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公开(公告)号：US08673893B2
公开(公告)日：2014-03-18
申请号：US13611679
申请日：2012-09-12
申请人： Andrea Lombardi Borgia , Maria Menichincheri , Paolo Orsini , Achille Panzeri , Ettore Perrone , Ermes Vanotti , Marcella Nesi , Chiara Marchionni
发明人： Andrea Lombardi Borgia , Maria Menichincheri , Paolo Orsini , Achille Panzeri , Ettore Perrone , Ermes Vanotti , Marcella Nesi , Chiara Marchionni
IPC分类号： A61K31/415 , A61K31/535 , A61K31/445
CPC分类号： C07D405/14 , A61K31/496 , A61K45/06 , C07D231/56 , C07D401/12 , C07D401/14 , C07D403/12 , C07D403/14 , C07D405/04 , C07D405/12
摘要： Substituted indazole derivatives of formula (I) and pharmaceutically acceptable salts thereof, as defined in the specification, process for their preparation and pharmaceutical compositions comprising them are disclosed; the compounds of the invention may be useful in therapy in the treatment of diseases associated with a deregulated protein kinase activity, like cancer.
摘要翻译： 公开了本说明书中定义的式（I）的取代的吲唑衍生物及其药学上可接受的盐，其制备方法和包含它们的药物组合物; 本发明的化合物可用于治疗与失调的蛋白激酶活性相关的疾病，如癌症。
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公开(公告)号：US20100292207A1
公开(公告)日：2010-11-18
申请号：US12668745
申请日：2008-07-08
申请人： Andrea Lombardi Borgia , Maria Menichincheri , Paolo Orsini , Achille Panzeri , Ettore Perrone , Ermes Vanotti , Marcella Nesi , Chiara Marchionni
发明人： Andrea Lombardi Borgia , Maria Menichincheri , Paolo Orsini , Achille Panzeri , Ettore Perrone , Ermes Vanotti , Marcella Nesi , Chiara Marchionni
IPC分类号： A61K31/416 , C07D403/12 , C07D231/56 , C07D405/14 , C07D405/12 , C07D413/14 , C07D403/14 , C07D413/12 , A61K31/497 , A61K31/5513 , A61K31/454 , A61K31/5377 , A61P35/00 , A61P29/00 , A61P27/02 , A61P17/06 , A61P35/04 , A61P9/00 , A61P11/00
CPC分类号： C07D405/14 , A61K31/496 , A61K45/06 , C07D231/56 , C07D401/12 , C07D401/14 , C07D403/12 , C07D403/14 , C07D405/04 , C07D405/12
摘要： Substituted indazole derivatives of formula (I) and pharmaceutically acceptable salts thereof, as defined in the specification, process for their preparation and pharmaceutical compositions comprising them are disclosed; the compounds of the invention may be useful in therapy in the treatment of diseases associated with a deregulated protein kinase activity, like cancer.
摘要翻译： 公开了本说明书中定义的式（I）的取代的吲唑衍生物及其药学上可接受的盐，其制备方法和包含它们的药物组合物; 本发明的化合物可用于治疗与失调的蛋白激酶活性相关的疾病，如癌症。
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公开(公告)号：US08299057B2
公开(公告)日：2012-10-30
申请号：US12668745
申请日：2008-07-08
申请人： Andrea Lombardi Borgia , Maria Menichincheri , Paolo Orsini , Achille Panzeri , Ettore Perrone , Ermes Vanotti , Marcella Nesi , Chiara Marchionni
发明人： Andrea Lombardi Borgia , Maria Menichincheri , Paolo Orsini , Achille Panzeri , Ettore Perrone , Ermes Vanotti , Marcella Nesi , Chiara Marchionni
IPC分类号： A61K31/035 , A61K31/55 , A61K31/535 , A61K31/497 , A61K31/445 , A61K31/415 , C07D413/10 , C07D231/56 , C07D243/08
CPC分类号： C07D405/14 , A61K31/496 , A61K45/06 , C07D231/56 , C07D401/12 , C07D401/14 , C07D403/12 , C07D403/14 , C07D405/04 , C07D405/12
摘要： Substituted indazole derivatives of formula (I) and pharmaceutically acceptable salts thereof, as defined in the specification, process for their preparation and pharmaceutical compositions comprising them are disclosed; the compounds of the invention may be useful in therapy in the treatment of diseases associated with a deregulated protein kinase activity, like cancer.
摘要翻译： 公开了本说明书中定义的式（I）的取代的吲唑衍生物及其药学上可接受的盐，其制备方法和包含它们的药物组合物; 本发明的化合物可用于治疗与失调的蛋白激酶活性相关的疾病，如癌症。
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公开(公告)号：US08114865B2
公开(公告)日：2012-02-14
申请号：US12520387
申请日：2007-12-14
申请人： Tiziano Bandiera , Andrea Lombardi Borgia , Marcella Nesi , Ettore Perrone , Roberto Bossi , Paolo Polucci
发明人： Tiziano Bandiera , Andrea Lombardi Borgia , Marcella Nesi , Ettore Perrone , Roberto Bossi , Paolo Polucci
IPC分类号： A61K31/415 , A61K31/497 , A61K31/445 , A61K31/44 , A61K31/40 , C07D243/08 , C07D403/12 , C07D211/32 , C07D401/12 , C07D231/56
CPC分类号： C07D231/56 , C07D401/12 , C07D403/12 , C07D403/14 , C07D405/12 , C07D405/14 , C07D471/04
摘要： Substituted indazole derivatives of formula (I) and pharmaceutically acceptable salts thereof, as defined in the specification, process for their preparation and pharmaceutical compositions comprising them are disclosed; the compounds of the invention may be useful in therapy in the treatment of diseases associated with a dysregulated protein kinase activity, like cancer formula (I).
摘要翻译： 公开了本说明书中定义的式（I）的取代的吲唑衍生物及其药学上可接受的盐，其制备方法和包含它们的药物组合物; 本发明的化合物可用于治疗与失调的蛋白激酶活性相关的疾病的治疗，如癌症配方（I）。
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公开(公告)号：US20100197665A1
公开(公告)日：2010-08-05
申请号：US12520387
申请日：2007-12-14
申请人： Tiziano Bandiera , Andrea Lombardi Borgia , Marcella Nesi , Ettore Perrone , Roberto Bossi , Paolo Polucci
发明人： Tiziano Bandiera , Andrea Lombardi Borgia , Marcella Nesi , Ettore Perrone , Roberto Bossi , Paolo Polucci
IPC分类号： A61K31/551 , C07D231/56 , A61K31/416 , C07D403/12 , A61K31/496 , C07D211/06 , A61K31/454 , C07D243/08 , C07D413/14 , A61K31/5377 , C07D405/14 , A61K31/4439 , A61P35/00 , A61P11/00 , A61P19/02
CPC分类号： C07D231/56 , C07D401/12 , C07D403/12 , C07D403/14 , C07D405/12 , C07D405/14 , C07D471/04
摘要： Substituted indazole derivatives of formula (I) and pharmaceutically acceptable salts thereof, as defined in the specification, process for their preparation and pharmaceutical compositions comprising them are disclosed; the compounds of the invention may be useful in therapy in the treatment of diseases associated with a dysregulated protein kinase activity, like cancer formula (I).
摘要翻译： 公开了本说明书中定义的式（I）的取代的吲唑衍生物及其药学上可接受的盐，其制备方法和包含它们的药物组合物; 本发明的化合物可用于治疗与失调的蛋白激酶活性相关的疾病的治疗，如癌症配方（I）。
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公开(公告)号：US09012487B2
公开(公告)日：2015-04-21
申请号：US12281602
申请日：2007-03-02
申请人： Tiziano Bandiera , Jay Aaron Bertrand , Paolo Pevarello , Ettore Perrone , Andrea Lombardi Borgia , Sten Christian Orrenius , Mauro Angiolini , Daniele Fancelli
发明人： Tiziano Bandiera , Jay Aaron Bertrand , Paolo Pevarello , Ettore Perrone , Andrea Lombardi Borgia , Sten Christian Orrenius , Mauro Angiolini , Daniele Fancelli
IPC分类号： C07D487/04 , A61K31/496 , A61K31/5377 , A61K31/4162
CPC分类号： C07D487/04 , A61K31/4162 , A61K31/496 , A61K31/5377
摘要： A compound having formula (I): wherein: R, A, R1 and R2, are as defined in the specification, and pharmaceutical formulas thereof, and methods of use thereof, as Kinase inhibitors.
摘要翻译： 具有式（I）的化合物：其中：R，A，R 1和R 2如说明书中所定义，及其药物配方及其使用方法作为激酶抑制剂。
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7.发明授权公开(公告)号：US07968583B2
公开(公告)日：2011-06-28
申请号：US12096989
申请日：2006-12-06
申请人： Tiziano Bandiera , Andrea Lombardi Borgia , Sten Christian Orrenius , Ettore Perrone , Italo Beria , Daniele Fancelli , Arturo Galvani
发明人： Tiziano Bandiera , Andrea Lombardi Borgia , Sten Christian Orrenius , Ettore Perrone , Italo Beria , Daniele Fancelli , Arturo Galvani
IPC分类号： A61K31/415 , A01N43/56 , C07D231/56
CPC分类号： C07D487/04
摘要： Substituted pyrrolo-pyrazole derivatives of formula (I) and pharmaceutically acceptable salts thereof, as defined in the specification, process for their preparation and pharmaceutical compositions comprising them are disclosed; the compounds of the invention may be useful in therapy in the treatment of diseases associated with dysregulated protein kinase activity, like cancer.
摘要翻译： 公开了如说明书中定义的式（I）的取代吡咯并吡唑衍生物及其药学上可接受的盐，其制备方法和包含它们的药物组合物; 本发明的化合物可用于治疗与失调的蛋白激酶活性相关的疾病如癌症。
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8.发明授权公开(公告)号：US08461193B2
公开(公告)日：2013-06-11
申请号：US13109564
申请日：2011-05-17
申请人： Tiziano Bandiera , Andrea Lombardi Borgia , Sten Christian Orrenius , Ettore Perrone , Italo Beria , Daniele Fancelli , Arturo Galvani
发明人： Tiziano Bandiera , Andrea Lombardi Borgia , Sten Christian Orrenius , Ettore Perrone , Italo Beria , Daniele Fancelli , Arturo Galvani
IPC分类号： A01N43/56 , A01N43/38 , A61K31/415 , A61K31/40 , C07D231/54 , C07D487/02
CPC分类号： C07D487/04
摘要： Substituted pyrrolo-pyrazole derivatives of formula (I) and pharmaceutically acceptable salts thereof, as defined in the specification, process for their preparation and pharmaceutical compositions comprising them are disclosed; the compounds of the invention may be useful in therapy in the treatment of diseases associated with dysregulated protein kinase activity, like cancer.
摘要翻译： 公开了如说明书中定义的式（I）的取代吡咯并吡唑衍生物及其药学上可接受的盐，其制备方法和包含它们的药物组合物; 本发明的化合物可用于治疗与失调的蛋白激酶活性相关的疾病如癌症。
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公开(公告)号：US20090136513A1
公开(公告)日：2009-05-28
申请号：US12281602
申请日：2007-03-02
申请人： Tiziano Bandiera , Jay Aaron Bertrand , Paolo Pevarello , Ettore Perrone , Andrea Lombardi Borgia , Sten Christian Orrenius , Mauro Angiolini , Daniele Fancelli
发明人： Tiziano Bandiera , Jay Aaron Bertrand , Paolo Pevarello , Ettore Perrone , Andrea Lombardi Borgia , Sten Christian Orrenius , Mauro Angiolini , Daniele Fancelli
IPC分类号： A61K31/4162 , C07D487/04 , A61K31/5377 , A61K39/395 , A61P35/00 , A61K31/496
CPC分类号： C07D487/04 , A61K31/4162 , A61K31/496 , A61K31/5377
摘要： A compound having formula (I): wherein: R, A, R1 and R2, are as defined in the specification, and pharmaceutical formulas thereof, and methods of use thereof, as Kinase inhibitors.
摘要翻译： 具有式（I）的化合物：其中：R，A，R 1和R 2如说明书中所定义，及其药物配方及其使用方法作为激酶抑制剂。
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10.发明申请公开(公告)号：US20090163503A1
公开(公告)日：2009-06-25
申请号：US12096989
申请日：2006-12-06
申请人： Tiziano Bandiera , Andrea Lombardi Borgia , Sten Christian Orrenius , Ettore Perrone , Italo Beria , Daniele Fancelli , Arturo Galvani
发明人： Tiziano Bandiera , Andrea Lombardi Borgia , Sten Christian Orrenius , Ettore Perrone , Italo Beria , Daniele Fancelli , Arturo Galvani
IPC分类号： A61K31/5355 , C07D403/14 , C07D413/14 , A61K31/497 , A61P35/00
CPC分类号： C07D487/04
摘要： Substituted pyrrolo-pyrazole derivatives of formula (I) and pharmaceutically acceptable salts thereof, as defined in the specification, process for their preparation and pharmaceutical compositions comprising them are disclosed; the compounds of the invention may be useful in therapy in the treatment of diseases associated with dysregulated protein kinase activity, like cancer.
摘要翻译： 公开了如说明书中定义的式（I）的取代吡咯并吡唑衍生物及其药学上可接受的盐，其制备方法和包含它们的药物组合物; 本发明的化合物可用于治疗与失调的蛋白激酶活性相关的疾病如癌症。
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