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公开(公告)号：US20130183269A1
公开(公告)日：2013-07-18
申请号：US13735224
申请日：2013-01-07
Applicant: Bristol-Myers Squibb Company
Inventor： Piyasena Hewawasam , John F. Kadow , Omar D. Lopez , Nicholas A. Meanwell , Yong Tu , Alan Xiangdong Wang , Ningning Xu , Samayamunthula Venkata Satya Arun Kumar Gupta , Pothukanuri Srinivasu , Indasi Gopi Kumar , Ponugupati Suresh Kumar , Makonen Belema , Robert A. Fridell , Min Gao , Julie A. Lemm , Donald R. O'Boyle, II , Jin-Hua Sun , Chunfu Wang , Ying-Kai Wang
IPC: A61K31/4178 , A61K31/407 , A61K31/422 , A61K31/444 , A61K31/423 , A61K31/497 , A61K31/4545 , A61K31/498 , A61K31/506 , A61K31/5377 , A61K31/4709 , A61K31/437 , A61K31/519 , A61K31/428 , A61K31/501 , A61K31/55 , A61K31/496 , A61K31/4184 , A61K45/06 , C07D403/14 , C07D491/113 , A61K31/7056 , A61K38/21 , A61K38/05
CPC classification number: A61K31/4178 , A61K31/407 , A61K31/4184 , A61K31/422 , A61K31/423 , A61K31/428 , A61K31/437 , A61K31/4439 , A61K31/444 , A61K31/4545 , A61K31/4709 , A61K31/4725 , A61K31/496 , A61K31/497 , A61K31/498 , A61K31/501 , A61K31/506 , A61K31/519 , A61K31/5377 , A61K31/55 , A61K31/7056 , A61K38/05 , A61K38/21 , A61K38/212 , A61K38/217 , A61K45/06 , C07D403/14 , C07D491/113 , A61K2300/00
Abstract: The present disclosure is generally directed to antiviral compounds, and more specifically directed to combinations of compounds which can inhibit the function of the NS5A protein encoded by Hepatitis C virus (HCV), compositions comprising such combinations, and methods for inhibiting the function of the NS5A protein.
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Patent Agency Ranking
公开(公告)号：US09242966B2
公开(公告)日：2016-01-26
申请号：US14200063
申请日：2014-03-07
Applicant: BRISTOL-MYERS SQUIBB COMPANY
Inventor： Heather Finlay , Ashok Kumar Adisechan , Prashantha Gunaga , John Lloyd , Pothukanuri Srinivasu
IPC: C07D405/14 , C07D401/14 , C07D401/04 , C07D401/12 , C07D403/04 , A61K31/502 , A61K31/506
CPC classification number: C07D405/14 , A61K31/502 , A61K31/506 , C07D401/04 , C07D401/12 , C07D401/14 , C07D403/04
Abstract: A compound of formula (I) wherein A, R1, R3, and R24 are described herein. The compounds are useful as inhibitors of potassium channel function and in the treatment and prevention of arrhythmia, IKur-associated disorders, and other disorders mediated by ion channel function.
Abstract translation: 其中A，R1，R3和R24的式（I）化合物在此描述。 这些化合物可用作钾通道功能的抑制剂和治疗和预防心律失常，IKur相关疾病以及由离子通道功能介导的其它病症。
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公开(公告)号：US09050345B2
公开(公告)日：2015-06-09
申请号：US14200055
申请日：2014-03-07
Applicant: BRISTOL-MYERS SQUIBB COMPANY
Inventor： Heather Finlay , Ashok Kumar Adisechan , Naveen Kumar Dhondi , Kavitha Govindrajulu , Prashantha Gunaga , John Lloyd , Pothukanuri Srinivasu
IPC: C07D487/04 , C07D401/04 , C07D401/14 , C07D403/04 , C07D403/14 , A61K31/53 , A61P9/06 , A61P9/04 , C07D405/04 , C07D405/14 , C07D413/04 , C07D413/14 , C07D417/04 , A61K31/5377 , C07D519/00
CPC classification number: A61K31/5377 , A61K31/53 , C07D487/04 , C07D519/00
Abstract: A compound of formula (I) wherein A, R1, R3, and R24 are described herein. The compounds are useful as inhibitors of potassium channel function and in the treatment of arrhythmia, maintaining normal sinus rhythm, IKur-associated disorders, and other disorders mediated by ion channel function.
Abstract translation: 其中A，R1，R3和R24的式（I）化合物在此描述。 该化合物可用作钾通道功能的抑制剂和治疗心律不齐，维持正常窦性心律，IKur相关疾病以及由离子通道功能介导的其它病症。
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公开(公告)号：US20140256719A1
公开(公告)日：2014-09-11
申请号：US14200055
申请日：2014-03-07
Applicant: BRISTOL-MYERS SQUIBB COMPANY
Inventor： Heather Finlay , Ashok Kumar Adisechan , Naveen Kumar Dhondi , Kavitha Govindrajulu , Prashantha Gunaga , John Lloyd , Pothukanuri Srinivasu
IPC: A61K31/5377 , C07D487/04 , A61K31/53
CPC classification number: A61K31/5377 , A61K31/53 , C07D487/04 , C07D519/00
Abstract: A compound of formula (I) wherein A, R1, R3, and R24 are described herein. The compounds are useful as inhibitors of potassium channel function and in the treatment of arrhythmia, maintaining normal sinus rhythm, IKur-associated disorders, and other disorders mediated by ion channel function.
Abstract translation: 其中A，R1，R3和R24的式（I）化合物在此描述。 该化合物可用作钾通道功能的抑制剂和治疗心律不齐，维持正常窦性心律，IKur相关疾病以及由离子通道功能介导的其它病症。
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公开(公告)号：US09326973B2
公开(公告)日：2016-05-03
申请号：US13735224
申请日：2013-01-07
Applicant: Bristol-Myers Squibb Company
Inventor： Piyasena Hewawasam , John F. Kadow , Omar D. Lopez , Nicholas A. Meanwell , Yong Tu , Alan Xiangdong Wang , Ningning Xu , Samayamunthula Venkata Satya Arun Kumar Gupta , Pothukanuri Srinivasu , Indasi Gopi Kumar , Ponugupati Suresh Kumar , Makonen Belema , Robert A. Fridell , Min Gao , Julie A. Lemm , Donald R. O'Boyle, II , Jin-Hua Sun , Chunfu Wang , Ying-Kai Wang
IPC: A61K31/415 , A61K31/675 , A61K38/00 , A61K31/4178 , A61K31/407 , A61K31/4184 , A61K31/422 , A61K31/423 , A61K31/428 , A61K31/437 , A61K31/444 , A61K31/4545 , A61K31/4709 , A61K31/496 , A61K31/497 , A61K31/498 , A61K31/501 , A61K31/506 , A61K31/519 , A61K31/5377 , A61K31/55 , A61K31/7056 , A61K38/05 , A61K38/21 , A61K45/06 , C07D403/14 , C07D491/113
CPC classification number: A61K31/4178 , A61K31/407 , A61K31/4184 , A61K31/422 , A61K31/423 , A61K31/428 , A61K31/437 , A61K31/4439 , A61K31/444 , A61K31/4545 , A61K31/4709 , A61K31/4725 , A61K31/496 , A61K31/497 , A61K31/498 , A61K31/501 , A61K31/506 , A61K31/519 , A61K31/5377 , A61K31/55 , A61K31/7056 , A61K38/05 , A61K38/21 , A61K38/212 , A61K38/217 , A61K45/06 , C07D403/14 , C07D491/113 , A61K2300/00
Abstract: The present disclosure is generally directed to antiviral compounds, and more specifically directed to combinations of compounds which can inhibit the function of the NS5A protein encoded by Hepatitis C virus (HCV), compositions comprising such combinations, and methods for inhibiting the function of the NS5A protein.
Abstract translation: 本公开通常涉及抗病毒化合物，更具体地涉及可以抑制丙型肝炎病毒（HCV）编码的NS5A蛋白的功能的化合物的组合，包含这些组合的组合物，以及用于抑制NS5A的功能的方法 蛋白。
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公开(公告)号：US20140303168A1
公开(公告)日：2014-10-09
申请号：US14200063
申请日：2014-03-07
Applicant: BRISTOL-MYERS SQUIBB COMPANY
Inventor： Heather Finlay , Ashok Kumar Adisechan , Prashantha Gunaga , John Lloyd , Pothukanuri Srinivasu
IPC: C07D405/14 , C07D403/04 , C07D401/04 , A61K31/506 , C07D401/14 , A61K31/502
CPC classification number: C07D405/14 , A61K31/502 , A61K31/506 , C07D401/04 , C07D401/12 , C07D401/14 , C07D403/04
Abstract: A compound of formula (I) wherein A, R1, R3, and R24 are described herein. The compounds are useful as inhibitors of potassium channel function and in the treatment and prevention of arrhythmia, IKur-associated disorders, and other disorders mediated by ion channel function.
Abstract translation: 其中A，R1，R3和R24的式（I）化合物在此描述。 这些化合物可用作钾通道功能的抑制剂和治疗和预防心律失常，IKur相关疾病以及由离子通道功能介导的其它病症。
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