公开(公告)号：US09637794B2

公开(公告)日：2017-05-02

申请号：US13796094

申请日：2013-03-12

Applicant: BioNTech AG

Inventor： Ugur Sahin ,  Özlem Türeci ,  Michael Koslowski

IPC: C12Q1/68 ,  C07K14/47 ,  C07K16/30 ,  A61K39/395 ,  A61K38/00 ,  A61K39/00 ,  A61K48/00 ,  G01N33/574

CPC classification number: C07K16/30 ,  A61K38/00 ,  A61K39/00 ,  A61K39/39558 ,  A61K48/00 ,  C07K14/4748 ,  C07K16/3015 ,  C07K16/3023 ,  C07K16/3053 ,  C07K16/3069 ,  C07K2317/34 ,  C07K2317/76 ,  C12Q1/6886 ,  C12Q2600/112 ,  C12Q2600/158 ,  G01N33/574

Abstract: The invention relates to the identification of genetic products that are expressed in association with a tumor and the nucleic acid coding therefor. The invention relates to the therapy and diagnosis of diseases in which the genetic products that are expressed in association with a tumor are expressed in an aberrant manner. The invention also relates to proteins, polypeptides, and peptides which are expressed in association with a tumor and the nucleic acids coding therefor.

公开(公告)号：US20170072035A1

公开(公告)日：2017-03-16

申请号：US15341528

申请日：2016-11-02

Applicant: BioNTech AG

Inventor： Thorsten Klamp ,  Ugur Sahin ,  Ozlem Tureci ,  Michael Koslowski ,  Thomas Hiller ,  Jens Schumacher

IPC: A61K39/00 ,  C07K14/47 ,  C12N7/00 ,  C07K14/005

Abstract: The present invention relates to tumor immunotherapy, in particular to tumor vaccination, using chimeric proteins comprising all or a portion of a hepatitis B virus core antigen protein and an amino acid sequence comprising an epitope derived from the extracellular portion of a tumor-associated antigen. In particular, the present invention provides virus-like particles comprising said chimeric proteins, which are useful for eliciting a humoral immune response in a subject against the tumor-associated antigen, in particular against cells carrying said tumor-associated antigen on their surface, wherein the tumor-associated antigen is a self-protein in said subject.

Abstract translation: 本发明涉及使用包含全部或部分乙型肝炎病毒核心抗原蛋白的嵌合蛋白和包含衍生自肿瘤相关抗原的细胞外部分的表位的氨基酸序列的肿瘤免疫治疗，特别是肿瘤免疫治疗。 特别地，本发明提供了包含所述嵌合蛋白的病毒样颗粒，其可用于在受试者内针对肿瘤相关抗原，特别是针对在其表面上携带所述肿瘤相关抗原的细胞引起体液免疫应答，其中 肿瘤相关抗原是所述受试者中的自身蛋白质。

公开(公告)号：US09533043B2

公开(公告)日：2017-01-03

申请号：US14036969

申请日：2013-09-25

Applicant: BioNTech AG

Inventor： Özlem Türeci ,  Ugur Sahin ,  Sandra Schneider ,  Gerd Helftenbein ,  Volker Schlüter ,  Dirk Usener ,  Philippe Thiel ,  Michael Koslowski

IPC: A61K39/395 ,  A61K51/10 ,  A61K47/42 ,  C07K16/30 ,  C12Q1/68 ,  C07K14/47 ,  A61K45/06 ,  C07K16/28 ,  A61P35/00 ,  G01N33/53

CPC classification number: A61K39/39558 ,  A61K39/395 ,  A61K45/06 ,  C07K14/4748 ,  C07K16/28 ,  C07K16/30 ,  C12Q1/6886 ,  C12Q2600/106 ,  C12Q2600/156 ,  G01N33/53

Abstract: An isolated truncated desmoglein 4 (DSG4) polypeptide splice variant of the invention is characterized by an amino acid sequence that lacks a region encoded before exon 9 or beyond exon 10 of the DSG4 gene having the polynucleotide sequence of SEQ ID NO: 75. Also disclosed is a method of diagnosing a cancer, or monitoring the course thereof, in a patient. The method comprises detecting in a tissue sample of a patient the expression of a tumor-associated antigen comprising the extracellular domain of a DSG4 polypeptide encoded by a DSG4 gene having the polynucleotide sequence of SEQ ID NO: 75, or a truncated DSG4 polypeptide splice variant characterized by an amino acid sequence that lacks a region encoded before exon 9 or beyond exon 10 of the DSG4 gene.

Abstract translation: 本发明的分离的截短的脱骨髓蛋白4（DSG4）多肽剪接变体的特征在于缺乏在具有SEQ ID NO：75的多核苷酸序列的DSG4基因的外显子9或超出外显子10之前编码的区域的氨基酸序列。还公开了 是在患者中诊断癌症或监测其过程的方法。 该方法包括在患者的组织样品中检测包含由具有SEQ ID NO：75的多核苷酸序列的DSG4基因或截短的DSG4多肽剪接变体编码的DSG4多肽的细胞外结构域的肿瘤相关抗原的表达 其特征在于缺乏在DSG4基因的外显子9或超出外显子10之前编码的区域的氨基酸序列。

公开(公告)号：US09061007B2

公开(公告)日：2015-06-23

申请号：US13826030

申请日：2013-03-14

Applicant: BioNTech AG ,  Johannes Gutenberg-Universität Mainz

Inventor： Ugur Sahin ,  Ozlem Tureci ,  Michael Koslowski

IPC: A61K31/21 ,  A61K39/395 ,  C12Q1/68 ,  G01N33/574 ,  A61K31/7088 ,  C12N15/82 ,  A61K47/48

CPC classification number: C12Q1/6886 ,  A61K31/7088 ,  A61K39/39558 ,  A61K47/6807 ,  C07K16/28 ,  C07K16/2866 ,  C07K16/40 ,  C07K2317/76 ,  C12N15/1138 ,  C12N15/8218 ,  C12N2310/11 ,  C12N2310/14 ,  C12Q2600/118 ,  C12Q2600/154 ,  C12Q2600/158 ,  G01N33/57484 ,  G01N33/57492 ,  G01N2333/715 ,  G01N2333/7158 ,  G01N2333/916

Abstract: The present invention relates to methods which make possible to assess and/or prognose a cancer disease, the metastatic behavior of a cancer disease and/or the occurrence of a relapse of cancer. In particular, the methods of the invention make possible to assess and/or prognose the occurrence of cancer metastasis, in particular distant metastasis. Preferably, the methods of the invention allow to discriminate malign from benign conditions.

Abstract translation: 本发明涉及有可能评估和/或预测癌症疾病，癌症疾病的转移行为和/或癌症复发的方法。 特别地，本发明的方法使得有可能评估和/或预测癌症转移的发生，特别是远处转移。 优选地，本发明的方法允许区分恶性与良性状况。

公开(公告)号：US20180169236A1

公开(公告)日：2018-06-21

申请号：US15675148

申请日：2017-08-11

Applicant: BioNTech AG

Inventor： Ozlem Tureci ,  Ugur Sahin ,  Sandra Schneider ,  Gerd Helftenbein ,  Volker Schluter ,  Dirk Usener ,  Philippe Thiel ,  Michael Koslowski

IPC: A61K39/395 ,  C07K16/30 ,  C07K16/28 ,  A61K45/06

Abstract: The invention relates to the identification of gene products that are the result of tumor-associated expression and the nucleic acids encoding the same. The invention also relates to the therapy and diagnosis of diseases wherein these gene products are the result of an aberrant tumor-associated expression. The invention also relates to the proteins, polypeptides and peptides that are the result of tumor-associated expression and to the nucleic acids encoding the same.

公开(公告)号：US09194004B2

公开(公告)日：2015-11-24

申请号：US13864411

申请日：2013-04-17

Applicant: BioNTech AG

Inventor： Ugur Sahin ,  Ozlem Tureci ,  Michael Koslowski ,  Gerd Helftenbein ,  Dirk Usener ,  Volker Schluter

IPC: C12Q1/68 ,  G01N33/574

CPC classification number: G01N33/57492 ,  C12Q1/6886 ,  C12Q2600/118 ,  C12Q2600/158 ,  G06F19/22

Abstract: The invention relates to identifying tumor-associated genetic products and encoding nucleic acids thereof. A therapy and diagnosis of diseases in which the tumor-associated genetic products are aberrantly expressed, proteins, polypeptides and peptides which are expressed in association with tumor and the encoding nucleic acids for said proteins, polypeptides and peptides are also disclosed.

公开(公告)号：US20150247206A1

公开(公告)日：2015-09-03

申请号：US14712233

申请日：2015-05-14

Applicant: BioNTech AG ,  Johannes Gutenberg-Universität Mainz

Inventor： Ugur Sahin ,  Ozlem Tureci ,  Michael Koslowski

IPC: C12Q1/68 ,  C07K16/40 ,  C07K16/28 ,  G01N33/574 ,  C12N15/113

CPC classification number: C12Q1/6886 ,  A61K31/7088 ,  A61K39/39558 ,  A61K47/6807 ,  C07K16/28 ,  C07K16/2866 ,  C07K16/40 ,  C07K2317/76 ,  C12N15/1138 ,  C12N15/8218 ,  C12N2310/11 ,  C12N2310/14 ,  C12Q2600/118 ,  C12Q2600/154 ,  C12Q2600/158 ,  G01N33/57484 ,  G01N33/57492 ,  G01N2333/715 ,  G01N2333/7158 ,  G01N2333/916

Abstract: The present invention relates to methods which make possible to assess and/or prognose a cancer disease, the metastatic behaviour of a cancer disease and/or the occurrence of a relapse of cancer. In particular, the methods of the invention make possible to assess and/or prognose the occurrence of cancer metastasis, in particular distant metastasis. Preferably, the methods of the invention allow to discriminate malign from benign conditions.

公开(公告)号：US20150152154A1

公开(公告)日：2015-06-04

申请号：US14457897

申请日：2014-08-12

Applicant: BioNTech AG

Inventor： Thorsten Klamp ,  Ugur Sahin ,  Ozlem Tureci ,  Michael Koslowski ,  Thomas Hiller ,  Jens Schumacher

IPC: C07K14/47 ,  A61K39/00 ,  C12N7/00 ,  C07K14/005

CPC classification number: C07K14/4748 ,  A61K39/0011 ,  A61K2039/5156 ,  A61K2039/523 ,  A61K2039/5258 ,  A61K2039/53 ,  A61K2039/57 ,  A61K2039/575 ,  A61K2039/6075 ,  C07K14/005 ,  C07K2319/00 ,  C07K2319/40 ,  C12N7/00 ,  C12N2730/10123 ,  C12N2730/10134 ,  C12N2730/10143 ,  C12N2730/10171

Abstract: The present invention relates to tumor immunotherapy, in particular to tumor vaccination, using chimeric proteins comprising all or a portion of a hepatitis B virus core antigen protein and an amino acid sequence comprising an epitope derived from the extracellular portion of a tumor-associated antigen. In particular, the present invention provides virus-like particles comprising said chimeric proteins, which are useful for eliciting a humoral immune response in a subject against the tumor-associated antigen, in particular against cells carrying said tumor-associated antigen on their surface, wherein the tumor-associated antigen is a self-protein in said subject.

Abstract translation: 本发明涉及使用包含全部或部分乙型肝炎病毒核心抗原蛋白的嵌合蛋白和包含衍生自肿瘤相关抗原的细胞外部分的表位的氨基酸序列的肿瘤免疫治疗，特别是肿瘤免疫接种。 特别地，本发明提供了包含所述嵌合蛋白的病毒样颗粒，其可用于在受试者内针对肿瘤相关抗原，特别是针对在其表面上携带所述肿瘤相关抗原的细胞引起体液免疫应答，其中 肿瘤相关抗原是所述受试者的自身蛋白质。

公开(公告)号：US10724103B2

公开(公告)日：2020-07-28

申请号：US15675148

申请日：2017-08-11

Applicant: BioNTech AG

Inventor： Ozlem Tureci ,  Ugur Sahin ,  Sandra Schneider ,  Gerd Helftenbein ,  Volker Schluter ,  Dirk Usener ,  Philippe Thiel ,  Michael Koslowski

IPC: C12Q1/686 ,  C12Q1/6886 ,  C07K14/47 ,  A61K39/395 ,  A61K45/06 ,  C07K16/28 ,  C07K16/30 ,  G01N33/53

Abstract: The invention relates to the identification of gene products that are the result of tumor-associated expression and the nucleic acids encoding the same. The invention also relates to the therapy and diagnosis of diseases wherein these gene products are the result of an aberrant tumor-associated expression. The invention also relates to the proteins, polypeptides and peptides that are the result of tumor-associated expression and to the nucleic acids encoding the same.

公开(公告)号：US10302647B2

公开(公告)日：2019-05-28

申请号：US14887979

申请日：2016-03-07

Applicant: BioNTech AG

Inventor： Ugur Sahin ,  Ozlem Tureci ,  Michael Koslowski ,  Gerd Helftenbein ,  Dirk Usener ,  Volker Schluter

IPC: C12Q1/686 ,  G01N33/574 ,  C12Q1/6886 ,  G06F19/22

Abstract: The invention relates to identifying tumor-associated genetic products and encoding nucleic acids thereof. A therapy and diagnosis of diseases in which the tumor-associated genetic products are aberrantly expressed, proteins, polypeptides and peptides which are expressed in association with tumor and the encoding nucleic acids for said proteins, polypeptides and peptides are also disclosed.