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    Method and Apparatus for Manipulating Samples Using Optoelectronic Forces
    1.
    发明申请
    Method and Apparatus for Manipulating Samples Using Optoelectronic Forces 审中-公开
    使用光电力来操作样品的方法和装置

    公开(公告)号：US20150346148A1

    公开(公告)日：2015-12-03

    申请号：US14289405

    申请日：2014-05-28

    Applicant: Agilent Technologies, Inc. ,  Agilent Technologies, Inc.

    Inventor： Curt A. Flory ,  Arthur Schleifer

    IPC: G01N27/447

    CPC classification number: B03C5/028

    Abstract: An apparatus for controlling the motion of a particle and a method for using the same are disclosed. The apparatus includes a channel containing liquid between first and second electrodes. The apparatus also includes an array of variable impedance elements, each variable impedance element connecting the first electrode to a corresponding location in the channel by a path having an average impedance that is continuously variable between first and second impedances when averaged over an update time interval. A controller sets the average impedance of each of the variable impedance elements such that a particle in the channel moves in a predetermined direction when voltage is applied between the first and second electrodes. At least one of the variable impedance elements has an average impedance that is intermediate between the first and second impedances.

    Abstract translation: 公开了一种用于控制颗粒运动的装置及其使用方法。 该装置包括在第一和第二电极之间包含液体的通道。 该装置还包括可变阻抗元件的阵列，每个可变阻抗元件通过具有在更新时间间隔上平均的第一和第二阻抗之间可连续变化的平均阻抗的路径将第一电极连接到通道中的对应位置。 控制器设置每个可变阻抗元件的平均阻抗，使得当在第一和第二电极之间施加电压时，通道中的粒子沿预定方向移动。 至少一个可变阻抗元件具有介于第一和第二阻抗之间的平均阻抗。

    Sample sprayer with adjustable conduit and related methods
    2.
    发明授权
    Sample sprayer with adjustable conduit and related methods 有权

    公开(公告)号：US09673032B1

    公开(公告)日：2017-06-06

    申请号：US15087312

    申请日：2016-03-31

    Applicant: Agilent Technologies, Inc.

    Inventor： Arthur Schleifer ,  Nigel P. Gore

    IPC: H01J49/10 ,  H01J49/04 ,  H01J49/14 ,  H01J49/34

    CPC classification number: H01J49/045

    Abstract: A sample sprayer includes a first conduit for conducting a liquid sample, a second conduit surrounding the first conduit to define an annular passage for conducting a gas, a sprayer tip in which a fluid interaction region receives the liquid sample and the gas. The sprayer tip is configured to produce a sample spray by contact between the liquid sample and the gas in the fluid interaction region and emit the sample spray from the orifice. An adjustable positioning device is configured to translate the first conduit along the longitudinal axis in response to adjustment of the positioning device, wherein an axial position of the first conduit is adjustable relative to the orifice.

    Systems and methods for transferring liquids
    4.
    发明授权
    Systems and methods for transferring liquids 有权

    公开(公告)号：US10761104B2

    公开(公告)日：2020-09-01

    申请号：US15593228

    申请日：2017-05-11

    Applicant: Agilent Technologies, Inc.

    Inventor： Reid A. Brennen ,  Bo Curry ,  Joel Myerson ,  Paige Anderson ,  Arthur Schleifer ,  Rolfe Anderson

    IPC: G01N35/00 ,  G01N35/10 ,  C12N15/10

    Abstract: One or more liquids are transferred from a source array to one or more remotely positioned destination sites such as chambers by utilizing one or more movable transfer elements, such as contact pins or capillaries. The source array may include a predetermined organization of addresses at which materials are positioned. One or more materials may be selected for transfer. Based on the selection, one or more addresses may be accessed by the transfer element(s). The addresses may correspond to spots on a surface of the source array. Each spot may be a feature containing one or more (bio)chemical compounds. At the chamber(s), the material(s) may be processed, such by reaction with one or more reagents. The reaction(s) may entail synthesis of one or more desired products. Alternatively, reaction(s) may be performed at the source array, and the product(s) then transferred to the chamber(s).

    SYSTEMS AND METHODS FOR TRANSFERRING LIQUIDS
    5.
    发明申请
    SYSTEMS AND METHODS FOR TRANSFERRING LIQUIDS 审中-公开

    公开(公告)号：US20170328928A1

    公开(公告)日：2017-11-16

    申请号：US15593228

    申请日：2017-05-11

    Applicant: Agilent Technologies, Inc.

    Inventor： Reid A. Brennen ,  Bo Curry ,  Joel Myerson ,  Paige Anderson ,  Arthur Schleifer ,  Rolfe Anderson

    IPC: G01N35/10 ,  G01N35/00 ,  C12N15/10

    CPC classification number: G01N35/1074 ,  G01N35/1009 ,  G01N35/1065 ,  G01N2035/1037 ,  G01N2035/1039 ,  G01N2035/1044

    Abstract: One or more liquids are transferred from a source array to one or more remotely positioned destination sites such as chambers by utilizing one or more movable transfer elements, such as contact pins or capillaries. The source array may include a predetermined organization of addresses at which materials are positioned. One or more materials may be selected for transfer. Based on the selection, one or more addresses may be accessed by the transfer element(s). The addresses may correspond to spots on a surface of the source array. Each spot may be a feature containing one or more (bio)chemical compounds. At the chamber(s), the material(s) may be processed, such by reaction with one or more reagents. The reaction(s) may entail synthesis of one or more desired products. Alternatively, reaction(s) may be performed at the source array, and the product(s) then transferred to the chamber(s).

    Sample atomization with reduced clogging for analytical instruments
    8.
    发明授权
    Sample atomization with reduced clogging for analytical instruments 有权
    样品雾化与分析仪器堵塞减少

    公开(公告)号：US09165751B1

    公开(公告)日：2015-10-20

    申请号：US14298753

    申请日：2014-06-06

    Applicant: Agilent Technologies, Inc.

    Inventor： Arthur Schleifer

    IPC: H01J49/04 ,  H01J49/10 ,  H01J49/26 ,  G01J3/443 ,  G01N1/28 ,  B05B7/04

    CPC classification number: B05B7/0416 ,  G01N1/28 ,  G01N1/38 ,  H01J49/045

    Abstract: An aerosol is produced by flowing a liquid sample through a gas-assisted nebulizer. The liquid exits from an outlet into a coaxial flow of gas. The outlet includes a sharp edge that inhibits or prevents accumulation of precipitates from the liquid, thereby reducing or eliminating clogging, which is particularly useful for a samples containing high concentrations of dissolved particles. The aerosol may be introduced into a plasma such that molecules are broken into atoms. The atomization may be followed by an analysis such as by optical emission spectrometry or mass spectrometry.

    Abstract translation: 通过使液体样品流过气体辅助雾化器来产生气溶胶。 液体从出口流入同轴气流。 出口包括尖锐边缘，其抑制或防止沉淀物从液体中积聚，从而减少或消除堵塞，这对含有高浓度溶解颗粒的样品特别有用。 气溶胶可以被引入等离子体，使得分子被分解成原子。 雾化后可以进行分析，例如通过光发射光谱法或质谱法。

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