公开(公告)号：US20200095231A1

公开(公告)日：2020-03-26

申请号：US16612076

申请日：2018-05-10

Applicant: BRISTOL-MYERS SQUIBB COMPANY

Inventor： James Aaron BALOG ,  Emily Charlotte CHERNEY ,  Liping ZHANG ,  Audris HUANG ,  Weifang SHAN ,  David K. WILLIAMS ,  Xiao ZHU ,  Weiwei GUO

IPC: C07D403/12 ,  C07D213/85 ,  C07D401/12 ,  C07D471/04

Abstract: There are disclosed compounds that modulate or inhibit the enzymatic activity of indoleamine 2,3-dioxygenase (IDO), pharmaceutical compositions containing said compounds and methods of treating proliferative disorders, such as cancer, viral infections and/or inflammatory disorders utilizing the compounds of the invention.

公开(公告)号：US20190135758A1

公开(公告)日：2019-05-09

申请号：US16098288

申请日：2017-05-04

Applicant: BRISTOL-MYERS SQUIBB COMPANY

Inventor： Emily Charlotte CHERNEY ,  Weifang SHAN ,  Liping ZHANG ,  David K. WILLIAMS ,  Weiwei GUO ,  Audris HUANG ,  James Aaron BALOG

IPC: C07D215/18 ,  C07D401/04 ,  A61K31/4709 ,  A61P35/00 ,  A61K47/42

Abstract: There are disclosed compounds that modulate or inhibit the enzymatic activity of indoleamine 2,3-dioxygenase (IDO), pharmaceutical compositions containing said compounds and methods of treating proliferative disorders, such as cancer, viral infections and/or inflammatory disorders utilizing the compounds of the invention.