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1.发明申请NOVEL SUBSTITUTED BIPYRIDINE DERIVATIVES AND THEIR USE AS ADENOSINE RECEPTOR LIGANDS 审中-公开新的替代苄嘧啶衍生物及其作为腺苷受体配体使用公开(公告)号：US20140155401A1
公开(公告)日：2014-06-05
申请号：US14175719
申请日：2014-02-07
IPC分类号： C07D417/14 , A61K45/06 , C07D401/14 , A61K31/5377 , A61K31/501 , C07D409/14 , C07D413/14 , A61K31/444 , A61K31/506
CPC分类号： A61K31/444 , A61K31/501 , A61K31/506 , A61K31/5377 , A61K45/06 , C07D213/85 , C07D401/14 , C07D409/14 , C07D413/14 , C07D417/14
摘要： The present invention relates to novel substituted 2,4′- and 3,4′-bipyridine derivatives, to processes for their preparation, to their use for the treatment and/or prophylaxis of diseases and to their use for preparing medicaments for the treatment and/or prophylaxis of diseases, preferably for the treatment and/or prevention of hypertension and other cardiovascular disorders.
摘要翻译： 本发明涉及新的取代的2,4'-和3,4'-联吡啶衍生物，其制备方法，其用于治疗和/或预防疾病的用途及其用于制备治疗用药物和 /或预防疾病，优选用于治疗和/或预防高血压和其它心血管疾病。
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公开(公告)号：US20140162981A1
公开(公告)日：2014-06-12
申请号：US13893344
申请日：2013-05-14
发明人： Peter NELL , Walter HÜBSCH , Barbara ALBRECHT-KÜPPER , Jorg KELDENICH , Alexandros VAKALOPOULOS , Frank SÜSSMEIER , Katja ZIMMERMANN , Dieter LANG , Daniel MEIBOM
IPC分类号： C07D413/14 , C07D413/12 , C07F7/10 , A61K31/695 , A61K31/4439 , A61K45/06
CPC分类号： A61K31/4439 , A61K31/695 , A61K45/06 , C07D413/12 , C07D413/14 , C07D419/14 , C07F7/10
摘要： The present application relates to novel substituted aryloxazole derivatives, to processes for their preparation, to their use for the treatment and/or prophylaxis of diseases and to their use for preparing medicaments for the treatment and/or prophylaxis of diseases, preferably for the treatment and/or prevention of cardiovascular and metabolic disorders.
摘要翻译： 本申请涉及新型取代的芳氧唑衍生物，其制备方法，其用于治疗和/或预防疾病的用途及其用于制备用于治疗和/或预防疾病的药物的用途，优选用于治疗和/ /或预防心血管和代谢紊乱。
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3.发明申请ALKYLAMINE-SUBSTITUTED DICYANOPYRIDINE AND AMINO ACID ESTER PRODRUGS THEREOF 有权烷基取代的二亚氨基吡啶和氨基酸酯的制备方法公开(公告)号：US20130267700A1
公开(公告)日：2013-10-10
申请号：US13801484
申请日：2013-03-13
发明人： Alexandros VAKALOPOULOS , Daniel MEIBOM , Barbara ALBRECHT-KÜPPER , Katja ZIMMERMANN , Jörg KELDENICH , Hans-Georg LERCHEN , Peter NELL , Frank SÜßMEIER , Ursula KRENZ
IPC分类号： C07D417/14 , C07D417/12
CPC分类号： C07D417/14 , A61K47/64 , C07D417/12 , C07K5/0202 , C07K5/06026 , C07K5/06034 , C07K5/06086 , C07K5/06147 , C07K5/06165
摘要： The present application relates to novel 6-alkylamino-substituted dicyanopyridines, to their amino acid ester prodrugs, to processes for their preparation, to their use for the treatment and/or prophylaxis of diseases and to their use for preparing medicaments for the treatment and/or prophylaxis of diseases, preferably for the treatment and/or prevention of cardiovascular disorders.
摘要翻译： 本申请涉及新的6-烷基氨基取代的二氰基吡啶，其氨基酸酯前药，其制备方法，其用于治疗和/或预防疾病的用途及其用于制备用于治疗和/ 或预防疾病，优选用于治疗和/或预防心血管疾病。
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4.发明申请ALKYLAMINE-SUBSTITUTED DICYANOPYRIDINE AND AMINO ACID ESTER PRODRUGS THEREOF 审中-公开烷基取代的二亚氨基吡啶和氨基酸酯的制备方法公开(公告)号：US20140296515A1
公开(公告)日：2014-10-02
申请号：US14306781
申请日：2014-06-17
发明人： Alexandros VAKALOPOULOS , Daniel MEIBOM , Barbara ALBRECHT-KÜPPER , Katja ZIMMERMANN , Jörg KELDENICH , Hans-Georg LERCHEN , Peter NELL , Frank SÜßMEIER , Ursula KRENZ
IPC分类号： C07D417/14 , C07D417/12
CPC分类号： C07D417/14 , A61K47/64 , C07D417/12 , C07K5/0202 , C07K5/06026 , C07K5/06034 , C07K5/06086 , C07K5/06147 , C07K5/06165
摘要： The present application relates to novel 6-alkylamino-substituted dicyanopyridines, to their amino acid ester prodrugs, to processes for their preparation, to their use for the treatment and/or prophylaxis of diseases and to their use for preparing medicaments for the treatment and/or prophylaxis of diseases, preferably for the treatment and/or prevention of cardiovascular disorders.
摘要翻译： 本申请涉及新的6-烷基氨基取代的二氰基吡啶，其氨基酸酯前药，其制备方法，其用于治疗和/或预防疾病的用途及其用于制备用于治疗和/ 或预防疾病，优选用于治疗和/或预防心血管疾病。
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公开(公告)号：US20140296295A1
公开(公告)日：2014-10-02
申请号：US14304801
申请日：2014-06-13
发明人： Walter HÜBSCH , Daniel MEIBOM , Alexandros VAKALOPOULOS , Barbara ALBRECHT-KÜPPER , Peter NELL , Katja ZIMMERMANN , Frank SÜßMEIER , Joerg KELDENICH
IPC分类号： C07D417/14 , A61K31/4439 , A61K31/44 , A61K45/06 , C07D413/12 , C07D401/12 , C07D213/85 , A61K31/444 , C07D417/12
CPC分类号： A61K31/44 , A61K31/4439 , A61K31/444 , A61K45/06 , C07D213/70 , C07D213/85 , C07D401/12 , C07D413/12 , C07D417/12 , C07D417/14
摘要： The present application relates to novel 2-alkoxy-substituted dicyanopyridines, to processes for their preparation, to their use for the treatment and/or prophylaxis of diseases and to their use for preparing medicaments for the treatment and/or prophylaxis of diseases, preferably for the treatment and/or prevention of cardiovascular disorders.
摘要翻译： 本申请涉及新的2-烷氧基取代的二氰基吡啶，其制备方法，其用于治疗和/或预防疾病的用途及其用于制备用于治疗和/或预防疾病的药物的用途，优选用于 治疗和/或预防心血管疾病。
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