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公开(公告)号：US20220315569A1
公开(公告)日：2022-10-06
申请号：US17836596
申请日：2022-06-09
Applicant: BRISTOL-MYERS SQUIBB COMPANY
Inventor： Wei Meng , Hannguang J. Chao , Heather Finlay , R. Michael Lawrence , Michael C. Myers
IPC: C07D413/10 , C07D239/54 , C07D401/10 , C07D401/12 , C07D401/14 , C07D403/10 , C07D413/06 , C07D417/06 , C07D417/14
Abstract: The present invention provides compounds of Formula (I): wherein all variables are as defined in the specification, and compositions comprising any of such novel compounds. These compounds are APJ agonists which may be used as medicaments.
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公开(公告)号：US20160355507A1
公开(公告)日：2016-12-08
申请号：US15171276
申请日：2016-06-02
Applicant: BRISTOL-MYERS SQUIBB COMPANY
Inventor： James A. Johnson , Soong-Hoon Kim , R. Michael Lawrence , Michael C. Myers , Hannguang J. Chao , Monique Phillips , Ji Jiang
IPC: C07D413/04 , C07D417/14 , C07D498/04 , C07D413/14
CPC classification number: C07D413/04 , C07D401/04 , C07D413/14 , C07D417/14 , C07D498/04
Abstract: The present invention provides compounds of Formula (I): wherein all variables are as defined in the specification, and compositions comprising any of such novel compounds. These compounds are APJ agonists which may be used as medicaments.
Abstract translation: 其中所有变量如说明书中所定义，以及包含任何这些新化合物的组合物。 这些化合物是可用作药物的APJ激动剂。
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公开(公告)号：US20210198246A1
公开(公告)日：2021-07-01
申请号：US15779194
申请日：2016-12-02
Applicant: BRISTOL-MYERS SQUIBB COMPANY
Inventor： Wei Meng , Hannguang J. Chao , Heather Finlay , R. Michael Lawrence , Michael C. Myers
IPC: C07D413/10 , C07D401/12 , C07D239/54 , C07D403/10 , C07D413/06 , C07D417/06 , C07D401/10 , C07D401/14 , C07D417/14
Abstract: The present invention provides compounds of Formula (I): wherein all variables are as defined in the specification, and compositions comprising any of such novel compounds. These compounds are APJ agonists which may be used as medicaments.
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公开(公告)号：US20190263791A1
公开(公告)日：2019-08-29
申请号：US16411221
申请日：2019-05-14
Applicant: BRISTOL-MYERS SQUIBB COMPANY
Inventor： James A. Johnson , Soong-Hoon Kim , R. Michael Lawrence , Michael C. Myers , Hannguang J. Chao , Monique Phillips , Ji Jiang
IPC: C07D413/04 , C07D417/14 , C07D498/04 , C07D413/14 , C07D401/04
Abstract: The present invention provides compounds of Formula (I): wherein all variables are as defined in the specification, and compositions comprising any of such novel compounds. These compounds are APJ agonists which may be used as medicaments.
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公开(公告)号：US20200231547A1
公开(公告)日：2020-07-23
申请号：US16639145
申请日：2018-08-16
Applicant: BRISTOL-MYERS SQUIBB COMPANY
Inventor： Shun Su , Hannguang J. Chao , Adam James Clarke , R. Michael Lawrence
IPC: C07D235/16 , C07D413/12 , C07D413/10 , C07D471/04 , C07D491/056 , C07D473/00 , C07D235/18
Abstract: The present invention provides compounds of Formula (I): wherein all variables are as defined in the specification. The compounds are apelin and APJ agonists for treating cardiovascular diseases. Preferred compounds are 2-(1,1′-biphe-1H-benzo[d]imidazole derivatives. The invention further provides compositions comprising the compounds and the compounds for use in methods of medical treatment.
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Patent Agency Ranking
公开(公告)号：US12168655B2
公开(公告)日：2024-12-17
申请号：US17836596
申请日：2022-06-09
Applicant: BRISTOL-MYERS SQUIBB COMPANY
Inventor： Wei Meng , Hannguang J. Chao , Heather Finlay , R. Michael Lawrence , Michael C. Myers
IPC: C07D413/10 , C07D239/54 , C07D401/10 , C07D401/12 , C07D401/14 , C07D403/10 , C07D413/06 , C07D417/06 , C07D417/14
Abstract: The present invention provides compounds of Formula (I): wherein all variables are as defined in the specification, and compositions comprising any of such novel compounds. These compounds are APJ agonists which may be used as medicaments.
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公开(公告)号：US11498903B2
公开(公告)日：2022-11-15
申请号：US16639145
申请日：2018-08-16
Applicant: BRISTOL-MYERS SQUIBB COMPANY
Inventor： Shun Su , Hannguang J. Chao , Adam James Clarke , R. Michael Lawrence
IPC: C07D235/16 , C07D413/12 , C07D413/10 , C07D471/04 , C07D491/056 , C07D473/00 , C07D235/18
Abstract: The present invention provides compounds of Formula (I): wherein all variables are as defined in the specification. The compounds are apelin and APJ agonists for treating cardiovascular diseases. Preferred compounds are 2-(1,1′-biphe-1H-benzo[d]imidazole derivatives. The invention further provides compositions comprising the compounds and the compounds for use in methods of medical treatment.
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公开(公告)号：US10392347B2
公开(公告)日：2019-08-27
申请号：US15767364
申请日：2016-10-13
Applicant: BRISTOL-MYERS SQUIBB COMPANY
Inventor： Soong-Hoon Kim , Hannguang J. Chao , Heather Finlay , Ji Jiang , James A. Johnson , R. Michael Lawrence , Michael C. Myers , Monique Phillips , George O. Tora , Wei Meng
IPC: C07D213/82 , C07D401/06 , C07D401/14 , C07D405/14 , C07D413/12 , C07D413/14 , C07D417/12 , C07D417/14 , C07D491/107 , C07D498/10 , C07D401/12 , C07D471/10
Abstract: The present invention provides compounds of Formula (I): wherein all variables are as defined in the specification, and compositions comprising any of such novel compounds. These compounds are APJ agonists which may be used as medicaments.
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公开(公告)号：US20180297954A1
公开(公告)日：2018-10-18
申请号：US15767364
申请日：2016-10-13
Applicant: BRISTOL-MYERS SQUIBB COMPANY
Inventor： Soong-Hoon Kim , Hannguang J. Chao , Heather Finlay , Ji Jang , James A. Johnson , R. Michael Lawrence , Michael C. Myers , Monique Phillips , George O. Tora , Wei Meng
IPC: C07D213/82 , C07D401/12 , C07D401/14 , C07D413/14 , C07D401/06 , C07D405/14 , C07D417/14 , C07D417/12 , C07D498/10 , C07D413/12 , C07D491/107 , C07D471/10
CPC classification number: C07D213/82 , C07D401/06 , C07D401/12 , C07D401/14 , C07D405/14 , C07D413/12 , C07D413/14 , C07D417/12 , C07D417/14 , C07D471/10 , C07D491/107 , C07D498/10
Abstract: The present invention provides compounds of Formula (I): wherein all variables are as defined in the specification, O and compositions comprising any of such novel compounds. These compounds are APJ agonists which may be used as medicaments.
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公开(公告)号：US20180273518A1
公开(公告)日：2018-09-27
申请号：US15990855
申请日：2018-05-29
Applicant: BRISTOL-MYERS SQUIBB COMPANY
Inventor： James A. Johnson , Soong-Hoon Kim , R. Michael Lawrence , Michael C. Myers , Hannguang J. Chao , Monique Phillips , Ji Jiang
IPC: C07D413/04 , C07D417/14 , C07D498/04 , C07D401/04 , C07D413/14
CPC classification number: C07D413/04 , C07D401/04 , C07D413/14 , C07D417/14 , C07D498/04
Abstract: The present invention provides compounds of Formula (I): wherein all variables are as defined in the specification, and compositions comprising any of such novel compounds. These compounds are APJ agonists which may be used as medicaments.
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