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公开(公告)号:US20190135758A1
公开(公告)日:2019-05-09
申请号:US16098288
申请日:2017-05-04
Applicant: BRISTOL-MYERS SQUIBB COMPANY
Inventor: Emily Charlotte CHERNEY , Weifang SHAN , Liping ZHANG , David K. WILLIAMS , Weiwei GUO , Audris HUANG , James Aaron BALOG
IPC: C07D215/18 , C07D401/04 , A61K31/4709 , A61P35/00 , A61K47/42
Abstract: There are disclosed compounds that modulate or inhibit the enzymatic activity of indoleamine 2,3-dioxygenase (IDO), pharmaceutical compositions containing said compounds and methods of treating proliferative disorders, such as cancer, viral infections and/or inflammatory disorders utilizing the compounds of the invention.
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公开(公告)号:US20210283123A1
公开(公告)日:2021-09-16
申请号:US16328473
申请日:2017-08-25
Applicant: BRISTOL-MYERS SQUIBB COMPANY
Inventor: Liping ZHANG , Emily Charlotte CHERNEY , James Aaron BALOG , Xiao ZHU
IPC: A61K31/4709 , A61K39/395 , C07D413/08 , C07D401/08 , C07D417/08 , C07D417/14 , C07D413/14 , C07D413/12 , C07D417/12 , C07D401/12
Abstract: There are disclosed compounds that modulate or inhibit the enzymatic activity of indoleamine 2,3-dioxygenase (IDO), pharmaceutical compositions containing said compound and methods of treating proliferative disorders, such as cancer, viral infections and/or inflammatory disorders utilizing the compounds of the invention.
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公开(公告)号:US20210221806A1
公开(公告)日:2021-07-22
申请号:US16754175
申请日:2018-10-08
Applicant: BRISTOL-MYERS SQUIBB COMPANY
Inventor: Steven P. SEITZ , Emily Charlotte CHERNEY , Xiau ZHU
IPC: C07D471/04 , C07D307/94 , C07D405/06 , C07K16/28
Abstract: The present invention provides compounds of formula (I): wherein all of the variables are as defined herein. These compounds are inhibitors of indoleamine 2,3-dioxygenase (IDO), which may be used as medicaments for the treatment of proliferative disorders, such as cancer, viral infections and/or autoimmune diseases.
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公开(公告)号:US20190144417A1
公开(公告)日:2019-05-16
申请号:US16098245
申请日:2017-05-04
Applicant: BRISTOL-MYERS SQUIBB COMPANY
Inventor: David K. WILLIAMS , Weifanq SHAN , Liping ZHANG , Emily Charlotte CHERNEY , James Aaron BALOG
IPC: C07D401/04 , A61P35/00 , C07D215/18 , A61K31/4709 , A61K31/47 , A61K31/496 , C07D401/06 , A61K31/444
Abstract: There are disclosed compounds that modulate or inhibit the enzymatic activity of indoleamine 2,3-dioxygenase (IDO), pharmaceutical compositions containing said compounds and methods of treating proliferative disorders, such as cancer, viral infections and/or inflammatory disorders utilizing the compounds of the invention.
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公开(公告)号:US20210290613A1
公开(公告)日:2021-09-23
申请号:US16328449
申请日:2017-08-25
Applicant: BRISTOL-MYERS SQUIBB COMPANY
Inventor: Emily Charlotte CHERNEY , Weifang SHAN , Liping ZHANG , Susheel Jethanand NARA , Audris HUANG , James Aaron BALOG
IPC: A61K31/4709 , C07D401/08 , C07D491/056 , C07D471/04 , C07D417/12 , C07D401/12 , C07D413/12 , C07D487/04 , A61K31/517 , A61K31/5025 , A61K31/4375 , A61K39/395
Abstract: There are disclosed compounds that modulate or inhibit the enzymatic activity of indoleamine 2,3-dioxygenase (IDO), pharmaceutical compositions containing said compounds and methods of treating proliferative disorders, such as cancer, viral infections and/or inflammatory disorders utilizing the compounds of the invention.
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公开(公告)号:US20190119216A1
公开(公告)日:2019-04-25
申请号:US16098260
申请日:2017-05-04
Applicant: BRISTOL-MYERS SQUIBB COMPANY
Inventor: Emily Charlotte CHERNEY , Liping ZHANG , David K. WILLIAMS , James Aaron BALOG
IPC: C07D215/18 , C07D401/04 , C07D215/233 , A61K31/4709 , A61K31/47 , A61K45/06 , A61P35/00
Abstract: There are disclosed compounds that modulate or inhibit the enzymatic activity of indoleamine 2,3-dioxygenase (IDO), pharmaceutical compositions containing said compounds and methods of treating proliferative disorders, such as cancer, viral infections and/or inflammatory disorders utilizing the compounds of the invention.
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公开(公告)号:US20250129061A1
公开(公告)日:2025-04-24
申请号:US18968101
申请日:2024-12-04
Applicant: Bristol-Myers Squibb Company
Inventor: Lan-Ying QIN , Zheming RUAN , Ashok Vinayak PURANDARE , Emily Charlotte CHERNEY , James Aaron BALOG , Arvind MATHUR , Samuel J. BONACORSI
IPC: C07D413/14 , A61K31/4545 , A61K45/06 , C07B59/00
Abstract: Disclosed are compounds of Formula (I): or stereoisomers, tautomers, or salts thereof, wherein each R is independently H or D. Also disclosed are methods of using such compounds to decrease the levels of IKZF1-4 proteins, and pharmaceutical compositions comprising the compound. The compounds are useful in the treatment of viral infections and proliferative disorders, such as cancer.
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公开(公告)号:US20210206723A1
公开(公告)日:2021-07-08
申请号:US16754171
申请日:2018-10-08
Applicant: BRISTOL-MYERS SQUIBB COMPANY
Inventor: James Aaron BALOG , Emily Charlotte CHERNEY , Weifang SHAN , David K. WILLIAMS , Liping ZHANG
IPC: C07D215/46 , C07D215/14 , C07D401/12 , C07D401/04 , C07D401/06 , C07K16/28
Abstract: The present invention provides compounds of formula (I), formula (II) or formula (III), wherein all of the variables are as defined herein. These compounds are inhibitors of indoleamine 2,3-dioxygenase (IDO), which may be used as medicaments for the treatment of proliferative disorders, such as cancer, viral infections and/or autoimmune diseases.
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公开(公告)号:US20200095231A1
公开(公告)日:2020-03-26
申请号:US16612076
申请日:2018-05-10
Applicant: BRISTOL-MYERS SQUIBB COMPANY
Inventor: James Aaron BALOG , Emily Charlotte CHERNEY , Liping ZHANG , Audris HUANG , Weifang SHAN , David K. WILLIAMS , Xiao ZHU , Weiwei GUO
IPC: C07D403/12 , C07D213/85 , C07D401/12 , C07D471/04
Abstract: There are disclosed compounds that modulate or inhibit the enzymatic activity of indoleamine 2,3-dioxygenase (IDO), pharmaceutical compositions containing said compounds and methods of treating proliferative disorders, such as cancer, viral infections and/or inflammatory disorders utilizing the compounds of the invention.
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