公开(公告)号：US20140308225A1

公开(公告)日：2014-10-16

申请号：US14358790

申请日：2012-11-20

Applicant: BASF SE

Inventor： Bernd Herzog ,  Cyrille Deshayes

IPC: A61K8/04 ,  A61K8/49 ,  A61K8/37 ,  A61Q17/04

CPC classification number: A61K8/042 ,  A61K8/31 ,  A61K8/34 ,  A61K8/342 ,  A61K8/37 ,  A61K8/375 ,  A61K8/4966 ,  A61K8/891 ,  A61K8/922 ,  A61Q17/04

Abstract: Disclosed is the use of oleogels (a) for increasing the sun protection factor of sunscreens comprising at least one organic or inorganic UV filter (b).

Abstract translation: 公开了使用油凝胶（a）来增加包含至少一种有机或无机UV过滤器（b）的防晒剂的防晒因子。

公开(公告)号：US11419804B2

公开(公告)日：2022-08-23

申请号：US15327071

申请日：2015-07-24

Applicant: BASF SE

Inventor： Bernd Herzog ,  Dieter Kockott ,  Heike Flösser-Müller

IPC: A61K8/44 ,  A61Q17/04 ,  A61K8/49 ,  A61K8/35 ,  A61K8/29 ,  A61K8/37 ,  A61K8/41 ,  A61K8/40

Abstract: The present invention relates to a sunscreen formulation comprising at least one of the UV filters (A) selected from (a) triazine derivatives; (b) cinnamic acid derivatives; (c) bis-resorcinyl triazines; (f) benzimidazole derivatives; (i5) 4-Methylbenzylidene Camphor; (h) benzoyl piperazine derivatives; (j) benzoxazole derivatives; (k) diarylbutadiene derivatives; (I) phenyl benzotriazole derivatives; (n) benzylidene malonates; (o3) TEA-Salicylate; (r) imidazoline derivatives; (u) inorganic UV filters selected from metal oxides; (v) naphthalates; and (w) merocyanine derivatives; and optionally comprising at least one of the UV filters (B) selected from (d) aminobenzophenone derivatives; (e) dibenzoylmethane derivatives; (g) β,β-Diphenylacrylate derivatives; (i5) camphor derivatives different from; (o3) salicylate derivatives different from; (p) anthranilate derivatives; and (s) benzalmalonate derivatives; wherein the ratio R of the effective irradiance for previtamin D3 formation Epvd to the effective irradiance for erythema formation Eer on the skin is at least 1.8, for increasing the transmittance of UV radiation on human skin for the production of cholecalciferol (previtamin D3) and simultaneously for the use in a method for protecting the human skin against UV radiation when exposed to the sun, which method comprises applying said sunscreen formulation to the skin.

公开(公告)号：US20220008298A1

公开(公告)日：2022-01-13

申请号：US17484062

申请日：2021-09-24

Applicant: BASF SE

Inventor： Bernd Herzog ,  Cyrille Deshayes

IPC: A61K8/04 ,  A61K8/37 ,  A61Q17/04 ,  A61K8/92 ,  A61K8/34 ,  A61K8/31 ,  A61K8/891 ,  A61K8/49

Abstract: Disclosed is the use of oleogels (a) for increasing the sun protection factor of sunscreens comprising at least one organic or inorganic UV filter (b).

公开(公告)号：US20160158132A1

公开(公告)日：2016-06-09

申请号：US15042704

申请日：2016-02-12

Applicant: BASF SE

Inventor： Bernd Herzog ,  Julie Grumelard

IPC: A61K8/49 ,  A61K8/41 ,  A61K8/37 ,  A61Q17/04

CPC classification number: A61K8/494 ,  A61K8/36 ,  A61K8/37 ,  A61K8/40 ,  A61K8/41 ,  A61K8/411 ,  A61K8/496 ,  A61K8/4966 ,  A61K2800/52 ,  A61K2800/592 ,  A61Q17/04

Abstract: Disclosed is the Use of UV absorbers selected from (a1) diphenylacrylates; and (a2) hydroxyphenyl triazines of formula wherein R1 is —O—R5; —COOR6; or —CO—NHR7; R2 is —O—R8, —COOR9; or —CO—NHR10; R3 is —O—R11; —COOR12; or —CO—NHR13; R5, R6, R7, R8, R9, R10, R11, R12 and R13 independently from each other are C1-C18alkyl; R4 is hydrogen; or hydroxy; and x is 0; or 1; for stabilizing cosmetic compositions comprising an organic UV absorber selected from (b1) a benzophenone derivatives of formula wherein R14 and R15 independently from each other are; C1-C20alkyl; C2-C20alkenyl; C3-C10cycloalkyl; C3-C10cycloalkenyl; or R14 and R15 together with the linking nitrogen atom form a 5- or 6-membered heterocyclic ring; n1 is a number from 1 to 4; when n1=1, R16 is a saturated or unsaturated heterocyclic radical; hydroxy-C1-C5alkyl; cyclohexyl optionally substituted with one or more C1-C5alkyl; phenyl optionally substituted with a heterocyclic radical, aminocarbonyl or C1-C5alkylcarboxy; when n1 is 2, R16 is an alkylene-, cycloalkylene alkenylene or phenylene radical which is optionally substituted by a carbonyl- or carboxy group; a radical of formula *-CH2—C≡C—CH2-* or R16 together with A forms a bivalent radical of the formula wherein n2 is a number from 1 to 3; when n1 is 3, R16 is an alkantriyl radical; when n1 is 4, R16 is an alkanetetrayl radical; A is —O—; or —N(R17)—; and R17 is hydrogen; C1-C5alkyl; or hydroxy-C1-C5alkyl; (b2) a benzotriazole derivative of formula wherein T1 is optionally phenyl-substituted C1-C12alkyl; and (b3) a triazine derivative of formula wherein A is a radical of formula R17 and R21 independently from each other are hydrogen; C1-C18alkyl; or C6-C12aryl; R18, R19 and R20 independently from each other are hydrogen; or a radical of formula wherein, in formula (4a), at least one of the radicals R18, R19 and R20 are a radical of formula (4c); R22, R23, R24, R25 and R26 independently from each other are hydrogen; hydroxy; halogen; C1-C18alkyl; C1-C18alkoxy; C6-C12aryl; biphenylyl; C6-C12aryloxy; C1-C18alkylthio; carboxy; —COOM; C1-C18-alkylcarboxyl; aminocarbonyl; or mono- or di-C1-C18alkylamino; C1-C10acylamino; —COOH; M is an alkali metal ion; x is 1 or 2; and y is a number from 2 to 10; and UV filters selected from (c1) cinnamic acid derivatives; and (c2) dibenzoylmethane derivatives.

公开(公告)号：US20150250695A1

公开(公告)日：2015-09-10

申请号：US14722037

申请日：2015-05-26

Applicant: BASF SE

Inventor： Bernd Herzog ,  Katja Quass ,  Stephanie Acker

IPC: A61K8/49 ,  A61K8/37 ,  A61K8/368 ,  A61Q17/04 ,  A61K8/40

CPC classification number: A61K8/4973 ,  A61K8/35 ,  A61K8/368 ,  A61K8/37 ,  A61K8/40 ,  A61K8/494 ,  A61K8/4966 ,  A61K2800/592 ,  A61Q17/04

Abstract: Disclosed is the use of UV absorbers selected from (a1) diphenylacrylates; (a2) hydroxyphenyl triazines of formula (1), in which R1, R2 and R3 independently of one another, are C1-C18alkyl; (a3) benzotriazole derivatives of formula (2), wherein R4 is a random statistical mixture of at least three isomeric branched secondary alkyl groups each having 8 to 30 carbon atoms and having the formula (2a); E1 is a straight-chain C1-C14alkyl; E2 is a straight-chain C4-C15alkyl; wherein the total number of carbon atoms in E1 plus E2 is from 7 to 29; and R5 is C1-C5alkyl; and (a4) dialkyl naphthalate; for stabilizing cosmetic compositions comprising (b) symmetrical triazine derivatives of formula (3), wherein A is a radical of formula (3a); or (3b) R6 and R10 independently from each other are hydrogen; C1-C18alkyl; or C6-C12aryl; R7, R8 and R9 independently from each other are hydrogen; or a radical of formula (3c), wherein, in formula (3a), at least one of the radicals R7, R8 and R9 are a radical of formula (3c); R11, R12, R13 and R14 independently from each other are hydrogen; hydroxy; halogen; C1-C18alkyl; C1-C18alkoxy; C6-C12aryl; biphenylyl; C6-C12aryloxy; C1-C18alkylthio; carboxy; —COOM; C1-C18-alkylcarboxyl; aminocarbonyl; mono- or di-C1-C18alkylamino; C1-C10acylamino; or —COOH; M is an alkali metal ion; x is 1 or 2; and y is a number from 2 to 10; and a UV-absorber selected from (c1) cinnamic acid derivatives; and (C2) dibenzoylmethane derivatives.

Abstract translation: 公开了使用选自（a1）二苯基丙烯酸酯的UV吸收剂; （a2）式（1）的羟基苯基三嗪，其中R 1，R 2和R 3彼此独立地是C 1 -C 18烷基; （a3）式（2）的苯并三唑衍生物，其中R4是至少三个具有8至30个碳原子并具有式（2a）的异构支链仲烷基的随机统计混合物; E1是直链C1-C14烷基; E2是直链C4-C15烷基; 其中E1加E2的总碳原子数为7〜29; R5是C1-C5烷基; 和（a4）萘二甲酸二烷基酯; 用于稳定化妆品组合物，其包含（b）式（3）的对称三嗪衍生物，其中A是式（3a）的基团; 或（3b）R 6和R 10彼此独立地为氢; C1-C18烷基; 或C6-C12芳基; R 7，R 8和R 9彼此独立地为氢; 或式（3c）的基团，其中在式（3a）中，基团R7，R8和R9中的至少一个是式（3c）的基团; R 11，R 12，R 13和R 14彼此独立地为氢; 羟基; 卤素; C1-C18烷基; C1-C18烷氧基; C6-C12芳基; 联苯基 C 6 -C 12芳氧基; C1-C18烷硫基; 羧基; -COOM; C 1 -C 18烷基羧基; 氨基羰基; 单或二C1-C18烷基氨基; C1-C10酰氨基; 或-COOH; M是碱金属离子; x为1或2; y为2〜10的数; 和选自（c1）肉桂酸衍生物的紫外线吸收剂; 和（C2）二苯甲酰甲烷衍生物。