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公开(公告)号：US20160152621A1
公开(公告)日：2016-06-02
申请号：US14902868
申请日：2014-07-01
Applicant: BRISTOL-MYERS SQUIBB COMPANY
Inventor： Richard A. Hartz , Vijay T. Ahuja , Joanne J. Bronson , Carolyn Diane Dzierba , John E. Macor , Susheel Jethanand Nara , Ramkumar Rajamani
IPC: C07D487/04 , C07D413/12 , C07D409/10 , C07D249/06 , C07D213/56 , C07D277/30 , C07D237/08 , C07D285/12 , C07D231/12 , C07D233/61 , C07D249/08 , C07D213/65 , C07D213/73 , C07D417/12 , C07D401/10 , C07D401/12 , C07D263/32
CPC classification number: C07D487/04 , C07D213/16 , C07D213/56 , C07D213/61 , C07D213/62 , C07D213/65 , C07D213/72 , C07D213/73 , C07D231/12 , C07D233/54 , C07D233/61 , C07D237/08 , C07D249/06 , C07D249/08 , C07D263/30 , C07D263/32 , C07D277/20 , C07D277/30 , C07D285/08 , C07D285/12 , C07D401/10 , C07D401/12 , C07D409/10 , C07D413/12 , C07D417/12
Abstract: The present disclosure is generally directed to compounds which can inhibit AAK1 (adaptor associated kinase 1), compositions comprising such compounds, and methods for inhibiting AAK1.
Abstract translation: 本公开一般涉及可以抑制AAK1（衔接子相关激酶1），包含这些化合物的组合物和抑制AAK1的方法的化合物。
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公开(公告)号：US12037323B2
公开(公告)日：2024-07-16
申请号：US17052232
申请日：2019-05-02
Applicant: BRISTOL-MYERS SQUIBB COMPANY
Inventor： Christine M. Tarby , Derek J. Norris , Julian C. Lo , Vijay T. Ahuja , Steven P. Seitz , Ashvinikumar V. Gavai , John S. Tokarski , Mohini Rajasagi , Michael Wichroski , Matthias Broekema
IPC: C07D401/14 , C07D405/14 , C07D417/14 , C07D471/04
CPC classification number: C07D401/14 , C07D405/14 , C07D417/14 , C07D471/04
Abstract: The invention relates generally to compounds that are Mer-Ax1 inhibitors, pharmaceutical compositions containing said compounds and methods of treating proliferative disorders and disorders of dysregulated apoptosis, such as cancer, utilizing the compounds of the invention.
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公开(公告)号：US20230339891A1
公开(公告)日：2023-10-26
申请号：US17052232
申请日：2019-05-02
Applicant: BRISTOL-MYERS SQUIBB COMPANY
Inventor： Christine M. Tarby , Derek J. Norris , Julian C. Lo , Vijay T. Ahuja , Steven P. Seitz , Ashvinikumar V. Gavai , John S. Tokarski , Mohini Rajasagi , Michael Wichroski , Matthias Broekema
IPC: C07D401/14 , C07D417/14 , C07D471/04 , C07D405/14
CPC classification number: C07D401/14 , C07D417/14 , C07D471/04 , C07D405/14
Abstract: The invention relates generally to compounds that are Mer-Ax1 inhibitors, pharmaceutical compositions containing said compounds and methods of treating proliferative disorders and disorders of dysregulated apoptosis, such as cancer, utilizing the compounds of the invention.
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公开(公告)号：US20190315714A1
公开(公告)日：2019-10-17
申请号：US16463467
申请日：2017-11-27
Applicant: BRISTOL-MYERS SQUIBB COMPANY
Inventor： Richard A. Hartz , Vijay T. Ahuja , Guanglin Luo , Ling Chen , Prasanna Sivaprakasam , Gene M. Dubowchik , Swannee E. Jacutin-Porte , John E. Macor
IPC: C07D401/12 , C07D401/14 , C07D403/12 , C07D405/14 , C07D417/14 , A61P25/28
Abstract: The disclosure generally relates to compounds of formula I, including their salts, as well as compositions and methods of using the compounds to treat disorders associated with GSK-3.
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公开(公告)号：US20160332985A1
公开(公告)日：2016-11-17
申请号：US15112294
申请日：2015-01-23
Applicant: BRISTOL-MYERS SQUIBB COMPANY
Inventor： Richard A. Hartz , Vijay T. Ahuja , John E. Macor , Joanne J. Bronson , Bireshwar Dasgupta , Carolyn Diane Dzierba , Susheel Jethanand Nara , Maheswaran Sivasamban Karatholuvhu
IPC: C07D401/04 , C07D401/14 , C07D215/12 , C07D413/04 , C07D471/04
CPC classification number: C07D401/04 , C07D215/12 , C07D215/18 , C07D401/14 , C07D413/04 , C07D471/04
Abstract: The present disclosure is generally directed to compounds of formula (I) which can inhibit AAKI (adaptor associated kinase 1), compositions comprising such compounds, and methods for inhibiting AAKI.
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Patent Agency Ranking
公开(公告)号：US10774086B2
公开(公告)日：2020-09-15
申请号：US16463451
申请日：2017-11-27
Applicant: BRISTOL-MYERS SQUIBB COMPANY
Inventor： Richard A. Hartz , Vijay T. Ahuja , Prasanna Sivaprakasam , Gene M. Dubowchik , John E. Macor
IPC: A61K31/5025 , C07D487/04
Abstract: The disclosure generally relates to compounds of formula (I), including their salts, as well as compositions and methods of using the compounds to treat disorders associated with GSK-3.
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公开(公告)号：US10752609B2
公开(公告)日：2020-08-25
申请号：US16463467
申请日：2017-11-27
Applicant: BRISTOL-MYERS SQUIBB COMPANY
Inventor： Richard A. Hartz , Vijay T. Ahuja , Guanglin Luo , Ling Chen , Prasanna Sivaprakasam , Gene M. Dubowchik , Swanee E. Jacutin-Porte , John E. Macor
IPC: C07D401/12 , A61P25/28 , C07D401/14 , C07D403/12 , C07D405/14 , C07D417/14
Abstract: The disclosure generally relates to compounds of formula I, including their salts, as well as compositions and methods of using the compounds to treat disorders associated with GSK-3.
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公开(公告)号：US20190276463A1
公开(公告)日：2019-09-12
申请号：US16463451
申请日：2017-11-27
Applicant: BRISTOL-MYERS SQUIBB COMPANY
Inventor： Richard A. Hartz , Vijay T. Ahuja , Prasanna Sivaprakasam , Gene M. Dubowchik , John E. Macor
IPC: C07D487/04
Abstract: The disclosure generally relates to compounds of formula (I), including their salts, as well as compositions and methods of using the compounds to treat disorders associated with GSK-3.
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公开(公告)号：US10253027B2
公开(公告)日：2019-04-09
申请号：US14902868
申请日：2014-07-01
Applicant: Bristol-Myers Squibb Company
Inventor： Richard A. Hartz , Vijay T. Ahuja , Joanne J. Bronson , Carolyn Diane Dzierba , John E. Macor , Susheel Jethanand Nara , Ramkumar Rajamani
IPC: C07D487/04 , C07D409/10 , C07D233/61 , C07D401/12 , C07D401/10 , C07D263/32 , C07D213/56 , C07D285/12 , C07D277/30 , C07D213/73 , C07D213/65 , C07D249/08 , C07D233/54 , C07D249/06 , C07D237/08 , C07D213/72 , C07D213/16 , C07D285/08 , C07D231/12 , C07D213/62 , C07D277/20 , C07D213/61 , C07D263/30 , C07D413/12 , C07D417/12
Abstract: The present disclosure is generally directed to compounds which can inhibit AAK1 (adaptor associated kinase 1), compositions comprising such compounds, and methods for inhibiting AAK1.
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公开(公告)号：US09932320B2
公开(公告)日：2018-04-03
申请号：US15112294
申请日：2015-01-23
Applicant: BRISTOL-MYERS SQUIBB COMPANY
Inventor： Richard A. Hartz , Vijay T. Ahuja , John E. Macor , Joanne J. Bronson , Bireshwar Dasgupta , Carolyn Diane Dzierba , Susheel Jethanand Nara , Maheswaran Sivasamban Karatholuvhu
IPC: C07D401/14 , C07D401/04 , C07D215/12 , C07D215/18 , C07D413/04 , C07D471/04
CPC classification number: C07D401/04 , C07D215/12 , C07D215/18 , C07D401/14 , C07D413/04 , C07D471/04
Abstract: The present disclosure is generally directed to compounds of formula (I) which can inhibit AAKI (adaptor associated kinase 1), compositions comprising such compounds, and methods for inhibiting AAKI.
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