公开(公告)号：US09829434B2

公开(公告)日：2017-11-28

申请号：US15070211

申请日：2016-03-15

Applicant: Bio-Rad Laboratories Inc.

Inventor： Yochanan Uri ,  Boaz Ran ,  Ariel G. Notcovich ,  Shay Nimri

IPC: G01N21/01 ,  G01N21/65 ,  G01N21/25 ,  G01N21/552 ,  G01N33/543 ,  G01N21/03

CPC classification number: G01N21/553 ,  G01N21/253 ,  G01N21/658 ,  G01N33/54373 ,  G01N2021/0328 ,  G01N2201/0407 ,  G01N2201/0484 ,  G01N2201/062

Abstract: A tip for use in an optical detection system to analyze an analyte in a fluid sample drawn into the tip, using light reflected from a detection surface inside the tip that the analyte binds to, comprising a first detection surface and a second detection surface located in a same flow path with no controllable valve separating them, wherein the first and second detection surfaces have different surface chemistries.

公开(公告)号：US08743369B2

公开(公告)日：2014-06-03

申请号：US13966364

申请日：2013-08-14

Applicant: Bio-Rad Laboratories Inc.

Inventor： Boaz Ran ,  Ariel G. Notcovich ,  Ariel Lipson ,  Shay Nimri ,  Stephen G. Lipson ,  Doron Lipson

IPC: G01N21/55

CPC classification number: G01N21/55 ,  G01N21/553 ,  G01N2021/058

Abstract: An SPR sensor comprising a thin conducting layer comprising at least one conductive element formed on a surface of a transparent substrate, a light source that illuminates an interface between the conducting layer and the substrate, a photosensitive surface that generates signals from light reflected from the interface, a flow cell formed with at least one flow channel having a lumen defined by a wall formed from an elastic material and from a region of the conducting layer, and at least one hollow fluid-providing flow control apparatus having a lumen and an orifice communicating with its lumen. Fluid flow is enabled between the flow channel and the lumen of the flow control apparatus by forcing an end of the flow control apparatus through the elastic material so that the orifice communicates with the flow channel lumen.

Abstract translation: 一种SPR传感器，包括薄导电层，该导电层包括形成在透明基板的表面上的至少一个导电元件，照亮导电层和基板之间的界面的光源，从该界面反射的光产生信号的光敏表面 ，形成有至少一个流动通道的流动池，所述流动通道具有由由弹性材料形成的壁和从导电层的区域限定的内腔，以及至少一个中空流体供应流量控制装置，其具有内腔和孔口连通 与其流明。 通过迫使流量控制装置的一端通过弹性材料使得流体通道与流动控制装置的内腔之间能够进行流体流动，使得孔口与流动通道内腔连通。

公开(公告)号：US09354179B2

公开(公告)日：2016-05-31

申请号：US13911115

申请日：2013-06-06

Applicant: Bio-Rad Laboratories Inc.

Inventor： Yochanan Uri ,  Boaz Ran ,  Ariel G. Notcovich ,  Shay Nimri

IPC: G01N21/01 ,  G01N30/60 ,  G01N30/88 ,  G01N21/65 ,  G01N21/552 ,  G01N21/25 ,  G01N21/03

CPC classification number: G01N21/553 ,  G01N21/253 ,  G01N21/658 ,  G01N33/54373 ,  G01N2021/0328 ,  G01N2201/0407 ,  G01N2201/0484 ,  G01N2201/062

Abstract: A tip for use in an optical detection system to analyze an analyte in a fluid sample drawn into the tip, using light reflected from a detection surface inside the tip that the analyte binds to, comprising a first detection surface and a second detection surface located in a same flow path with no controllable valve separating them, wherein the first and second detection surfaces have different surface chemistries.

Abstract translation: 一种用于光学检测系统的尖端，用于使用从分析物结合到所述尖端内部的检测表面反射的光来分析吸入所述尖端的流体样品中的分析物，所述检测表面包括第一检测表面和位于 相同的流动路径，没有可分离它们的可控阀，其中第一和第二检测表面具有不同的表面化学性质。

公开(公告)号：US20130330838A1

公开(公告)日：2013-12-12

申请号：US13966364

申请日：2013-08-14

Applicant: Bio-Rad Laboratories Inc.

Inventor： Boaz RAN ,  Ariel G. Notcovich ,  Ariel Lipson ,  Shay Nimri ,  Stephen G. Lipson ,  Doron Lipson

IPC: G01N21/55

CPC classification number: G01N21/55 ,  G01N21/553 ,  G01N2021/058

Abstract: An SPR sensor comprising a thin conducting layer comprising at least one conductive element formed on a surface of a transparent substrate, a light source that illuminates an interface between the conducting layer and the substrate, a photosensitive surface that generates signals from light reflected from the interface, a flow cell formed with at least one flow channel having a lumen defined by a wall formed from an elastic material and from a region of the conducting layer, and at least one hollow fluid-providing flow control apparatus having a lumen and an orifice communicating with its lumen. Fluid flow is enabled between the flow channel and the lumen of the flow control apparatus by forcing an end of the flow control apparatus through the elastic material so that the orifice communicates with the flow channel lumen.

公开(公告)号：US20130330230A1

公开(公告)日：2013-12-12

申请号：US13911115

申请日：2013-06-06

Applicant: Bio-Rad Laboratories Inc.

Inventor： Yochanan URI ,  Boaz Ran ,  Ariel G. Notcovich ,  Shay Nimri

IPC: G01N21/65

CPC classification number: G01N21/553 ,  G01N21/253 ,  G01N21/658 ,  G01N33/54373 ,  G01N2021/0328 ,  G01N2201/0407 ,  G01N2201/0484 ,  G01N2201/062

Abstract: A tip for use in an optical detection system to analyze an analyte in a fluid sample drawn into the tip, using light reflected from a detection surface inside the tip that the analyte binds to, comprising a first detection surface and a second detection surface located in a same flow path with no controllable valve separating them, wherein the first and second detection surfaces have different surface chemistries.

Abstract translation: 一种用于光学检测系统的尖端，用于使用从分析物结合到所述尖端内部的检测表面反射的光来分析吸入所述尖端的流体样品中的分析物，所述检测表面包括第一检测表面和位于 相同的流动路径，没有可分离它们的可控阀，其中第一和第二检测表面具有不同的表面化学性质。

公开(公告)号：US20130196448A1

公开(公告)日：2013-08-01

申请号：US13751175

申请日：2013-01-28

Applicant: Bio-Rad Laboratories Inc.

Inventor： Boaz RAN ,  Ariel G. Notcovich ,  Ariel Lipson ,  Shay Nimri ,  Stephen G. Lipson ,  Doron Lipson

IPC: G01N21/55

CPC classification number: G01N21/55 ,  G01N21/553 ,  G01N2021/058

Abstract: An SPR sensor comprising a thin conducting layer comprising at least one conductive element formed on a surface of a transparent substrate, a light source that illuminates an interface between the conducting layer and the substrate, a photosensitive surface that generates signals from light reflected from the interface, a flow cell formed with at least one flow channel having a lumen defined by a wall formed from an elastic material and from a region of the conducting layer, and at least one hollow fluid-providing flow control apparatus having a lumen and an orifice communicating with its lumen. Fluid flow is enabled between the flow channel and the lumen of the flow control apparatus by forcing an end of the flow control apparatus through the elastic material so that the orifice communicates with the flow channel lumen.