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1.发明申请公开(公告)号：US20070155000A1
公开(公告)日：2007-07-05
申请号：US11560490
申请日：2006-11-16
申请人： Anneli Nilsson , Gunnar Lidén , Marie-Francoise Gorwa-Grauslund , Bärbel Hahn-Hägerdal , Carl Modig , Joao Moreira De Almeida
发明人： Anneli Nilsson , Gunnar Lidén , Marie-Francoise Gorwa-Grauslund , Bärbel Hahn-Hägerdal , Carl Modig , Joao Moreira De Almeida
CPC分类号： C12N9/0006 , C12N9/1205 , C12N9/92 , C12P7/10 , C12P17/04 , Y02E50/16 , Y02E50/17
摘要： The present invention relates to an ethanol producing microbial strain, such as Saccharomyces cerevisiae strain, being able to grow and produce ethanol from lignocellulosic hydrolysates comprising growth inhibiting compounds of the group furfural and 5-hydroxy-methyl furfural, in a batch, fed-batch or continuous fermentation, said microbial strain being tolerant to such inhibiting compounds, which strain is upregulated and/or over expressed with regard to one or more of the following genes: LAT1, ALD6, ADH5, ADH6, GDH3, OYE3, SER3, GND2, MDH2, IDP3, ADH7, AAD15, ERG27, HMG1, LYS5, SPS19, SGE1.
摘要翻译： 本发明涉及一种生产乙醇的微生物菌株，例如酿酒酵母菌株，能够从包含糠醛和5-羟甲基糠醛的生长抑制化合物的木质纤维素水解产物中分批生产和生产乙醇，补料分批 或连续发酵，所述微生物菌株对这种抑制化合物是耐受的，该菌株对于以下一个或多个基因：上调和/或过度表达：LAT1，ALD6，ADH5，ADH6，GDH3，OYE3，SER3，GND2， MDH2，IDP3，ADH7，AAD15，ERG27，HMG1，LYS5，SPS19，SGE1。
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公开(公告)号：US20130023021A1
公开(公告)日：2013-01-24
申请号：US13545301
申请日：2012-07-10
申请人： Anneli Nilsson , Gunnar Lidén , Marie-Francoise Gorwa-Grauslund , Bärbel Hahn-Hägerdal , Carl Tobias Modig , Joao Ricardo Moreira De Almeida
发明人： Anneli Nilsson , Gunnar Lidén , Marie-Francoise Gorwa-Grauslund , Bärbel Hahn-Hägerdal , Carl Tobias Modig , Joao Ricardo Moreira De Almeida
CPC分类号： C12N9/0006 , C12N9/1205 , C12N9/92 , C12P7/10 , C12P17/04 , Y02E50/16 , Y02E50/17
摘要： The present invention relates to an ethanol producing microbial strain, such as Saccharomyces cerevisiae strain, being able to grow and produce ethanol from lignocellulosic hydrolysates comprising growth inhibiting compounds of the group furfural and 5-hydroxy-methyl furfural, in a batch, fed-batch or continuous fermentation, said microbial strain being tolerant to such inhibiting compounds, which strain is upregulated and/or over expressed with regard to one or more of the following genes: LAT1, ALD6, ADH5, ADH6, GDH3, OYE3, SER3, GND2, MDH2, IDP3, ADH7, AAD15, ERG27, HMG1, LYS5, SPS19, SGE1.
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公开(公告)号：US20130023022A1
公开(公告)日：2013-01-24
申请号：US13545343
申请日：2012-07-10
申请人： Anneli Nilsson , Gunnar Lidén , Marie-Francoise Gorwa-Grauslund , Barbel Hahn-Hägerdal , Carl Tobias Modig , Joao Ricardo Moreira De Almeida
发明人： Anneli Nilsson , Gunnar Lidén , Marie-Francoise Gorwa-Grauslund , Barbel Hahn-Hägerdal , Carl Tobias Modig , Joao Ricardo Moreira De Almeida
CPC分类号： C12N9/0006 , C12N9/1205 , C12N9/92 , C12P7/10 , C12P17/04 , Y02E50/16 , Y02E50/17
摘要： The present invention relates to an ethanol producing microbial strain, such as Saccharomyces cerevisiae strain, being able to grow and produce ethanol from lignocellulosic hydrolysates comprising growth inhibiting compounds of the group furfural and 5-hydroxy-methyl furfural, in a batch, fed-batch or continuous fermentation, said microbial strain being tolerant to such inhibiting compounds, which strain is upregulated and/or over expressed with regard to one or more of the following genes: LAT1, ALD6, ADH5, ADH6, GDH3, OYE3, SER3, GND2, MDH2, IDP3, ADH7, AAD15, ERG27, HMG1, LYS5, SPS19, SGE1.
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4.发明授权公开(公告)号：US08367393B2
公开(公告)日：2013-02-05
申请号：US13130729
申请日：2009-11-20
申请人： Bärbel Hahn-Hägerdal , Oskar Bengtsson , Maurizio Bettiga , Rosa Garcia Sanchez , David Rundquist , Marie-Francoise Gorwa-Grauslund
发明人： Bärbel Hahn-Hägerdal , Oskar Bengtsson , Maurizio Bettiga , Rosa Garcia Sanchez , David Rundquist , Marie-Francoise Gorwa-Grauslund
IPC分类号： C12N1/20
CPC分类号： C12N15/81 , C12N9/0006 , C12N9/90 , C12P7/06 , C12Y101/01009 , Y02E50/17
摘要： The invention relates to an improved Saccharomyces strain displaying improved viability and growth during anaerobic fermentation of pentose carbon sources such as xylose and producing fermentation products such as ethanol.
摘要翻译： 本发明涉及一种改良的酵母属菌株，其在戊糖碳源（如木糖）的厌氧发酵过程中显示出改善的活力和生长，并产生发酵产物如乙醇。
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5.发明申请SACCHAROMYCES STRAIN WITH ABILITY TO GROW ON PENTOSE SUGARS UNDER ANAEROBIC CULTIVATION CONDITIONS 有权在厌氧培养条件下能够生长的松香糖的菌种菌株公开(公告)号：US20110294180A1
公开(公告)日：2011-12-01
申请号：US13130729
申请日：2009-11-20
申请人： Bärbel Hahn-Hägerdal , Oskar Bengtsson , Maurizio Bettiga , Rosa Garcia Sanchez , David Rundquist , Marie-Francoise Gorwa-Grauslund
发明人： Bärbel Hahn-Hägerdal , Oskar Bengtsson , Maurizio Bettiga , Rosa Garcia Sanchez , David Rundquist , Marie-Francoise Gorwa-Grauslund
CPC分类号： C12N15/81 , C12N9/0006 , C12N9/90 , C12P7/06 , C12Y101/01009 , Y02E50/17
摘要： The invention relates to an improved Saccharomyces strain displaying improved viability and growth during anaerobic fermentation of pentose carbon sources such as xylose and producing fermentation products such as ethanol.
摘要翻译： 本发明涉及一种改良的酵母属菌株，其在戊糖碳源（如木糖）的厌氧发酵过程中显示出改善的活力和生长，并产生发酵产物如乙醇。
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6.发明申请公开(公告)号：US20090061502A1
公开(公告)日：2009-03-05
申请号：US12201292
申请日：2008-08-29
申请人： Anneli Nilsson , Gunnar Liden , Marie-Francoise Gorwa-Grauslund , Barbel Hahn-Hagerdal , Carl Tobias Modig , Joao Ricardo Moreira De Almeida
发明人： Anneli Nilsson , Gunnar Liden , Marie-Francoise Gorwa-Grauslund , Barbel Hahn-Hagerdal , Carl Tobias Modig , Joao Ricardo Moreira De Almeida
IPC分类号： C12N1/16
CPC分类号： C12N9/0006 , C12N9/1205 , C12N9/92 , C12P7/10 , C12P17/04 , Y02E50/16 , Y02E50/17
摘要： The present invention relates to an ethanol producing microbial strain, such as Saccharomyces cerevisiae strain, being able to grow and produce ethanol from lignocellulosic hydrolysates comprising growth inhibiting compounds of the group furfural and 5-hydroxy-methyl furfural, in a batch, fed-batch or continuous fermentation, said microbial strain being tolerant to such inhibiting compounds, which strain is upregulated and/or over expressed with regard to one or more of the following genes: LAT1, ALD6, ADH5, ADH6, GDH3, OYE3, SER3, GND2, MDH2, IDP3, ADH7, AAD15, ERG27, HMG1, LYS5, SPS19, SGE1.
摘要翻译： 本发明涉及一种生产乙醇的微生物菌株，例如酿酒酵母菌株，能够从包含糠醛和5-羟甲基糠醛的生长抑制化合物的木质纤维素水解产物中分批生产和生产乙醇，补料分批 或连续发酵，所述微生物菌株对这种抑制化合物是耐受的，该菌株对于以下一个或多个基因：上调和/或过度表达：LAT1，ALD6，ADH5，ADH6，GDH3，OYE3，SER3，GND2， MDH2，IDP3，ADH7，AAD15，ERG27，HMG1，LYS5，SPS19，SGE1。
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公开(公告)号：US08129171B2
公开(公告)日：2012-03-06
申请号：US11852400
申请日：2007-09-10
申请人： Eckhard Boles , Barbel Hahn-Hagerdal , Marie-Francoise Gorwa-Grauslund , Kaisa Karhumaa , Beate Wiedemann
发明人： Eckhard Boles , Barbel Hahn-Hagerdal , Marie-Francoise Gorwa-Grauslund , Kaisa Karhumaa , Beate Wiedemann
IPC分类号： C12N1/15
摘要： A S. cerevisiae strain expressing both arabinose and xylose utilization pathways, and in particular to a S. cerevisiae strain fermenting both arabinose and xylose to ethanol, and more particularly a S. cerevisiae strain with overexpression or upregulation of xylose- or aldose reductase (XR, AR) with xylitol dehydrogenase (XDH) together with overexpression or upregulation of genes forming an arabinose utilization pathway. The invention encompasses both laboratory and industrial strain having these properties.
摘要翻译： 表达阿拉伯糖和木糖利用途径的酿酒酵母菌株，特别是发酵阿拉伯糖和木糖至乙醇的啤酒酵母菌株，更特别是具有过表达或上调木糖或醛糖还原酶（XR）的酿酒酵母菌株 ，AR）与木糖醇脱氢酶（XDH）一起，以及形成阿拉伯糖利用途径的基因的过表达或上调。 本发明包括具有这些性质的实验室和工业菌株。
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公开(公告)号：US20070128706A1
公开(公告)日：2007-06-07
申请号：US11518658
申请日：2006-09-11
CPC分类号： C12P7/06 , C12N9/0004 , Y02E50/17
摘要： New xylose-utilizing Saccharomyces cerevisiae mutant strain which ferments xylose to ethanol, wherein the strain expresses a K270M mutated P. stipitis XYL1 gene (1 or 2 copies of the mutated gene) together with the native P. stipitis XYL2 gene and overexpresses the endogenous XKS1 gene.
摘要翻译： 新型木糖利用的酿酒酵母突变菌株将木糖发酵成乙醇，其中菌株表达了K270M突变的树干特有的XYL1基因（突变基因的1或2个拷贝）以及天然的白喉树木XYL2基因，过表达内源性XKS1 基因。
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公开(公告)号：US20090311771A1
公开(公告)日：2009-12-17
申请号：US11852400
申请日：2007-09-10
申请人： Eckhard Boles , Barbel Hahn-Hagerdal , Marie-Francoise Gorwa-Grauslund , Kaisa Karhumaa , Beate Wiedemann
发明人： Eckhard Boles , Barbel Hahn-Hagerdal , Marie-Francoise Gorwa-Grauslund , Kaisa Karhumaa , Beate Wiedemann
IPC分类号： C12N1/19
摘要： The present invention relates to a S. cerevisiae strain expressing both arabinose and xylose utilization pathways, and in particular to a S. cerevisiae strain fermenting both arabinose and xylose to ethanol, and more particularly a S. cerevisiae strain with overexpression or upregulation of xylose- or aldose reductase (XR, AR) with xylitol dehydrogenase (XDH) together with overexpression or upregulation of genes forming an arabinose utilization pathway. The invention encompasses both laboratory and industrial strain having these properties.
摘要翻译： 本发明涉及表达阿拉伯糖和木糖利用途径的酿酒酵母菌株，特别涉及发酵阿拉伯糖和木糖至乙醇的酿酒酵母菌株，更具体地涉及具有过表达或上调木糖转化酶的酿酒酵母菌株， 或醛糖还原酶（XR，AR）与木糖醇脱氢酶（XDH）以及形成阿拉伯糖利用途径的基因的过表达或上调。 本发明包括具有这些性质的实验室和工业菌株。
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10.发明申请MUTANT SACCHAROMYCES CEREVISIAE STRAIN UTILIZING XYLOSE FOR ETHANOL PRODUCTION 审中-公开MTHANT SACCHAROMYCES CEREVISIAE STRAIN ETILIZING XYLOSE FOR ETHANOL PRODUCTION公开(公告)号：US20070141690A1
公开(公告)日：2007-06-21
申请号：US11557363
申请日：2006-11-07
CPC分类号： C12P7/06 , C12N9/0006 , C12N9/1205 , C12N15/52 , C12P7/10 , C12Y207/01017 , Y02E50/16 , Y02E50/17
摘要： The present invention relates to a new xylose utilizing Saccharomyces cerevisiae strain being able to utilize xylose for ethanol production which strain is up-regulated with regard to the genes for xylose reductase (XR) and xylulose dehydrogenase (XDH) as well as xululokinase (XK) and over-expressing the non-oxidative pentose phosphate pathway (PPP) and comprising a deletion of the gene GRE3 deletion, as well as the strain has been adapted to xylose feeding.
摘要翻译： 本发明涉及一种利用酿酒酵母菌株的新型木糖，能够利用木糖进行乙醇生产，其中木糖还原酶（XR）和木酮糖脱氢酶（XDH）以及xululokinase（XK）的基因是上调的， 并且过表达非氧化戊糖磷酸途径（PPP）并且包含基因GRE3缺失的缺失，以及该菌株已被适应于木糖喂养。
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