公开(公告)号：US20210283123A1

公开(公告)日：2021-09-16

申请号：US16328473

申请日：2017-08-25

Applicant: BRISTOL-MYERS SQUIBB COMPANY

Inventor： Liping ZHANG ,  Emily Charlotte CHERNEY ,  James Aaron BALOG ,  Xiao ZHU

IPC: A61K31/4709 ,  A61K39/395 ,  C07D413/08 ,  C07D401/08 ,  C07D417/08 ,  C07D417/14 ,  C07D413/14 ,  C07D413/12 ,  C07D417/12 ,  C07D401/12

Abstract: There are disclosed compounds that modulate or inhibit the enzymatic activity of indoleamine 2,3-dioxygenase (IDO), pharmaceutical compositions containing said compound and methods of treating proliferative disorders, such as cancer, viral infections and/or inflammatory disorders utilizing the compounds of the invention.

公开(公告)号：US20200095231A1

公开(公告)日：2020-03-26

申请号：US16612076

申请日：2018-05-10

Applicant: BRISTOL-MYERS SQUIBB COMPANY

Inventor： James Aaron BALOG ,  Emily Charlotte CHERNEY ,  Liping ZHANG ,  Audris HUANG ,  Weifang SHAN ,  David K. WILLIAMS ,  Xiao ZHU ,  Weiwei GUO

IPC: C07D403/12 ,  C07D213/85 ,  C07D401/12 ,  C07D471/04

Abstract: There are disclosed compounds that modulate or inhibit the enzymatic activity of indoleamine 2,3-dioxygenase (IDO), pharmaceutical compositions containing said compounds and methods of treating proliferative disorders, such as cancer, viral infections and/or inflammatory disorders utilizing the compounds of the invention.