公开(公告)号：US10781176B2

公开(公告)日：2020-09-22

申请号：US15569528

申请日：2016-04-26

Applicant: BAYER CROPSCIENCE AKTIENGESELLSCHAFT

Inventor： Wahed Ahmed Moradi ,  Günter Schlegel ,  Albert Schnatterer ,  Frank Volz

IPC: C07D213/61 ,  C07D213/40

Abstract: The present invention relates to novel processes for the preparation of substituted pyridyl-methylbenzamide derivatives of formula (I), in particular 2,6-dichloro-N-{[3-chloro-5-(trifluoromethyl)-2-pyridyl]methyl}benzamide (Fluopicolide), and for the catalytic hydrogenation of substituted cyanopyridine derivatives, in particular 3-chloro-2-cyano-5-trifluoromethylpyridine [=Py-CN] to the corresponding substituted 2-methylaminopyridine derivatives, in particular 2-aminomethyl-3-chloro-5-trifluoromethylpyridine [=Py-methylamine] or salts thereof in the presence of metal catalysts such as in particular palladium catalysts, catalytic modifiers and acids.

公开(公告)号：US10766859B2

公开(公告)日：2020-09-08

申请号：US16471144

申请日：2017-12-18

Applicant: BAYER CROPSCIENCE AKTIENGESELLSCHAFT

Inventor： Wahed Ahmed Moradi ,  Thomas Himmler ,  Thomas Norbert Mueller

IPC: C07D213/26 ,  C07D213/40 ,  C07D213/60 ,  C07D213/61

Abstract: The present invention relates to a novel catalytic hydrogenation of substituted 2-methyl cyanopyridyl derivatives, in particular 3-chloro-5-(trifluoromethyl)pyridin-2-yl]acetonitrile [=Py-CN] to substituted 2-ethylaminopyridine derivatives, in particular 2-[3-chloro-5-(trifluoromethyl)pyridin-2-yl]ethanamine [=Py-ethanamine] or salts thereof in the presence of Raney catalysts, in particular Raney nickel or cobalt.

公开(公告)号：US10647674B2

公开(公告)日：2020-05-12

申请号：US15569528

申请日：2016-04-26

Applicant: BAYER CROPSCIENCE AKTIENGESELLSCHAFT

Inventor： Wahed Ahmed Moradi ,  Günter Schlegel ,  Albert Schnatterer ,  Frank Volz

IPC: C07D213/61 ,  C07D213/40

Abstract: The present invention relates to novel processes for the preparation of substituted pyridyl-methylbenzamide derivatives of formula (I), in particular 2,6-dichloro-N-{[3-chloro-5-(trifluoromethyl)-2-pyridyl]methyl}benzamide (Fluopicolide), and for the catalytic hydrogenation of substituted cyanopyridine derivatives, in particular 3-chloro-2-cyano-5-trifluoromethylpyridine [=Py-CN] to the corresponding substituted 2-methylaminopyridine derivatives, in particular 2-aminomethyl-3-chloro-5-trifluoromethylpyridine [=Py-methylamine] or salts thereof in the presence of metal catalysts such as in particular palladium catalysts, catalytic modifiers and acids.

公开(公告)号：US11161840B2

公开(公告)日：2021-11-02

申请号：US16306180

申请日：2017-05-26

Applicant: Bayer CropScience Aktiengesellschaft

Inventor： Stefan Antons ,  Martin Littmann ,  Joerg Schulz ,  Wahed Ahmed Moradi ,  Thomas Geller

IPC: C07D417/06

Abstract: The present invention relates to a process for producing compounds of formula (I) in which R1, A, X and Z are as defined in the description by reaction of compounds of formula (II) or salts thereof with 2-chloro-5-chloromethylpyridine in a nonpolar aliphatic or aromatic solvent, preferably in the presence of a phase transfer catalyst.

公开(公告)号：US10807955B2

公开(公告)日：2020-10-20

申请号：US16471132

申请日：2017-12-12

Applicant: Bayer CropScience Aktiengesellschaft

Inventor： Wahed Ahmed Moradi ,  Albert Schnatterer ,  Dietmar Bielefeldt ,  Rolf Gertzmann ,  Dirk Havekost

IPC: C07D213/61

Abstract: Described is a process for the preparation of a N-[2-(2-pyridinyl)ethyl]carboxamide derivative of general formula (I) or a salt thereof.

公开(公告)号：US09988353B2

公开(公告)日：2018-06-05

申请号：US15033987

申请日：2014-11-11

Applicant: BAYER CROPSCIENCE AKTIENGESELLSCHAFT

Inventor： Wahed Ahmed Moradi ,  Thomas Himmler ,  Thomas Norbert Mueller ,  Albert Schnatterer ,  Guenter Schlegel

IPC: C07D213/56 ,  C07D213/89 ,  C07D213/38 ,  C07D213/57

CPC classification number: C07D213/56 ,  C07D213/38 ,  C07D213/57 ,  C07D213/89

Abstract: The present invention relates to a novel catalytic hydrogenation of substituted 2-methyl cyanopyridyl derivatives, in particular 3-chloro-5-(trifluoromethyl)pyridin-2-yl]acetonitrile [=Py-CN] to substituted 2-ethylaminopyridine derivatives, in particular 2-[3-chloro-5-(trifluoromethyl)pyridin-2-yl]ethanamine [=Py-ethanamine] or salts thereof in the presence of metal catalysts, in particular palladium catalysts.

公开(公告)号：US09890120B2

公开(公告)日：2018-02-13

申请号：US15126593

申请日：2015-03-18

Applicant: BAYER CROPSCIENCE AKTIENGESELLSCHAFT

Inventor： Wahed Ahmed Moradi ,  Guenter Schlegel ,  Albert Schnatterer

IPC: C07D213/61 ,  C07D213/38

CPC classification number: C07D213/38 ,  C07D213/61

Abstract: A process for preparing N-[(6-chloropyridin-3-yl)methyl]-2,2-difluoroethan-1-amine of formula (III) wherein 2,2-difluoroethylamine of formula (I) is reacted with a halide of formula (II) in the presence of a hydroxide of an alkali metal or alkaline earth metal.

公开(公告)号：US10414730B2

公开(公告)日：2019-09-17

申请号：US15969633

申请日：2018-05-02

Applicant: BAYER CROPSCIENCE AKTIENGESELLSCHAFT

Inventor： Wahed Ahmed Moradi ,  Thomas Himmler ,  Thomas Norbert Müller ,  Albert Schnatterer ,  Günter Schlegel

IPC: C07D213/56 ,  C07D213/89 ,  C07D213/38 ,  C07D213/57

Abstract: The present invention relates to a novel catalytic hydrogenation of substituted 2-methyl cyanopyridyl derivatives, in particular 3-chloro-5-(trifluoromethyl)pyridin-2-yl]acetonitrile [=Py-CN] to substituted 2-ethylaminopyridine derivatives, in particular 2-[3-chloro-5-(trifluoromethyl)pyridin-2-yl]ethanamine [=Py-ethanamine] or salts thereof in the presence of metal catalysts, in particular palladium catalysts.

公开(公告)号：US20180244621A1

公开(公告)日：2018-08-30

申请号：US15969633

申请日：2018-05-02

Applicant: Bayer Cropscience Aktiengesellschaft

Inventor： Wahed Ahmed Moradi ,  Thomas Himmler ,  Thomas Norbert Müller ,  Albert Schnatterer ,  Günter Schlegel

IPC: C07D213/56 ,  C07D213/89 ,  C07D213/38 ,  C07D213/57

CPC classification number: C07D213/56 ,  C07D213/38 ,  C07D213/57 ,  C07D213/89

Abstract: The present invention relates to a novel catalytic hydrogenation of substituted 2-methyl cyanopyridyl derivatives, in particular 3-chloro-5-(trifluoromethyl)pyridin-2-yl]acetonitrile [=Py-CN] to substituted 2-ethylaminopyridine derivatives, in particular 2-[3-chloro-5-(trifluoromethyl)pyridin-2-yl]ethanamine [=Py-ethanamine] or salts thereof in the presence of metal catalysts, in particular palladium catalysts.