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公开(公告)号：US5885551A
公开(公告)日：1999-03-23
申请号：US904984
申请日：1997-08-01
申请人： Alfred J. Smetana , Jon Hayes , Kuo-Chen Yeh , Laura McCulloch
发明人： Alfred J. Smetana , Jon Hayes , Kuo-Chen Yeh , Laura McCulloch
CPC分类号： A61K8/733 , A61K6/0017 , A61Q11/00
摘要： A method for treating dentinal hypersensitivity by administering a therapeutic amount of an alginate to a hypersensitive tooth.
摘要翻译： 一种通过将治疗量的藻酸盐施用于过敏性牙齿来治疗牙质过敏的方法。
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公开(公告)号：US20050202056A1
公开(公告)日：2005-09-15
申请号：US10960862
申请日：2004-10-07
申请人： Laura McCulloch , John Hopkins
发明人： Laura McCulloch , John Hopkins
CPC分类号： A61K8/19 , A61K8/25 , A61K2800/75 , A61Q19/00
摘要： A composition that is useful for reducing irritation to skin caused by enzymes is disclosed. The composition contains a swellable clay having layers in a lattice structure and a peptizing agent. The composition may be a solid, colloidal suspension, or emulsion formulation. Methods of treating skin to reduce or prevent irritation caused by enzymes are also disclosed.
摘要翻译： 公开了一种可用于减少由酶引起的对皮肤的刺激的组合物。 该组合物包含具有晶格结构层和溶胶剂层的可溶胀粘土。 组合物可以是固体，胶体悬浮液或乳液制剂。 还公开了治疗皮肤以减少或预防由酶引起的刺激的方法。
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公开(公告)号：US06986747B2
公开(公告)日：2006-01-17
申请号：US10353525
申请日：2003-01-29
CPC分类号： A61B5/1455 , A61B5/4035
摘要： A method of measuring the stress or relaxation level of a mammal and a method of measuring the activity of the sympathetic nervous system of a mammal by measuring quantititative levels of deoxyhemoglobin and oxyhemoglobin are disclosed. Preferably, the levels of deoxyhemoglobin and hemoglobin are measured by a noninvasive technique, such as spectroscopy. A method of changing the activity of the sympathetic nervous system of a mammal is also disclosed, wherein the method includes a step of administering an effective amount of sensory regimen to the mammal. The method is useful for humans who are operating vehicles or machinery, who are suffering from cardiovascular disease or related complications, who are pregnant, or who are preparing for sleep. In addition, a method of improving the complexion of the skin of a mammal is disclosed.
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公开(公告)号：US20050065100A1
公开(公告)日：2005-03-24
申请号：US10980501
申请日：2004-11-03
申请人： Benjamin Wiegand , Laura McCulloch , Rachel Grossman , Lynn Halas
发明人： Benjamin Wiegand , Laura McCulloch , Rachel Grossman , Lynn Halas
IPC分类号： A61K31/198 , A61K31/203 , A61K31/60 , A61K31/7048 , A61K33/04 , A61N1/30
CPC分类号： A61K31/7048 , A61K31/60
摘要： The present invention relates to methods for (1) reducing the number and severity of acne lesions on the skin of a mammal; (2) ameliorating the inflammation of acne lesions on the skin of a mammal; (3) improving the skin tone of a mammal, (4) treating skin disorders; (5) treating stress related skin diseases; (6) reducing stress and improving the emotional well being of an acne sufferer; (7) reducing sebaceous gland output; and (8) increasing compliance of the administration of anti-acne products. The method comprises the administration of a sensory regimen in an amount effective to downregulate the activity of the hypothalamus-pituitary-adrenal (HPA) axis in combination with the administration of an anti-acne composition.
摘要翻译： 本发明涉及（1）减少哺乳动物皮肤上痤疮损伤的数量和严重程度的方法; （2）改善哺乳动物皮肤上痤疮病变的炎症; （3）改善哺乳动物的肤色，（4）治疗皮肤病; （5）治疗压力相关的皮肤病; （6）减轻压力，改善痤疮患者的情绪健康; （7）减少皮脂腺输出; 和（8）增加抗痤疮产品的施用顺应性。 该方法包括以有效下调下丘脑 - 垂体 - 肾上腺（HPA）轴的活性的量施用感觉方案，同时施用抗痤疮组合物。
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公开(公告)号：US20070275102A9
公开(公告)日：2007-11-29
申请号：US11623181
申请日：2007-01-15
申请人： Laura McCulloch , Benjamin Wiegand
发明人： Laura McCulloch , Benjamin Wiegand
IPC分类号： A61K31/56 , A61K36/185 , A61B5/00
CPC分类号： A61B5/4815 , A61K38/2228 , A61M21/00 , A61M2021/0016 , A61M2021/0022 , A61M2021/0027 , A61M2021/0044
摘要： A method of affecting sleep and sleep-related behaviors of a mammal having a diurnal rhythm, by reducing the basal activity of the hypothalamus-pituitary-adrenal axis by administering an effective amount of a sensory regimen is disclosed. Such reduction may be accomplished by reducing at least one of the following: a. the average total daily amount of adrenocortical hormone; or b. the average total daily amount adrenocortical hormone minus the integrative measure of morning peak adrenocortical hormone. Preferably, such reduction also includes reducing at least one of the following: c. the level of adrenocortical hormone 4 hours to 8 hours after waking; d. the level of adrenocortical hormone in the period of time preceding bedtime; or e. the level of adrenocortical hormone below the onset of sleep threshold.
摘要翻译： 公开了通过施用有效量的感官方案降低下丘脑 - 垂体 - 肾上腺轴的基础活性来影响具有昼夜节律的哺乳动物的睡眠和睡眠相关行为的方法。 这种减少可以通过减少以下中的至少一个来实现：a。 肾上腺皮质激素平均每日总量; 或b。 平均每日总金额肾上腺皮质激素减去早期高峰肾上腺皮质激素的综合指标。 优选地，这种还原还包括减少以下中的至少一个：c。 唤醒后4小时至8小时的肾上腺皮质激素水平; d。 睡前期肾上腺皮质激素水平; 或e。 肾上腺皮质激素水平低于睡眠起始阈值。
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公开(公告)号：US20070149492A1
公开(公告)日：2007-06-28
申请号：US11623181
申请日：2007-03-14
申请人： Laura McCulloch , Benjamin Wiegand
发明人： Laura McCulloch , Benjamin Wiegand
IPC分类号： A61K31/56
CPC分类号： A61B5/4815 , A61K38/2228 , A61M21/00 , A61M2021/0016 , A61M2021/0022 , A61M2021/0027 , A61M2021/0044
摘要： A method of affecting sleep and sleep-related behaviors of a mammal having a diurnal rhythm, by reducing the basal activity of the hypothalamus-pituitary-adrenal axis by administering an effective amount of a sensory regimen is disclosed. Such reduction may be accomplished by reducing at least one of the following: a. the average total daily amount of adrenocortical hormone; or b. the average total daily amount adrenocortical hormone minus the integrative measure of morning peak adrenocortical hormone. Preferably, such reduction also includes reducing at least one of the following: c. the level of adrenocortical hormone 4 hours to 8 hours after waking; d. the level of adrenocortical hormone in the period of time preceding bedtime; or e. the level of adrenocortical hormone below the onset of sleep threshold.
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公开(公告)号：US20050112214A1
公开(公告)日：2005-05-26
申请号：US10980395
申请日：2004-11-03
申请人： Benjamin Wiegand , Laura McCulloch , Rachel Grossman , Lynn Halas
发明人： Benjamin Wiegand , Laura McCulloch , Rachel Grossman , Lynn Halas
IPC分类号： A61K31/198 , A61K31/203 , A61K31/60 , A61K31/7048 , A61K33/04 , A61N1/30
CPC分类号： A61K31/7048 , A61K31/60
摘要： The present invention relates to methods for (1) reducing the number and severity of acne lesions on the skin of a mammal; (2) ameliorating the inflammation of acne lesions on the skin of a mammal; (3) improving the skin tone of a mammal, (4) treating skin disorders; (5) treating stress related skin diseases; (6) reducing stress and improving the emotional well being of an acne sufferer; (7) reducing sebaceous gland output; and (8) increasing compliance of the administration of anti-acne products. The method comprises the administration of a sensory regimen in an amount effective to downregulate the activity of the hypothalamus-pituitary-adrenal (HPA) axis in combination with the administration of an anti-acne composition.
摘要翻译： 本发明涉及（1）减少哺乳动物皮肤上痤疮损伤的数量和严重程度的方法; （2）改善哺乳动物皮肤上痤疮病变的炎症; （3）改善哺乳动物的肤色，（4）治疗皮肤病; （5）治疗压力相关的皮肤病; （6）减轻压力，改善痤疮患者的情绪健康; （7）减少皮脂腺输出; 和（8）增加抗痤疮产品的施用顺应性。 该方法包括以有效下调下丘脑 - 垂体 - 肾上腺（HPA）轴的活性的量施用感觉方案，同时施用抗痤疮组合物。
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公开(公告)号：US06830755B2
公开(公告)日：2004-12-14
申请号：US10218774
申请日：2002-08-14
申请人： Joseph Librizzi , Benjamin Carl Wiegand , Teresita Diaz , Laura McCulloch , John Hopkins , Theodore L. Barba , Anthony Joseph Leardi , Gerard William Appert
发明人： Joseph Librizzi , Benjamin Carl Wiegand , Teresita Diaz , Laura McCulloch , John Hopkins , Theodore L. Barba , Anthony Joseph Leardi , Gerard William Appert
IPC分类号： A61K900
CPC分类号： A61K36/13 , A61K36/15 , A61K36/185 , A61K36/28 , A61K36/53 , A61K36/73 , A61K36/738 , A61K36/752 , A61K36/88 , A61K2300/00
摘要： This invention relates to a method of relaxing mammals comprising administering to said mammals a personal care composition which comprises an effective amount of a sensory fragrance that is effective in reducing cortisol levels and/or increasing sIgA levels.
摘要翻译： 本发明涉及一种放松哺乳动物的方法，包括向所述哺乳动物施用个人护理组合物，其包含有效量的有效降低皮质醇水平和/或增加sIgA水平的感官香料。
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公开(公告)号：US06489286B1
公开(公告)日：2002-12-03
申请号：US09487109
申请日：2000-01-19
申请人： Elvin R. Lukenbach , Victoria F. Dole , Glenn A. Nystrand , Laura McCulloch , William D. Allan , Jonathan R. Hill , Charles J. Taylor
发明人： Elvin R. Lukenbach , Victoria F. Dole , Glenn A. Nystrand , Laura McCulloch , William D. Allan , Jonathan R. Hill , Charles J. Taylor
IPC分类号： C11D900
CPC分类号： A61Q5/12 , A61K8/44 , A61K8/463 , A61K8/731 , A61K8/737 , A61K8/8152 , A61K8/8158 , A61K8/86 , A61K2800/5426 , A61K2800/596 , A61Q5/02 , A61Q19/005
摘要： A conditioning shampoo composition comprised of a mixture of anionic and amphoteric surfactants and optional conditioners which imparts cleansing, wet detangling, dry detangling and manageability to hair and which is relatively non-irritating and thus suitable for use by young children and adults having sensitive skin and eyes.
摘要翻译： 由阴离子和两性表面活性剂和任选的调理剂的混合物组成的调理洗发剂组合物，其赋予头发清洁，湿去丝解，干燥去缠结和可处理性，并且相对不刺激，因此适合于具有敏感皮肤的幼儿和成年人使用， 眼睛
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公开(公告)号：US6090773A
公开(公告)日：2000-07-18
申请号：US789593
申请日：1997-01-24
申请人： Elvin R. Lukenbach , Victoria F. Dole , Glenn A. Nystrand , Laura McCulloch , William D. Allan , Jonathan R. Hill , Charles J. Taylor
发明人： Elvin R. Lukenbach , Victoria F. Dole , Glenn A. Nystrand , Laura McCulloch , William D. Allan , Jonathan R. Hill , Charles J. Taylor
IPC分类号： A61K8/44 , A61K8/46 , A61K8/72 , A61K8/73 , A61K8/81 , A61K8/86 , A61Q5/02 , A61Q5/12 , A61Q19/00 , C11D9/00 , C11D15/00
CPC分类号： A61Q5/12 , A61K8/44 , A61K8/463 , A61K8/731 , A61K8/737 , A61K8/8152 , A61K8/8158 , A61K8/86 , A61Q19/005 , A61Q5/02 , A61K2800/5426 , A61K2800/596
摘要： A conditioning shampoo composition comprised of a mixture of anionic and amphoteric surfactants and optional conditioners which imparts cleansing, wet detangling, dry detangling and manageability to hair and which is relatively non-irritating and thus suitable for use by young children and adults having sensitive skin and eyes.
摘要翻译： 由阴离子和两性表面活性剂和任选的调理剂的混合物组成的调理洗发剂组合物，其赋予头发清洁，湿去丝解，干燥去缠结和可处理性，并且相对不刺激，因此适合于具有敏感皮肤的幼儿和成年人使用， 眼睛
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