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公开(公告)号：US11299479B1
公开(公告)日：2022-04-12
申请号：US17068518
申请日：2020-10-12
Applicant: AMGEN INC. , CYTOKINETICS, INC.
Inventor： Luke Ashcraft , Alessandro Boezio , John Butler , Aroop Chandra , Chihyuan Chuang , Scott E. Collibee , Mikkel V. Debenedetto , Vincent DiMassa , Russell Graceffa , Justin Malinowski , David Moebius , Bradley Paul Morgan , Joshua Payette , Antonio Romero , David St. Jean, Jr. , Richard Vargas , John Yeoman , Hanmo Zhang , Alan Cheng , Felix Gonzalez Lopez De Turiso , Michael Garrett Johnson
IPC: C07D403/12 , C07D401/14 , C07D401/12 , A61P9/00 , C07D413/14 , C07D207/16 , C07D413/12 , C07D405/12 , C07D417/14 , C07D401/06 , C07D403/14 , C07D209/02 , C07D209/52
Abstract: The present invention provides a compound of formula (I) or a pharmaceutically acceptable salt thereof, pharmaceutical compositions comprising a compound of the invention, a method for manufacturing compounds of the invention and therapeutic uses thereof.
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公开(公告)号：US20200223830A1
公开(公告)日：2020-07-16
申请号：US16833336
申请日：2020-03-27
Applicant: AMGEN INC. , CYTOKINETICS, INC.
Inventor： Luke Ashcraft , Alessandro Boezio , John Butler , Aroop Chandra , Chihyuan Chuang , Scott E. Collibee , Mikkel V. Debenedetto , Vincent DiMassa , Russell Graceffa , Justin Malinowski , David Moebius , Bradley Paul Morgan , Joshua Payette , Antonio Romero , David St. Jean, JR. , Richard Vargas , John Yeoman , Hanmo Zhang , Alan Cheng , Felix Gonzalez Lopez De Turiso , Michael Garrett Johnson
IPC: C07D403/12 , C07D401/14 , C07D401/12 , A61P9/00 , C07D413/14 , C07D207/16 , C07D209/52 , C07D405/12 , C07D417/14 , C07D401/06 , C07D403/14 , C07D209/02 , C07D413/12
Abstract: The present invention provides a compound of formula (I) or a pharmaceutically acceptable salt thereof, pharmaceutical compositions comprising a compound of the invention, a method for manufacturing compounds of the invention and therapeutic uses thereof.
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公开(公告)号：US20190077793A1
公开(公告)日：2019-03-14
申请号：US16129862
申请日：2018-09-13
Applicant: AMGEN INC. , CYTOKINETICS, INC.
Inventor： Luke Ashcraft , Alessandro Boezio , John Butler , Aroop Chandra , Chihyuan Chuang , Scott E. Collibee , Mikkel Debenedetto , Vincent DiMassa , Russell Graceffa , Justin Malinowski , David Moebius , Bradley P. Morgan , Joshua Payette , Antonio Romero , David St. Jean, JR. , Richard Vargas , John Yeoman , Hanmo Zhang
IPC: C07D403/12 , C07D401/14 , C07D401/12 , C07D405/12 , C07D413/14 , C07D207/16 , C07D209/52 , A61P9/00
Abstract: The present invention provides a compound of formula (I) or a pharmaceutically acceptable salt thereof, pharmaceutical compositions comprising a compound of the invention, a method for manufacturing compounds of the invention and therapeutic uses thereof.
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公开(公告)号：US20200223829A1
公开(公告)日：2020-07-16
申请号：US16833321
申请日：2020-03-27
Applicant: AMGEN INC. , CYTOKINETICS, INC.
Inventor： Luke Ashcraft , Alessandro Boezio , John Butler , Aroop Chandra , Chihyuan Chuang , Scott E. Collibee , Mikkel V. Debenedetto , Vincent DiMassa , Russell Graceffa , Justin Malinowski , David Moebius , Bradley Paul Morgan , Joshua Payette , Antonio Romero , David St. Jean, JR. , Richard Vargas , John Yeoman , Hanmo Zhang , Alan Cheng , Felix Gonzalez Lopez De Turiso , Michael Garrett Johnson
IPC: C07D403/12 , C07D401/14 , C07D401/12 , A61P9/00 , C07D413/14 , C07D207/16 , C07D209/52 , C07D405/12 , C07D417/14 , C07D401/06 , C07D403/14 , C07D209/02 , C07D413/12
Abstract: The present invention provides a compound of formula (I) or a pharmaceutically acceptable salt thereof, pharmaceutical compositions comprising a compound of the invention, a method for manufacturing compounds of the invention and therapeutic uses thereof.
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公开(公告)号：US09776995B2
公开(公告)日：2017-10-03
申请号：US14898070
申请日：2014-06-11
Applicant: AMGEN INC.
Inventor： Matthew Weiss , Erin F. DiMauro , Thomas Dineen , Russell Graceffa , Angel Guzman-Perez , Hongbing Huang , Charles Kreiman , Isaac E. Marx , Hanh Nho Nguyen , Emily Anne Peterson , Holly L. Deak
IPC: C07D417/14 , C07D471/04 , C07D413/12 , C07D401/12 , C07D413/14 , C07D417/12 , C07C53/18 , C07D215/227 , C07D403/12 , C07D215/36 , C07D241/44 , C07D401/14
CPC classification number: C07D417/14 , C07C53/18 , C07D215/227 , C07D215/36 , C07D241/44 , C07D401/12 , C07D401/14 , C07D403/12 , C07D413/12 , C07D413/14 , C07D417/12 , C07D471/04
Abstract: The present invention provides compounds of Formula I or pharmaceutically acceptable salts thereof, that are inhibitors of voltage-gated sodium channels, in particular Nav1.7. The compounds are useful for the treatment of diseases treatable by inhibition of sodium channels such as pain disorders. Also provided are pharmaceutical compositions containing compounds of the present invention.
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Patent Agency Ranking
公开(公告)号：US11780826B2
公开(公告)日：2023-10-10
申请号：US17672594
申请日：2022-02-15
Applicant: Amgen Inc. , Cytokinetics, Inc.
Inventor： Luke Ashcraft , Alessandro Boezio , John Butler , Aroop Chandra , Chihyuan Chuang , Scott E. Collibee , Mikkel Debenedetto , Vincent Dimassa , Russell Graceffa , Justin Malinowski , David Moebius , Bradley P. Morgan , Joshua Payette , Antonio Romero , David St. Jean, Jr. , Richard Vargas , John Yeoman , Hanmo Zhang , Alan Cheng , Felix Gonzalez Lopez De Turiso , Michael Garrett Johnson
IPC: C07D403/12 , C07D401/14 , C07D401/12 , A61P9/00 , C07D413/14 , C07D207/16 , C07D209/52 , C07D405/12 , C07D417/14 , C07D401/06 , C07D403/14 , C07D209/02 , C07D413/12
CPC classification number: C07D403/12 , A61P9/00 , C07D207/16 , C07D209/02 , C07D209/52 , C07D401/06 , C07D401/12 , C07D401/14 , C07D403/14 , C07D405/12 , C07D413/12 , C07D413/14 , C07D417/14
Abstract: The present invention provides a compound of formula (I) or a pharmaceutically acceptable salt thereof, pharmaceutical compositions comprising a compound of the invention, a method for manufacturing compounds of the invention and therapeutic uses thereof.
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公开(公告)号：US10899746B2
公开(公告)日：2021-01-26
申请号：US16833336
申请日：2020-03-27
Applicant: AMGEN INC. , CYTOKINETICS, INC.
Inventor： Luke Ashcraft , Alessandro Boezio , John Butler , Aroop Chandra , Chihyuan Chuang , Scott E. Collibee , Mikkel V. Debenedetto , Vincent DiMassa , Russell Graceffa , Justin Malinowski , David Moebius , Bradley Paul Morgan , Joshua Payette , Antonio Romero , David St. Jean, Jr. , Richard Vargas , John Yeoman , Hanmo Zhang , Alan Cheng , Felix Gonzalez Lopez De Turiso , Michael Garrett Johnson
IPC: C07D403/12 , C07D401/14 , C07D401/12 , C07D413/14 , C07D207/16 , C07D405/12 , C07D417/14 , C07D401/06 , C07D403/14 , C07D209/02 , C07D209/52 , A61P9/00 , C07D413/12
Abstract: The present invention provides a compound of formula (I) or a pharmaceutically acceptable salt thereof, pharmaceutical compositions comprising a compound of the invention, a method for manufacturing compounds of the invention and therapeutic uses thereof.
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公开(公告)号：US09458152B2
公开(公告)日：2016-10-04
申请号：US14920833
申请日：2015-10-22
Applicant: AMGEN INC.
Inventor： Matthew Weiss , Alessandro Boezio , Christiane Boezio , John R. Butler , Margaret Yuhua Chu-Moyer , Erin F. Dimauro , Thomas Dineen , Russell Graceffa , Angel Guzman-Perez , Hongbing Huang , Charles Kreiman , Daniel La , Isaac E. Marx , Benjamin Charles Milgram , Hanh Nho Nguyen , Emily Anne Peterson , Karina R. Vaida , Brian Sparling
IPC: A61K31/00 , C07D417/14 , C07D471/04 , C07D413/12 , C07D401/12 , C07D413/14 , C07D417/12 , C07C53/18 , C07D215/227 , C07D403/12 , C07D215/36 , C07D241/44 , C07D401/14
CPC classification number: C07D417/14 , C07C53/18 , C07D215/227 , C07D215/36 , C07D241/44 , C07D401/12 , C07D401/14 , C07D403/12 , C07D413/12 , C07D413/14 , C07D417/12 , C07D471/04
Abstract: The present invention provides compounds of Formula I, and pharmaceutically acceptable salts thereof, that are inhibitors of voltage-gated sodium channels, in particular Nav1.7. The compounds are useful for the treatment of diseases associated with the activity of sodium channels such as pain disorders and itch. Also provided are pharmaceutical compositions containing compounds of the present invention.
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公开(公告)号：US11572374B2
公开(公告)日：2023-02-07
申请号：US17266466
申请日：2019-08-13
Applicant: Amgen Inc. , Carmot Therapeutics, Inc.
Inventor： John R. Butler , Daniel Erlanson , Russell Graceffa , Jeffrey Iwig , Joon Won Jeong , Ryan D. White , Yongwei Wu , Shuyan Yi , Xiao Mei Zheng , Jesse M. McFarland , Abhisek Banerjee
IPC: C07D519/00 , C07D487/18
Abstract: The present invention provides a compound of formula (I) or a pharmaceutically acceptable salt thereof, pharmaceutical compositions comprising a compound of the invention, a method for manufacturing compounds of the invention and therapeutic uses thereof.
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公开(公告)号：US10723720B2
公开(公告)日：2020-07-28
申请号：US16129862
申请日：2018-09-13
Applicant: AMGEN INC. , CYTOKINETICS, INC.
Inventor： Luke Ashcraft , Alessandro Boezio , John Butler , Aroop Chandra , Chihyuan Chuang , Scott E. Collibee , Mikkel Debenedetto , Vincent DiMassa , Russell Graceffa , Justin Malinowski , David Moebius , Bradley P. Morgan , Joshua Payette , Antonio Romero , David St. Jean, Jr. , Richard Vargas , John Yeoman , Hanmo Zhang , Alan Cheng , Felix Gonzalez Lopez De Turiso , Michael Garrett Johnson
IPC: C07D403/12 , C07D401/14 , C07D401/12 , C07D405/12 , C07D413/14 , C07D207/16 , C07D209/52 , A61P9/00 , C07D417/14 , C07D401/06 , C07D403/14 , C07D209/02 , C07D413/12
Abstract: The present invention provides a compound of formula (I) or a pharmaceutically acceptable salt thereof, pharmaceutical compositions comprising a compound of the invention, a method for manufacturing compounds of the invention and therapeutic uses thereof.
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