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公开(公告)号：US20160356712A1
公开(公告)日：2016-12-08
申请号：US15176181
申请日：2016-06-08
Applicant: Bio-Rad Laboratories Inc.
Inventor： Boaz RAN , Itay BARAK
IPC: G01N21/552
CPC classification number: G01N21/553 , G02B3/005 , G02B5/008
Abstract: A system for measuring an evanescent wave phenomenon at total internal reflection, the system comprising: a) a sensing surface comprising a plurality of areas of interest; b) an illumination sub-system comprising a light source, which illuminates each area of interest on the sensing surface over a range of angles of incidence; c) a detector which responds differently to an intensity of light received by it at different locations; and d) projection optics comprising primary optics and a plurality of secondary elements, the primary optics projecting an image of the illuminated sensing surface onto the secondary elements, which project their received light onto the detector in such a way that it is possible to determine, from the response of the detector, how much light is reflected from each area of interest, as a function of angle of incidence over the range of angles for that area.
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公开(公告)号：US20170366768A1
公开(公告)日：2017-12-21
申请号：US15675494
申请日：2017-08-11
Applicant: Bio-Rad Laboratories, Inc.
Inventor： Boaz RAN , Steve SWIHART , Evan THRUSH , Itay BARAK
Abstract: In one application, an imaging device includes an image sensor having an array of pixels, and a mask coupled with the image sensor. The mask is configured to darken a plurality of isolated pixels or groups of pixels interspersed within the array of pixels. The imaging device also includes a processor coupled with the image sensor and configured to receive image data from the image sensor, and determine a dark current fixed pattern noise based on the image data received from the plurality of darkened pixels or groups of pixels.
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公开(公告)号：US20170016829A1
公开(公告)日：2017-01-19
申请号：US15211728
申请日：2016-07-15
Applicant: Bio-Rad Laboratories, Inc.
Inventor： Steve SWIHART , Evan THRUSH , Yochanan URI , Boaz RAN , Itay BARAK , Kevin MCDONAL
CPC classification number: G02B6/08 , G01N21/6454 , G01N27/44721 , G01N2021/6484 , G02B5/22 , G02B5/28
Abstract: Devices, systems, methods, and kits for contact imaging are provided. A contact imaging device includes an imaging sensor, a fixed fiber faceplate mechanically coupled to the imaging sensor, and an optical filtering layer mechanically coupled to the fixed fiber faceplate. The optical filtering layer can include an interference filter, an absorptive filter, and/or a removable fiber faceplate. The contact imaging device can be used to image fluorescent samples by filtering out excitation light on the basis of wavelength and/or angle of incidence.
Abstract translation: 提供了用于接触成像的设备，系统，方法和套件。 接触成像装置包括成像传感器，机械耦合到成像传感器的固定光纤面板以及机械耦合到固定光纤面板的光学滤光层。 光学滤光层可以包括干涉滤光器，吸收滤光器和/或可移除的光纤面板。 接触成像装置可用于通过基于波长和/或入射角滤除激发光来对荧光样品进行成像。
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公开(公告)号：US20130344623A1
公开(公告)日：2013-12-26
申请号：US14013068
申请日：2013-08-29
Applicant: Bio-Rad Laboratories Inc.
Inventor： Boaz RAN , Itay Barak
IPC: G01N21/55
CPC classification number: G01N21/553 , G02B3/005 , G02B5/008
Abstract: A system for measuring an evanescent wave phenomenon at total internal reflection, the system comprising: a) a sensing surface comprising a plurality of areas of interest; b) an illumination sub-system comprising a light source, which illuminates each area of interest on the sensing surface over a range of angles of incidence; c) a detector which responds differently to an intensity of light received by it at different locations; and d) projection optics comprising primary optics and a plurality of secondary elements, the primary optics projecting an image of the illuminated sensing surface onto the secondary elements, which project their received light onto the detector in such a way that it is possible to determine, from the response of the detector, how much light is reflected from each area of interest, as a function of angle of incidence over the range of angles for that area.
Abstract translation: 一种用于在全内反射下测量ev逝波现象的系统，所述系统包括：a）感测表面，包括多个感兴趣的区域; b）照明子系统，包括光源，其在入射角范围上照射感测表面上的每个感兴趣区域; c）检测器，其响应于其在不同位置处接收的光的强度不同; 以及d）包括主要光学元件和多个次要元件的投影光学元件，所述主要光学器件将所述照射的感测表面的图像投影到所述次级元件上，所述次级元件将其接收的光投射到所述检测器上，使得可以确定， 根据检测器的响应，从感兴趣区域反射多少光，作为该区域的角度范围内的入射角的函数。
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Patent Agency Ranking
公开(公告)号：US20130196448A1
公开(公告)日：2013-08-01
申请号：US13751175
申请日：2013-01-28
Applicant: Bio-Rad Laboratories Inc.
Inventor： Boaz RAN , Ariel G. Notcovich , Ariel Lipson , Shay Nimri , Stephen G. Lipson , Doron Lipson
IPC: G01N21/55
CPC classification number: G01N21/55 , G01N21/553 , G01N2021/058
Abstract: An SPR sensor comprising a thin conducting layer comprising at least one conductive element formed on a surface of a transparent substrate, a light source that illuminates an interface between the conducting layer and the substrate, a photosensitive surface that generates signals from light reflected from the interface, a flow cell formed with at least one flow channel having a lumen defined by a wall formed from an elastic material and from a region of the conducting layer, and at least one hollow fluid-providing flow control apparatus having a lumen and an orifice communicating with its lumen. Fluid flow is enabled between the flow channel and the lumen of the flow control apparatus by forcing an end of the flow control apparatus through the elastic material so that the orifice communicates with the flow channel lumen.
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公开(公告)号：US20210389305A1
公开(公告)日：2021-12-16
申请号：US16900577
申请日：2020-06-12
Applicant: Bio-Rad Laboratories, Inc.
Inventor： Shai NIMRI , Yochanan URI , Boaz RAN
Abstract: An instrument for detecting signal from a biological sample includes a pipettor module configured to hold a plurality of pipettes in respective pipette positions, to hold liquid in one or more pipette tips, and to pipette liquid in and out of the one or more pipette tips. Each of the one or more pipette tips has a pipette tip point. The instrument further includes one or more magnets positioned such that each of the one or more pipette tips is adjacent one of the one or more magnets.
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公开(公告)号：US20170332001A1
公开(公告)日：2017-11-16
申请号：US15667435
申请日：2017-08-02
Applicant: Bio-Rad Laboratories, Inc.
Inventor： Steve SWIHART , Evan THRUSH , Boaz RAN
CPC classification number: H04N5/2355 , G01N21/272 , G01N21/6408 , G01N21/6456 , G01N21/76 , H04N5/2173 , H04N5/2353 , H04N5/35545 , H04N5/361 , H04N5/365
Abstract: Methods and digital imaging devices disclosed herein are adapted to capture images of a specimen in a chemical reaction using a series of short exposures of light emissions from the specimen over a period of time. The series of short exposures is captured using an array of pixels of an image sensor in the digital imaging device that are configured for performing continuous non-destructive read operations to read out a set of non-destructive read images of the specimen from the pixel array. In one embodiment, images are captured by delaying the read out until at or near the end of the chemical reaction to reduce read noise in the images. The signals read out from the image sensor can be continuously monitored and the capturing of images can be discontinued either automatically or based on a command from a user. The captured images can then be displayed in a graphical display.
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公开(公告)号：US20160299070A1
公开(公告)日：2016-10-13
申请号：US15070211
申请日：2016-03-15
Applicant: Bio-Rad Laboratories Inc.
Inventor： Yochanan URI , Boaz RAN , Ariel G. NOTCOVICH , Shay NIMRI
IPC: G01N21/552 , G01N33/543
CPC classification number: G01N21/553 , G01N21/253 , G01N21/658 , G01N33/54373 , G01N2021/0328 , G01N2201/0407 , G01N2201/0484 , G01N2201/062
Abstract: A tip for use in an optical detection system to analyze an analyte in a fluid sample drawn into the tip, using light reflected from a detection surface inside the tip that the analyte binds to, comprising a first detection surface and a second detection surface located in a same flow path with no controllable valve separating them, wherein the first and second detection surfaces have different surface chemistries.
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公开(公告)号：US20130330838A1
公开(公告)日：2013-12-12
申请号：US13966364
申请日：2013-08-14
Applicant: Bio-Rad Laboratories Inc.
Inventor： Boaz RAN , Ariel G. Notcovich , Ariel Lipson , Shay Nimri , Stephen G. Lipson , Doron Lipson
IPC: G01N21/55
CPC classification number: G01N21/55 , G01N21/553 , G01N2021/058
Abstract: An SPR sensor comprising a thin conducting layer comprising at least one conductive element formed on a surface of a transparent substrate, a light source that illuminates an interface between the conducting layer and the substrate, a photosensitive surface that generates signals from light reflected from the interface, a flow cell formed with at least one flow channel having a lumen defined by a wall formed from an elastic material and from a region of the conducting layer, and at least one hollow fluid-providing flow control apparatus having a lumen and an orifice communicating with its lumen. Fluid flow is enabled between the flow channel and the lumen of the flow control apparatus by forcing an end of the flow control apparatus through the elastic material so that the orifice communicates with the flow channel lumen.
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