公开(公告)号：US20250059258A1

公开(公告)日：2025-02-20

申请号：US18721454

申请日：2022-12-23

Applicant: AVITIDE LLC

Inventor： Thomas Scanlon ,  Jonathan Belk ,  Kelley Kearns ,  Sarah Valentini

IPC: C07K16/00 ,  C07K1/22 ,  C07K14/00 ,  C07K17/08

Abstract: The present disclosure relates to the field of chromatography, and more specifically to novel affinity ligands and affinity agents which are suitable for use in isolation of antibody and antibody fragments that contain the heavy chain first constant region (CHI). The disclosure encompasses affinity ligands as such, chromatography separation matrices (affinity agents) comprising an affinity ligand according to the disclosure, and a process of isolating antibodies, especially IgGs, and CHI-containing antibody fragments thereof using an affinity ligand according to the disclosure. Methods of making the affinity ligands and separation matrices are also provided.

公开(公告)号：US20230391829A1

公开(公告)日：2023-12-07

申请号：US18031833

申请日：2021-10-13

Applicant: Avitide LLC

Inventor： Sarmistha Bhattacharya ,  Brandon Coyle ,  Sarah Valentini ,  Kelley Kearns ,  Thomas Scanlon ,  William Wellborn ,  Warren Kett

IPC: C07K14/00 ,  C07K1/22 ,  B01D15/38

CPC classification number: C07K14/001 ,  C07K2319/21 ,  B01D15/3804 ,  C07K1/22

Abstract: Provided herein are affinity ligands that specifically interact with AAV8 capsid and/or AAV8 variant capsid, affinity agents comprising the affinity ligands, and methods of their use for binding, isolation, and/or purification of AAV8 and variants thereof.

公开(公告)号：US20240137538A1

公开(公告)日：2024-04-25

申请号：US18277683

申请日：2022-02-22

Applicant: Avitide LLC

Inventor： Christian Ndong ,  Jonathan Belk ,  Sarah Mallon ,  Kelley Kearns ,  Thomas Scanlon ,  Warren Kett

IPC: H04N19/44 ,  H04N19/105 ,  H04N19/119 ,  H04N19/176

CPC classification number: H04N19/44 ,  H04N19/105 ,  H04N19/119 ,  H04N19/176

Abstract: Aspects of the disclosure provide methods and apparatuses for video encoding/decoding. In some examples, an apparatus for video decoding includes receiving circuitry and processing circuitry. The processing circuitry decodes prediction information of a current block from a coded video bitstream. In some embodiments, the processing circuitry determines a first subpartition and a second sub-partition of the current block based on the decoded prediction information, and then reconstructs the first sub-partition and the second sub-partition of the current block based on at least a neighboring sample of the current block that is out of a neighboring area of at least one of the first sub-partition and the second sub-partition.

公开(公告)号：US20240026344A1

公开(公告)日：2024-01-25

申请号：US18031808

申请日：2021-10-13

Applicant: Avitide LLC

Inventor： Brandon Kier ,  Molly North ,  Sarmistha Bhattacharya ,  Thomas Scanlon ,  Warren Kett

IPC: C12N15/10

CPC classification number: C12N15/1037

Abstract: The present disclosure relates to the field of affinity chromatography, and more specifically to the provision of nucleic acid and polypeptide libraries encoding three-helix bundle protein domains suitable for selecting affinity ligands that specifically binds to a target molecule of interest. The disclosure also relates to methods of using those libraries to identify and isolate such affinity ligands to a target molecule.

公开(公告)号：US20240236347A9

公开(公告)日：2024-07-11

申请号：US18277683

申请日：2022-02-22

Applicant: Avitide LLC

Inventor： Christian Ndong ,  Jonathan Belk ,  Sarah Mallon ,  Kelley Kearns ,  Thomas Scanlon ,  Warren Kett

IPC: H04N19/44 ,  H04N19/105 ,  H04N19/119 ,  H04N19/176

CPC classification number: H04N19/44 ,  H04N19/105 ,  H04N19/119 ,  H04N19/176

Abstract: Aspects of the disclosure provide methods and apparatuses for video encoding/decoding. In some examples, an apparatus for video decoding includes receiving circuitry and processing circuitry. The processing circuitry decodes prediction information of a current block from a coded video bitstream. In some embodiments, the processing circuitry determines a first subpartition and a second sub-partition of the current block based on the decoded prediction information, and then reconstructs the first sub-partition and the second sub-partition of the current block based on at least a neighboring sample of the current block that is out of a neighboring area of at least one of the first sub-partition and the second sub-partition.

公开(公告)号：US20220213447A1

公开(公告)日：2022-07-07

申请号：US17613427

申请日：2020-05-22

Applicant: Avitide LLC

Inventor： William Scott Dodson ,  Brandon Kier ,  Brandon Coyle ,  Sarah Valentini ,  Thomas Scanlon ,  Warren Kett

IPC: C12N7/00 ,  C07K7/02 ,  C07K7/06 ,  C07K7/08 ,  B01D15/32 ,  B01D15/38

Abstract: Provided herein are affinity agents comprising ligands that specifically bind adeno-associated virus. The affinity agents are useful for binding, isolation, and/or purification of adeno-associated virus. Further disclosed are amino acid sequences of binding motifs or polypeptides comprised by the ligands, and associated modifications of the binding motifs and/or polypeptides, as well as a method of making the affinity agents.