公开(公告)号：US20050059956A1

公开(公告)日：2005-03-17

申请号：US10823089

申请日：2004-04-12

申请人： Signe Varner ,  Eugene Dejuan ,  Terry Shelley ,  Aaron Barnes ,  Mark Humayun

发明人： Signe Varner ,  Eugene Dejuan ,  Terry Shelley ,  Aaron Barnes ,  Mark Humayun

IPC分类号： A61F9/007 ,  A61B17/00 ,  A61F9/00 ,  A61K9/00 ,  A61K9/22 ,  A61K45/00 ,  A61L31/00 ,  A61P27/02 ,  A61M31/00

CPC分类号： A61K9/0051 ,  A61B2017/00867 ,  A61F9/0017

摘要： An therapeutic agent delivery device that can allows is particularly suitable for delivery of a therapeutic agent to limited access regions, such as the posterior chamber of the eye and inner ear. Preferred devices of the invention are minimally invasive, refillable and may be easily fixed to the treatment area. Preferred delivery devices of the invention also include those that comprise a non-linear shaped body member body housing one or more substances and a delivery mechanism for the sustained delivery of the one or more substances from the non-linear shaped body member to the patient.

摘要翻译： 可以允许的治疗剂递送装置特别适合于将治疗剂递送到有限的进入区域，例如眼睛的后室和内耳。 本发明的优选装置是微创的，可再填充的并且可以容易地固定到治疗区域。 本发明的优选输送装置还包括包含一个或多个物质的非线性形状的身体构件体和用于将一种或多种物质从非线性形状的身体构件持续递送至患者的输送机构的输送装置。

公开(公告)号：US08096972B2

公开(公告)日：2012-01-17

申请号：US10740698

申请日：2003-12-19

申请人： Sign Erickson Varner ,  Eugene Dejuan, Jr. ,  Terry Shelley ,  Aaron Christopher Barnes ,  Mark Humayun

发明人： Sign Erickson Varner ,  Eugene Dejuan, Jr. ,  Terry Shelley ,  Aaron Christopher Barnes ,  Mark Humayun

IPC分类号： A61M31/00

CPC分类号： A61K9/0051 ,  A61B2017/00867 ,  A61F9/0017

摘要： A therapeutic agent delivery device that is particularly suitable for delivery of a therapeutic agent to limited access regions, such as the posterior chamber of the eye and inner ear. Preferred devices of the invention are minimally invasive, refillable and may be easily fixed to the treatment area. Preferred delivery devices of the invention also include those that comprise a non-linear shaped body member housing one or more substances and a delivery mechanism for the sustained delivery of the one or more substances from the non-linear shaped body member to the patient.

摘要翻译： 一种治疗剂递送装置，其特别适用于将治疗剂递送至限制的进入区域，例如眼睛后内腔和内耳。 本发明的优选装置是微创的，可再填充的并且可以容易地固定到治疗区域。 本发明的优选的输送装置还包括包含一个或多个物质的非线性形状的本体构件和用于将一种或多种物质从非线性体状构件持续递送至患者的输送机构的输送装置。

公开(公告)号：US06719750B2

公开(公告)日：2004-04-13

申请号：US09888092

申请日：2001-06-22

申请人： Signe Erickson Varner ,  Eugene DeJuan, Jr. ,  Terry Shelley ,  Aaron Christopher Barnes ,  Mark Humayun

发明人： Signe Erickson Varner ,  Eugene DeJuan, Jr. ,  Terry Shelley ,  Aaron Christopher Barnes ,  Mark Humayun

IPC分类号： A61F922

CPC分类号： A61K9/0051 ,  A61B2017/00867 ,  A61F9/0017

摘要： An therapeutic agent delivery device that can allows is particularly suitable for delivery of a therapeutic agent to limited access regions, such as the posterior chamber of the eye and inner ear. Preferred devices of the invention are minimally invasive, refillable and may be easily fixed to the treatment area. Preferred delivery devices of the invention also include those that comprise a non-linear shaped body member body housing one or more substances and a delivery mechanism for the sustained delivery of the one or more substances from the non-linear shaped body member to the patient.

摘要翻译： 可以允许的治疗剂递送装置特别适合于将治疗剂递送到有限的进入区域，例如眼睛的后室和内耳。 本发明的优选装置是微创的，可再填充的并且可以容易地固定到治疗区域。 本发明的优选输送装置还包括包含一个或多个物质的非线性形状的身体构件体和用于将一种或多种物质从非线性形状的身体构件持续递送至患者的输送机构的输送装置。

公开(公告)号：US07563222B2

公开(公告)日：2009-07-21

申请号：US11228030

申请日：2005-09-15

申请人： Charles E. Larsen ,  Richard A. Hillstead ,  Roelof Trip ,  Eugene deJuan ,  Mark Humayun ,  Eberhard Fritz ,  Rainer Pintaske

发明人： Charles E. Larsen ,  Richard A. Hillstead ,  Roelof Trip ,  Eugene deJuan ,  Mark Humayun ,  Eberhard Fritz ,  Rainer Pintaske

IPC分类号： A61N5/00

CPC分类号： A61N5/1017 ,  A61N5/1049 ,  A61N2005/1058

摘要： A method for performing intraocular brachytherapy and an apparatus for performing the same is disclosed. The apparatus preferably comprises a hand-held delivery device that advances a radiation source into an associated cannula or probe that is positioned adjacent the target tissue. The handpiece provides for shielded storage of the radiation source when retracted from the cannula and includes a slider mechanism for advancing and retracting the radiation source. The radiation source is mounted to a wire that has a flexible distal end and a relatively stiffer proximal end.

摘要翻译： 公开了一种用于进行眼内近距离放射治疗的方法及其执行装置。 该装置优选地包括将辐射源前进到与靶组织相邻定位的相关套管或探针中的手持递送装置。 所述手持件在从套管缩回时提供辐射源的屏蔽存储，并且包括用于前进和后退辐射源的滑块机构。 辐射源安装到具有柔性远端和较硬的近端的导线上。

公开(公告)号：US20100268013A1

公开(公告)日：2010-10-21

申请号：US12792005

申请日：2010-06-02

申请人： Charles E. Larsen ,  Richard A. Hillstead ,  Roelof Trip ,  Eugene deJuan ,  Mark Humayun ,  Eberhard Fritz ,  Rainer Pintaske

发明人： Charles E. Larsen ,  Richard A. Hillstead ,  Roelof Trip ,  Eugene deJuan ,  Mark Humayun ,  Eberhard Fritz ,  Rainer Pintaske

IPC分类号： A61M36/04

CPC分类号： A61N5/1017

摘要： A method for performing intraocular brachytherapy and an apparatus for performing the same is disclosed. The apparatus preferably comprises a hand-held delivery device that advances a radiation source into an associated cannula or probe that is positioned adjacent the target tissue. The handpiece provides for shielded storage of the radiation source when retracted from the cannula and includes a slider mechanism for advancing and retracting the radiation source. The radiation source is mounted to a wire that has a flexible distal end and a relatively stiffer proximal end. A positioning system for the cannula is also disclosed.

摘要翻译： 公开了一种用于进行眼内近距离放射治疗的方法及其执行装置。 该装置优选地包括将辐射源前进到与靶组织相邻定位的相关套管或探针中的手持递送装置。 所述手持件在从套管缩回时提供辐射源的屏蔽存储，并且包括用于前进和后退辐射源的滑块机构。 辐射源安装到具有柔性远端和较硬的近端的导线上。 还公开了用于套管的定位系统。

公开(公告)号：US20070055089A1

公开(公告)日：2007-03-08

申请号：US11593683

申请日：2006-11-07

申请人： Charles Larsen ,  Richard Hillstead ,  Roelof Trip ,  Eugene deJuan ,  Mark Humayun ,  Eberhard Fritz ,  Rainer Pintaske

发明人： Charles Larsen ,  Richard Hillstead ,  Roelof Trip ,  Eugene deJuan ,  Mark Humayun ,  Eberhard Fritz ,  Rainer Pintaske

IPC分类号： A61N5/00

CPC分类号： A61N5/1017

摘要： A method for performing intraocular brachytherapy and an apparatus for performing the same is disclosed. The apparatus preferably comprises a hand-held delivery device that advances a radiation source into an associated cannula or probe that is positioned adjacent the target tissue. The handpiece provides for shielded storage of the radiation source when retracted from the cannula and includes a slider mechanism for advancing and retracting the radiation source. The radiation source is mounted to a wire that has a flexible distal end and a relatively stiffer proximal end. A positioning system for the cannula is also disclosed.

摘要翻译： 公开了一种用于进行眼内近距离放射治疗的方法及其执行装置。 该装置优选地包括将辐射源前进到与靶组织相邻定位的相关套管或探针中的手持递送装置。 所述手持件在从套管缩回时提供辐射源的屏蔽存储，并且包括用于前进和后退辐射源的滑块机构。 辐射源安装到具有柔性远端和较硬的近端的导线上。 还公开了用于套管的定位系统。

公开(公告)号：US20060111605A1

公开(公告)日：2006-05-25

申请号：US11228030

申请日：2005-09-15

申请人： Charles Larsen ,  Richard Hillstead ,  Roelof Trip ,  Eugene deJuan ,  Mark Humayun ,  Eberhard Fritz ,  Rainer Pintaske

发明人： Charles Larsen ,  Richard Hillstead ,  Roelof Trip ,  Eugene deJuan ,  Mark Humayun ,  Eberhard Fritz ,  Rainer Pintaske

IPC分类号： A61N5/00

CPC分类号： A61N5/1017 ,  A61N5/1049 ,  A61N2005/1058

摘要： A method for performing intraocular brachytherapy and an apparatus for performing the same is disclosed. The apparatus preferably comprises a hand-held delivery device that advances a radiation source into an associated cannula or probe that is positioned adjacent the target tissue. The handpiece provides for shielded storage of the radiation source when retracted from the cannula and includes a slider mechanism for advancing and retracting the radiation source. The radiation source is mounted to a wire that has a flexible distal end and a relatively stiffer proximal end.

公开(公告)号：US20100157620A1

公开(公告)日：2010-06-24

申请号：US12641269

申请日：2009-12-17

申请人： Prashant Bhadri ,  James Lescoulie ,  Sophia Fang ,  Matthew McCormick ,  Ralph Kerns ,  Mark Humayun ,  Aaron Barnes

发明人： Prashant Bhadri ,  James Lescoulie ,  Sophia Fang ,  Matthew McCormick ,  Ralph Kerns ,  Mark Humayun ,  Aaron Barnes

IPC分类号： G02B6/04 ,  F21V7/00 ,  F21V9/00 ,  F21S8/00

CPC分类号： A61B3/13

摘要： A first light source producing a first light beam with a first intensity and a second light source producing a second light beam with a second intensity. A light filter device receives the first light beam and transmits a filtered portion of the first light beam. A first angling device reflects the filtered portion of the first light beam in a first angled direction and a second angling device reflects the second light beam in a second angled direction. A mirror receives and in turn reflects the filtered portion of the first light beam reflected by the first angling device and the second light beam reflected by the second angling device to form a converged light beam with a third intensity.

摘要翻译： 产生具有第一强度的第一光束的第一光源和产生具有第二强度的第二光束的第二光源。 光过滤器装置接收第一光束并透射第一光束的滤波部分。 第一倾斜装置以第一倾斜方向反射第一光束的过滤部分，而第二垂直装置以第二倾斜方向反射第二光束。 反射镜接收反射由第一钓鱼装置反射的第一光束的过滤部分和由第二钓鱼装置反射的第二光束，以形成具有第三强度的会聚光束。

公开(公告)号：US07654716B1

公开(公告)日：2010-02-02

申请号：US11938233

申请日：2007-11-09

申请人： Prashant Bhadri ,  James Lescoulie ,  Sophia Fang ,  Matthew McCormick ,  Ralph Kerns ,  Mark Humayun ,  Aaron Barnes

发明人： Prashant Bhadri ,  James Lescoulie ,  Sophia Fang ,  Matthew McCormick ,  Ralph Kerns ,  Mark Humayun ,  Aaron Barnes

IPC分类号： A61B1/06

CPC分类号： A61B3/13

摘要： A first light source producing a first light beam with a first intensity and a second light source producing a second light beam with a second intensity. A light filter device receives the first light beam and transmits a filtered portion of the first light beam. A first angling device reflects the filtered portion of the first light beam in a first angled direction and a second angling device reflects the second light beam in a second angled direction. A mirror receives and in turn reflects the filtered portion of the first light beam reflected by the first angling device and the second light beam reflected by the second angling device to form a converged light beam with a third intensity.

摘要翻译： 产生具有第一强度的第一光束的第一光源和产生具有第二强度的第二光束的第二光源。 光过滤器装置接收第一光束并透射第一光束的滤波部分。 第一倾斜装置以第一倾斜方向反射第一光束的过滤部分，而第二垂直装置以第二倾斜方向反射第二光束。 反射镜接收反射由第一钓鱼装置反射的第一光束的过滤部分和由第二钓鱼装置反射的第二光束，以形成具有第三强度的会聚光束。

公开(公告)号：US20110282161A1

公开(公告)日：2011-11-17

申请号：US13190142

申请日：2011-07-25

申请人： Prashant Bhadri ,  James Lescoulie ,  Sophia Fang ,  Matthew McCormick ,  Ralph Kems ,  Mark Humayun ,  Aaron Barnes

发明人： Prashant Bhadri ,  James Lescoulie ,  Sophia Fang ,  Matthew McCormick ,  Ralph Kems ,  Mark Humayun ,  Aaron Barnes

IPC分类号： A61B1/06

CPC分类号： A61B3/13

摘要： A first light source producing a first light beam with a first intensity and a second light source producing a second light beam with a second intensity. A light filter device receives the first light beam and transmits a filtered portion of the first light beam. A first angling device reflects the filtered portion of the first light beam in a first angled direction and a second angling device reflects the second light beam in a second angled direction. A mirror receives and in turn reflects the filtered portion of the first light beam reflected by the first angling device and the second light beam reflected by the second angling device to form a converged light beam with a third intensity.

摘要翻译： 产生具有第一强度的第一光束的第一光源和产生具有第二强度的第二光束的第二光源。 光过滤器装置接收第一光束并透射第一光束的滤波部分。 第一倾斜装置以第一倾斜方向反射第一光束的过滤部分，而第二垂直装置以第二倾斜方向反射第二光束。 反射镜接收反射由第一钓鱼装置反射的第一光束的过滤部分和由第二钓鱼装置反射的第二光束，以形成具有第三强度的会聚光束。