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1.发明授权Pyrazolo-quinazoline derivatives, process for their preparation and their use as kinase inhibitors 有权吡唑并喹唑啉衍生物，其制备方法及其作为激酶抑制剂的用途公开(公告)号：US08981089B2
公开(公告)日：2015-03-17
申请号：US13972659
申请日：2013-08-21
申请人： Gabriella Traquandi , Maria Gabriella Brasca , Roberto D'Alessio , Paolo Polucci , Fulvia Roletto , Anna Vulpetti , Paolo Pevarello , Achille Panzeri , Francesca Quartieri , Ron Ferguson , Paola Vianello , Daniele Fancelli
发明人： Gabriella Traquandi , Maria Gabriella Brasca , Roberto D'Alessio , Paolo Polucci , Fulvia Roletto , Anna Vulpetti , Paolo Pevarello , Achille Panzeri , Francesca Quartieri , Ron Ferguson , Paola Vianello , Daniele Fancelli
IPC分类号： C07D487/04 , C07D403/14 , C07D413/14 , C07D487/14 , C07D231/56 , C07D239/72
CPC分类号： C07D487/14 , A61K31/519 , A61K31/5377 , A61K31/551 , C07D231/56 , C07D239/72 , C07D401/10 , C07D403/14 , C07D413/14 , C07D487/04
摘要： Pyrazolo-quinazoline derivatives of formula (Ia) or (Ib) as defined in the specification, and pharmaceutically acceptable salts thereof, process for their preparation and pharmaceutical compositions comprising them are disclosed; the compounds of the invention may be useful, in therapy, in the treatment of diseases associated with a disregulated protein kinase activity, like cancer.
摘要翻译： 公开了说明书中定义的式（Ia）或（Ib）的吡唑并喹唑啉衍生物及其药学上可接受的盐，其制备方法和包含它们的药物组合物; 本发明的化合物在治疗中可用于治疗与失调的蛋白激酶活性相关的疾病，如癌症。
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![[1,2,4]TRIAZOLO[1,5-C]PYRIMIDINE DERIVATIVES AS HSP90 MODULATORS](/abs-image/US/2014/02/13/US20140045836A1/abs.jpg.150x150.jpg)
2.发明申请[1,2,4]TRIAZOLO[1,5-C]PYRIMIDINE DERIVATIVES AS HSP90 MODULATORS 审中-公开[1,2,4]三唑并[1,5-C]嘧啶衍生物作为HSP90调节剂公开(公告)号：US20140045836A1
公开(公告)日：2014-02-13
申请号：US14055388
申请日：2013-10-16
IPC分类号： C07D487/04
CPC分类号： C07D487/04
摘要： The present invention relates to [1,2,4]triazolo[1,5-c]pyrimidine derivatives which inhibit the activity of Heat Shock Protein Hsp90. The compounds of the invention are therefore useful in treating proliferative diseases such as cancer and neurodegenerative diseases. The present invention also provides processes for preparing these compounds, methods of treating diseases and the pharmaceutical compositions comprising these compounds.
摘要翻译： 本发明涉及抑制热休克蛋白Hsp90活性的[1,2,4]三唑并[1,5-c]嘧啶衍生物。 因此，本发明的化合物可用于治疗增殖性疾病如癌症和神经变性疾病。 本发明还提供了制备这些化合物的方法，治疗疾病的方法和包含这些化合物的药物组合物。
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公开(公告)号：US08114865B2
公开(公告)日：2012-02-14
申请号：US12520387
申请日：2007-12-14
申请人： Tiziano Bandiera , Andrea Lombardi Borgia , Marcella Nesi , Ettore Perrone , Roberto Bossi , Paolo Polucci
发明人： Tiziano Bandiera , Andrea Lombardi Borgia , Marcella Nesi , Ettore Perrone , Roberto Bossi , Paolo Polucci
IPC分类号： A61K31/415 , A61K31/497 , A61K31/445 , A61K31/44 , A61K31/40 , C07D243/08 , C07D403/12 , C07D211/32 , C07D401/12 , C07D231/56
CPC分类号： C07D231/56 , C07D401/12 , C07D403/12 , C07D403/14 , C07D405/12 , C07D405/14 , C07D471/04
摘要： Substituted indazole derivatives of formula (I) and pharmaceutically acceptable salts thereof, as defined in the specification, process for their preparation and pharmaceutical compositions comprising them are disclosed; the compounds of the invention may be useful in therapy in the treatment of diseases associated with a dysregulated protein kinase activity, like cancer formula (I).
摘要翻译： 公开了本说明书中定义的式（I）的取代的吲唑衍生物及其药学上可接受的盐，其制备方法和包含它们的药物组合物; 本发明的化合物可用于治疗与失调的蛋白激酶活性相关的疾病的治疗，如癌症配方（I）。
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公开(公告)号：US20100197665A1
公开(公告)日：2010-08-05
申请号：US12520387
申请日：2007-12-14
申请人： Tiziano Bandiera , Andrea Lombardi Borgia , Marcella Nesi , Ettore Perrone , Roberto Bossi , Paolo Polucci
发明人： Tiziano Bandiera , Andrea Lombardi Borgia , Marcella Nesi , Ettore Perrone , Roberto Bossi , Paolo Polucci
IPC分类号： A61K31/551 , C07D231/56 , A61K31/416 , C07D403/12 , A61K31/496 , C07D211/06 , A61K31/454 , C07D243/08 , C07D413/14 , A61K31/5377 , C07D405/14 , A61K31/4439 , A61P35/00 , A61P11/00 , A61P19/02
CPC分类号： C07D231/56 , C07D401/12 , C07D403/12 , C07D403/14 , C07D405/12 , C07D405/14 , C07D471/04
摘要： Substituted indazole derivatives of formula (I) and pharmaceutically acceptable salts thereof, as defined in the specification, process for their preparation and pharmaceutical compositions comprising them are disclosed; the compounds of the invention may be useful in therapy in the treatment of diseases associated with a dysregulated protein kinase activity, like cancer formula (I).
摘要翻译： 公开了本说明书中定义的式（I）的取代的吲唑衍生物及其药学上可接受的盐，其制备方法和包含它们的药物组合物; 本发明的化合物可用于治疗与失调的蛋白激酶活性相关的疾病的治疗，如癌症配方（I）。
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![[1,2,4]triazolo [1,5-c]pyrimidine derivatives as Hsp90 modulators](/abs-image/US/2013/11/12/US08580783B2/abs.jpg.150x150.jpg)
5.发明授权[1,2,4]triazolo [1,5-c]pyrimidine derivatives as Hsp90 modulators 失效[1,2,4]三唑并[1,5-c]嘧啶衍生物，为Hsp90调节剂公开(公告)号：US08580783B2
公开(公告)日：2013-11-12
申请号：US13394255
申请日：2010-09-03
IPC分类号： A61K31/519 , A61K31/5377 , C12N9/99 , A61P35/00
CPC分类号： C07D487/04
摘要： The present invention relates to [1,2,4]triazolo[1,5-c]pyrimidine derivatives of formula (I) which inhibit the activity of Heat Shock Protein Hsp90. The compounds of the invention are therefore useful in treating proliferative diseases such as cancer and neurodegenerative diseases. The present invention also provides processes for preparing these compounds, methods of treating diseases and the pharmaceutical compositions comprising these compounds.
摘要翻译： 本发明涉及抑制热休克蛋白Hsp90活性的式（I）的[1,2,4]三唑并[1,5-c]嘧啶衍生物。 因此，本发明的化合物可用于治疗增殖性疾病如癌症和神经变性疾病。 本发明还提供了制备这些化合物的方法，治疗疾病的方法和包含这些化合物的药物组合物。
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![Substituted pyrazolo[4,3-C]pyridine derivatives active as kinase inhibitors](/abs-image/US/2012/05/08/US08173659B2/abs.jpg.150x150.jpg)
6.发明授权Substituted pyrazolo[4,3-C]pyridine derivatives active as kinase inhibitors 有权作为激酶抑制剂活性的取代的吡唑并[4,3-C]吡啶衍生物公开(公告)号：US08173659B2
公开(公告)日：2012-05-08
申请号：US13085889
申请日：2011-04-13
申请人： Tiziano Bandiera , Andrea Lombardi Borgia , Paolo Polucci , Manuela Villa , Marcella Nesi , Mauro Angiolini , Mario Varasi
发明人： Tiziano Bandiera , Andrea Lombardi Borgia , Paolo Polucci , Manuela Villa , Marcella Nesi , Mauro Angiolini , Mario Varasi
IPC分类号： A61K31/496 , A61K31/437
CPC分类号： C07D471/04
摘要： Substituted pyrazolo[4,3-c]pyridine derivatives of formula (I) and pharmaceutically acceptable salts thereof, as defined in the specification, process for their preparation and pharmaceutical compositions comprising them are disclosed; the compounds of the invention may be useful in therapy in the treatment of diseases associated with a dysregulated protein kinase activity, like cancer.
摘要翻译： 公开了如本说明书中定义的式（I）的吡唑并[4,3-c]吡啶衍生物及其药学上可接受的盐，其制备方法和包含它们的药物组合物; 本发明的化合物可用于治疗与失调的蛋白激酶活性相关的疾病如癌症。
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公开(公告)号：US20120046266A1
公开(公告)日：2012-02-23
申请号：US13264888
申请日：2010-04-16
IPC分类号： A61K31/42 , C07D413/12 , A61K31/454 , C07D453/02 , A61K31/439 , A61K31/5377 , A61K31/496 , C07D231/14 , A61P35/00 , A61P25/28 , A61P35/02 , A61P25/16 , A61P25/14 , A61P25/00 , C12N9/99 , C07D261/18
CPC分类号： C07D231/14 , C07D261/14 , C07D261/18 , C07D413/12 , C07D413/14 , C07D453/02
摘要： The present invention relates to substituted resorcinol derivatives which inhibit the activity of Heat Shock Protein HSP90. The compounds of the invention are therefore useful in treating proliferative diseases such as cancer and neurodegenerative diseases. The present invention also provides processes for preparing these compounds, pharmaceutical compositions comprising them, methods of treating diseases and the pharmaceutical compositions comprising these compounds.
摘要翻译： 本发明涉及抑制热休克蛋白HSP90活性的取代间苯二酚衍生物。 因此，本发明的化合物可用于治疗增殖性疾病如癌症和神经变性疾病。 本发明还提供了制备这些化合物的方法，包含它们的药物组合物，治疗疾病的方法和包含这些化合物的药物组合物。
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8.发明申请公开(公告)号：US20130338148A1
公开(公告)日：2013-12-19
申请号：US13972659
申请日：2013-08-21
申请人： Gabriella Traquandi , Maria Gabriella Brasca , Roberto D'Alessio , Paolo Polucci , Fulvia Roletto , Anna Vulpetti , Paolo Pevarello , Achille Panzeri , Francesca Quartieri , Ron Ferguson , Paola Vianello , Daniele Fancelli
发明人： Gabriella Traquandi , Maria Gabriella Brasca , Roberto D'Alessio , Paolo Polucci , Fulvia Roletto , Anna Vulpetti , Paolo Pevarello , Achille Panzeri , Francesca Quartieri , Ron Ferguson , Paola Vianello , Daniele Fancelli
IPC分类号： A61K31/551 , C07D401/10 , C07D487/14 , A61K31/519 , A61K31/5377 , C07D231/56 , C07D487/04
CPC分类号： C07D487/14 , A61K31/519 , A61K31/5377 , A61K31/551 , C07D231/56 , C07D239/72 , C07D401/10 , C07D403/14 , C07D413/14 , C07D487/04
摘要： Pyrazolo-quinazoline derivatives of formula (Ia) or (Ib) as defined in the specification, and pharmaceutically acceptable salts thereof, process for their preparation and pharmaceutical compositions comprising them are disclosed; the compounds of the invention may be useful, in therapy, in the treatment of diseases associated with a disregulated protein kinase activity, like cancer.
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![[1,2,4]TRIAZOLO [1,5-C]PYRIMIDINE DERIVATIVES AS HSP90 MODULATORS](/abs-image/US/2012/07/19/US20120184546A1/abs.jpg.150x150.jpg)
9.发明申请[1,2,4]TRIAZOLO [1,5-C]PYRIMIDINE DERIVATIVES AS HSP90 MODULATORS 失效[1,2,4]三唑并[1,5-C]嘧啶衍生物作为HSP90调节剂公开(公告)号：US20120184546A1
公开(公告)日：2012-07-19
申请号：US13394255
申请日：2010-09-03
IPC分类号： A61K31/519 , C12N9/99 , A61P35/00 , C07D487/04 , A61K31/5377
CPC分类号： C07D487/04
摘要： The present invention relates to [1,2,4]triazolo[1,5-c]pyrimidine derivatives of formula (I) which inhibit the activity of Heat Shock Protein Hsp90. The compounds of the invention are therefore useful in treating proliferative diseases such as cancer and neurodegenerative diseases. The present invention also provides processes for preparing these compounds, methods of treating diseases and the pharmaceutical compositions comprising these compounds.
摘要翻译： 本发明涉及抑制热休克蛋白Hsp90活性的式（I）的[1,2,4]三唑并[1,5-c]嘧啶衍生物。 因此，本发明的化合物可用于治疗增殖性疾病如癌症和神经变性疾病。 本发明还提供了制备这些化合物的方法，治疗疾病的方法和包含这些化合物的药物组合物。
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10.发明授权Pyrazolo-quinazoline derivatives, process for their preparation and their use as kinase inhibitors 有权吡唑并喹唑啉衍生物，其制备方法及其作为激酶抑制剂的用途公开(公告)号：US07482354B2
公开(公告)日：2009-01-27
申请号：US10557565
申请日：2004-04-27
申请人： Gabriella Traquandi , Maria Gabriella Brasca , Roberto D'Alessio , Paolo Polucci , Fulvia Roletto , Anna Vulpetti , Paolo Pevarello , Achille Panzeri , Francesca Quartieri , Ron Ferguson , Paola Vianello , Daniele Fancelli
发明人： Gabriella Traquandi , Maria Gabriella Brasca , Roberto D'Alessio , Paolo Polucci , Fulvia Roletto , Anna Vulpetti , Paolo Pevarello , Achille Panzeri , Francesca Quartieri , Ron Ferguson , Paola Vianello , Daniele Fancelli
IPC分类号： A61K31/505 , A01N43/54 , C07D239/00 , C07D471/00 , C07D487/00 , C07D491/00
CPC分类号： C07D487/14 , A61K31/519 , A61K31/5377 , A61K31/551 , C07D231/56 , C07D239/72 , C07D401/10 , C07D403/14 , C07D413/14 , C07D487/04
摘要： Pyrazolo-quinazoline derivatives of formula (Ia) or (Ib) as defined in the specification, and pharmaceutically acceptable salts thereof, process for their preparation and pharmaceutical compositions comprising them are disclosed; the compounds of the invention may be useful in therapy, in the treatment of diseases associated with a disregulated protein kinase activity, like cancer.
摘要翻译： 公开了说明书中定义的式（Ia）或（Ib）的吡唑并喹唑啉衍生物及其药学上可接受的盐，其制备方法和包含它们的药物组合物; 本发明的化合物可用于治疗与失调的蛋白激酶活性相关的疾病，如癌症。
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