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1.发明申请ALKYLAMINE-SUBSTITUTED DICYANOPYRIDINE AND AMINO ACID ESTER PRODRUGS THEREOF 有权烷基取代的二亚氨基吡啶和氨基酸酯的制备方法公开(公告)号：US20130267700A1
公开(公告)日：2013-10-10
申请号：US13801484
申请日：2013-03-13
发明人： Alexandros VAKALOPOULOS , Daniel MEIBOM , Barbara ALBRECHT-KÜPPER , Katja ZIMMERMANN , Jörg KELDENICH , Hans-Georg LERCHEN , Peter NELL , Frank SÜßMEIER , Ursula KRENZ
IPC分类号： C07D417/14 , C07D417/12
CPC分类号： C07D417/14 , A61K47/64 , C07D417/12 , C07K5/0202 , C07K5/06026 , C07K5/06034 , C07K5/06086 , C07K5/06147 , C07K5/06165
摘要： The present application relates to novel 6-alkylamino-substituted dicyanopyridines, to their amino acid ester prodrugs, to processes for their preparation, to their use for the treatment and/or prophylaxis of diseases and to their use for preparing medicaments for the treatment and/or prophylaxis of diseases, preferably for the treatment and/or prevention of cardiovascular disorders.
摘要翻译： 本申请涉及新的6-烷基氨基取代的二氰基吡啶，其氨基酸酯前药，其制备方法，其用于治疗和/或预防疾病的用途及其用于制备用于治疗和/ 或预防疾病，优选用于治疗和/或预防心血管疾病。
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公开(公告)号：US20150133364A1
公开(公告)日：2015-05-14
申请号：US14598902
申请日：2015-01-16
发明人： Hans-Georg LERCHEN , Ursula KRENZ , Jörg KELDENICH , Nicole DIEDRICHS , Thomas KRAHN , Claudia HIRTH-DIETRICH , Barbara ALBRECHT-KÜPPER
IPC分类号： A61K47/48 , A61K31/4439
CPC分类号： A61K31/4439 , A61K47/542 , A61K47/64 , C07D417/12 , C07K5/06086
摘要： The present application relates to prodrug derivatives of 2-amino-6-({[2-(4-chlorophenyl)-1,3-thiazol-4-yl]methyl}thio)-4-[4-(2-hydroxyethoxy)phenyl]pyridine-3,5-dicarbonitrile, processes for their preparation, their use for the treatment and/or prophylaxis of diseases, and their use for the manufacture of medicaments for the treatment and/or prophylaxis of diseases, especially of cardiovascular disorders.
摘要翻译： 本申请涉及2-氨基-6 - （{[2-（4-氯苯基）-1,3-噻唑-4-基]甲基}硫基）-4- [4-（2-羟基乙氧基） 苯基]吡啶-3,5-二腈，其制备方法，它们用于治疗和/或预防疾病的用途，及其用于制备用于治疗和/或预防疾病，特别是心血管疾病的药物的用途。
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3.发明申请ALKYLAMINE-SUBSTITUTED DICYANOPYRIDINE AND AMINO ACID ESTER PRODRUGS THEREOF 审中-公开烷基取代的二亚氨基吡啶和氨基酸酯的制备方法公开(公告)号：US20140296515A1
公开(公告)日：2014-10-02
申请号：US14306781
申请日：2014-06-17
发明人： Alexandros VAKALOPOULOS , Daniel MEIBOM , Barbara ALBRECHT-KÜPPER , Katja ZIMMERMANN , Jörg KELDENICH , Hans-Georg LERCHEN , Peter NELL , Frank SÜßMEIER , Ursula KRENZ
IPC分类号： C07D417/14 , C07D417/12
CPC分类号： C07D417/14 , A61K47/64 , C07D417/12 , C07K5/0202 , C07K5/06026 , C07K5/06034 , C07K5/06086 , C07K5/06147 , C07K5/06165
摘要： The present application relates to novel 6-alkylamino-substituted dicyanopyridines, to their amino acid ester prodrugs, to processes for their preparation, to their use for the treatment and/or prophylaxis of diseases and to their use for preparing medicaments for the treatment and/or prophylaxis of diseases, preferably for the treatment and/or prevention of cardiovascular disorders.
摘要翻译： 本申请涉及新的6-烷基氨基取代的二氰基吡啶，其氨基酸酯前药，其制备方法，其用于治疗和/或预防疾病的用途及其用于制备用于治疗和/ 或预防疾病，优选用于治疗和/或预防心血管疾病。
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公开(公告)号：US20140206879A1
公开(公告)日：2014-07-24
申请号：US14219872
申请日：2014-03-19
发明人： Hans-Georg LERCHEN , Ursula KRENZ , Jörg KELDENICH , Nicole DIEDRICHS , Thomas KRAHN , Claudia HIRTH-DIETRICH , Barbara ALBRECHT-KÜPPER
IPC分类号： C07K5/068
CPC分类号： A61K47/48246 , A61K31/4439 , A61K47/542 , A61K47/64 , C07D417/12 , C07K5/06086
摘要： The present application relates to prodrug derivatives of 2-amino-6-({[2-(4-chlorophenyl)-1,3-thiazol-4-yl]methyl}thio)-4-[4-(2-hydroxyethoxy)phenyl]pyridine-3,5-dicarbonitrile, processes for their preparation, their use for the treatment and/or prophylaxis of diseases, and their use for the manufacture of medicaments for the treatment and/or prophylaxis of diseases, especially of cardiovascular disorders.
摘要翻译： 本申请涉及2-氨基-6 - （{[2-（4-氯苯基）-1,3-噻唑-4-基]甲基}硫基）-4- [4-（2-羟基乙氧基） 苯基]吡啶-3,5-二腈，其制备方法，它们用于治疗和/或预防疾病的用途，及其用于制备用于治疗和/或预防疾病，特别是心血管疾病的药物的用途。
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