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1.发明申请SOLUBLE EPOXIDE HYDROLASE INHIBITORS FOR THE TREATMENT OF ENDOTHELIAL DYSFUNCTION 审中-公开用于治疗内皮功能障碍的可溶性环氧化物水解酶抑制剂公开(公告)号：US20090247521A1
公开(公告)日：2009-10-01
申请号：US12343358
申请日：2008-12-23
申请人： Bhasker R. Aavula , Sampath-Kumar Anandan , Richard D. Gless, JR. , Dinesh Patel , Gabor Rubanyi , Yi-Xin Wang , Heather K. Webb Hsu
发明人： Bhasker R. Aavula , Sampath-Kumar Anandan , Richard D. Gless, JR. , Dinesh Patel , Gabor Rubanyi , Yi-Xin Wang , Heather K. Webb Hsu
IPC分类号： A61K31/445 , A61K31/17 , A61K31/215 , A61K31/19 , A61K31/5377 , A61K31/4545 , A61K31/454 , A61K31/4709 , A61P9/00
CPC分类号： A61K31/17 , A61K31/00 , A61K31/192 , A61K31/215 , A61K31/4412 , A61K31/445 , A61K31/454 , A61K31/4545 , A61K31/5375
摘要： The present invention generally relates to methods useful for a therapy using a class of urea or amide compounds and related compositions, wherein the compound is a soluble epoxide hydrolase inhibitor, for treating and ameliorating the symptoms of diseases related to endothelial dysfunction.
摘要翻译： 本发明一般涉及可用于使用一类尿素或酰胺化合物和相关组合物的治疗的方法，其中所述化合物是可溶性环氧化物水解酶抑制剂，用于治疗和改善与内皮功能障碍有关的疾病的症状。
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公开(公告)号：US20090270382A1
公开(公告)日：2009-10-29
申请号：US12426136
申请日：2009-04-17
IPC分类号： A61K31/5365 , C07D213/02 , A61K31/4545 , C12N9/99 , C07D413/14 , A61K31/5377 , C07D498/02 , A61P9/12 , A61P29/00 , A61P11/00 , A61P3/10
CPC分类号： C07D401/06 , C07D405/14 , C07D489/04
摘要： Disclosed are amide, thioamide, urea and thiourea compounds and compositions that inhibit soluble epoxide hydrolase (sEH), methods for preparing the compounds and compositions, and methods for treating patients with such compounds and compositions. The compounds, compositions, and methods are useful for treating a variety of sEH mediated diseases, including hypertensive, cardiovascular, inflammatory, and diabetic-related diseases.
摘要翻译： 公开了酰胺，硫代酰胺，脲和硫脲化合物和抑制可溶性环氧化物水解酶（sEH）的组合物，制备化合物和组合物的方法以及用这些化合物和组合物治疗患者的方法。 化合物，组合物和方法可用于治疗各种sEH介导的疾病，包括高血压，心血管，炎症和糖尿病相关疾病。
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公开(公告)号：US20090082350A1
公开(公告)日：2009-03-26
申请号：US12207666
申请日：2008-09-10
IPC分类号： A61K31/5377 , C07D231/38 , C07D413/06 , A61K31/44 , A61K31/433 , C07D277/38 , A61K31/42 , C12N9/99 , A61K31/426 , C07D261/14 , C07D285/135 , C07D211/72 , A61K31/415
CPC分类号： C07D213/75 , C07D231/40 , C07D261/14 , C07D277/46 , C07D307/66 , C07D333/36
摘要： Disclosed are heterocylic or heteroaryl compounds and compositions that inhibit soluble epoxide hydrolase (sEH), methods for preparing the compounds and compositions, and methods for treating patients with such compounds and compositions. The compounds, compositions, and methods are useful for treating a variety of sEH mediated diseases, including hypertensive, cardiovascular, inflammatory, pulmonary, and diabetic-related diseases.
摘要翻译： 公开了抑制可溶性环氧化物水解酶（sEH）的杂环或杂芳基化合物和组合物，用于制备化合物和组合物的方法，以及用这些化合物和组合物治疗患者的方法。 化合物，组合物和方法可用于治疗各种sEH介导的疾病，包括高血压，心血管，炎症，肺和糖尿病相关疾病。
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公开(公告)号：US20090082423A1
公开(公告)日：2009-03-26
申请号：US12207668
申请日：2008-09-10
IPC分类号： A61K31/351 , C07D315/00 , A61K31/382 , C07D335/02 , C07C275/30 , A61K31/17 , A61P9/00 , A61P9/12
CPC分类号： C07D309/04 , C07C275/26 , C07C275/28 , C07C2603/74 , C07D309/14 , C07D335/02
摘要： Disclosed are amide, thioamide, urea and thiourea compounds and compositions that inhibit soluble epoxide hydrolase (sEH), methods for preparing the compounds and compositions, and methods for treating patients with such compounds and compositions. The compounds, compositions, and methods are useful for treating a variety of sEH mediated diseases, including hypertensive, cardiovascular, inflammatory, and diabetic-related diseases.
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公开(公告)号：US09556216B2
公开(公告)日：2017-01-31
申请号：US14421249
申请日：2013-08-27
申请人： Sampath-Kumar Anandan , Virender Singh Aulakh , Martijn Fenaux , Xiaodong Lin , Liang Mao , Oliver Saunders , Zachary Kevin Sweeney , Fumiaki Yokokawa , Weidong Zhong
发明人： Sampath-Kumar Anandan , Virender Singh Aulakh , Martijn Fenaux , Xiaodong Lin , Liang Mao , Oliver Saunders , Zachary Kevin Sweeney , Fumiaki Yokokawa , Weidong Zhong
IPC分类号： C07H19/10 , A61K31/7072 , A61K31/7068 , A61K45/06
CPC分类号： A61K31/7072 , A61K31/7068 , A61K45/06 , A61K47/22 , C07H19/06 , C07H19/067 , C07H19/10
摘要： The present invention provides a compound of formula A: or a pharmaceutically acceptable salt thereof, wherein B, Q, R1, R5, R6, R7, R8 and Z are as defined herein, which is a 2′-branched nucleoside useful for the treatment or prevention of viral infections, particularly dengue fever, yellow fever, West Nile virus, Japanese encephalitis virus, tick-borne encephalitis virus, Kunjin virus, Murray Valley encephalitis, St Louis encephalitis, Omsk hemorrhagic fever virus, bovine viral diarrhea virus, Zika virus and Hepatitis C virus.
摘要翻译： 本发明提供式A化合物或其药学上可接受的盐，其中B，Q，R 1，R 5，R 6，R 7，R 8和Z如本文所定义，其为可用于治疗的2'-支链核苷 或预防病毒感染，特别是登革热，黄热病，西尼罗病毒，日本脑炎病毒，蜱传脑炎病毒，昆金病毒，墨累谷脑炎，圣路易脑炎，鄂木斯克出血热病毒，牛病毒性腹泻病毒，Zika病毒 和丙型肝炎病毒。
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公开(公告)号：US07199106B2
公开(公告)日：2007-04-03
申请号：US10871618
申请日：2004-06-17
CPC分类号： C07D405/12
摘要： Novel lincomycin derivatives are disclosed. These lincomycin derivatives exhibit antibacterial activity. The compounds of the subject invention may exhibit potent activities against bacteria, including gram positive organisms, and may be useful antimicrobial agents. Methods of synthesis and of use of the compounds are also disclosed.
摘要翻译： 公开了新的林可霉素衍生物。 这些林可霉素衍生物具有抗菌活性。 本发明的化合物可以表现出对细菌的有效活性，包括革兰氏阳性生物，并且可以是有用的抗微生物剂。 还公开了化合物的合成和使用方法。
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公开(公告)号：US20050043248A1
公开(公告)日：2005-02-24
申请号：US10871618
申请日：2004-06-17
IPC分类号： A61K20060101 , C07D405/12 , C07H20060101 , C07H15/16 , F16J20060101 , F16K20060101 , A61K31/7052
CPC分类号： C07D405/12
摘要： Novel lincomycin derivatives are disclosed. These lincomycin derivatives exhibit antibacterial activity. The compounds of the subject invention may exhibit potent activities against bacteria, including gram positive organisms, and may be useful antimicrobial agents. Methods of synthesis and of use of the compounds are also disclosed.
摘要翻译： 公开了新的林可霉素衍生物。 这些林可霉素衍生物具有抗菌活性。 本发明的化合物可以表现出对细菌的有效活性，包括革兰氏阳性生物，并且可以是有用的抗微生物剂。 还公开了化合物的合成和使用方法。
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