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1.发明申请Active-Ingredient-Containing Solid Dispersions Based on Diethylaminoethyl Methacrylate Copolymers 审中-公开基于甲基丙烯酸二乙基氨基乙酯共聚物的含活性成分的固体分散体公开(公告)号：US20130345320A1
公开(公告)日：2013-12-26
申请号：US13919092
申请日：2013-06-17
Applicant: BASF SE
Inventor： Karl Kolter , Maximilian Angel , Matthias Karl , Silke Gebert , Michael Klemens Müller
IPC: A61K47/32
CPC classification number: A61K47/32 , A61K9/146 , A61K9/1635
Abstract: Described are solid dispersions of hydrophobic active ingredients and cationic copolymers of N,N-diethylaminoethyl methacrylate and methyl methacrylate in a weight ratio of the monomers of from 35:65 to 55:45. Also described are the preparation and use of such solid dispersions for pharmaceutical dosage forms.
Abstract translation: 描述了单体重量比为35:65至55:45的疏水性活性成分和甲基丙烯酸N，N-二乙基氨基乙酯和甲基丙烯酸甲酯的阳离子共聚物的固体分散体。 还描述了用于药物剂型的这种固体分散体的制备和用途。
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2.发明申请Production Of Pharmaceutical Protective Coatings With Good Resistance In A Neutral Environment 审中-公开在中性环境中生产具有良好电阻的药用保护涂料公开(公告)号：US20130236505A1
公开(公告)日：2013-09-12
申请号：US13790101
申请日：2013-03-08
Applicant: BASF SE
Inventor： Karl Kolter , Silke Gebert , Michael Klemens Müller , Maximilian Angel
CPC classification number: A61K47/32 , A61K9/0002 , A61K9/282 , A61K9/2846 , A61K9/5015 , A61K9/5026 , A61K47/12
Abstract: Pharmaceutical coatings obtained from coating compositions based on film-forming copolymers of N,N-diethylaminoethyl methacrylate (DEAEMA) and methyl methacrylate (MMA) comprising a weight ratio of DEAEMA:MMA in the range of 35:65 to 55:45, where the copolymers are present partially neutralized with C3-C10-dicarboxylic acids.
Abstract translation: 由基于N，N-二乙基氨基乙基甲基丙烯酸酯（DEAEMA）和甲基丙烯酸甲酯（MMA）的成膜共聚物的涂料组合物获得的药物涂料，其重量比为DEAEMA:MMA，范围为35:65至55:45，其中 共聚物用C3-C10-二羧酸部分中和。
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公开(公告)号：US09789063B2
公开(公告)日：2017-10-17
申请号：US14036365
申请日：2013-09-25
Applicant: BASF SE
Inventor： Felicitas Guth , Karl Kolter , Michael Schönherr , Michael Klemens Müller
CPC classification number: A61K9/1617 , A61K9/1682 , A61K47/22 , A61K47/32
Abstract: Described is a storage-stable dust-free homogeneous particulate formulation. The formulation consists of (a) at least one water-soluble Vitamin E-derivative, (b) at least one hydrophilic polymer, (c) optionally additional surface-active substances, and (d) optionally additional pharmaceutical additives. The sum of (a), (b), (c) and (d) equals 100% by weight of the formulation. The fines fraction with particle diameters of less than 100 μm is less than 10% by weight. Describe also is a process for manufacturing the formulation, and use of the formulation as a solubilizing composition in pharmaceutical formulations.
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公开(公告)号：US20140086992A1
公开(公告)日：2014-03-27
申请号：US14036365
申请日：2013-09-25
Applicant: BASF SE
Inventor： Felicitas Guth , Karl Kolter , Michael Schönherr , Michael Klemens Müller
IPC: A61K9/16
CPC classification number: A61K9/1617 , A61K9/1682 , A61K47/22 , A61K47/32
Abstract: Described is a storage-stable dust-free homogeneous particulate formulation. The formulation consists of (a) at least one water-soluble Vitamin E-derivative, (b) at least one hydrophilic polymer, (c) optionally additional surface-active substances, and (d) optionally additional pharmaceutical additives. The sum of (a), (b), (c) and (d) equals 100% by weight of the formulation. The fines fraction with particle diameters of less than 100 μm is less than 10% by weight. Describe also is a process for manufacturing the formulation, and use of the formulation as a solubilizing composition in pharmaceutical formulations.
Abstract translation: 描述了储存稳定的无尘均匀颗粒制剂。 该制剂包含（a）至少一种水溶性维生素E衍生物，（b）至少一种亲水性聚合物，（c）任选地附加的表面活性物质，和（d）任选的另外的药物添加剂。 （a），（b），（c）和（d）的总和等于制剂重量的100％。 粒径小于100μm的细小部分小于10重量％。 还描述了制备制剂的方法，以及在药物制剂中使用该制剂作为增溶组合物。
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5.发明授权公开(公告)号：US10912835B2
公开(公告)日：2021-02-09
申请号：US15848124
申请日：2017-12-20
Applicant: BASF SE
Inventor： Karl Kolter , Silke Gebert , Michael Klemens Müller , Maximilian Angel
Abstract: Pharmaceutical coatings obtained from coating compositions based on film-forming copolymers of N,N-diethylaminoethyl methacrylate (DEAEMA) and methyl methacrylate (MMA) comprising a weight ratio of DEAEMA:MMA in the range of 35:65 to 55:45, where the copolymers are present partially neutralized with C3-C10-dicarboxylic acids.
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6.发明申请公开(公告)号：US20180110858A1
公开(公告)日：2018-04-26
申请号：US15848124
申请日：2017-12-20
Applicant: BASF SE
Inventor： Karl Kolter , Silke Gebert , Michael Klemens Müller , Maximilian Angel
CPC classification number: A61K47/32 , A61K9/0002 , A61K9/282 , A61K9/2846 , A61K9/5015 , A61K9/5026 , A61K47/12
Abstract: Pharmaceutical coatings obtained from coating compositions based on film-forming copolymers of N,N-diethylaminoethyl methacrylate (DEAEMA) and methyl methacrylate (MMA) comprising a weight ratio of DEAEMA:MMA in the range of 35:65 to 55:45, where the copolymers are present partially neutralized with C3-C10-dicarboxylic acids.
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