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公开(公告)号：US20180221342A1
公开(公告)日：2018-08-09
申请号：US15749557
申请日：2016-07-27
发明人： David B. Frennesson , Piyasena Hewawasam , Omar D. Lopez , Van N. Nguyen , Mark G. Saulnier , Yong Tu , Alan Xiangdong Wang , Gan Wang , Ningning Xu , Roshan Yadavrao Nimje , Hasibur Rahaman , Samayamunthula Venkata Satya Arun Kumar Gupta , Nicholas A. Meanwell , Makonen Belema
IPC分类号： A61K31/4178 , A61P31/14
CPC分类号： A61K31/4178 , A61K31/417 , A61K31/4184 , A61K31/4439 , A61K31/497 , A61K31/7056 , A61K38/21 , A61K45/06 , A61K2300/00 , A61P31/14
摘要： The present disclosure is generally directed to antiviral compounds, and more specifically directed to combinations of compounds which can inhibit the function of the NS5A protein encoded by Hepatitis C virus (HCV), compositions comprising such combinations, and methods for inhibiting the function of the NS5A protein.
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公开(公告)号：US20170107202A1
公开(公告)日：2017-04-20
申请号：US15290167
申请日：2016-10-11
发明人： KAP-SUN YEUNG , Timothy P. Connolly , David B. Frennesson , Katharine A. Grant-Young , Piyasena Hewawasam , David R. Langley , Zhaoxing Meng , Eric Mull , Kyle E. Parcella , Mark George Saulnier , Li-Qiang Sun , Alan Xiangdong Wang , Ningning Xu , Juliang Zhu , Paul Michael Scola
IPC分类号： C07D401/14 , A61K31/5377 , C07D213/85 , A61K31/4439 , C07D401/12 , A61K31/4545 , A61K31/44 , C07D471/04 , C07D405/14 , A61K31/454 , C07D403/12 , A61K31/4025 , A61K31/496 , C07D205/04 , A61K31/397 , A61K31/4427 , A61K31/4453 , C07D211/22 , A61K31/40 , C07D207/14 , C07D207/12 , A61K31/138 , C07C215/20 , C07D413/14 , C07D213/82 , C07D491/08 , C07D417/14 , A61K31/541 , C07D471/08 , C07D405/12 , A61K31/135 , C07D213/80 , C07D207/16 , C07D265/30 , A61K31/5375 , A61K31/166 , C07C235/46 , C07D417/12 , A61K45/06
摘要： The present disclosure generally relates to compounds useful as immunomodulators. Provided herein are compounds, compositions comprising such compounds, and methods of their use. The disclosure further pertains to pharmaceutical compositions comprising at least one compound according to the disclosure that are useful for the treatment of various diseases, including cancer and infectious diseases.
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公开(公告)号：US09326973B2
公开(公告)日：2016-05-03
申请号：US13735224
申请日：2013-01-07
发明人： Piyasena Hewawasam , John F. Kadow , Omar D. Lopez , Nicholas A. Meanwell , Yong Tu , Alan Xiangdong Wang , Ningning Xu , Samayamunthula Venkata Satya Arun Kumar Gupta , Pothukanuri Srinivasu , Indasi Gopi Kumar , Ponugupati Suresh Kumar , Makonen Belema , Robert A. Fridell , Min Gao , Julie A. Lemm , Donald R. O'Boyle, II , Jin-Hua Sun , Chunfu Wang , Ying-Kai Wang
IPC分类号： A61K31/415 , A61K31/675 , A61K38/00 , A61K31/4178 , A61K31/407 , A61K31/4184 , A61K31/422 , A61K31/423 , A61K31/428 , A61K31/437 , A61K31/444 , A61K31/4545 , A61K31/4709 , A61K31/496 , A61K31/497 , A61K31/498 , A61K31/501 , A61K31/506 , A61K31/519 , A61K31/5377 , A61K31/55 , A61K31/7056 , A61K38/05 , A61K38/21 , A61K45/06 , C07D403/14 , C07D491/113
CPC分类号： A61K31/4178 , A61K31/407 , A61K31/4184 , A61K31/422 , A61K31/423 , A61K31/428 , A61K31/437 , A61K31/4439 , A61K31/444 , A61K31/4545 , A61K31/4709 , A61K31/4725 , A61K31/496 , A61K31/497 , A61K31/498 , A61K31/501 , A61K31/506 , A61K31/519 , A61K31/5377 , A61K31/55 , A61K31/7056 , A61K38/05 , A61K38/21 , A61K38/212 , A61K38/217 , A61K45/06 , C07D403/14 , C07D491/113 , A61K2300/00
摘要： The present disclosure is generally directed to antiviral compounds, and more specifically directed to combinations of compounds which can inhibit the function of the NS5A protein encoded by Hepatitis C virus (HCV), compositions comprising such combinations, and methods for inhibiting the function of the NS5A protein.
摘要翻译： 本公开通常涉及抗病毒化合物，更具体地涉及可以抑制丙型肝炎病毒（HCV）编码的NS5A蛋白的功能的化合物的组合，包含这些组合的组合物，以及用于抑制NS5A的功能的方法 蛋白。
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公开(公告)号：US10745382B2
公开(公告)日：2020-08-18
申请号：US15290167
申请日：2016-10-11
发明人： Kap-Sun Yeung , Timothy P. Connolly , David B. Frennesson , Katharine A. Grant-Young , Piyasena Hewawasam , David R. Langley , Zhaoxing Meng , Eric Mull , Kyle E. Parcella , Mark George Saulnier , Li-Qiang Sun , Alan Xiangdong Wang , Ningning Xu , Juliang Zhu , Paul Michael Scola
IPC分类号： C07D401/14 , C07D213/71 , C07D455/02 , A61K31/135 , A61K31/138 , A61K31/166 , A61K31/397 , A61K31/40 , A61K31/4025 , A61K31/44 , A61K31/4427 , A61K31/4439 , A61K31/4453 , A61K31/454 , A61K31/4545 , A61K31/496 , A61K31/5375 , A61K31/5377 , A61K31/541 , A61K45/06 , C07C215/20 , C07C235/46 , C07D205/04 , C07D207/12 , C07D207/14 , C07D207/16 , C07D211/22 , C07D213/80 , C07D213/82 , C07D213/85 , C07D265/30 , C07D401/12 , C07D403/12 , C07D405/12 , C07D405/14 , C07D413/14 , C07D417/12 , C07D417/14 , C07D471/04 , C07D471/08 , C07D491/08
摘要： The present disclosure generally relates to compounds useful as immunomodulators. Provided herein are compounds, compositions comprising such compounds, and methods of their use. The disclosure further pertains to pharmaceutical compositions comprising at least one compound according to the disclosure that are useful for the treatment of various diseases, including cancer and infectious diseases.
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公开(公告)号：US09770439B2
公开(公告)日：2017-09-26
申请号：US14753564
申请日：2015-06-29
发明人： Piyasena Hewawasam , Omar D. Lopez , Yong Tu , Alan Xiangdong Wang , Ningning Xu , John F. Kadow , Nicholas A. Meanwell , Samayamunthula Venkata Satya Arun Kumar Gupta , Indasi J. Gopi Kumar , Suresh Kumar Ponugupati , Makonen Belema
IPC分类号： A61K31/415 , A61K31/535 , C07D471/04 , A61K31/40 , A61K31/44 , A61K31/4178 , A61K38/21 , A61K31/4245 , A61K31/4725 , A61K31/7056 , A61K45/06 , C07D233/64 , C07D403/14 , C07D405/14 , C07D493/08 , A61K31/437 , A61K31/439 , A61K31/402 , A61K31/4184 , A61K31/4188 , A61K31/454 , A61K31/4545 , A61K31/519 , A61K31/5365 , A61K31/5377 , A61K31/695 , A61K38/20
CPC分类号： A61K31/4178 , A61K31/402 , A61K31/4184 , A61K31/4188 , A61K31/4245 , A61K31/437 , A61K31/439 , A61K31/454 , A61K31/4545 , A61K31/4725 , A61K31/519 , A61K31/5365 , A61K31/5377 , A61K31/695 , A61K31/7056 , A61K38/2013 , A61K38/204 , A61K38/208 , A61K38/21 , A61K45/06 , C07D233/64 , C07D403/14 , C07D405/14 , C07D493/08 , A61K2300/00
摘要： The present disclosure is generally directed to antiviral compounds, and more specifically directed to combinations of compounds which can inhibit the function of the NS5A protein encoded by Hepatitis C virus (HCV), compositions comprising such combinations, and methods for inhibiting the function of the NS5A protein.
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6.发明授权N-((3-benzyl)-2,2-(bis-phenyl)-propan-1-amine derivatives as CETP inhibitors for the treatment of atherosclerosis and cardiovascular diseases 有权N - （（3-苄基）-2,2-（双 - 苯基） - 丙-1-胺衍生物作为治疗动脉粥样硬化和心血管疾病的CETP抑制剂公开(公告)号：US09102599B2
公开(公告)日：2015-08-11
申请号：US13717871
申请日：2012-12-18
发明人： Mark E. Salvati , James A. Johnson , Ningning Xu
IPC分类号： C07C211/00 , C07D213/00 , C07C311/04 , C07C215/08 , C07C217/64 , C07C217/84 , C07C229/34 , C07C233/18 , C07C233/60 , C07C235/08 , C07C271/16 , C07C271/48 , C07C275/24 , C07C275/26 , C07C307/06 , C07C311/10 , C07C311/14 , C07C311/17 , C07C323/32 , C07D209/14 , C07D213/38 , C07D213/61 , C07D213/64 , C07D231/12 , C07D231/14 , C07D231/16 , C07D231/20 , C07D239/42 , C07D239/48 , C07D261/08 , C07D307/33 , C07D309/04 , C07D309/14 , C07D317/46 , C07C211/03 , C07C233/22 , C07C275/18 , C07D307/20
CPC分类号： C07C311/04 , C07B2200/07 , C07C211/03 , C07C215/08 , C07C217/64 , C07C217/84 , C07C229/34 , C07C233/18 , C07C233/22 , C07C233/60 , C07C235/08 , C07C271/16 , C07C271/48 , C07C275/18 , C07C275/24 , C07C275/26 , C07C307/06 , C07C311/10 , C07C311/14 , C07C311/17 , C07C323/32 , C07C2601/02 , C07C2601/04 , C07C2601/08 , C07C2601/14 , C07D209/14 , C07D213/38 , C07D213/61 , C07D213/64 , C07D231/12 , C07D231/14 , C07D231/16 , C07D231/20 , C07D239/42 , C07D239/48 , C07D261/08 , C07D307/20 , C07D307/33 , C07D309/04 , C07D309/14 , C07D317/46
摘要： Compounds of formula Ia and Ib wherein A, B, C, R1 and R14 are described herein.
摘要翻译： 其中A，B，C，R 1和R 14如本文所述的式Ia和Ib化合物。
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公开(公告)号：US09850225B2
公开(公告)日：2017-12-26
申请号：US14681772
申请日：2015-04-08
发明人： Louis S. Chupak , Min Ding , Scott W. Martin , Xiaofan Zheng , Piyasena Hewawasam , Timothy P. Connolly , Ningning Xu , Kap-Sun Yeung , Juliang Zhu , David R. Langley , Paul Michael Scola
IPC分类号： C07D319/18 , A61K31/357 , C07D405/12 , A61K31/453 , C07D405/14 , A61K31/4545 , C07D217/16 , A61K31/472 , C07D413/12 , A61K31/5377 , C07D417/12 , A61K31/541 , A61K31/496 , A61K45/06 , C07C255/54 , C07D215/14 , C07D215/18 , C07D231/56 , C07D405/04 , C07D239/26 , C07D261/08 , C07D271/06 , C07D207/26 , C07D207/335 , C07D213/30 , C07C271/28 , C07C317/22 , C07C233/36 , C07C235/42 , C07C255/13 , A61K31/165 , A61K31/277 , A61K31/40 , A61K31/4015 , A61K31/416 , A61K31/4178 , A61K31/4245 , A61K31/427 , A61K31/4433 , A61K31/47 , A61K31/505
CPC分类号： C07D319/18 , A61K31/165 , A61K31/277 , A61K31/357 , A61K31/40 , A61K31/4015 , A61K31/416 , A61K31/4178 , A61K31/4245 , A61K31/427 , A61K31/4433 , A61K31/453 , A61K31/4545 , A61K31/47 , A61K31/472 , A61K31/496 , A61K31/505 , A61K31/5377 , A61K31/541 , A61K45/06 , C07C233/36 , C07C235/42 , C07C255/13 , C07C255/54 , C07C271/28 , C07C317/22 , C07D207/26 , C07D207/335 , C07D213/30 , C07D215/14 , C07D215/18 , C07D217/16 , C07D231/56 , C07D239/26 , C07D261/08 , C07D271/06 , C07D405/04 , C07D405/12 , C07D405/14 , C07D413/12 , C07D417/12 , Y02A50/463 , A61K2300/00
摘要： The present disclosure generally relates to compounds useful as immunomodulators. Provided herein are compounds, compositions comprising such compounds, and methods of their use. The disclosure further pertains to pharmaceutical compositions comprising at least one compound according to the disclosure that are useful for the treatment of various diseases, including cancer and infectious diseases.
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公开(公告)号：US20150291549A1
公开(公告)日：2015-10-15
申请号：US14681772
申请日：2015-04-08
发明人： Louis S. Chupak , Min Ding , Scott W. Martin , Xiaofan Zheng , Piyasena Hewawasam , Timothy P. Connolly , Ningning Xu , Kap-Sun Yeung , Juliang Zhu , David R. Langley , Daniel J. Tenney , Paul Michael Scola
IPC分类号： C07D319/18 , C07D405/12 , A61K31/453 , C07D405/14 , A61K31/4545 , A61K45/06 , A61K31/472 , C07D413/12 , A61K31/5377 , C07D417/12 , A61K31/541 , A61K31/496 , A61K31/357 , C07D217/16
CPC分类号： C07D319/18 , A61K31/165 , A61K31/277 , A61K31/357 , A61K31/40 , A61K31/4015 , A61K31/416 , A61K31/4178 , A61K31/4245 , A61K31/427 , A61K31/4433 , A61K31/453 , A61K31/4545 , A61K31/47 , A61K31/472 , A61K31/496 , A61K31/505 , A61K31/5377 , A61K31/541 , A61K45/06 , C07C233/36 , C07C235/42 , C07C255/13 , C07C255/54 , C07C271/28 , C07C317/22 , C07D207/26 , C07D207/335 , C07D213/30 , C07D215/14 , C07D215/18 , C07D217/16 , C07D231/56 , C07D239/26 , C07D261/08 , C07D271/06 , C07D405/04 , C07D405/12 , C07D405/14 , C07D413/12 , C07D417/12 , Y02A50/463 , A61K2300/00
摘要： The present disclosure generally relates to compounds useful as immunomodulators. Provided herein are compounds, compositions comprising such compounds, and methods of their use. The disclosure further pertains to pharmaceutical compositions comprising at least one compound according to the disclosure that are useful for the treatment of various diseases, including cancer and infectious diseases.
摘要翻译： 本公开一般涉及可用作免疫调节剂的化合物。 本文提供的化合物，包含这些化合物的组合物及其使用方法。 本公开还涉及包含至少一种根据本公开的化合物的药物组合物，其可用于治疗各种疾病，包括癌症和感染性疾病。
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9.发明申请N-((3-BENZYL)-2,2-(BIS-PHENYL)-PROPAN-1-AMINE DERIVATIVES AS CETP INHIBITORS FOR THE TREATMENT OF ATHEROSCLEROSIS AND CARDIOVASCULAR DISEASES 审中-公开N - （（3-苄基）-2,2-（双 - 苯基） - 丙-1-胺衍生物作为用于治疗甲状腺功能亢进和心血管疾病的CETP抑制剂公开(公告)号：US20130184279A1
公开(公告)日：2013-07-18
申请号：US13717871
申请日：2012-12-18
发明人： Mark E. Salvati , James A. Johnson , Ningning Xu
IPC分类号： C07C311/04 , C07C211/03 , C07C233/22 , C07C233/60 , C07C271/16 , C07D309/14 , C07C275/18 , C07D307/20 , C07D261/08 , C07D239/42 , C07D213/61 , C07D231/12
CPC分类号： C07C311/04 , C07B2200/07 , C07C211/03 , C07C215/08 , C07C217/64 , C07C217/84 , C07C229/34 , C07C233/18 , C07C233/22 , C07C233/60 , C07C235/08 , C07C271/16 , C07C271/48 , C07C275/18 , C07C275/24 , C07C275/26 , C07C307/06 , C07C311/10 , C07C311/14 , C07C311/17 , C07C323/32 , C07C2601/02 , C07C2601/04 , C07C2601/08 , C07C2601/14 , C07D209/14 , C07D213/38 , C07D213/61 , C07D213/64 , C07D231/12 , C07D231/14 , C07D231/16 , C07D231/20 , C07D239/42 , C07D239/48 , C07D261/08 , C07D307/20 , C07D307/33 , C07D309/04 , C07D309/14 , C07D317/46
摘要： Compounds of formula Ia and Ib wherein A, B, C, R1 and R14 are described herein.
摘要翻译： 其中A，B，C，R 1和R 14如本文所述的式Ia和Ib化合物。
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公开(公告)号：US20130183269A1
公开(公告)日：2013-07-18
申请号：US13735224
申请日：2013-01-07
发明人： Piyasena Hewawasam , John F. Kadow , Omar D. Lopez , Nicholas A. Meanwell , Yong Tu , Alan Xiangdong Wang , Ningning Xu , Samayamunthula Venkata Satya Arun Kumar Gupta , Pothukanuri Srinivasu , Indasi Gopi Kumar , Ponugupati Suresh Kumar , Makonen Belema , Robert A. Fridell , Min Gao , Julie A. Lemm , Donald R. O'Boyle, II , Jin-Hua Sun , Chunfu Wang , Ying-Kai Wang
IPC分类号： A61K31/4178 , A61K31/407 , A61K31/422 , A61K31/444 , A61K31/423 , A61K31/497 , A61K31/4545 , A61K31/498 , A61K31/506 , A61K31/5377 , A61K31/4709 , A61K31/437 , A61K31/519 , A61K31/428 , A61K31/501 , A61K31/55 , A61K31/496 , A61K31/4184 , A61K45/06 , C07D403/14 , C07D491/113 , A61K31/7056 , A61K38/21 , A61K38/05
CPC分类号： A61K31/4178 , A61K31/407 , A61K31/4184 , A61K31/422 , A61K31/423 , A61K31/428 , A61K31/437 , A61K31/4439 , A61K31/444 , A61K31/4545 , A61K31/4709 , A61K31/4725 , A61K31/496 , A61K31/497 , A61K31/498 , A61K31/501 , A61K31/506 , A61K31/519 , A61K31/5377 , A61K31/55 , A61K31/7056 , A61K38/05 , A61K38/21 , A61K38/212 , A61K38/217 , A61K45/06 , C07D403/14 , C07D491/113 , A61K2300/00
摘要： The present disclosure is generally directed to antiviral compounds, and more specifically directed to combinations of compounds which can inhibit the function of the NS5A protein encoded by Hepatitis C virus (HCV), compositions comprising such combinations, and methods for inhibiting the function of the NS5A protein.
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