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公开(公告)号：US20060024350A1
公开(公告)日：2006-02-02
申请号：US11165884
申请日：2005-06-24
申请人： Signe Varner , Patrick Guire , Kristin Taton , Jie Wen , Nathan Beeley , Laurie Lawin , Robert Hergenrother , Ralph Chappa , Aron Anderson
发明人： Signe Varner , Patrick Guire , Kristin Taton , Jie Wen , Nathan Beeley , Laurie Lawin , Robert Hergenrother , Ralph Chappa , Aron Anderson
IPC分类号： A61F2/00
CPC分类号： A61K9/0051 , A61F9/0017 , A61F2210/0004 , A61L31/06 , C08L67/025
摘要： The invention provides implantable medical devices that are fabricated of biodegradable materials for delivery of bioactive agent to limited access regions of a patient's body, such as the eye. The invention further provides methods of treatment utilizing the devices.
摘要翻译： 本发明提供了由可生物降解材料制成的植入式医疗装置，用于将生物活性剂递送到患者身体如眼睛的有限进入区域。 本发明还提供了利用这些装置的治疗方法。
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公开(公告)号：US20050281863A1
公开(公告)日：2005-12-22
申请号：US11203931
申请日：2005-08-15
申请人： Aron Anderson , Laurie Lawin , Byron Shen , Eugene de Juan , Signe Varner , Ralph Chappa
发明人： Aron Anderson , Laurie Lawin , Byron Shen , Eugene de Juan , Signe Varner , Ralph Chappa
CPC分类号： A61K31/58 , A61F2310/00353 , A61K9/0051
摘要： The invention provides controlled release bioactive agent delivery devices that include a body member having a direction of extension, a longitudinal axis along the direction of extension, and a proximal end and a distal end, wherein at least a portion of the body member deviates from the direction of extension, and a polymeric coated composition in contact with the body member, the polymeric coated composition including a first polymer, a second polymer, and a bioactive agent, wherein the first polymer and the second polymer are hydrophobic. The invention also provides methods of delivering a bioactive agent to a patient in a controlled release manner, as well as methods of making controlled release bioactive agent delivery devices.
摘要翻译： 本发明提供控制释放的生物活性剂递送装置，其包括具有延伸方向的本体构件，沿着延伸方向的纵向轴线，以及近端和远端，其中，身体构件的至少一部分偏离 所述聚合物涂覆组合物包括第一聚合物，第二聚合物和生物活性剂，其中所述第一聚合物和所述第二聚合物是疏水性的。 本发明还提供了以受控释放方式将生物活性剂递送至患者的方法，以及制备控制释放的生物活性剂递送装置的方法。
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公开(公告)号：US20050287188A1
公开(公告)日：2005-12-29
申请号：US11203981
申请日：2005-08-15
申请人： Aron Anderson , Laurie Lawin , Byron Shen , Eugene de Juan , Signe Varner , Ralph Chappa
发明人： Aron Anderson , Laurie Lawin , Byron Shen , Eugene de Juan , Signe Varner , Ralph Chappa
CPC分类号： A61K31/58 , A61F2310/00353 , A61K9/0051
摘要： The invention provides retrievable devices for sustained delivery of bioactive agent to a site within a patient, the devices including a body member having a direction of extension, a longitudinal axis along the direction of extension, and a proximal end and a distal end, wherein at least a portion of the body member deviates from the direction of extension; a cap at the proximal end of the body member; and a polymeric coated composition in contact with a surface of the body member, the polymeric coated composition including a first polymer, a second polymer, and a bioactive agent.
摘要翻译： 本发明提供了用于将生物活性剂持续递送到患者内的部位的可回收装置，所述装置包括具有延伸方向的本体构件，沿着延伸方向的纵向轴线，以及近端和远端，其中， 身体构件的至少一部分偏离延伸方向; 在主体构件的近端处的帽; 以及与本体构件的表面接触的聚合物涂覆的组合物，所述聚合物涂覆的组合物包含第一聚合物，第二聚合物和生物活性剂。
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公开(公告)号：US20050271706A1
公开(公告)日：2005-12-08
申请号：US11204271
申请日：2005-08-15
申请人： Aron Anderson , Laurie Lawin , Byron Shen , Eugene Juan , Signe Varner , Ralph Chappa
发明人： Aron Anderson , Laurie Lawin , Byron Shen , Eugene Juan , Signe Varner , Ralph Chappa
CPC分类号： A61K31/58 , A61F2310/00353 , A61K9/0051
摘要： The invention provides methods for delivering bioactive agent to an eye, the methods including steps of providing a device at an implantation site within the eye, and maintaining the device at the implantation site to provide a therapeutically effective amount of the bioactive agent to the eye. The device includes a body member having a direction of extension, a longitudinal axis along the direction of extension, and a proximal end and a distal end, wherein at least a portion of the body member deviates from the direction of extension. A polymeric coated composition is provided in contact with a surface of the body member, the polymeric coated composition including a first polymer, a second polymer, and a bioactive agent. The invention also provides methods of administering a therapeutically effective amount of bioactive agent to a posterior segment of an eye.
摘要翻译： 本发明提供了将生物活性剂递送到眼睛的方法，所述方法包括以下步骤：在眼睛内的植入部位提供装置，并将装置保持在植入部位以向眼睛提供治疗有效量的生物活性剂。 该装置包括具有延伸方向的本体构件，沿着延伸方向的纵向轴线，以及近端和远端，其中主体构件的至少一部分偏离延伸方向。 提供与主体构件的表面接触的聚合物涂覆的组合物，聚合物涂覆的组合物包括第一聚合物，第二聚合物和生物活性剂。 本发明还提供了将治疗有效量的生物活性剂施用于眼后段的方法。
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公开(公告)号：US20060013835A1
公开(公告)日：2006-01-19
申请号：US11225301
申请日：2005-09-12
申请人： Aron Anderson , Laurie Lawin , Byron Shen , Eugene de Juan , Signe Varner , Ralph Chappa
发明人： Aron Anderson , Laurie Lawin , Byron Shen , Eugene de Juan , Signe Varner , Ralph Chappa
CPC分类号： A61K31/58 , A61F2310/00353 , A61K9/0051
摘要： The invention provides a controlled release bioactive agent delivery device for treatment of an eye that includes a body member having a direction of extension, a longitudinal axis along the direction of extension, and a proximal end and a distal end, wherein at least a portion of the body member deviates from the direction of extension, and a polymeric coated composition in contact with a surface of the body member, the polymeric coated composition including a first polymer, a second polymer, and a bioactive agent. The first polymer and the second polymer are hydrophobic, and the body member has a length such that, upon placement of the device at an implantation site within a posterior segment of an eye, the device does not enter a central visual field of the eye. The invention also provides methods method of delivering bioactive agent to a posterior region of an eye.
摘要翻译： 本发明提供一种用于治疗眼睛的控制释放生物活性剂递送装置，其包括具有延伸方向的本体构件，沿着延伸方向的纵向轴线，以及近端和远端，其中至少一部分 身体构件偏离延伸方向，以及与本体构件的表面接触的聚合物涂覆的组合物，聚合物涂覆的组合物包括第一聚合物，第二聚合物和生物活性剂。 第一聚合物和第二聚合物是疏水性的，并且本体构件具有这样的长度，使得当将该装置放置在眼睛后部的植入部位时，该装置不进入眼睛的中心视野。 本发明还提供了将生物活性剂递送到眼后部区域的方法。
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公开(公告)号：US20050276837A1
公开(公告)日：2005-12-15
申请号：US11204195
申请日：2005-08-15
申请人： Aron Anderson , Laurie Lawin , Byron Shen , Eugene de Juan , Signe Varner , Ralph Chappa
发明人： Aron Anderson , Laurie Lawin , Byron Shen , Eugene de Juan , Signe Varner , Ralph Chappa
CPC分类号： A61K31/58 , A61F2310/00353 , A61K9/0051
摘要： The invention provides a controlled release bioactive agent delivery device that includes a body member having a direction of extension, a longitudinal axis along the direction of extension, and a proximal end and a distal end, wherein at least a portion of the body member deviates from the direction of extension, and a polymeric coated composition in contact with the body member, the polymeric coated composition including a first polymer, a second polymer, and a bioactive agent. The invention also provides methods of delivering a bioactive agent to a patient in a controlled release manner, as well as methods of making a controlled release bioactive agent delivery device.
摘要翻译： 本发明提供一种控制释放的生物活性剂递送装置，其包括具有延伸方向的本体构件，沿着延伸方向的纵向轴线，以及近端和远端，其中，身体构件的至少一部分偏离 所述延伸方向以及与所述主体构件接触的聚合物涂覆组合物，所述聚合物涂覆的组合物包括第一聚合物，第二聚合物和生物活性剂。 本发明还提供了以受控释放方式将生物活性剂递送到患者的方法，以及制备受控释放的生物活性剂递送装置的方法。
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公开(公告)号：US20050271703A1
公开(公告)日：2005-12-08
申请号：US11203879
申请日：2005-08-15
申请人： Aron Anderson , Laurie Lawin , Byron Shen , Eugene de Juan , Signe Varner , Ralph Chappa
发明人： Aron Anderson , Laurie Lawin , Byron Shen , Eugene de Juan , Signe Varner , Ralph Chappa
CPC分类号： A61K31/58 , A61F2310/00353 , A61K9/0051
摘要： The invention provides implantable sustained release bioactive agent delivery devices that include a body member having a direction of extension, a longitudinal axis along the direction of extension, and a proximal end and a distal end, wherein at least a portion of the body member deviates from the direction of extension; and a polymeric coated composition in contact with a surface of the body member, the polymeric coated composition including a first polymer, a second polymer, and a bioactive agent. The polymeric coated composition is formulated to provide controlled release of bioactive agent over time when introduced into physiological conditions. Methods of preparing implantable devices configured and formulated to provide controlled release of bioactive agent are also provided.
摘要翻译： 本发明提供可植入的缓释生物活性剂递送装置，其包括具有延伸方向的本体构件，沿着延伸方向的纵向轴线，以及近端和远端，其中，身体构件的至少一部分偏离 延伸方向; 以及与本体构件的表面接触的聚合物涂覆的组合物，所述聚合物涂覆的组合物包含第一聚合物，第二聚合物和生物活性剂。 配制聚合物涂覆的组合物以在引入生理条件时随时间提供生物活性剂的受控释放。 还提供了配制和配制以提供生物活性剂的受控释放的可植入装置的制备方法。
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公开(公告)号：US20050260246A1
公开(公告)日：2005-11-24
申请号：US11123835
申请日：2005-05-06
申请人： Stephen Chudzik , Aron Anderson , Ralph Chappa , Timothy Kloke , Laurie Lawin , Klaus Wormuth
发明人： Stephen Chudzik , Aron Anderson , Ralph Chappa , Timothy Kloke , Laurie Lawin , Klaus Wormuth
CPC分类号： A61L29/085 , A61L29/16 , A61L31/10 , A61L31/16 , A61L2300/602 , A61L2300/606 , C08L33/06
摘要： A coating composition for use in coating implantable medical devices to improve their ability to release bioactive agents in vivo. The coating composition is particularly adapted for use with devices that undergo significant flexion and/or expansion in the course of their delivery and/or use, such as stents and catheters. The composition includes the bioactive agent in combination with a mixture of a first polymer component such as poly(butyl methacrylate) and a second polymer component such as poly(ethylene-co-vinyl acetate).
摘要翻译： 用于涂覆可植入医疗装置以提高其在体内释放生物活性剂的能力的涂料组合物。 涂料组合物特别适用于在其输送和/或使用过程（例如支架和导管）中经历显着弯曲和/或膨胀的装置。 组合物包括与第一聚合物组分如聚（甲基丙烯酸丁酯）和第二聚合物组分如聚（乙烯 - 共 - 乙酸乙烯酯）的混合物的组合的生物活性剂。
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公开(公告)号：US20050170427A1
公开(公告)日：2005-08-04
申请号：US11101271
申请日：2005-04-06
申请人： Ralph Chappa , Sheau-Ping Hu , Dale Swan , Melvin Swanson , Patrick Guire
发明人： Ralph Chappa , Sheau-Ping Hu , Dale Swan , Melvin Swanson , Patrick Guire
IPC分类号： G01N33/53 , C07B61/00 , C07C45/63 , C07C235/84 , C07C323/42 , C07H21/00 , C12M1/00 , C12N15/09 , C12Q1/68 , C12Q1/6834 , C40B40/06 , C40B60/14 , G01N1/28 , G01N21/78 , G01N33/566 , G01N37/00 , C07H21/04 , C12M1/34
CPC分类号： B82Y30/00 , B01J2219/00317 , B01J2219/00531 , B01J2219/00605 , B01J2219/00608 , B01J2219/0061 , B01J2219/00612 , B01J2219/00621 , B01J2219/00626 , B01J2219/00635 , B01J2219/00637 , B01J2219/00659 , B01J2219/00677 , B01J2219/00711 , B01J2219/00716 , B01J2219/00722 , C07B2200/11 , C07C45/63 , C07C235/84 , C07C323/42 , C07H21/00 , C12Q1/6834 , C40B40/06 , C40B60/14 , C07C49/813
摘要： Method and reagent composition for covalent attachment of target molecules, such as nucleic acids, onto the surface of a substrate. The reagent composition includes groups capable of covalently binding to the target molecule. Optionally, the composition can contain photoreactive groups for use in attaching the reagent composition to the surface. The reagent composition can be used to provide activated slides for use in preparing microarrays of nucleic acids.
摘要翻译： 用于将目标分子（例如核酸）共价连接到基底表面上的方法和试剂组合物。 试剂组合物包括能够共价结合靶分子的基团。 任选地，组合物可以含有用于将试剂组合物附着到表面上的光反应性基团。 试剂组合物可用于提供用于制备核酸微阵列的活性载玻片。
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公开(公告)号：US20050244453A1
公开(公告)日：2005-11-03
申请号：US11090655
申请日：2005-03-25
申请人： Sean Stucke , Ralph Chappa , Joseph Chinn , Aron Anderson
发明人： Sean Stucke , Ralph Chappa , Joseph Chinn , Aron Anderson
IPC分类号： A61F2/00 , A61L27/34 , A61L27/54 , A61L29/08 , A61L29/16 , A61L31/10 , A61L31/16 , A61L33/00
CPC分类号： A61L31/16 , A61L27/34 , A61L27/54 , A61L31/10 , A61L33/0011 , A61L2300/406 , A61L2300/416 , A61L2300/42 , A61L2300/608 , C08L33/10 , C08L29/04 , C08L39/06
摘要： The invention provides methods and compositions for providing biocompatible surfaces to medical articles. In particular the invention provides biocompatible coatings with heparin activity. In some aspects, the biocompatible coatings of the invention are able to release a bioactive agent. The coatings can be formed using biostable or biodegradable polymeric material and photoreactive groups. The invention also provides methods for improving the quality of bioactive agent-containing coatings by performing pre-irradiation of biocompatible coating compositions.
摘要翻译： 本发明提供了用于向医疗制品提供生物相容性表面的方法和组合物。 特别地，本发明提供具有肝素活性的生物相容性涂层。 在一些方面，本发明的生物相容性涂层能够释放生物活性剂。 可以使用生物稳定或可生物降解的聚合物材料和光反应性基团形成涂层。 本发明还提供了通过进行生物相容性涂料组合物的预辐射来提高含生物活性剂的涂层的质量的方法。
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