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公开(公告)号：US12145927B2
公开(公告)日：2024-11-19
申请号：US17261968
申请日：2019-07-22
Applicant: BRISTOL-MYERS SQUIBB COMPANY
Inventor： James Aaron Balog , Steven P. Seitz , Jay A. Markwalder , David K. Williams , Weifang Shan , Susheel Jethanand Nara , Saumya Roy , Srinivas Cheruku , Nagalakshmi Pulicharla
IPC: C07D405/14 , C07D307/79 , C07D313/08 , C07D405/10 , C07D413/10 , C07D413/14 , C07D417/14 , C07K16/28
Abstract: The present invention provides compounds of formula (I) wherein all of the variables are as defined herein. These compounds are inhibitors of indoleamine 2,3-dioxygenase (IDO), which may be used as medicaments for the treatment of proliferative disorders, such as cancer, viral infections and/or autoimmune diseases.
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公开(公告)号：US11203592B2
公开(公告)日：2021-12-21
申请号：US16754175
申请日：2018-10-08
Applicant: BRISTOL-MYERS SQUIBB COMPANY
Inventor： Steven P. Seitz , Emily Charlotte Cherney , Xiao Zhu
IPC: C07D471/04 , C07D307/94 , C07D405/06 , C07K16/28
Abstract: The present invention provides compounds of formula (I): wherein all of the variables are as defined herein. These compounds are inhibitors of indoleamine 2,3-dioxygenase (IDO), which may be used as medicaments for the treatment of proliferative disorders, such as cancer, viral infections and/or autoimmune diseases.
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公开(公告)号：US20180079712A1
公开(公告)日：2018-03-22
申请号：US15564146
申请日：2016-04-01
Applicant: BRISTOL-MYERS SQUIBB COMPANY
Inventor： James Aaron Balog , Emily Charlotte Cherney , Jay A. Markwalder , Steven P. Seitz , Weifang Shan , David K. Williams , Audris Huang , Susheel Jethanand Nara , Saumya Roy , Soodamani Thangavel , Ramesh Kumar Sistla , Srinivas Cheruku , Srinivasan Thangathirupathy , Yadagiri Kanyaboina , Nagalakshmi Pulicharla
IPC: C07C229/42 , C07C275/42 , C07D295/155 , C07D239/47 , C07D277/64 , C07D335/02 , C07D409/12 , C07D309/14 , C07D405/12 , C07D211/14 , C07D401/12 , C07D317/46 , C07D239/34 , C07D413/12 , C07D265/30 , C07C233/81 , C07D405/14 , C07D207/12 , C07D487/08 , C07D487/04 , C07D471/08 , C07D265/36 , C07D413/14
Abstract: There are disclosed compounds of formula (I) that modulate or inhibit the enzymatic activity of indoleamine-2,3-dioxygenase (IDO), pharmaceutical compositions containing said compounds and methods of treating proliferative disorders, such as cancer, viral infections and/or inflammatory disorders utilizing the compounds of the invention.
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公开(公告)号：US20160289171A1
公开(公告)日：2016-10-06
申请号：US15088211
申请日：2016-04-01
Applicant: BRISTOL-MYERS SQUIBB COMPANY
Inventor： James Aaron Balog , Emily Charlotte Cherney , Weiwei Guo , Audris Huang , Jay A. Markwalder , Steven P. Seitz , Weifang Shan , David K. Williams , Natesan Murugesan , Susheel Jethanand Nara , Saumya Roy , Soodamani Thangavel , Ramesh Kumar Sistla , Srinivas Cheruku , Srinivasan Thangathirupathy , Yadagiri Kanyaboina , Nagalakshmi Pulicharla
IPC: C07C229/42 , A61K31/196 , C07D239/47 , A61K31/505 , C07C255/58 , A61K31/277 , C07C275/40 , A61K31/17 , C07D295/155 , A61K31/5375 , C07D277/64 , A61K31/428 , C07D335/02 , A61K31/382 , C07D409/12 , A61K31/506 , C07D309/04 , A61K31/351 , C07D405/12 , C07D211/14 , A61K31/445 , C07D401/12 , C07D413/12 , A61K31/5377 , C07D405/14 , C07D417/12 , C07D487/04 , A61K31/519 , A61K31/501 , C07D471/04 , A61K31/437 , C07D205/04 , A61K31/397 , A61K31/538 , C07D265/36 , A61K39/395
CPC classification number: C07C275/40 , A61K31/17 , A61K31/196 , A61K31/277 , A61K31/351 , A61K31/382 , A61K31/397 , A61K31/428 , A61K31/437 , A61K31/445 , A61K31/501 , A61K31/505 , A61K31/506 , A61K31/519 , A61K31/5375 , A61K31/5377 , A61K31/538 , A61K39/3955 , A61K39/39558 , A61K45/06 , C07C229/42 , C07C233/81 , C07C235/38 , C07C235/56 , C07C255/57 , C07C255/58 , C07C275/30 , C07C275/42 , C07D205/04 , C07D207/08 , C07D207/12 , C07D211/08 , C07D211/14 , C07D239/34 , C07D239/47 , C07D265/30 , C07D265/36 , C07D277/64 , C07D295/155 , C07D307/22 , C07D309/04 , C07D309/14 , C07D317/46 , C07D335/02 , C07D401/12 , C07D405/12 , C07D405/14 , C07D407/12 , C07D409/12 , C07D413/12 , C07D413/14 , C07D417/12 , C07D471/04 , C07D471/08 , C07D487/04 , C07D487/08
Abstract: There are disclosed compounds that modulate or inhibit the enzymatic activity of indoleamine 2,3-dioxygenase (IDO), pharmaceutical compositions containing said compounds and methods of treating proliferative disorders, such as cancer, viral infections and/or inflammatory disorders utilizing the compounds of the invention.
Abstract translation: 公开了调节或抑制吲哚胺2,3-双加氧酶（IDO）的酶活性的化合物，含有所述化合物的药物组合物和治疗增殖性疾病如癌症，病毒感染和/或炎症性疾病的方法，其利用 发明。
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公开(公告)号：US10167254B2
公开(公告)日：2019-01-01
申请号：US15584818
申请日：2017-05-02
Applicant: BRISTOL-MYERS SQUIBB COMPANY
Inventor： James Aaron Balog , Emily Charlotte Cherney , Weiwei Guo , Audris Huang , Jay A. Markwalder , Steven P. Seitz , Weifang Shan , David K. Williams , Natesan Murugesan , Susheel Jethanand Nara , Saumya Roy , Soodamani Thangavel , Ramesh Kumar Sistla , Srinivas Cheruku , Srinivasan Thangathirupathy , Yadagiri Kanyaboina , Nagalakshmi Pulicharla
IPC: A61K31/17 , C07C275/40 , A61K31/196 , A61K31/277 , A61K31/351 , A61K31/382 , A61K31/397 , A61K31/428 , A61K31/437 , A61K31/445 , A61K31/501 , A61K31/505 , A61K31/506 , A61K31/519 , A61K31/5375 , A61K31/5377 , A61K31/538 , A61K39/395 , C07C229/42 , C07C255/58 , C07D205/04 , C07D211/14 , C07D239/47 , C07D265/36 , C07D277/64 , C07D295/155 , C07D309/04 , C07D335/02 , C07D401/12 , C07D405/12 , C07D405/14 , C07D409/12 , C07D413/12 , C07D417/12 , C07D471/04 , C07D487/04 , C07D309/14 , C07D407/12 , C07D487/08 , C07D265/30 , C07D207/08 , C07D211/08 , C07D307/22 , C07C255/57 , C07C235/38 , C07C235/56 , C07C233/81 , C07C275/42 , C07D207/12 , C07D239/34 , C07D317/46 , C07D413/14 , C07D471/08 , C07C275/30 , A61K45/06
Abstract: There are disclosed compounds that modulate or inhibit the enzymatic activity of indoleamine 2,3-dioxygenase (IDO), pharmaceutical compositions containing said compounds and methods of treating proliferative disorders, such as cancer, viral infections and/or inflammatory disorders utilizing the compounds of the invention.
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Patent Agency Ranking
公开(公告)号：US09765018B2
公开(公告)日：2017-09-19
申请号：US14897668
申请日：2014-07-01
Applicant: BRISTOL-MYERS SQUIBB COMPANY
Inventor： Jay A. Markwalder , Steven P. Seitz , James Aaron Balog , Audris Huang , Sunil Kumar Mandal , David K. Williams , Amy C. Hart , Jennifer Inghrim
IPC: C07C275/42 , C07C311/51 , C07D213/75 , C07D257/04 , C07D401/04 , A61K31/18 , A61K31/41 , A61K31/44 , C07D213/79 , C07D307/86 , A61K31/196 , A61K31/277 , A61K31/343 , A61K31/4418 , A61K31/444 , A61K45/06 , C07C311/09 , C07D307/79
CPC classification number: C07C275/42 , A61K31/18 , A61K31/196 , A61K31/277 , A61K31/343 , A61K31/41 , A61K31/4418 , A61K31/444 , A61K45/06 , C07C311/09 , C07C311/51 , C07C2601/02 , C07C2601/14 , C07C2602/08 , C07C2602/10 , C07D213/75 , C07D213/79 , C07D257/04 , C07D307/79 , C07D307/86 , C07D401/04
Abstract: There are disclosed compounds of formula (I) that modulate or inhibit the enzymatic activity of indoleamine 2,3-dioxygenase (IDO), pharmaceutical compositions containing said compounds and methods of treating proliferative disorders, such as cancer, viral infections and/or inflammatory disorders utilizing the compounds of the invention.
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公开(公告)号：US20160297806A1
公开(公告)日：2016-10-13
申请号：US15037081
申请日：2014-11-18
Applicant: BRISTOL-MYERS SQUIBB COMPANY
Inventor： Kyoung S. Kim , Liping Zhang , Ashok Vinandare Purandara , Steven P. Seitz
IPC: C07D405/12 , A61K31/5377 , A61K31/496 , C07D417/14 , C07D405/14 , A61K45/06 , A61K31/541
CPC classification number: C07D405/12 , A61K31/4725 , A61K31/496 , A61K31/5377 , A61K31/541 , A61K45/06 , C07D401/14 , C07D405/14 , C07D407/14 , C07D413/14 , C07D417/14 , Y02A50/411 , Y02A50/414 , A61K2300/00
Abstract: There are disclosed compounds that are inhibitors of EZH2, pharmaceutical compositions containing said compounds and methods of treating hyperproliferative, inflammatory, infectious, and immunoregulatory disorders and diseases, utilizing the compounds of the invention.
Abstract translation: 公开了作为EZH2抑制剂的化合物，含有所述化合物的药物组合物和利用本发明化合物治疗过度增殖，炎症，感染和免疫调节性疾病和疾病的方法。
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公开(公告)号：US20160137595A1
公开(公告)日：2016-05-19
申请号：US14897668
申请日：2014-07-01
Applicant: BRISTOL-MYERS SQUIBB COMPANY
Inventor： Jay A. Markwalder , Steven P. Seitz , James Aaron Balog , Audris Huang , Sunil Kumar Mandal , David K. William , Amy C. Hart , Jennifer Inghrim
IPC: C07C275/42 , C07D213/79 , C07D257/04 , C07C311/51 , C07C311/09 , C07D307/79 , A61K45/06 , A61K31/196 , A61K31/4418 , A61K31/444 , A61K31/41 , A61K31/18 , A61K31/343 , A61K31/277 , C07D213/75
CPC classification number: C07C275/42 , A61K31/18 , A61K31/196 , A61K31/277 , A61K31/343 , A61K31/41 , A61K31/4418 , A61K31/444 , A61K45/06 , C07C311/09 , C07C311/51 , C07C2601/02 , C07C2601/14 , C07C2602/08 , C07C2602/10 , C07D213/75 , C07D213/79 , C07D257/04 , C07D307/79 , C07D307/86 , C07D401/04
Abstract: There are disclosed compounds of formula (I) that modulate or inhibit the enzymatic activity of indoleamine 2,3-di-oxygenase (IDO), pharmaceutical compositions containing said compounds and methods of treating proliferative disorders, such as cancer, viral infections and/or inflammatory disorders utilizing the compounds of the invention.
Abstract translation: 公开了调节或抑制吲哚胺2,3-二加氧酶（IDO）的酶活性的式（I）化合物，含有所述化合物的药物组合物和治疗增殖性疾病如癌症，病毒感染和/或 使用本发明化合物的炎症性疾病。
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公开(公告)号：US11253525B2
公开(公告)日：2022-02-22
申请号：US16555431
申请日：2019-08-29
Applicant: BRISTOL-MYERS SQUIBB COMPANY
Inventor： James Aaron Balog , Steven P. Seitz , Susheel Jethanand Nara , Saumya Roy , Srinivasan Thangathirupathy , Soodamani Thangavel , Srinivas Cheruku
IPC: A61P35/00 , A61K31/17 , A61K31/44 , A61K31/50 , A61K31/136 , A61K31/275 , A61K31/351 , A61K31/428 , A61K31/4965 , A61K31/505 , A61K31/5375 , A61K31/5377 , C07C211/54 , C07C229/42 , C07C255/58 , C07C275/42 , C07D213/90 , C07D237/22 , C07D239/42 , C07D239/47 , C07D241/18 , C07D265/30 , C07D277/64 , C07D295/03 , C07D407/12 , C07D413/12
Abstract: There are disclosed compounds that modulate or inhibit the enzymatic activity of indoleamine 2,3-dioxygenase (IDO), pharmaceutical compositions containing said compounds and methods of treating proliferative disorders, such as cancer, viral infections and/or inflammatory disorders utilizing the compounds of the disclosure.
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公开(公告)号：US10399932B2
公开(公告)日：2019-09-03
申请号：US15564146
申请日：2016-04-01
Applicant: BRISTOL-MYERS SQUIBB COMPANY
Inventor： James Aaron Balog , Emily Charlotte Cherney , Jay A. Markwalder , Steven P. Seitz , Weifang Shan , David K. Williams , Audris Huang , Susheel Jethanand Nara , Saumya Roy , Soodamani Thangavel , Ramesh Kumar Sistla , Srinivas Cheruku , Srinivasan Thangathirupathy , Yadagiri Kanyaboina , Nagalakshmi Pulicharla
IPC: C07D309/14 , C07D405/12 , C07D413/12 , C07D335/02 , C07D211/10 , C07D265/30 , C07D409/12 , C07C275/40 , A61K31/17 , A61K31/196 , A61K31/277 , A61K31/351 , A61K31/382 , A61K31/397 , A61K31/428 , A61K31/437 , A61K31/445 , A61K31/501 , A61K31/505 , A61K31/506 , A61K31/519 , A61K31/5375 , A61K31/5377 , A61K31/538 , A61K39/395 , C07C229/42 , C07C255/58 , C07D205/04 , C07D211/14 , C07D239/47 , C07D265/36 , C07D277/64 , C07D295/155 , C07D309/04 , C07D401/12 , C07D405/14 , C07D417/12 , C07D471/04 , C07D487/04 , C07D407/12 , C07D487/08 , C07D207/08 , C07D211/08 , C07D307/22 , C07C255/57 , C07C235/38 , C07C235/56 , C07C233/81 , C07C275/42 , C07D207/12 , C07D239/34 , C07D317/46 , C07D413/14 , C07D471/08 , C07C275/30 , A61K45/06
Abstract: There are disclosed compounds of formula (I) that modulate or inhibit the enzymatic activity of indoleamine-2,3-dioxygenase (IDO), pharmaceutical compositions containing said compounds and methods of treating proliferative disorders, such as cancer, viral infections and/or inflammatory disorders utilizing the compounds of the invention.
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