公开(公告)号：US20190135758A1

公开(公告)日：2019-05-09

申请号：US16098288

申请日：2017-05-04

Applicant: BRISTOL-MYERS SQUIBB COMPANY

Inventor： Emily Charlotte CHERNEY ,  Weifang SHAN ,  Liping ZHANG ,  David K. WILLIAMS ,  Weiwei GUO ,  Audris HUANG ,  James Aaron BALOG

IPC: C07D215/18 ,  C07D401/04 ,  A61K31/4709 ,  A61P35/00 ,  A61K47/42

Abstract: There are disclosed compounds that modulate or inhibit the enzymatic activity of indoleamine 2,3-dioxygenase (IDO), pharmaceutical compositions containing said compounds and methods of treating proliferative disorders, such as cancer, viral infections and/or inflammatory disorders utilizing the compounds of the invention.

公开(公告)号：US20210070698A1

公开(公告)日：2021-03-11

申请号：US16959487

申请日：2019-01-03

Applicant: BRISTOL-MYERS SQUIBB COMPANY

Inventor： James Aaron BALOG ,  Steven P. SEITZ ,  David K. WILLIAMS ,  Murugaiah ANDAPPAN MURUGAIAH SUBBAIAH

IPC: C07C275/42

Abstract: The present invention provides a compound of formula (II): an inhibitor of indoleamine 2,3-dioxygenase (IDO), which may be used as medicaments for the treatment of proliferative disorders, such as cancer, viral infections and/or autoimmune diseases. Its prodrugs are disclosed.

公开(公告)号：US20190144417A1

公开(公告)日：2019-05-16

申请号：US16098245

申请日：2017-05-04

Applicant: BRISTOL-MYERS SQUIBB COMPANY

Inventor： David K. WILLIAMS ,  Weifanq SHAN ,  Liping ZHANG ,  Emily Charlotte CHERNEY ,  James Aaron BALOG

IPC: C07D401/04 ,  A61P35/00 ,  C07D215/18 ,  A61K31/4709 ,  A61K31/47 ,  A61K31/496 ,  C07D401/06 ,  A61K31/444

Abstract: There are disclosed compounds that modulate or inhibit the enzymatic activity of indoleamine 2,3-dioxygenase (IDO), pharmaceutical compositions containing said compounds and methods of treating proliferative disorders, such as cancer, viral infections and/or inflammatory disorders utilizing the compounds of the invention.

公开(公告)号：US20250129061A1

公开(公告)日：2025-04-24

申请号：US18968101

申请日：2024-12-04

Applicant: Bristol-Myers Squibb Company

Inventor： Lan-Ying QIN ,  Zheming RUAN ,  Ashok Vinayak PURANDARE ,  Emily Charlotte CHERNEY ,  James Aaron BALOG ,  Arvind MATHUR ,  Samuel J. BONACORSI

IPC: C07D413/14 ,  A61K31/4545 ,  A61K45/06 ,  C07B59/00

Abstract: Disclosed are compounds of Formula (I): or stereoisomers, tautomers, or salts thereof, wherein each R is independently H or D. Also disclosed are methods of using such compounds to decrease the levels of IKZF1-4 proteins, and pharmaceutical compositions comprising the compound. The compounds are useful in the treatment of viral infections and proliferative disorders, such as cancer.

公开(公告)号：US20210206723A1

公开(公告)日：2021-07-08

申请号：US16754171

申请日：2018-10-08

Applicant: BRISTOL-MYERS SQUIBB COMPANY

Inventor： James Aaron BALOG ,  Emily Charlotte CHERNEY ,  Weifang SHAN ,  David K. WILLIAMS ,  Liping ZHANG

IPC: C07D215/46 ,  C07D215/14 ,  C07D401/12 ,  C07D401/04 ,  C07D401/06 ,  C07K16/28

Abstract: The present invention provides compounds of formula (I), formula (II) or formula (III), wherein all of the variables are as defined herein. These compounds are inhibitors of indoleamine 2,3-dioxygenase (IDO), which may be used as medicaments for the treatment of proliferative disorders, such as cancer, viral infections and/or autoimmune diseases.

公开(公告)号：US20200095231A1

公开(公告)日：2020-03-26

申请号：US16612076

申请日：2018-05-10

Applicant: BRISTOL-MYERS SQUIBB COMPANY

Inventor： James Aaron BALOG ,  Emily Charlotte CHERNEY ,  Liping ZHANG ,  Audris HUANG ,  Weifang SHAN ,  David K. WILLIAMS ,  Xiao ZHU ,  Weiwei GUO

IPC: C07D403/12 ,  C07D213/85 ,  C07D401/12 ,  C07D471/04

Abstract: There are disclosed compounds that modulate or inhibit the enzymatic activity of indoleamine 2,3-dioxygenase (IDO), pharmaceutical compositions containing said compounds and methods of treating proliferative disorders, such as cancer, viral infections and/or inflammatory disorders utilizing the compounds of the invention.

公开(公告)号：US20210283123A1

公开(公告)日：2021-09-16

申请号：US16328473

申请日：2017-08-25

Applicant: BRISTOL-MYERS SQUIBB COMPANY

Inventor： Liping ZHANG ,  Emily Charlotte CHERNEY ,  James Aaron BALOG ,  Xiao ZHU

IPC: A61K31/4709 ,  A61K39/395 ,  C07D413/08 ,  C07D401/08 ,  C07D417/08 ,  C07D417/14 ,  C07D413/14 ,  C07D413/12 ,  C07D417/12 ,  C07D401/12

Abstract: There are disclosed compounds that modulate or inhibit the enzymatic activity of indoleamine 2,3-dioxygenase (IDO), pharmaceutical compositions containing said compound and methods of treating proliferative disorders, such as cancer, viral infections and/or inflammatory disorders utilizing the compounds of the invention.

公开(公告)号：US20190144416A1

公开(公告)日：2019-05-16

申请号：US16098239

申请日：2017-05-04

Applicant: BRISTOL-MYERS SQUIBB COMPANY

Inventor： David K. WILLIAMS ,  Weifang SHAN ,  James Aaron BALOG

IPC: C07D401/04 ,  C07C275/30 ,  C07D215/18 ,  A61P35/00 ,  A61K31/4709 ,  C07C275/36 ,  C07C275/34 ,  C07C275/28 ,  C07C275/42 ,  C07C275/26 ,  A61K31/47 ,  A61K31/277 ,  A61K31/17

Abstract: There are disclosed compounds that modulate or inhibit the enzymatic activity of indoleamine 2,3-dioxygenase (IDO), pharmaceutical compositions containing said compounds and methods of treating proliferative disorders, such as cancer, viral infections and/or inflammatory disorders utilizing the compounds of the invention.

公开(公告)号：US20190119215A1

公开(公告)日：2019-04-25

申请号：US16098257

申请日：2017-05-04

Applicant: BRISTOL-MYERS SQUIBB COMPANY

Inventor： Weifang SHAN ,  James Aaron BALOG

IPC: C07D215/12 ,  A61K31/47 ,  A61K45/06 ,  A61P35/00

Abstract: There are disclosed compounds that modulate or inhibit the enzymatic activity of indoleamine 2,3-dioxygenase (IDO), pharmaceutical compositions containing said compounds and methods of treating proliferative disorders, such as cancer, viral infections and/or inflammatory disorders utilizing the compounds of the invention.

公开(公告)号：US20210355113A1

公开(公告)日：2021-11-18

申请号：US17261968

申请日：2019-07-20

Applicant: BRISTOL-MYERS SQUIBB COMPANY

Inventor： James Aaron BALOG ,  Steven P. SEITZ ,  Jay A. MARKWALDER ,  David K. WILLIAMS ,  Weifang SHAN ,  Susheel Jethanand NARA ,  Saumya ROY ,  Srinivas CHERUKU ,  Nagalakshmi PULICHARLA

IPC: C07D405/14 ,  C07D405/10 ,  C07D413/14 ,  C07D313/08 ,  C07D413/10 ,  C07D417/14 ,  C07D307/79 ,  C07K16/28

Abstract: The present invention provides compounds of formula (I) wherein all of the variables are as defined herein. These compounds are inhibitors of indoleamine 2,3-dioxygenase (IDO), which may be used as medicaments for the treatment of proliferative disorders, such as cancer, viral infections and/or autoimmune diseases.