translation: 电子捕获离解（ECD）装置包括用于产生等离子体的等离子体源。 分析离子在等离子体源的内部或外部的ECD相互作用区域中暴露于等离子体。 该装置可以包括用于精制等离子体以准备与分析物离子相互作用的一个或多个装置。 精炼可能需要从等离子体中除去不想要的物质，例如不适合于ECD的光子，亚稳颗粒，中性粒子和/或高能电子，和/或控制等离子体中低能电子的密度。
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公开(公告)号：US08637816B1
公开(公告)日：2014-01-28
申请号：US13827685
申请日：2013-03-14
Applicant: Agilent Technologies, Inc.
Inventor： Alexander Mordehai , Kenneth R. Newton
CPC classification number: H01J49/02 , H01J49/004 , H01J49/40 , H01J49/429
Abstract: A mass spectrum is acquired by accumulating parent ions in an ion trap, ejecting parent ions of a selected m/z ratio into a collision cell, producing fragment ions from the parent ions, and analyzing the fragment ions in a mass analyzer. The other parent ions remain stored in the ion trap, and thus the process may be repeated by mass-selectively scanning parent ions from the ion trap. In this manner, the full mass range of parent ions or any desired subset of the full mass range may be analyzed without significant ion loss or undue time expenditure. The collision cell may provide a large ion acceptance aperture and relatively smaller ion emission aperture. The collision cell may pulse ions out to the mass analyzer. The mass analyzer may be a time-of-flight analyzer. The timing of pulsing of ions out from the collision cell may be matched with the timing of pulsing of ions into the time-of-flight analyzer.
Abstract translation: 通过在离子阱中积聚母体离子获得质谱，将所选择的m / z比的母体离子喷射到碰撞池中，从母体离子产生碎片离子，并分析质量分析器中的碎片离子。 其他母体离子保留在离子阱中，因此可以通过从离子阱中大量选择性地扫描母体离子来重复该过程。 以这种方式，可以分析母体离子的全质量范围或完全质量范围的任何所需子集，而没有显着的离子损失或不适当的时间支出。 碰撞池可以提供大的离子接受孔和相对较小的离子发射孔。 碰撞单元可以将离子脉冲输出到质量分析器。 质量分析仪可以是飞行时间分析仪。 从碰撞池中脉冲离子的时间可以与离子脉冲到飞行时间分析仪的时间相匹配。
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公开(公告)号：US20230343574A1
公开(公告)日：2023-10-26
申请号：US17730032
申请日：2022-04-26
Applicant: Agilent Technologies, Inc.
Inventor： Kai Chen , Kenneth R. Newton , Christian Wisner-Carlson
CPC classification number: H01J49/4215 , H01J49/0031 , H01J49/0045
Abstract: A quadrupole transmitting window applied by a quadrupole mass filter is characterized by a method that utilizes the noise band of a transmitted chemical noise ion signal. The mass filter may be utilized in a mass spectrometry (MS) system.
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Patent Agency Ranking
6.发明授权公开(公告)号：US11217437B2
公开(公告)日：2022-01-04
申请号：US16298654
申请日：2019-03-11
Applicant: Agilent Technologies, Inc.
Inventor： Kenneth R. Newton , Nigel P. Gore , Mark Denning
Abstract: Electron capture dissociation (ECD) is performed by transmitting an electron beam through a cell along an electron beam axis, generating plasma in the cell by energizing a gas with the electron beam, and transmitting an ion beam through the interaction region along an ion beam axis to produce fragment ions. Generating the plasma forms an interaction region in the cell spaced from and not intersecting the electron beam, and including low-energy electrons effective for ECD. The ion beam axis may be at an angle to and offset from the ion beam axis, such that the electron beam does not intersect the ion beam.
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公开(公告)号：US20140034827A1
公开(公告)日：2014-02-06
申请号：US13827685
申请日：2013-03-14
Applicant: AGILENT TECHNOLOGIES, INC.
Inventor： Alexander Mordehai , Kenneth R. Newton
CPC classification number: H01J49/02 , H01J49/004 , H01J49/40 , H01J49/429
Abstract: A mass spectrum is acquired by accumulating parent ions in an ion trap, ejecting parent ions of a selected m/z ratio into a collision cell, producing fragment ions from the parent ions, and analyzing the fragment ions in a mass analyzer. The other parent ions remain stored in the ion trap, and thus the process may be repeated by mass-selectively scanning parent ions from the ion trap. In this manner, the full mass range of parent ions or any desired subset of the full mass range may be analyzed without significant ion loss or undue time expenditure. The collision cell may provide a large ion acceptance aperture and relatively smaller ion emission aperture. The collision cell may pulse ions out to the mass analyzer. The mass analyzer may be a time-of-flight analyzer. The timing of pulsing of ions out from the collision cell may be matched with the timing of pulsing of ions into the time-of-flight analyzer.
Abstract translation: 通过在离子阱中积聚母体离子获得质谱，将所选择的m / z比的母体离子喷射到碰撞池中，从母体离子产生碎片离子，并分析质量分析器中的碎片离子。 其他母体离子保留在离子阱中，因此可以通过从离子阱中大量选择性地扫描母体离子来重复该过程。 以这种方式，可以分析母体离子的全质量范围或完全质量范围的任何所需子集，而没有显着的离子损失或不适当的时间支出。 碰撞池可以提供大的离子接受孔和相对较小的离子发射孔。 碰撞单元可以将离子脉冲输出到质量分析器。 质量分析仪可以是飞行时间分析仪。 从碰撞池中脉冲离子的时间可以与离子脉冲到飞行时间分析仪的时间相匹配。
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8.发明申请公开(公告)号：US20190287775A1
公开(公告)日：2019-09-19
申请号：US16298654
申请日：2019-03-11
Applicant: Agilent Technologies, Inc.
Inventor： Kenneth R. Newton , Nigel P. Gore , Mark Denning
Abstract: Electron capture dissociation (ECD) is performed by transmitting an electron beam through a cell along an electron beam axis, generating plasma in the cell by energizing a gas with the electron beam, and transmitting an ion beam through the interaction region along an ion beam axis to produce fragment ions. Generating the plasma forms an interaction region in the cell spaced from and not intersecting the electron beam, and including low-energy electrons effective for ECD. The ion beam axis may be at an angle to and offset from the ion beam axis, such that the electron beam does not intersect the ion beam.
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公开(公告)号：US10103014B2
公开(公告)日：2018-10-16
申请号：US15256626
申请日：2016-09-05
Applicant: Agilent Technologies, Inc.
Inventor： Kenneth R. Newton
Abstract: An ion transfer device for transferring ions from one chamber to another, reduced-pressure chamber includes an inlet section and a main capillary section. The inlet section has a lumen and the main capillary section has a bore communicating with the lumen. The inside diameter of the lumen is less than that of the bore. The inlet section may be removable from an installation site separately from the main capillary section. The ion transfer device may be utilized, for example, in an atmospheric-pressure interface of a mass spectrometer.
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10.发明授权Dual field multipole converging ion guides, hyperbolic ion guides, and related methods 有权双场多极会聚离子导向器，双曲线离子导向器及相关方法公开(公告)号：US09449804B2
公开(公告)日：2016-09-20
申请号：US14538382
申请日：2014-11-11
Applicant: Agilent Technologies, Inc.
Inventor： James L. Bertsch , Kenneth R. Newton , Layne Howard
CPC classification number: H01J49/063 , H01J49/068
Abstract: An ion guide generates a first RF field of Nth order where N is an integer equal to or greater than 2, and a second RF field of 2Nth order superimposed on the first RF field. The first and second RF fields may be generated by respective first and second sets of electrodes. Another ion guide may include a converging entrance section followed by an exit section. The converging section may have a hyperbolic profile. A hyperbolic profile may be presented by electrodes having a twisted configuration relative to an ion guide axis.
Abstract translation: 离子导向器产生N等于或大于2的整数的N阶的第一RF场，以及叠加在第一RF场上的第2N次的第二RF场。 第一和第二RF场可以由相应的第一和第二组电极产生。 另一个离子导向器可以包括会聚进口部分，随后是出口部分。 收敛部分可以具有双曲线轮廓。 双曲线轮廓可以由具有相对于离子导向轴线的扭曲构造的电极呈现。
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