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公开(公告)号：US20050271706A1
公开(公告)日：2005-12-08
申请号：US11204271
申请日：2005-08-15
申请人： Aron Anderson , Laurie Lawin , Byron Shen , Eugene Juan , Signe Varner , Ralph Chappa
发明人： Aron Anderson , Laurie Lawin , Byron Shen , Eugene Juan , Signe Varner , Ralph Chappa
CPC分类号： A61K31/58 , A61F2310/00353 , A61K9/0051
摘要： The invention provides methods for delivering bioactive agent to an eye, the methods including steps of providing a device at an implantation site within the eye, and maintaining the device at the implantation site to provide a therapeutically effective amount of the bioactive agent to the eye. The device includes a body member having a direction of extension, a longitudinal axis along the direction of extension, and a proximal end and a distal end, wherein at least a portion of the body member deviates from the direction of extension. A polymeric coated composition is provided in contact with a surface of the body member, the polymeric coated composition including a first polymer, a second polymer, and a bioactive agent. The invention also provides methods of administering a therapeutically effective amount of bioactive agent to a posterior segment of an eye.
摘要翻译： 本发明提供了将生物活性剂递送到眼睛的方法，所述方法包括以下步骤：在眼睛内的植入部位提供装置，并将装置保持在植入部位以向眼睛提供治疗有效量的生物活性剂。 该装置包括具有延伸方向的本体构件，沿着延伸方向的纵向轴线，以及近端和远端，其中主体构件的至少一部分偏离延伸方向。 提供与主体构件的表面接触的聚合物涂覆的组合物，聚合物涂覆的组合物包括第一聚合物，第二聚合物和生物活性剂。 本发明还提供了将治疗有效量的生物活性剂施用于眼后段的方法。
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公开(公告)号：US20050281863A1
公开(公告)日：2005-12-22
申请号：US11203931
申请日：2005-08-15
申请人： Aron Anderson , Laurie Lawin , Byron Shen , Eugene de Juan , Signe Varner , Ralph Chappa
发明人： Aron Anderson , Laurie Lawin , Byron Shen , Eugene de Juan , Signe Varner , Ralph Chappa
CPC分类号： A61K31/58 , A61F2310/00353 , A61K9/0051
摘要： The invention provides controlled release bioactive agent delivery devices that include a body member having a direction of extension, a longitudinal axis along the direction of extension, and a proximal end and a distal end, wherein at least a portion of the body member deviates from the direction of extension, and a polymeric coated composition in contact with the body member, the polymeric coated composition including a first polymer, a second polymer, and a bioactive agent, wherein the first polymer and the second polymer are hydrophobic. The invention also provides methods of delivering a bioactive agent to a patient in a controlled release manner, as well as methods of making controlled release bioactive agent delivery devices.
摘要翻译： 本发明提供控制释放的生物活性剂递送装置，其包括具有延伸方向的本体构件，沿着延伸方向的纵向轴线，以及近端和远端，其中，身体构件的至少一部分偏离 所述聚合物涂覆组合物包括第一聚合物，第二聚合物和生物活性剂，其中所述第一聚合物和所述第二聚合物是疏水性的。 本发明还提供了以受控释放方式将生物活性剂递送至患者的方法，以及制备控制释放的生物活性剂递送装置的方法。
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公开(公告)号：US20050287188A1
公开(公告)日：2005-12-29
申请号：US11203981
申请日：2005-08-15
申请人： Aron Anderson , Laurie Lawin , Byron Shen , Eugene de Juan , Signe Varner , Ralph Chappa
发明人： Aron Anderson , Laurie Lawin , Byron Shen , Eugene de Juan , Signe Varner , Ralph Chappa
CPC分类号： A61K31/58 , A61F2310/00353 , A61K9/0051
摘要： The invention provides retrievable devices for sustained delivery of bioactive agent to a site within a patient, the devices including a body member having a direction of extension, a longitudinal axis along the direction of extension, and a proximal end and a distal end, wherein at least a portion of the body member deviates from the direction of extension; a cap at the proximal end of the body member; and a polymeric coated composition in contact with a surface of the body member, the polymeric coated composition including a first polymer, a second polymer, and a bioactive agent.
摘要翻译： 本发明提供了用于将生物活性剂持续递送到患者内的部位的可回收装置，所述装置包括具有延伸方向的本体构件，沿着延伸方向的纵向轴线，以及近端和远端，其中， 身体构件的至少一部分偏离延伸方向; 在主体构件的近端处的帽; 以及与本体构件的表面接触的聚合物涂覆的组合物，所述聚合物涂覆的组合物包含第一聚合物，第二聚合物和生物活性剂。
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公开(公告)号：US20060013835A1
公开(公告)日：2006-01-19
申请号：US11225301
申请日：2005-09-12
申请人： Aron Anderson , Laurie Lawin , Byron Shen , Eugene de Juan , Signe Varner , Ralph Chappa
发明人： Aron Anderson , Laurie Lawin , Byron Shen , Eugene de Juan , Signe Varner , Ralph Chappa
CPC分类号： A61K31/58 , A61F2310/00353 , A61K9/0051
摘要： The invention provides a controlled release bioactive agent delivery device for treatment of an eye that includes a body member having a direction of extension, a longitudinal axis along the direction of extension, and a proximal end and a distal end, wherein at least a portion of the body member deviates from the direction of extension, and a polymeric coated composition in contact with a surface of the body member, the polymeric coated composition including a first polymer, a second polymer, and a bioactive agent. The first polymer and the second polymer are hydrophobic, and the body member has a length such that, upon placement of the device at an implantation site within a posterior segment of an eye, the device does not enter a central visual field of the eye. The invention also provides methods method of delivering bioactive agent to a posterior region of an eye.
摘要翻译： 本发明提供一种用于治疗眼睛的控制释放生物活性剂递送装置，其包括具有延伸方向的本体构件，沿着延伸方向的纵向轴线，以及近端和远端，其中至少一部分 身体构件偏离延伸方向，以及与本体构件的表面接触的聚合物涂覆的组合物，聚合物涂覆的组合物包括第一聚合物，第二聚合物和生物活性剂。 第一聚合物和第二聚合物是疏水性的，并且本体构件具有这样的长度，使得当将该装置放置在眼睛后部的植入部位时，该装置不进入眼睛的中心视野。 本发明还提供了将生物活性剂递送到眼后部区域的方法。
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公开(公告)号：US20050276837A1
公开(公告)日：2005-12-15
申请号：US11204195
申请日：2005-08-15
申请人： Aron Anderson , Laurie Lawin , Byron Shen , Eugene de Juan , Signe Varner , Ralph Chappa
发明人： Aron Anderson , Laurie Lawin , Byron Shen , Eugene de Juan , Signe Varner , Ralph Chappa
CPC分类号： A61K31/58 , A61F2310/00353 , A61K9/0051
摘要： The invention provides a controlled release bioactive agent delivery device that includes a body member having a direction of extension, a longitudinal axis along the direction of extension, and a proximal end and a distal end, wherein at least a portion of the body member deviates from the direction of extension, and a polymeric coated composition in contact with the body member, the polymeric coated composition including a first polymer, a second polymer, and a bioactive agent. The invention also provides methods of delivering a bioactive agent to a patient in a controlled release manner, as well as methods of making a controlled release bioactive agent delivery device.
摘要翻译： 本发明提供一种控制释放的生物活性剂递送装置，其包括具有延伸方向的本体构件，沿着延伸方向的纵向轴线，以及近端和远端，其中，身体构件的至少一部分偏离 所述延伸方向以及与所述主体构件接触的聚合物涂覆组合物，所述聚合物涂覆的组合物包括第一聚合物，第二聚合物和生物活性剂。 本发明还提供了以受控释放方式将生物活性剂递送到患者的方法，以及制备受控释放的生物活性剂递送装置的方法。
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公开(公告)号：US20050271703A1
公开(公告)日：2005-12-08
申请号：US11203879
申请日：2005-08-15
申请人： Aron Anderson , Laurie Lawin , Byron Shen , Eugene de Juan , Signe Varner , Ralph Chappa
发明人： Aron Anderson , Laurie Lawin , Byron Shen , Eugene de Juan , Signe Varner , Ralph Chappa
CPC分类号： A61K31/58 , A61F2310/00353 , A61K9/0051
摘要： The invention provides implantable sustained release bioactive agent delivery devices that include a body member having a direction of extension, a longitudinal axis along the direction of extension, and a proximal end and a distal end, wherein at least a portion of the body member deviates from the direction of extension; and a polymeric coated composition in contact with a surface of the body member, the polymeric coated composition including a first polymer, a second polymer, and a bioactive agent. The polymeric coated composition is formulated to provide controlled release of bioactive agent over time when introduced into physiological conditions. Methods of preparing implantable devices configured and formulated to provide controlled release of bioactive agent are also provided.
摘要翻译： 本发明提供可植入的缓释生物活性剂递送装置，其包括具有延伸方向的本体构件，沿着延伸方向的纵向轴线，以及近端和远端，其中，身体构件的至少一部分偏离 延伸方向; 以及与本体构件的表面接触的聚合物涂覆的组合物，所述聚合物涂覆的组合物包含第一聚合物，第二聚合物和生物活性剂。 配制聚合物涂覆的组合物以在引入生理条件时随时间提供生物活性剂的受控释放。 还提供了配制和配制以提供生物活性剂的受控释放的可植入装置的制备方法。
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公开(公告)号：US20050019371A1
公开(公告)日：2005-01-27
申请号：US10835530
申请日：2004-04-29
申请人： Aron Anderson , Laurie Lawin , Byron Shen , Eugene Juan , Signe Varner
发明人： Aron Anderson , Laurie Lawin , Byron Shen , Eugene Juan , Signe Varner
CPC分类号： A61K31/58 , A61F2310/00353 , A61K9/0051
摘要： The invention provides a controlled release bioactive agent delivery device that includes a body member having a direction of extension, a longitudinal axis along the direction of extension, and a proximal end and a distal end, wherein at least a portion of the body member deviates from the direction of extension, and a polymeric coated composition in contact with the body member, the polymeric coated composition including a first polymer, a second polymer, and a bioactive agent, wherein the first polymer comprises polyalkyl(meth)acrylate, aromatic poly(meth)acrylate, or a combination of polyalkyl(meth)acrylate and aromatic poly(meth)acrylate, and wherein the second polymer comprises poly(ethylene-co-vinyl acetate). The invention also provides methods of delivering a bioactive agent to a patient in a controlled release manner, as well as methods of making a controlled release bioactive agent delivery device.
摘要翻译： 本发明提供一种控制释放的生物活性剂递送装置，其包括具有延伸方向的本体构件，沿着延伸方向的纵向轴线，以及近端和远端，其中，身体构件的至少一部分偏离 所述聚合物涂覆组合物包括第一聚合物，第二聚合物和生物活性剂，其中所述第一聚合物包含（甲基）丙烯酸烷基酯，（甲基）丙烯酸烷基酯，芳族聚（甲基）丙烯酸酯， ）丙烯酸酯或聚（甲基）丙烯酸烷基酯和芳族聚（甲基）丙烯酸酯的组合，其中第二聚合物包括聚（乙烯 - 共 - 乙酸乙烯酯）。 本发明还提供了以受控释放方式将生物活性剂递送到患者的方法，以及制备受控释放的生物活性剂递送装置的方法。
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公开(公告)号：US20060024350A1
公开(公告)日：2006-02-02
申请号：US11165884
申请日：2005-06-24
申请人： Signe Varner , Patrick Guire , Kristin Taton , Jie Wen , Nathan Beeley , Laurie Lawin , Robert Hergenrother , Ralph Chappa , Aron Anderson
发明人： Signe Varner , Patrick Guire , Kristin Taton , Jie Wen , Nathan Beeley , Laurie Lawin , Robert Hergenrother , Ralph Chappa , Aron Anderson
IPC分类号： A61F2/00
CPC分类号： A61K9/0051 , A61F9/0017 , A61F2210/0004 , A61L31/06 , C08L67/025
摘要： The invention provides implantable medical devices that are fabricated of biodegradable materials for delivery of bioactive agent to limited access regions of a patient's body, such as the eye. The invention further provides methods of treatment utilizing the devices.
摘要翻译： 本发明提供了由可生物降解材料制成的植入式医疗装置，用于将生物活性剂递送到患者身体如眼睛的有限进入区域。 本发明还提供了利用这些装置的治疗方法。
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公开(公告)号：US20060110428A1
公开(公告)日：2006-05-25
申请号：US11175850
申请日：2005-07-05
申请人： Eugene deJuan , Signe Varner , Laurie Lawin
发明人： Eugene deJuan , Signe Varner , Laurie Lawin
IPC分类号： A61F2/00
CPC分类号： A61K9/0051 , A61F9/0017 , A61L27/54 , A61L2300/41 , A61L2300/416 , A61L2300/43 , A61L2300/602 , A61L2430/16
摘要： Featured is a method for instilling one or more bioactive agents into ocular tissue within an eye of a patient for the treatment of an ocular condition, the method comprising concurrently using at least two of the following bioactive agent delivery methods (A)-(C): (A) implanting a sustained release delivery device comprising one or more bioactive agents in a posterior region of the eye so that it delivers the one or more bioactive agents into the vitreous humor of the eye; (B) instilling (e.g., injecting or implanting) one or more bioactive agents subretinally; and (C) instilling (e.g., injecting or delivering by ocular iontophoresis) one or more bioactive agents into the vitreous humor of the eye.
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公开(公告)号：US20050059956A1
公开(公告)日：2005-03-17
申请号：US10823089
申请日：2004-04-12
申请人： Signe Varner , Eugene Dejuan , Terry Shelley , Aaron Barnes , Mark Humayun
发明人： Signe Varner , Eugene Dejuan , Terry Shelley , Aaron Barnes , Mark Humayun
IPC分类号： A61F9/007 , A61B17/00 , A61F9/00 , A61K9/00 , A61K9/22 , A61K45/00 , A61L31/00 , A61P27/02 , A61M31/00
CPC分类号： A61K9/0051 , A61B2017/00867 , A61F9/0017
摘要： An therapeutic agent delivery device that can allows is particularly suitable for delivery of a therapeutic agent to limited access regions, such as the posterior chamber of the eye and inner ear. Preferred devices of the invention are minimally invasive, refillable and may be easily fixed to the treatment area. Preferred delivery devices of the invention also include those that comprise a non-linear shaped body member body housing one or more substances and a delivery mechanism for the sustained delivery of the one or more substances from the non-linear shaped body member to the patient.
摘要翻译： 可以允许的治疗剂递送装置特别适合于将治疗剂递送到有限的进入区域，例如眼睛的后室和内耳。 本发明的优选装置是微创的，可再填充的并且可以容易地固定到治疗区域。 本发明的优选输送装置还包括包含一个或多个物质的非线性形状的身体构件体和用于将一种或多种物质从非线性形状的身体构件持续递送至患者的输送机构的输送装置。
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