公开(公告)号：US10807955B2

公开(公告)日：2020-10-20

申请号：US16471132

申请日：2017-12-12

Applicant: Bayer CropScience Aktiengesellschaft

Inventor： Wahed Ahmed Moradi ,  Albert Schnatterer ,  Dietmar Bielefeldt ,  Rolf Gertzmann ,  Dirk Havekost

IPC: C07D213/61

Abstract: Described is a process for the preparation of a N-[2-(2-pyridinyl)ethyl]carboxamide derivative of general formula (I) or a salt thereof.

公开(公告)号：US09988353B2

公开(公告)日：2018-06-05

申请号：US15033987

申请日：2014-11-11

Applicant: BAYER CROPSCIENCE AKTIENGESELLSCHAFT

Inventor： Wahed Ahmed Moradi ,  Thomas Himmler ,  Thomas Norbert Mueller ,  Albert Schnatterer ,  Guenter Schlegel

IPC: C07D213/56 ,  C07D213/89 ,  C07D213/38 ,  C07D213/57

CPC classification number: C07D213/56 ,  C07D213/38 ,  C07D213/57 ,  C07D213/89

Abstract: The present invention relates to a novel catalytic hydrogenation of substituted 2-methyl cyanopyridyl derivatives, in particular 3-chloro-5-(trifluoromethyl)pyridin-2-yl]acetonitrile [=Py-CN] to substituted 2-ethylaminopyridine derivatives, in particular 2-[3-chloro-5-(trifluoromethyl)pyridin-2-yl]ethanamine [=Py-ethanamine] or salts thereof in the presence of metal catalysts, in particular palladium catalysts.

公开(公告)号：US09890120B2

公开(公告)日：2018-02-13

申请号：US15126593

申请日：2015-03-18

Applicant: BAYER CROPSCIENCE AKTIENGESELLSCHAFT

Inventor： Wahed Ahmed Moradi ,  Guenter Schlegel ,  Albert Schnatterer

IPC: C07D213/61 ,  C07D213/38

CPC classification number: C07D213/38 ,  C07D213/61

Abstract: A process for preparing N-[(6-chloropyridin-3-yl)methyl]-2,2-difluoroethan-1-amine of formula (III) wherein 2,2-difluoroethylamine of formula (I) is reacted with a halide of formula (II) in the presence of a hydroxide of an alkali metal or alkaline earth metal.

公开(公告)号：US11339137B2

公开(公告)日：2022-05-24

申请号：US17045069

申请日：2019-04-02

Applicant: Bayer Aktiengesellschaft ,  Bayer CropScience Aktiengesellschaft

Inventor： Taraneh Farida ,  Martin Littmann ,  Ali Sanli ,  Kyra Larissa Pabst ,  Juergen Ludwig ,  Albert Schnatterer

IPC: C07D275/03

Abstract: The present invention relates to a novel, one-stage method for preparing and isolating 3,4-dichloro-N-(2-cyanophenyl)-5-isothiazolecarboxamide (isotianil), which has microbicidal and plant-fortifying (host defence inducer) properties. In the method according to the invention, the amount of waste from the production process (e.g. solvent) is significantly reduced. The product is provided in high yield and purity (minimal amount of by-products and impurities). Compared to existing preparation methods, the method according to the invention has the advantage of low corrosiveness and high yield and high selectivity.

公开(公告)号：US10899722B2

公开(公告)日：2021-01-26

申请号：US16488289

申请日：2018-02-22

Applicant: Bayer CropScience Aktiengesellschaft

Inventor： Albert Schnatterer ,  Jan Vermehren ,  Edith Beckmann ,  Claus-Christian Haeselhoff ,  Tim Hammerer ,  Stefan Grasser

IPC: C07D257/04 ,  C07C253/20 ,  B01J29/40 ,  B01J29/70 ,  C07C253/34

Abstract: The present invention relates to a process for the preparation of fluoroalkylnitriles and the corresponding fluoroalkyltetrazoles starting from fluorinated carboxamides.

公开(公告)号：US10781176B2

公开(公告)日：2020-09-22

申请号：US15569528

申请日：2016-04-26

Applicant: BAYER CROPSCIENCE AKTIENGESELLSCHAFT

Inventor： Wahed Ahmed Moradi ,  Günter Schlegel ,  Albert Schnatterer ,  Frank Volz

IPC: C07D213/61 ,  C07D213/40

Abstract: The present invention relates to novel processes for the preparation of substituted pyridyl-methylbenzamide derivatives of formula (I), in particular 2,6-dichloro-N-{[3-chloro-5-(trifluoromethyl)-2-pyridyl]methyl}benzamide (Fluopicolide), and for the catalytic hydrogenation of substituted cyanopyridine derivatives, in particular 3-chloro-2-cyano-5-trifluoromethylpyridine [=Py-CN] to the corresponding substituted 2-methylaminopyridine derivatives, in particular 2-aminomethyl-3-chloro-5-trifluoromethylpyridine [=Py-methylamine] or salts thereof in the presence of metal catalysts such as in particular palladium catalysts, catalytic modifiers and acids.

公开(公告)号：US10577320B2

公开(公告)日：2020-03-03

申请号：US16098138

申请日：2017-04-26

Applicant: Bayer CropScience Aktiengesellschaft

Inventor： Taraneh Farida ,  Martin Littmann ,  Rafael Warsitz ,  Michael Esser ,  Albert Schnatterer

IPC: C07D201/08 ,  C07D207/38 ,  C07D201/02

Abstract: The present invention relates to novel methods for preparing cis-alkoxy-substituted spirocyclic 1-H-pyrrolidine-2,4-dione derivatives and also to novel intermediates and starting compounds, which are passed through or used in the method according to the invention.

公开(公告)号：US10647674B2

公开(公告)日：2020-05-12

申请号：US15569528

申请日：2016-04-26

Applicant: BAYER CROPSCIENCE AKTIENGESELLSCHAFT

Inventor： Wahed Ahmed Moradi ,  Günter Schlegel ,  Albert Schnatterer ,  Frank Volz

IPC: C07D213/61 ,  C07D213/40

Abstract: The present invention relates to novel processes for the preparation of substituted pyridyl-methylbenzamide derivatives of formula (I), in particular 2,6-dichloro-N-{[3-chloro-5-(trifluoromethyl)-2-pyridyl]methyl}benzamide (Fluopicolide), and for the catalytic hydrogenation of substituted cyanopyridine derivatives, in particular 3-chloro-2-cyano-5-trifluoromethylpyridine [=Py-CN] to the corresponding substituted 2-methylaminopyridine derivatives, in particular 2-aminomethyl-3-chloro-5-trifluoromethylpyridine [=Py-methylamine] or salts thereof in the presence of metal catalysts such as in particular palladium catalysts, catalytic modifiers and acids.

公开(公告)号：US10414730B2

公开(公告)日：2019-09-17

申请号：US15969633

申请日：2018-05-02

Applicant: BAYER CROPSCIENCE AKTIENGESELLSCHAFT

Inventor： Wahed Ahmed Moradi ,  Thomas Himmler ,  Thomas Norbert Müller ,  Albert Schnatterer ,  Günter Schlegel

IPC: C07D213/56 ,  C07D213/89 ,  C07D213/38 ,  C07D213/57

Abstract: The present invention relates to a novel catalytic hydrogenation of substituted 2-methyl cyanopyridyl derivatives, in particular 3-chloro-5-(trifluoromethyl)pyridin-2-yl]acetonitrile [=Py-CN] to substituted 2-ethylaminopyridine derivatives, in particular 2-[3-chloro-5-(trifluoromethyl)pyridin-2-yl]ethanamine [=Py-ethanamine] or salts thereof in the presence of metal catalysts, in particular palladium catalysts.

公开(公告)号：US20180244621A1

公开(公告)日：2018-08-30

申请号：US15969633

申请日：2018-05-02

Applicant: Bayer Cropscience Aktiengesellschaft

Inventor： Wahed Ahmed Moradi ,  Thomas Himmler ,  Thomas Norbert Müller ,  Albert Schnatterer ,  Günter Schlegel

IPC: C07D213/56 ,  C07D213/89 ,  C07D213/38 ,  C07D213/57

CPC classification number: C07D213/56 ,  C07D213/38 ,  C07D213/57 ,  C07D213/89

Abstract: The present invention relates to a novel catalytic hydrogenation of substituted 2-methyl cyanopyridyl derivatives, in particular 3-chloro-5-(trifluoromethyl)pyridin-2-yl]acetonitrile [=Py-CN] to substituted 2-ethylaminopyridine derivatives, in particular 2-[3-chloro-5-(trifluoromethyl)pyridin-2-yl]ethanamine [=Py-ethanamine] or salts thereof in the presence of metal catalysts, in particular palladium catalysts.