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公开(公告)号：US12084426B2
公开(公告)日：2024-09-10
申请号：US17274227
申请日：2019-09-12
Applicant: BRISTOL-MYERS SQUIBB COMPANY
Inventor： Junqing Guo , Carolyn Diane Dzierba , Amy C. Hart , John E. Macor , William J. Pitts
IPC: C07D401/04 , C07D401/14 , C07D403/04 , C07D413/04 , C07D413/14
CPC classification number: C07D401/04 , C07D401/14 , C07D403/04 , C07D413/04 , C07D413/14
Abstract: Compounds having formula (I), and enantiomers, and diastereomers, stereoisomers, pharmaceutically-acceptable salts thereof, are useful as kinase modulators, including RIPK1 modulation. All the variables are as defined herein.
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公开(公告)号：US11767322B2
公开(公告)日：2023-09-26
申请号：US17503516
申请日：2021-10-18
Applicant: BRISTOL-MYERS SQUIBB COMPANY
Inventor： Guanglin Luo , Jie Chen , Carolyn Diane Dzierba , David B. Frennesson , Junqing Guo , Amy C. Hart , Xirui Hu , Michael C. Mertzman , Matthew Reiser Patton , Jianliang Shi , Steven H. Spergel , Brian Lee Venables , Yong-Jin Wu , Zili Xiao , Michael G. Yang
IPC: C07D471/04
CPC classification number: C07D471/04
Abstract: Compounds having formula (I), and enantiomers, and diastereomers, stereoisomers, pharmaceutically-acceptable salts thereof,
are useful as kinase modulators, including RIPK1 modulation. All the variables are as defined herein.-
公开(公告)号：US20220315580A1
公开(公告)日：2022-10-06
申请号：US17116016
申请日：2020-12-09
Applicant: BRISTOL-MYERS SQUIBB COMPANY
Inventor： Junqing Guo , Amy C. Hart , John E. Macor , Michael E. Mertzman , William J. Pitts , Steven H. Spergel , Scott Hunter Watterson , Murugaiah Andappan Murugaiah Subbaiah , Jie Chen , Carolyn Diane Dzierba , Guanglin Luo , Jianliang Shi , Sing-Yuen Sit
IPC: C07D471/04
Abstract: Compounds having formula (I)-(IX), and enantiomers, and diastereomers, stereoisomers, pharmaceutically acceptable salts and prodrugs thereof, are useful as kinase modulators, including RIPK1 modulation. All the variables are as defined herein.
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公开(公告)号：US20200347071A1
公开(公告)日：2020-11-05
申请号：US16963886
申请日：2019-01-24
Applicant: BRISTOL-MYERS SQUIBB COMPANY
Inventor： Scott Hunter Watterson , Murugaiah Andappan Murugaiah Subbaiah , Carolyn Diane Dzierba , Hua Gong , Jason M. Guernon , Junqing Guo , Amy C. Hart , Guanglin Luo , John E. Macor , William J. Pitts , Jianliang Shi , Brian Lee Venables , Carolyn A. Weigelt , Yong-Jin Wu , Zhizhen Barbara Zheng , Sing-Yuen Sit , Jie Chen
IPC: C07D487/04
Abstract: The disclosure relates to compounds of formula I which are useful as kinase modulators including RIPK 1 modulation. The disclosure also provides methods of making and using the compounds for example in treatments related to necrosis or inflammation as well as other indications.
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公开(公告)号：US09902722B2
公开(公告)日：2018-02-27
申请号：US15300618
申请日：2015-04-01
Applicant: BRISTOL-MYERS SQUIBB COMPANY
Inventor： Guanglin Luo , Ling Chen , Carolyn Diane Dzierba , Jonathan L. Ditta , John E. Macor , Joanne J. Bronson
IPC: C07D401/04 , C07D401/14 , C07D403/04 , C07D403/14 , C07D237/08 , C07D239/26 , C07D213/34 , A61K31/50 , A61K31/51 , A61K31/505 , A61K31/506 , A61K31/44 , C07D471/04 , C07D213/75 , C07D213/73 , C07D413/10 , C07D213/57 , C07D213/64 , C07D213/30 , C07D213/61 , C07D215/14 , C07D213/80 , C07D309/22 , C07C233/25 , A61K31/4427 , A61P25/28
CPC classification number: C07D471/04 , A61K31/4427 , A61K31/50 , A61P25/28 , C07C233/25 , C07D213/30 , C07D213/34 , C07D213/57 , C07D213/61 , C07D213/64 , C07D213/73 , C07D213/74 , C07D213/75 , C07D213/80 , C07D215/14 , C07D237/08 , C07D239/26 , C07D309/18 , C07D309/22 , C07D401/04 , C07D401/14 , C07D413/10
Abstract: The present disclosure is generally directed to compounds which can inhibit AAK1 (adaptor associated kinase 1), compositions comprising such compounds, and methods for inhibiting AAK1.
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Patent Agency Ranking
公开(公告)号：US20160332985A1
公开(公告)日：2016-11-17
申请号：US15112294
申请日：2015-01-23
Applicant: BRISTOL-MYERS SQUIBB COMPANY
Inventor： Richard A. Hartz , Vijay T. Ahuja , John E. Macor , Joanne J. Bronson , Bireshwar Dasgupta , Carolyn Diane Dzierba , Susheel Jethanand Nara , Maheswaran Sivasamban Karatholuvhu
IPC: C07D401/04 , C07D401/14 , C07D215/12 , C07D413/04 , C07D471/04
CPC classification number: C07D401/04 , C07D215/12 , C07D215/18 , C07D401/14 , C07D413/04 , C07D471/04
Abstract: The present disclosure is generally directed to compounds of formula (I) which can inhibit AAKI (adaptor associated kinase 1), compositions comprising such compounds, and methods for inhibiting AAKI.
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公开(公告)号：US20160016967A1
公开(公告)日：2016-01-21
申请号：US14767952
申请日：2014-02-06
Applicant: BRISTOL-MYERS SQUIBB COMPANY
Inventor： Vivekananda M. Vrudhula , Carolyn Diane Dzierba , Joanne J. Bronson , John E. Macor , Susheel Jethanand Nara , Ramkumar Rajamani , Maheswaran Sivasamban Karatholuvhu
IPC: C07D491/052
CPC classification number: C07D491/052
Abstract: The present disclosure is generally directed to compounds which can inhibit AAK1 (adaptor associated kinase 1), compositions comprising such compounds, and methods for inhibiting AAK1.
Abstract translation: 本公开一般涉及可以抑制AAK1（衔接子相关激酶1），包含这些化合物的组合物和抑制AAK1的方法的化合物。
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公开(公告)号：US08901305B2
公开(公告)日：2014-12-02
申请号：US13946344
申请日：2013-07-19
Applicant: Bristol-Myers Squibb Company
Inventor： Vivekananda M. Vrudhula , Senliang Pan , Ramkumar Rajamani , Susheel Jethanand Nara , Maheswaran Sivasamban Karatholuvhu , Tarun Kumar Maishal , Jonathan L. Ditta , Carolyn Diane Dzierba , Joanne J. Bronson , John E. Macor
IPC: A61K31/44 , C07D471/00 , C07D471/04
CPC classification number: C07D471/04
Abstract: The present disclosure is generally directed to compounds which can inhibit AAK1 (adaptor associated kinase 1), compositions comprising such compounds, and methods for inhibiting AAK1.
Abstract translation: 本公开一般涉及可抑制AAK1（衔接子相关激酶1），包含这些化合物的组合物和抑制AAK1的方法的化合物。
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公开(公告)号：US12110290B2
公开(公告)日：2024-10-08
申请号：US18347703
申请日：2023-07-06
Applicant: BRISTOL-MYERS SQUIBB COMPANY
Inventor： Guanglin Luo , Jie Chen , Carolyn Diane Dzierba , David B. Frennesson , Junqing Guo , Amy C. Hart , Xirui Hu , Michael E. Mertzman , Matthew Reiser Patton , Jianliang Shi , Steven H. Spergel , Brian Lee Venables , Yong-Jin Wu , Zili Xiao , Michael G. Yang
IPC: C07D471/04
CPC classification number: C07D471/04
Abstract: Compounds having formula (I), and enantiomers, and diastereomers, stereoisomers, pharmaceutically-acceptable salts thereof,
are useful as kinase modulators, including RIPK1 modulation. All the variables are as defined herein.-
公开(公告)号：US20240109888A1
公开(公告)日：2024-04-04
申请号：US18347703
申请日：2023-07-06
Applicant: BRISTOL-MYERS SQUIBB COMPANY
Inventor： Guanglin Luo , Jie Chen , Carolyn Diane Dzierba , David B. Frennesson , Junqing Guo , Amy C. Hart , Xirui Hu , Michael E. Mertzman , Matthew Reiser Patton , Jianliang Shi , Steven H. Spergel , Brian Lee Venables , Yong-Jin Wu , Zili Xiao , Michael G. Yang
IPC: C07D471/04
CPC classification number: C07D471/04
Abstract: Compounds having formula (I), and enantiomers, and diastereomers, stereoisomers, pharmaceutically-acceptable salts thereof,
are useful as kinase modulators, including RIPK1 modulation. All the variables are as defined herein.
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