公开(公告)号：US12018097B2

公开(公告)日：2024-06-25

申请号：US17943532

申请日：2022-09-13

Applicant: BRISTOL-MYERS SQUIBB COMPANY

Inventor： Gardner S. Creech ,  Mahboubeh Kheirabadi ,  Martin D. Eastgate ,  David S. Nirschl ,  Percy H Carter

IPC: C07C309/73 ,  C07C309/07 ,  C07C309/75 ,  C07C309/77 ,  C07D225/02 ,  C07D225/08 ,  C07K1/04 ,  C07K1/107 ,  C07K7/64 ,  C07K17/08

CPC classification number: C07K7/64 ,  C07C309/07 ,  C07C309/73 ,  C07C309/75 ,  C07D225/08 ,  C07K1/042 ,  C07K1/1077 ,  C07K17/08

Abstract: The disclosure is directed to the synthesis and improved methods for purifying macrocyclic peptides produced by solid phase peptide synthesis. The synthesized peptide is capped with an alkyne-functionalized or azide-functionalized compound of formula (I):




prior to cleavage of the peptide from the solid phase support.