公开(公告)号：US5352704A

公开(公告)日：1994-10-04

申请号：US963528

申请日：1992-10-20

申请人： Akira Okuyama ,  Kyozo Naito ,  Hidetoshi Ogino ,  Toshio Nagase ,  Kiyofumi Ishikawa ,  Nobuo Tanaka

发明人： Akira Okuyama ,  Kyozo Naito ,  Hidetoshi Ogino ,  Toshio Nagase ,  Kiyofumi Ishikawa ,  Nobuo Tanaka

IPC分类号： C07C279/18 ,  A61K31/165 ,  C07C233/64

CPC分类号： C07C279/18

摘要： A guanidinobenzene derivative represented by the formula (I): ##STR1## wherein R.sup.1 represents a substituent selected from the group consisting of a phenyl group substituted by an amidino group and a naphthyl group substituted by an amidino group, and salt thereof; a process for the production thereof; and an antiviral pharmaceutical composition comprising the compound.

摘要翻译： 由式（I）表示的胍基苯衍生物：其中R1表示选自被脒基取代的苯基和被脒基取代的萘基的取代基及其盐; 一种生产过程; 和包含该化合物的抗病毒药物组合物。

公开(公告)号：US5391486A

公开(公告)日：1995-02-21

申请号：US720828

申请日：1991-07-11

申请人： Akira Okuyama ,  Nobuo Kanbayashi ,  Kyozo Naito ,  Hajime Suzuki ,  Shigeru Nakajima ,  Hiroyuki Suda ,  Masanori Okanishi

发明人： Akira Okuyama ,  Nobuo Kanbayashi ,  Kyozo Naito ,  Hajime Suzuki ,  Shigeru Nakajima ,  Hiroyuki Suda ,  Masanori Okanishi

IPC分类号： A61K38/00 ,  C07K5/06 ,  C07C229/08 ,  C12N1/20 ,  C12P21/02

CPC分类号： C12R1/465 ,  C07K5/06069 ,  A61K38/00

摘要： The present invention relates to new stromelysin (human)-inhibitors, i.e., physiologically active substances BE-16627 represented by the general formula: ##STR1## wherein R represents a hydrogen atom or a methyl group, or pharmaceutically acceptable salts thereof, a process for the production and use thereof, and a microorganism producing the substance BE-16627.

摘要翻译： 本发明涉及新的基质溶素（人）抑制剂，即由以下通式表示的生理活性物质BE-16627：其中R表示氢原子或甲基，或药学上可接受的 其盐，其生产和使用的方法，以及产生物质BE-16627的微生物。

公开(公告)号：US4990537A

公开(公告)日：1991-02-05

申请号：US369029

申请日：1989-06-21

申请人： Akira Okuyama ,  Akira Someya ,  Takashi Murai ,  Nobuo Tanaka

发明人： Akira Okuyama ,  Akira Someya ,  Takashi Murai ,  Nobuo Tanaka

IPC分类号： A61K31/245

CPC分类号： A61K31/245

摘要： An antiviral agent which comprises a p-guanidinobenzoic acid derivative of the formula: ##STR1## wherein R is ##STR2## or its non-toxic salt as an active ingredient.

公开(公告)号：US20090207548A1

公开(公告)日：2009-08-20

申请号：US11884488

申请日：2006-02-20

申请人： Takafumi Seto ,  Makoto Hirasawa ,  Masaaki Tsuji ,  Akira Okuyama ,  Susumu Saito

发明人： Takafumi Seto ,  Makoto Hirasawa ,  Masaaki Tsuji ,  Akira Okuyama ,  Susumu Saito

IPC分类号： H01T23/00

CPC分类号： H01T23/00

摘要： An ion generating element capable of cost reduction and space saving while exhibiting a high generation efficiency of positive ions and negative ions and stabilized generation capacity with less variation, and an ion generator and a neutralizer employing it. The ion generating element comprises a dielectric body having at least two faces, at least two discharge electrodes arranged on the at least two faces of the dielectric body, and an induction electrode arranged in the dielectric body and subjected to the action of the at least two discharge electrodes and is characterized in that positive ions and negative ions are generated on the body, and ions are generated from the at least two faces of the dielectric body through discharge generated because of the potential difference between the discharge electrode of the ion generating element and the induction electrode when a drive voltage is applied between them.

摘要翻译： 一种离子发生元件，其能够显着提高正离子和负离子的发电效率，并且具有较小变化的稳定的发电容量，并且使用离子发生器和使用其的中和器能够节省成本并节约空间。 离子产生元件包括具有至少两个表面的电介质体，布置在电介质体的至少两个表面上的至少两个放电电极，以及布置在电介质体中并受到至少两个 放电电极，其特征在于，在体上产生正离子和负离子，并且通过由于离子产生元件的放电电极和放电电极之间的电位差而产生的放电产生离子从电介质体的至少两个面产生 当在它们之间施加驱动电压时，感应电极。

公开(公告)号：US07612981B2

公开(公告)日：2009-11-03

申请号：US12010928

申请日：2008-01-31

申请人： Takafumi Seto ,  Makoto Hirasawa ,  Yasufumi Hozumi ,  Masaaki Tsuji ,  Akira Okuyama ,  Susumu Saito

发明人： Takafumi Seto ,  Makoto Hirasawa ,  Yasufumi Hozumi ,  Masaaki Tsuji ,  Akira Okuyama ,  Susumu Saito

IPC分类号： H01T23/00 ,  G03G15/02 ,  H05F3/00

CPC分类号： A61L9/22 ,  H01T23/00

摘要： The present invention is relating to an ion generator and an ionizer, in which the ion generator can obtain stable ion generation even if the electrode and the power supply slightly change, satisfies voltage and frequency conditions for realizing an ozone concentration less than 50 ppb as an allowable concentration. The ion generator of the present invention is characterized as a fan-type ion generator including a dielectric body, a discharge electrode having fine protrusions arranged on the surface of this dielectric body, and an induction electrode arranged on the back surface of the dielectric body, comprising: an ion element in which by applying a sinusoidal AC high voltage to the discharge electrode, a potential difference from the induction electrode is generated, plasma is formed on the surface of the dielectric body, and positive ions, negative ions, and ozone are produced according to air ionization; and a fan which generates an airflow with respect to the discharge electrode, wherein the peak-to-peak voltage is not less than 3.5 kV and not more than 7 kV, the frequency f, and the relationship between the voltage V and the frequency f satisfies a specific parameter. And, the ionizer of the present invention is characterized that ionization is performed by using the above mentioned fan-type ion generator.

摘要翻译： 本发明涉及一种离子发生器和离子发生器，其中即使电极和电源稍微改变，离子发生器也可获得稳定的离子产生，满足用于实现小于50ppb的臭氧浓度的电压和频率条件，作为 容许浓度 本发明的离子发生器的特征在于：一种风扇式离子发生器，其包括电介质体，具有设置在该电介质体表面上的微细突起的放电电极，以及布置在电介质体的背面上的感应电极， 包括：离子元件，其中通过向放电电极施加正弦AC高电压，产生与感应电极的电位差，在电介质体的表面上形成等离子体，正离子，负离子和臭氧为 根据空气电离产生; 以及相对于放电电极产生气流的风扇，其峰值电压不小于3.5kV且不大于7kV，频率f以及电压V与频率f之间的关系 满足特定参数。 并且，本发明的电离器的特征在于，使用上述风扇式离子发生器进行离子化。

公开(公告)号：US20090027825A1

公开(公告)日：2009-01-29

申请号：US12224564

申请日：2006-03-03

申请人： Takafumi Seto ,  Makoto Hirasawa ,  Masaaki Tsuji ,  Akira Okuyama ,  Susumu Saito

发明人： Takafumi Seto ,  Makoto Hirasawa ,  Masaaki Tsuji ,  Akira Okuyama ,  Susumu Saito

IPC分类号： H05F3/06 ,  H01J27/02

CPC分类号： H01T23/00 ,  B03C3/383 ,  B03C2201/10 ,  B03C2201/24 ,  B03C2201/32

摘要： A neutralization apparatus comprising an ion generation element employing a novel, high efficiency discharge system capable of generating high concentration ions with a low ozone concentration. In the neutralization apparatus, the ion generation element is a minute electrode ion generation element consisting of a discharge electrode and an induction electrode having minute protrusions arranged in one direction on a plane, and a thin dielectric film sandwiched between them. The ion generation element is constituted of a set of a minute electrode ion generation element for generating positive ions and a minute electrode ion generation element for generating negative ions, characterized in that at least one or more ion generating elements are disposed so that the plane including each discharge electrode is parallel with the direction of gas flow and discharge electrodes are arranged perpendicularly to the direction of gas flow, and balanced control of positive and negative ions can be carried out at a position on the downstream side of gas flow by regulating a voltage applied to the discharge electrode of the ion generation element.

摘要翻译： 一种中和装置，其包括使用能够产生臭氧浓度低的高浓度离子的新型高效率放电系统的离子发生元件。 在中和装置中，离子产生元件是由放电电极和感应电极构成的微小电极离子产生元件，其具有在一个方向上沿平面布置的微小突起，以及夹在它们之间的薄电介质膜。 离子产生元件由一组用于产生正离子的微小电极离子产生元件和用于产生负离子的微小电极离子产生元件组成，其特征在于，至少一个或多个离子产生元件被设置成使得包括 每个放电电极与气体流动的方向平行，并且放电电极垂直于气流方向布置，并且可以通过调节电压在气流的下游侧的位置处进行正负离子的平衡控制 施加到离子产生元件的放电电极。

公开(公告)号：US20080191146A1

公开(公告)日：2008-08-14

申请号：US12010928

申请日：2008-01-31

申请人： Takafumi Seto ,  Makoto Hirasawa ,  Yasufumi Hozumi ,  Masaaki Tsuji ,  Akira Okuyama ,  Susumu Saito

发明人： Takafumi Seto ,  Makoto Hirasawa ,  Yasufumi Hozumi ,  Masaaki Tsuji ,  Akira Okuyama ,  Susumu Saito

IPC分类号： H01J27/00

CPC分类号： A61L9/22 ,  H01T23/00

摘要： The present invention is relating to an ion generator and an ionizer, in which the ion generator can obtain stable ion generation even if the electrode and the power supply slightly change, satisfies voltage and frequency conditions for realizing an ozone concentration less than 50 ppb as an allowable concentration. The ion generator of the present invention is characterized as a fan-type ion generator including a dielectric body, a discharge electrode having fine protrusions arranged on the surface of this dielectric body, and an induction electrode arranged on the back surface of the dielectric body, comprising: an ion element in which by applying a sinusoidal AC high voltage to the discharge electrode, a potential difference from the induction electrode is generated, plasma is formed on the surface of the dielectric body, and positive ions, negative ions, and ozone are produced according to air ionization; and a fan which generates an airflow with respect to the discharge electrode, wherein the peak-to-peak voltage is not less than 3.5 kV and not more than 7 kV, the frequency f, and the relationship between the voltage V and the frequency f satisfies a specific parameter. And, the ionizer of the present invention is characterized that ionization is performed by using the above mentioned fan-type ion generator.

摘要翻译： 本发明涉及一种离子发生器和离子发生器，其中即使电极和电源稍微改变，离子发生器也可获得稳定的离子产生，满足用于实现小于50ppb的臭氧浓度的电压和频率条件，作为 容许浓度 本发明的离子发生器的特征在于：一种风扇式离子发生器，其包括电介质体，具有设置在该电介质体表面上的微细突起的放电电极，以及布置在电介质体的背面上的感应电极， 包括：离子元件，其中通过向放电电极施加正弦AC高电压，产生与感应电极的电位差，在电介质体的表面上形成等离子体，正离子，负离子和臭氧为 根据空气电离产生; 以及相对于放电电极产生气流的风扇，其峰值电压不小于3.5kV且不大于7kV，频率f以及电压V与频率f之间的关系 满足特定参数。 并且，本发明的电离器的特征在于，使用上述风扇式离子发生器进行离子化。

公开(公告)号：US06981698B2

公开(公告)日：2006-01-03

申请号：US10384972

申请日：2003-03-10

申请人： Takahito Yamamiya ,  Akira Okuyama

发明人： Takahito Yamamiya ,  Akira Okuyama

IPC分类号： B65H5/00

CPC分类号： G07F11/14 ,  G07F11/045 ,  G07F11/24

摘要： An automatic dispensing machine of substantially flat goods is provided which detects the over-dispensing of goods while accommodating for varying thickness of the substantially flat goods. The automatic dispensing machine includes a table which supports goods such as cards, a suctioning device which pulls the cards, a transporting device which transports the cards after they are pulled by the suctioning device, a position-control device which controls the distance between the uppermost card and the suctioning device. The position-control device is configured to increase the distance between the uppermost card and the suctioning device based on a dispensing signal. The distance between the uppermost card and the suctioning device is then decreased until a predetermined distance is reached.

公开(公告)号：US07965487B2

公开(公告)日：2011-06-21

申请号：US12224564

申请日：2006-03-03

申请人： Takafumi Seto ,  Makoto Hirasawa ,  Masaaki Tsuji ,  Akira Okuyama ,  Susumu Saito

发明人： Takafumi Seto ,  Makoto Hirasawa ,  Masaaki Tsuji ,  Akira Okuyama ,  Susumu Saito

IPC分类号： H02H3/00 ,  H02H3/04 ,  G03G15/02

CPC分类号： H01T23/00 ,  B03C3/383 ,  B03C2201/10 ,  B03C2201/24 ,  B03C2201/32

摘要： A neutralization apparatus comprising an ion generation element employing a novel, high efficiency discharge system capable of generating high concentration ions with a low ozone concentration. In the neutralization apparatus, the ion generation element is a minute electrode ion generation element consisting of a discharge electrode and an induction electrode having minute protrusions arranged in one direction on a plane, and a thin dielectric film sandwiched between them. The ion generation element is constituted of a set of a minute electrode ion generation element for generating positive ions and a minute electrode ion generation element for generating negative ions, characterized in that at least one or more ion generating elements are disposed so that the plane including each discharge electrode is parallel with the direction of gas flow and discharge electrodes are arranged perpendicularly to the direction of gas flow, and balanced control of positive and negative ions can be carried out at a position on the downstream side of gas flow by regulating a voltage applied to the discharge electrode of the ion generation element.

摘要翻译： 一种中和装置，其包括使用能够产生臭氧浓度低的高浓度离子的新型高效率放电系统的离子发生元件。 在中和装置中，离子产生元件是由放电电极和感应电极构成的微小电极离子产生元件，其具有在一个方向上沿平面布置的微小突起，以及夹在它们之间的薄电介质膜。 离子产生元件由一组用于产生正离子的微小电极离子产生元件和用于产生负离子的微小电极离子产生元件组成，其特征在于，至少一个或多个离子产生元件被设置成使得包括 每个放电电极与气体流动的方向平行，并且放电电极垂直于气流方向布置，并且可以通过调节电压在气流的下游侧的位置处进行正负离子的平衡控制 施加到离子产生元件的放电电极。

公开(公告)号：US07767409B2

公开(公告)日：2010-08-03

申请号：US11887477

申请日：2005-12-13

申请人： Haruki Mizukami ,  Akira Okuyama ,  Yasuhiko Hatano

发明人： Haruki Mizukami ,  Akira Okuyama ,  Yasuhiko Hatano

IPC分类号： G01N33/53

CPC分类号： G01N33/743 ,  G01N2333/723 ,  G01N2500/04

摘要： Provided is a detection method including exposing, to contact with a surface to which a cofactor has been bound, a nuclear receptor protein serving as a counterpart of the cofactor and a test sample; and detecting a substance which is contained in the test sample and which binds to the nuclear receptor, on the basis of a change in degree of binding between the nuclear receptor protein and the cofactor. The detection method is means for detecting a living-body-related substance, which means employs a nuclear receptor-cofactor system, exhibits detection high sensitivity, provides a convenient detection process, and realizes efficient establishment of a detection system.

摘要翻译： 提供了一种检测方法，包括暴露于与辅因子结合的表面接触，用作辅因子的对应物的核受体蛋白质和测试样品; 并且基于核受体蛋白质和辅因子之间的结合程度的变化来检测测试样品中包含的并与核受体结合的物质。 检测方法是用于检测活体相关物质的手段，这意味着采用核受体辅因子系统，具有高灵敏度的检测，提供方便的检测过程，并且实现了检测系统的有效建立。