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1.发明申请公开(公告)号：US20150306084A1
公开(公告)日：2015-10-29
申请号：US14705967
申请日：2015-05-07
发明人： Hans-Georg LERCHEN , Barbara ALBRECHT-KÜPPER , Andreas KNORR , Peter SANDNER , Daniel MEIBOM , Carsten SCHMECK , Hubert TRÜBEL
IPC分类号： A61K31/4439 , A61K38/05 , A61K45/06
CPC分类号： A61K31/4439 , A61K9/0048 , A61K9/08 , A61K38/05 , A61K45/06 , C07D413/12 , C07D417/12 , C07D417/14
摘要： The present invention relates to the use of selective adenosine A1 agonists, in particular the dicyanopyridines of formula (I), for the treatment and/or prophylaxis of glaucoma and ocular hypertension as well as the their use for the production of a medicament for the treatment and/or prophylaxis of glaucoma and ocular hypertension.
摘要翻译： 本发明涉及选择性腺苷A1激动剂，特别是式（I）的二氰基吡啶用于治疗和/或预防青光眼和高眼压症及其用于生产治疗药物的用途的用途 和/或预防青光眼和高眼压症。
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2.发明申请TRIAZOLO AND TETRAZOLO PYRIMIDINE DERIVATIVES AS HNE INHIBITORS FOR TREATING COPD 有权三唑和四氮唑吡啶衍生物作为治疗COPD的HNE抑制剂公开(公告)号：US20140038988A1
公开(公告)日：2014-02-06
申请号：US14047458
申请日：2013-10-07
发明人： Franz VON NUSSBAUM , Dagmar KARTHAUS , SONJA ANLAUF , Martina DELBECK , Volkhart Min-Jian LI , Daniel MEIBOM , Klemens LUSTIG
IPC分类号： C07D487/04 , A61K45/06 , C07D487/14 , A61K31/519
CPC分类号： C07D487/04 , A61K31/519 , A61K45/06 , C07D487/14
摘要： The present invention relates to novel heterocyclically fused diaryldihydropyrimidine derivatives, to processes for their preparation, to their use alone or in combination for the treatment and/or prevention of diseases and also to their use for preparing medicaments for the treatment and/or prevention of diseases, in particular for the treatment and/or prevention of disorders of the lung and the cardiovascular system.
摘要翻译： 本发明涉及新颖的杂环稠合二芳基二氢嘧啶衍生物，其制备方法，单独使用或组合用于治疗和/或预防疾病的用途，以及其用于制备用于治疗和/或预防疾病的药物的用途 ，特别是用于治疗和/或预防肺和心血管系统疾病。
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公开(公告)号：US20150045344A1
公开(公告)日：2015-02-12
申请号：US14522510
申请日：2014-10-23
发明人： Franz VON NUSSBAUM , Dagmar KARTHAUS , Sonja ANLAUF , Martina DELBECK , Volkhart Min-Jian LI , Daniel MEIBOM , Klemens LUSTIG , Jens SCHAMBERGER
IPC分类号： C07D487/04 , A61K31/513 , A61K45/06 , C07D409/12 , C07D403/06 , C07D413/12 , A61K31/519 , A61K31/541 , C07D401/14 , C07D413/06 , A61K31/5377 , C07D403/12 , C07D239/22 , C07D401/06
CPC分类号： C07D487/04 , A61K31/513 , A61K31/519 , A61K31/5377 , A61K31/541 , A61K45/06 , C07D239/22 , C07D401/06 , C07D401/12 , C07D401/14 , C07D403/06 , C07D403/12 , C07D405/12 , C07D409/12 , C07D413/06 , C07D413/12 , C07D417/12
摘要： The present invention relates to novel 4-(4-cyano-2-thioaryl)dihydropyrimidin-2-one derivatives, to processes for their preparation, to their use alone or in combination for the treatment and/or prevention of diseases and also to their use for preparing medicaments for the treatment and/or prevention of diseases, in particular for the treatment and/or prevention of disorders of the lung and the cardiovascular system.
摘要翻译： 本发明涉及新的4-（4-氰基-2-硫代芳基）二氢嘧啶-2-酮衍生物，其制备方法，单独使用或组合用于治疗和/或预防疾病，以及它们 用于制备治疗和/或预防疾病的药物，特别是用于治疗和/或预防肺和心血管系统疾病。
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4.发明申请ALKYLAMINE-SUBSTITUTED DICYANOPYRIDINE AND AMINO ACID ESTER PRODRUGS THEREOF 有权烷基取代的二亚氨基吡啶和氨基酸酯的制备方法公开(公告)号：US20130267700A1
公开(公告)日：2013-10-10
申请号：US13801484
申请日：2013-03-13
发明人： Alexandros VAKALOPOULOS , Daniel MEIBOM , Barbara ALBRECHT-KÜPPER , Katja ZIMMERMANN , Jörg KELDENICH , Hans-Georg LERCHEN , Peter NELL , Frank SÜßMEIER , Ursula KRENZ
IPC分类号： C07D417/14 , C07D417/12
CPC分类号： C07D417/14 , A61K47/64 , C07D417/12 , C07K5/0202 , C07K5/06026 , C07K5/06034 , C07K5/06086 , C07K5/06147 , C07K5/06165
摘要： The present application relates to novel 6-alkylamino-substituted dicyanopyridines, to their amino acid ester prodrugs, to processes for their preparation, to their use for the treatment and/or prophylaxis of diseases and to their use for preparing medicaments for the treatment and/or prophylaxis of diseases, preferably for the treatment and/or prevention of cardiovascular disorders.
摘要翻译： 本申请涉及新的6-烷基氨基取代的二氰基吡啶，其氨基酸酯前药，其制备方法，其用于治疗和/或预防疾病的用途及其用于制备用于治疗和/ 或预防疾病，优选用于治疗和/或预防心血管疾病。
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公开(公告)号：US20140162981A1
公开(公告)日：2014-06-12
申请号：US13893344
申请日：2013-05-14
发明人： Peter NELL , Walter HÜBSCH , Barbara ALBRECHT-KÜPPER , Jorg KELDENICH , Alexandros VAKALOPOULOS , Frank SÜSSMEIER , Katja ZIMMERMANN , Dieter LANG , Daniel MEIBOM
IPC分类号： C07D413/14 , C07D413/12 , C07F7/10 , A61K31/695 , A61K31/4439 , A61K45/06
CPC分类号： A61K31/4439 , A61K31/695 , A61K45/06 , C07D413/12 , C07D413/14 , C07D419/14 , C07F7/10
摘要： The present application relates to novel substituted aryloxazole derivatives, to processes for their preparation, to their use for the treatment and/or prophylaxis of diseases and to their use for preparing medicaments for the treatment and/or prophylaxis of diseases, preferably for the treatment and/or prevention of cardiovascular and metabolic disorders.
摘要翻译： 本申请涉及新型取代的芳氧唑衍生物，其制备方法，其用于治疗和/或预防疾病的用途及其用于制备用于治疗和/或预防疾病的药物的用途，优选用于治疗和/ /或预防心血管和代谢紊乱。
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6.发明申请ALKYLAMINE-SUBSTITUTED DICYANOPYRIDINE AND AMINO ACID ESTER PRODRUGS THEREOF 审中-公开烷基取代的二亚氨基吡啶和氨基酸酯的制备方法公开(公告)号：US20140296515A1
公开(公告)日：2014-10-02
申请号：US14306781
申请日：2014-06-17
发明人： Alexandros VAKALOPOULOS , Daniel MEIBOM , Barbara ALBRECHT-KÜPPER , Katja ZIMMERMANN , Jörg KELDENICH , Hans-Georg LERCHEN , Peter NELL , Frank SÜßMEIER , Ursula KRENZ
IPC分类号： C07D417/14 , C07D417/12
CPC分类号： C07D417/14 , A61K47/64 , C07D417/12 , C07K5/0202 , C07K5/06026 , C07K5/06034 , C07K5/06086 , C07K5/06147 , C07K5/06165
摘要： The present application relates to novel 6-alkylamino-substituted dicyanopyridines, to their amino acid ester prodrugs, to processes for their preparation, to their use for the treatment and/or prophylaxis of diseases and to their use for preparing medicaments for the treatment and/or prophylaxis of diseases, preferably for the treatment and/or prevention of cardiovascular disorders.
摘要翻译： 本申请涉及新的6-烷基氨基取代的二氰基吡啶，其氨基酸酯前药，其制备方法，其用于治疗和/或预防疾病的用途及其用于制备用于治疗和/ 或预防疾病，优选用于治疗和/或预防心血管疾病。
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公开(公告)号：US20140296295A1
公开(公告)日：2014-10-02
申请号：US14304801
申请日：2014-06-13
发明人： Walter HÜBSCH , Daniel MEIBOM , Alexandros VAKALOPOULOS , Barbara ALBRECHT-KÜPPER , Peter NELL , Katja ZIMMERMANN , Frank SÜßMEIER , Joerg KELDENICH
IPC分类号： C07D417/14 , A61K31/4439 , A61K31/44 , A61K45/06 , C07D413/12 , C07D401/12 , C07D213/85 , A61K31/444 , C07D417/12
CPC分类号： A61K31/44 , A61K31/4439 , A61K31/444 , A61K45/06 , C07D213/70 , C07D213/85 , C07D401/12 , C07D413/12 , C07D417/12 , C07D417/14
摘要： The present application relates to novel 2-alkoxy-substituted dicyanopyridines, to processes for their preparation, to their use for the treatment and/or prophylaxis of diseases and to their use for preparing medicaments for the treatment and/or prophylaxis of diseases, preferably for the treatment and/or prevention of cardiovascular disorders.
摘要翻译： 本申请涉及新的2-烷氧基取代的二氰基吡啶，其制备方法，其用于治疗和/或预防疾病的用途及其用于制备用于治疗和/或预防疾病的药物的用途，优选用于 治疗和/或预防心血管疾病。
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