Methods and apparatus for detecting bacterial growth by
spectrophotometric sampling of a fiber-optic array
    4.
    发明授权
    Methods and apparatus for detecting bacterial growth by spectrophotometric sampling of a fiber-optic array 失效
    通过光纤阵列的分光光度取样检测细菌生长的方法和装置

    公开(公告)号:US5473437A

    公开(公告)日:1995-12-05

    申请号:US420885

    申请日:1995-04-11

    Abstract: The detection of bacterial growth or the performance of other interrogative processes in multiple sample vials is accomplished using a moving rack that selectively couples optical locations to an optical excitation and detection system. The apparatus includes a drive mechanism combining agitation of the culture vials with a sequential scanning of an array of optical fibers, preferably by a spectrophotometric excitation and detection system. Selection of each culture vial provides, for example, optical detection of bacterial growth by fluorescence or other spectrophotometric measurements. A rack for holding vials is preferably the only moving assembly, and requires no mechanical or electrical interconnection with the excitation and detection system for its operation. In general, the present invention relates to the optically indexed presentation of the optical guides, to many remote sample sites in the form of a geometric array at the interface between the moving culture vial rack assembly and the spectrophotometric excitation and detection system fixed to the body of the instrument. Methods of transmitting and receiving electromagnetic radiation to and from sample vials held in a movable rack include the steps of coupling the sample vials to an optical fiber and terminating the optical fiber at an optical coupling location. The rack is then moved to align at least one of the coupling locations with an excitation and detection system.

    Abstract translation: 使用选择性地将光学位置耦合到光学激发和检测系统的移动架来实现多个样品瓶中细菌生长或其他询问过程的性能的检测。 该装置包括驱动机构,其结合培养小瓶的搅动和光纤阵列的顺序扫描,优选通过分光光度激发和检测系统。 每个培养瓶的选择提供例如通过荧光或其他分光光度测量法光学检测细菌生长。 用于保持小瓶的支架优选地是唯一的移动组件,并且不需要与用于其操作的激励和检测系统的机械或电气互连。 一般来说,本发明涉及光学引导件的光学索引呈现,在移动的培养瓶架组件和固定在身体上的分光光度激发和检测系统之间的界面处的几何阵列形式的许多远程采样部位 的仪器。 向携带在可移动机架中的样品瓶传送和接收电磁辐射的方法包括将样品瓶连接到光纤并在光耦合位置端接光纤的步骤。 然后移动机架以使至少一个耦合位置与激励和检测系统对准。

    OPTICAL DETECTION SYSTEM FOR LIQUID SAMPLES
    10.
    发明申请
    OPTICAL DETECTION SYSTEM FOR LIQUID SAMPLES 有权
    液体样品光学检测系统

    公开(公告)号:US20130330230A1

    公开(公告)日:2013-12-12

    申请号:US13911115

    申请日:2013-06-06

    Abstract: A tip for use in an optical detection system to analyze an analyte in a fluid sample drawn into the tip, using light reflected from a detection surface inside the tip that the analyte binds to, comprising a first detection surface and a second detection surface located in a same flow path with no controllable valve separating them, wherein the first and second detection surfaces have different surface chemistries.

    Abstract translation: 一种用于光学检测系统的尖端,用于使用从分析物结合到所述尖端内部的检测表面反射的光来分析吸入所述尖端的流体样品中的分析物,所述检测表面包括第一检测表面和位于 相同的流动路径,没有可分离它们的可控阀,其中第一和第二检测表面具有不同的表面化学性质。

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