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公开(公告)号：US20200223829A1
公开(公告)日：2020-07-16
申请号：US16833321
申请日：2020-03-27
申请人： AMGEN INC. , CYTOKINETICS, INC.
发明人： Luke Ashcraft , Alessandro Boezio , John Butler , Aroop Chandra , Chihyuan Chuang , Scott E. Collibee , Mikkel V. Debenedetto , Vincent DiMassa , Russell Graceffa , Justin Malinowski , David Moebius , Bradley Paul Morgan , Joshua Payette , Antonio Romero , David St. Jean, JR. , Richard Vargas , John Yeoman , Hanmo Zhang , Alan Cheng , Felix Gonzalez Lopez De Turiso , Michael Garrett Johnson
IPC分类号： C07D403/12 , C07D401/14 , C07D401/12 , A61P9/00 , C07D413/14 , C07D207/16 , C07D209/52 , C07D405/12 , C07D417/14 , C07D401/06 , C07D403/14 , C07D209/02 , C07D413/12
摘要： The present invention provides a compound of formula (I) or a pharmaceutically acceptable salt thereof, pharmaceutical compositions comprising a compound of the invention, a method for manufacturing compounds of the invention and therapeutic uses thereof.
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公开(公告)号：US20190077793A1
公开(公告)日：2019-03-14
申请号：US16129862
申请日：2018-09-13
申请人： AMGEN INC. , CYTOKINETICS, INC.
发明人： Luke Ashcraft , Alessandro Boezio , John Butler , Aroop Chandra , Chihyuan Chuang , Scott E. Collibee , Mikkel Debenedetto , Vincent DiMassa , Russell Graceffa , Justin Malinowski , David Moebius , Bradley P. Morgan , Joshua Payette , Antonio Romero , David St. Jean, JR. , Richard Vargas , John Yeoman , Hanmo Zhang
IPC分类号： C07D403/12 , C07D401/14 , C07D401/12 , C07D405/12 , C07D413/14 , C07D207/16 , C07D209/52 , A61P9/00
摘要： The present invention provides a compound of formula (I) or a pharmaceutically acceptable salt thereof, pharmaceutical compositions comprising a compound of the invention, a method for manufacturing compounds of the invention and therapeutic uses thereof.
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公开(公告)号：US10723720B2
公开(公告)日：2020-07-28
申请号：US16129862
申请日：2018-09-13
申请人： AMGEN INC. , CYTOKINETICS, INC.
发明人： Luke Ashcraft , Alessandro Boezio , John Butler , Aroop Chandra , Chihyuan Chuang , Scott E. Collibee , Mikkel Debenedetto , Vincent DiMassa , Russell Graceffa , Justin Malinowski , David Moebius , Bradley P. Morgan , Joshua Payette , Antonio Romero , David St. Jean, Jr. , Richard Vargas , John Yeoman , Hanmo Zhang , Alan Cheng , Felix Gonzalez Lopez De Turiso , Michael Garrett Johnson
IPC分类号： C07D403/12 , C07D401/14 , C07D401/12 , C07D405/12 , C07D413/14 , C07D207/16 , C07D209/52 , A61P9/00 , C07D417/14 , C07D401/06 , C07D403/14 , C07D209/02 , C07D413/12
摘要： The present invention provides a compound of formula (I) or a pharmaceutically acceptable salt thereof, pharmaceutical compositions comprising a compound of the invention, a method for manufacturing compounds of the invention and therapeutic uses thereof.
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公开(公告)号：US11299479B1
公开(公告)日：2022-04-12
申请号：US17068518
申请日：2020-10-12
申请人： AMGEN INC. , CYTOKINETICS, INC.
发明人： Luke Ashcraft , Alessandro Boezio , John Butler , Aroop Chandra , Chihyuan Chuang , Scott E. Collibee , Mikkel V. Debenedetto , Vincent DiMassa , Russell Graceffa , Justin Malinowski , David Moebius , Bradley Paul Morgan , Joshua Payette , Antonio Romero , David St. Jean, Jr. , Richard Vargas , John Yeoman , Hanmo Zhang , Alan Cheng , Felix Gonzalez Lopez De Turiso , Michael Garrett Johnson
IPC分类号： C07D403/12 , C07D401/14 , C07D401/12 , A61P9/00 , C07D413/14 , C07D207/16 , C07D413/12 , C07D405/12 , C07D417/14 , C07D401/06 , C07D403/14 , C07D209/02 , C07D209/52
摘要： The present invention provides a compound of formula (I) or a pharmaceutically acceptable salt thereof, pharmaceutical compositions comprising a compound of the invention, a method for manufacturing compounds of the invention and therapeutic uses thereof.
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公开(公告)号：US11254658B2
公开(公告)日：2022-02-22
申请号：US16833321
申请日：2020-03-27
申请人： AMGEN INC. , CYTOKINETICS, INC.
发明人： Mikkel V. Debenedetto , Justin Malinowski , Joshua Payette , Antonio Romero , David St. Jean, Jr.
IPC分类号： C07D403/12 , C07D401/14 , C07D401/12 , A61P9/00 , C07D413/14 , C07D207/16 , C07D209/52 , C07D405/12 , C07D417/14 , C07D401/06 , C07D403/14 , C07D209/02 , C07D413/12
摘要： The present invention provides a compound of formula (I) or a pharmaceutically acceptable salt thereof, pharmaceutical compositions comprising a compound of the invention, a method for manufacturing compounds of the invention and therapeutic uses thereof.
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公开(公告)号：US20200223830A1
公开(公告)日：2020-07-16
申请号：US16833336
申请日：2020-03-27
申请人： AMGEN INC. , CYTOKINETICS, INC.
发明人： Luke Ashcraft , Alessandro Boezio , John Butler , Aroop Chandra , Chihyuan Chuang , Scott E. Collibee , Mikkel V. Debenedetto , Vincent DiMassa , Russell Graceffa , Justin Malinowski , David Moebius , Bradley Paul Morgan , Joshua Payette , Antonio Romero , David St. Jean, JR. , Richard Vargas , John Yeoman , Hanmo Zhang , Alan Cheng , Felix Gonzalez Lopez De Turiso , Michael Garrett Johnson
IPC分类号： C07D403/12 , C07D401/14 , C07D401/12 , A61P9/00 , C07D413/14 , C07D207/16 , C07D209/52 , C07D405/12 , C07D417/14 , C07D401/06 , C07D403/14 , C07D209/02 , C07D413/12
摘要： The present invention provides a compound of formula (I) or a pharmaceutically acceptable salt thereof, pharmaceutical compositions comprising a compound of the invention, a method for manufacturing compounds of the invention and therapeutic uses thereof.
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公开(公告)号：US11780826B2
公开(公告)日：2023-10-10
申请号：US17672594
申请日：2022-02-15
申请人： Amgen Inc. , Cytokinetics, Inc.
发明人： Luke Ashcraft , Alessandro Boezio , John Butler , Aroop Chandra , Chihyuan Chuang , Scott E. Collibee , Mikkel Debenedetto , Vincent Dimassa , Russell Graceffa , Justin Malinowski , David Moebius , Bradley P. Morgan , Joshua Payette , Antonio Romero , David St. Jean, Jr. , Richard Vargas , John Yeoman , Hanmo Zhang , Alan Cheng , Felix Gonzalez Lopez De Turiso , Michael Garrett Johnson
IPC分类号： C07D403/12 , C07D401/14 , C07D401/12 , A61P9/00 , C07D413/14 , C07D207/16 , C07D209/52 , C07D405/12 , C07D417/14 , C07D401/06 , C07D403/14 , C07D209/02 , C07D413/12
CPC分类号： C07D403/12 , A61P9/00 , C07D207/16 , C07D209/02 , C07D209/52 , C07D401/06 , C07D401/12 , C07D401/14 , C07D403/14 , C07D405/12 , C07D413/12 , C07D413/14 , C07D417/14
摘要： The present invention provides a compound of formula (I) or a pharmaceutically acceptable salt thereof, pharmaceutical compositions comprising a compound of the invention, a method for manufacturing compounds of the invention and therapeutic uses thereof.
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公开(公告)号：US10899746B2
公开(公告)日：2021-01-26
申请号：US16833336
申请日：2020-03-27
申请人： AMGEN INC. , CYTOKINETICS, INC.
发明人： Luke Ashcraft , Alessandro Boezio , John Butler , Aroop Chandra , Chihyuan Chuang , Scott E. Collibee , Mikkel V. Debenedetto , Vincent DiMassa , Russell Graceffa , Justin Malinowski , David Moebius , Bradley Paul Morgan , Joshua Payette , Antonio Romero , David St. Jean, Jr. , Richard Vargas , John Yeoman , Hanmo Zhang , Alan Cheng , Felix Gonzalez Lopez De Turiso , Michael Garrett Johnson
IPC分类号： C07D403/12 , C07D401/14 , C07D401/12 , C07D413/14 , C07D207/16 , C07D405/12 , C07D417/14 , C07D401/06 , C07D403/14 , C07D209/02 , C07D209/52 , A61P9/00 , C07D413/12
摘要： The present invention provides a compound of formula (I) or a pharmaceutically acceptable salt thereof, pharmaceutical compositions comprising a compound of the invention, a method for manufacturing compounds of the invention and therapeutic uses thereof.
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公开(公告)号：US09604965B2
公开(公告)日：2017-03-28
申请号：US14594274
申请日：2015-01-12
申请人： Cytokinetics, Inc.
发明人： Luke W. Ashcraft , Gustave Bergnes , Scott Collibee , Chihyuan Chuang , Jeff Gardina , Bradley P. Morgan , Alex R. Muci , Xiangping Qian , Jeffrey Warrington , Zhe Yang , Pu-Ping Lu , Antonio Romero
IPC分类号： A61K31/50 , C07D237/20 , C07D401/12 , C07D237/24 , C07D401/04 , C07D403/04 , C07D403/06 , C07D409/14 , C07D411/04 , C07D413/04 , C07D413/14 , C07D417/14 , C07D487/04 , C07D487/10 , C07D513/04 , C07D401/14 , C07D405/14
CPC分类号： A61K31/50 , A61K31/16 , A61K31/166 , C07D207/26 , C07D211/76 , C07D213/16 , C07D231/56 , C07D237/06 , C07D237/20 , C07D237/24 , C07D401/04 , C07D401/12 , C07D401/14 , C07D403/04 , C07D403/06 , C07D405/14 , C07D409/14 , C07D411/04 , C07D413/04 , C07D413/14 , C07D417/14 , C07D487/04 , C07D487/10 , C07D513/04 , Y02A50/465
摘要： Provided are compounds of Formula I: or a pharmaceutically acceptable salt thereof, wherein R1, R2, R3, R4, R5, R6, R7, R8, R9, X and m are as defined herein. Also provided is a pharmaceutically acceptable composition comprising a compound of Formula I, or a pharmaceutically acceptable salt thereof.Also provided are methods of using a compound of Formula I, or a pharmaceutically acceptable salt thereof.
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10.发明申请公开(公告)号：US20160200717A1
公开(公告)日：2016-07-14
申请号：US14823605
申请日：2015-08-11
申请人： Cytokinetics, Inc.
发明人： Luke W. Ashcroft , Gustave Bergnes , Scott Collibee , Chihyuan Chuang , Jeff Gardina , Bradley P. Morgan , Alex R Muci , Xiangping Qian , Antonio Romero , Jeffrey Warrington , Zhe Yang
IPC分类号： C07D417/14 , C07D213/75 , C07D401/14 , C07D253/07 , C07D403/04 , C07D213/74 , C07D401/12
CPC分类号： C07D213/74 , C07D213/75 , C07D213/78 , C07D213/82 , C07D215/38 , C07D215/48 , C07D253/07 , C07D401/12 , C07D401/14 , C07D403/04 , C07D403/10 , C07D417/04 , C07D417/14
摘要： Provided are compounds of Formula I: or a pharmaceutically acceptable salt thereof, wherein R2, R4, R5, R6, R7, R8, R9, X, Z1, Z2, Z3, Z4 and m are as defined herein.Also provided is a pharmaceutically acceptable composition comprising a compound of Formula I, or a pharmaceutically acceptable salt thereof.Also provided are methods of using a compound of Formula I, or a pharmaceutically acceptable salt thereof.
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