公开(公告)号：US3804835A

公开(公告)日：1974-04-16

申请号：US12249771

申请日：1971-03-09

申请人： BOEHRINGER MANNHEIM GMBH

发明人： WIEDEMANN F ,  THIEL M ,  HARDEBECK K ,  STACH K ,  ROESCH E

IPC分类号： C07D471/04 ,  C07D57/20

CPC分类号： C07D471/04 ,  Y10S514/869

摘要： PYRIDO(2,3-D)PYRIMIDIN-4(3H)-ONES OF THE GENERAL FORMULA

2-(R-O-)PYRIDO(2,3-D)PYRIMIDIN-4(3H)-ONE

WHEREIN R IS A STRAIGHT OR BRANCHED-CHAIN LOWER ALKYL, WHICH CAN BE SUBSTITUTED BY HYDROXYL GROUPS OR ALKOXY RADICALS, OR AN ALKENYL RADICAL, AND THE SALTS THEREOF WITH PYSIOLOGICALLY COMPATIBLE ACIDS AND BASES. THESE COMPOUNDS EXHIBIT LONG-LASTING DIURECTIC ACTION.

公开(公告)号：US3840521A

公开(公告)日：1974-10-08

申请号：US28711572

申请日：1972-09-07

申请人： BOEHRINGER MANNHEIM GMBH

发明人： FAULAND E ,  KAMPE W ,  ROESCH E ,  THIEL M ,  STORK H

IPC分类号： C07H19/16 ,  C07D51/54

CPC分类号： C07H19/16

摘要： 1. N(6)-DISUBSTITUTED ADENOSINE COMPOUND OF THE FORMULA

6-(R1-N(-R2)-),9-(3,4,5-TRI(HO-)-TETRAHYROFUR-2-YL-)-

9H-PURINE

WHEREIN R1 IS ALKYL OF FROM 1 TO 6 CARBON ATOMS; AND R2 IS STRAIGHT-CHAINED OR BRANCHED ALKYL OF FROM 4 TO 10 CARBON ATOMS; CYCLOALKYL OR METHYLCYCLOALKYL WHEREIN THE CYCLOALKYL MOIETY CONTAINS FROM 3 TO 10 CARBON ATOMS, CYCLOALKYL-ALKYL WITH FROM 3 TO 10 CARBON ATOMS IN THE CYCLOALKYL GROUP AND FROM 1 TO 4 CARBON ATOMS IN THE ALKYL SIDE-CHAIN OR BICYCLOALKYL OF FROM 5 TO 7 CARBON ATOMS IN EACH RING; AND THE PHARMACOLOGICALLY COMPATIBLE SALTS THEREOF.

公开(公告)号：US3749724A

公开(公告)日：1973-07-31

申请号：US3749724D

申请日：1970-11-25

申请人： BOEHRINGER MANNHEIM GMBH

发明人： WIEDEMANN F ,  ROESCH E ,  HARDEBECK K ,  THIEL M ,  STACH K

IPC分类号： C07D471/04 ,  C07D57/20

CPC分类号： C07D471/04 ,  Y10S514/869

摘要： NEW 2 - MERCAPTO-PYRIDO(2,3-D)PYRIMIDIN-4(3H)-ONE COMPOUNDS OF THE FORMULA

AND PHYSIOLOGICALLY COMPATIBLE SALTS THEREOF, POSSESS EXCEPTIONAL DIURETIC AND NATRIURETIC ACTIVITY.

4-(O=),2-(R-S-)-3,4-DIHYDROPYRIDO(2,3-D)PYRIMIDINE

公开(公告)号：US3810896A

公开(公告)日：1974-05-14

申请号：US24213472

申请日：1972-04-07

申请人： BOEHRINGER MANNHEIM GMBH

发明人： WITTE E ,  STACH K ,  ROESCH E ,  THIEL M ,  ROESCH A

IPC分类号： C07D311/30 ,  C07D51/70

CPC分类号： C07D311/30

摘要： CERTAIN NOVEL 4-(FLAVON-7-OYLOXY)-ALKYL)-PIPERAZINE COMPOUNDS OF THE FORMULA

2-PHENYL,7-((4-R-PIPERAZINO)-(CH2)N-O-)-4H-CHROMEN-4-ONE

WHEREIN R IS AN UNSUBSTITUTED OR SUBSTITUTED PHENYL OR BENZYL RADICAL, THE SUBSTITUENTS BEING HALOGEN ATOMS OR LOWER ALKYL OR ALKOXY RADICALS, E.G., OF FROM 1 TO 6 CARBON ATOMS, AND N IS 1, 2 OR 3; AND THE PHRMACOLOGICALLY COMPATIBLE SALTS THEREOF. HAVE OUTSTANDING ANTI-EDEMATOUS ACTIVITY AND REDUCE INCREASED CAPILLARY PERMEABILITY.

公开(公告)号：US3794637A

公开(公告)日：1974-02-26

申请号：US3794637D

申请日：1971-07-22

申请人： BOEHRINGER MANNHEIM GMBH

发明人： WIEDEMANN F ,  THIEL M ,  HARDEBECK K ,  STACH K ,  ROESCH E

IPC分类号： C07D471/04 ,  C07D51/46

CPC分类号： C07D471/04 ,  Y10S514/869

摘要： PYRIDO-(2,3-D)PYRIMIDIN-4(3H)-ONES OF THE GENERAL FORMULA 2-(R1-N(-R2)-),4-(O=)-3,4-DIHYDROPYRIDO(2,3-D)PYRIMIDINE WHEREIN R1 IS A LOWER ALKYL, ALKENUL, CYCLOALKYL, ARALKYL, FURYLALKYL, THIENYLALKYL OR TETRAHYDROFURYLALKYL RADICAL, OPTIONALLY SUBSTITUTED BY HYDROXY. ALKOXY OR ALKYLMERCAPTO RADICALS AND R2 IS R1 OR HYDROGEN, AND THE SALTS THEREOF WITH PHYSIOLOGICALLY COMPATIBLE ACIDS. THESE COMPOUNDS EXHIBIT LONGLASTING DIURETIC ACTION.