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1.发明申请BENZIMIDAZOLE AND PYRAZOLOPYRIDINE DERIVATIVES FOR TREATING AND/OR PREVENTING CARDIOVASCULAR DISEASES 审中-公开用于治疗和/或预防心脏血管疾病的苯唑咪唑和吡唑并吡啶衍生物公开(公告)号：US20130303559A1
公开(公告)日：2013-11-14
申请号：US13941967
申请日：2013-07-15
发明人： Alexander STRAUB , Frank SÜßMEIER , Frank WUNDER , Johannes-Peter STASCH , Volkhart Min-Jian LI , Joachim MITTENDORF
IPC分类号： C07D403/04 , A61K31/506 , A61K45/06 , C07D471/04
CPC分类号： C07D403/04 , A61K31/506 , A61K45/06 , C07D403/14 , C07D471/04
摘要： The present application relates to novel fused, heteroatom-bridged pyrazole and imidazole derivatives, to processes for their preparation, to their use, alone or in combination, for the treatment and/or prevention of diseases and to their use for preparing medicaments for the treatment and/or prevention of diseases, in particular for the treatment and/or prevention of cardiovascular disorders.
摘要翻译： 本申请涉及新的稠合，杂原子桥连的吡唑和咪唑衍生物，其制备方法，单独或组合用于治疗和/或预防疾病及其用于制备用于治疗的药物的用途 和/或预防疾病，特别是用于治疗和/或预防心血管疾病。
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2.发明申请ALKYLAMINE-SUBSTITUTED DICYANOPYRIDINE AND AMINO ACID ESTER PRODRUGS THEREOF 有权烷基取代的二亚氨基吡啶和氨基酸酯的制备方法公开(公告)号：US20130267700A1
公开(公告)日：2013-10-10
申请号：US13801484
申请日：2013-03-13
发明人： Alexandros VAKALOPOULOS , Daniel MEIBOM , Barbara ALBRECHT-KÜPPER , Katja ZIMMERMANN , Jörg KELDENICH , Hans-Georg LERCHEN , Peter NELL , Frank SÜßMEIER , Ursula KRENZ
IPC分类号： C07D417/14 , C07D417/12
CPC分类号： C07D417/14 , A61K47/64 , C07D417/12 , C07K5/0202 , C07K5/06026 , C07K5/06034 , C07K5/06086 , C07K5/06147 , C07K5/06165
摘要： The present application relates to novel 6-alkylamino-substituted dicyanopyridines, to their amino acid ester prodrugs, to processes for their preparation, to their use for the treatment and/or prophylaxis of diseases and to their use for preparing medicaments for the treatment and/or prophylaxis of diseases, preferably for the treatment and/or prevention of cardiovascular disorders.
摘要翻译： 本申请涉及新的6-烷基氨基取代的二氰基吡啶，其氨基酸酯前药，其制备方法，其用于治疗和/或预防疾病的用途及其用于制备用于治疗和/ 或预防疾病，优选用于治疗和/或预防心血管疾病。
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公开(公告)号：US20130190290A1
公开(公告)日：2013-07-25
申请号：US13748043
申请日：2013-01-23
发明人： Frank SÜßMEIER , Mario LOBELL , Sylvia GRÜNEWALD , Michael HÄRTER , Bernd BUCHMANN , Joachim TELSER , Hannah JÖRIßEN , Melanie HEROULT , Antje KAHNERT , Klemens LUSTIG , Niels LINDNER
IPC分类号： C07D487/04 , A61K31/4439 , A61K31/5377 , A61K31/4188 , A61K31/496 , A61K45/06
CPC分类号： C07D487/04 , A61K31/4188 , A61K31/4439 , A61K31/4545 , A61K31/496 , A61K31/5377 , A61K45/06
摘要： The present application relates to novel 1-phenyl-1H-imidazo[1,2-b]pyrazole derivatives, to processes for their preparation, to their use for the treatment and/or prevention of diseases and to their use for preparing medicaments for the treatment and/or prevention of diseases, in particular angiogenic disorders and hyperproliferative disorders, where neovascularization plays a role, such as, for example, neoplastic disorders and tumour disorders. Such treatments can be carried out as monotherapy or else in combination with other medicaments or further therapeutic measures.
摘要翻译： 本申请涉及新颖的1-苯基-1H-咪唑并[1,2-b]吡唑衍生物，其制备方法，其用于治疗和/或预防疾病及其用于制备药物的用途 治疗和/或预防新生血管形成起作用的疾病，特别是血管生成障碍和过度增殖性疾病，例如肿瘤性疾病和肿瘤病症。 这样的治疗可以作为单一疗法进行，也可以与其他药物组合进行或进一步的治疗措施。
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4.发明申请ALKYLAMINE-SUBSTITUTED DICYANOPYRIDINE AND AMINO ACID ESTER PRODRUGS THEREOF 审中-公开烷基取代的二亚氨基吡啶和氨基酸酯的制备方法公开(公告)号：US20140296515A1
公开(公告)日：2014-10-02
申请号：US14306781
申请日：2014-06-17
发明人： Alexandros VAKALOPOULOS , Daniel MEIBOM , Barbara ALBRECHT-KÜPPER , Katja ZIMMERMANN , Jörg KELDENICH , Hans-Georg LERCHEN , Peter NELL , Frank SÜßMEIER , Ursula KRENZ
IPC分类号： C07D417/14 , C07D417/12
CPC分类号： C07D417/14 , A61K47/64 , C07D417/12 , C07K5/0202 , C07K5/06026 , C07K5/06034 , C07K5/06086 , C07K5/06147 , C07K5/06165
摘要： The present application relates to novel 6-alkylamino-substituted dicyanopyridines, to their amino acid ester prodrugs, to processes for their preparation, to their use for the treatment and/or prophylaxis of diseases and to their use for preparing medicaments for the treatment and/or prophylaxis of diseases, preferably for the treatment and/or prevention of cardiovascular disorders.
摘要翻译： 本申请涉及新的6-烷基氨基取代的二氰基吡啶，其氨基酸酯前药，其制备方法，其用于治疗和/或预防疾病的用途及其用于制备用于治疗和/ 或预防疾病，优选用于治疗和/或预防心血管疾病。
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公开(公告)号：US20140296295A1
公开(公告)日：2014-10-02
申请号：US14304801
申请日：2014-06-13
发明人： Walter HÜBSCH , Daniel MEIBOM , Alexandros VAKALOPOULOS , Barbara ALBRECHT-KÜPPER , Peter NELL , Katja ZIMMERMANN , Frank SÜßMEIER , Joerg KELDENICH
IPC分类号： C07D417/14 , A61K31/4439 , A61K31/44 , A61K45/06 , C07D413/12 , C07D401/12 , C07D213/85 , A61K31/444 , C07D417/12
CPC分类号： A61K31/44 , A61K31/4439 , A61K31/444 , A61K45/06 , C07D213/70 , C07D213/85 , C07D401/12 , C07D413/12 , C07D417/12 , C07D417/14
摘要： The present application relates to novel 2-alkoxy-substituted dicyanopyridines, to processes for their preparation, to their use for the treatment and/or prophylaxis of diseases and to their use for preparing medicaments for the treatment and/or prophylaxis of diseases, preferably for the treatment and/or prevention of cardiovascular disorders.
摘要翻译： 本申请涉及新的2-烷氧基取代的二氰基吡啶，其制备方法，其用于治疗和/或预防疾病的用途及其用于制备用于治疗和/或预防疾病的药物的用途，优选用于 治疗和/或预防心血管疾病。
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