公开(公告)号：US20170362324A1

公开(公告)日：2017-12-21

申请号：US15510422

申请日：2015-09-11

Applicant: Biogen MA Inc.

Inventor： Thomas Owen Cameron ,  Michael Adam Crackower ,  Brian M. Dolinski ,  Karl J.M. Hanf ,  Amy Theresa McCurley ,  Nels Eric Pederson ,  Martin Preyer ,  Fang Qian ,  Shelia M. Violette ,  Paul Henry Weinreb

IPC: C07K16/28

CPC classification number: C07K16/2839 ,  C07K2317/24 ,  C07K2317/41 ,  C07K2317/55 ,  C07K2317/56 ,  C07K2317/565 ,  C07K2317/567 ,  C07K2317/76 ,  C07K2317/92 ,  C07K2317/94

Abstract: Humanized antibodies and antibody fragments that bind to αvβ5 are disclosed. Also disclosed are methods of using the disclosed antibodies and antibody fragments to treat or prevent αvβ5-mediated diseases.

公开(公告)号：US20160017041A1

公开(公告)日：2016-01-21

申请号：US14770522

申请日：2014-03-13

Applicant: BIOGEN MA INC.

Inventor： Shelia M. Violette ,  Bradley J. Maroni

IPC: C07K16/28 ,  A61K45/06 ,  A61K39/395

CPC classification number: C07K16/2839 ,  A61K39/3955 ,  A61K45/06 ,  A61K2039/505 ,  C07K2317/24

Abstract: Methods of using antibodies and antibody fragments that specifically bind αvβ5 or β5 to treat or prevent acute kidney injury and/or its sequelae are disclosed.

Abstract translation: 公开了使用特异性结合αv和bgr5或bgr5的抗体和抗体片段治疗或预防急性肾损伤和/或其后遗症的方法。

公开(公告)号：US20160017042A1

公开(公告)日：2016-01-21

申请号：US14772863

申请日：2014-03-14

Applicant: BIOGEN MA INC.

Inventor： Shelia M. Violette ,  Paul H. Weinreb ,  Timothy David Jones ,  Francis Joseph Carr ,  Anja Sibylle Tessarz

IPC: C07K16/28 ,  G01N33/53

CPC classification number: C07K16/2839 ,  C07K2317/14 ,  C07K2317/24 ,  C07K2317/565 ,  G01N33/5308 ,  G01N2800/00

Abstract: Humanized antibodies and antibody fragments thereof that bind to αvβ6 are disclosed. Also disclosed are methods of using these antibodies and antibody fragments to diagnose, treat, and/or prevent αvβ6-mediated diseases such as acute tissue injury, fibrosis, and cancer.

Abstract translation: 公开了结合αv＆bgr6的人源化抗体及其抗体片段。 还公开了使用这些抗体和抗体片段诊断，治疗和/或预防αvβb介导的疾病如急性组织损伤，纤维化和癌症的方法。

公开(公告)号：US20200248257A1

公开(公告)日：2020-08-06

申请号：US16683644

申请日：2019-11-14

Applicant: Biogen MA Inc. ,  The Regents of the University of California

Inventor： Shelia M. Violette ,  Dean Sheppard

IPC: C12Q1/6876 ,  C12Q1/6883 ,  G01N33/68

Abstract: The present invention relates to biomarkers for use in determining the sensitivity of patients to therapy with αvβ6 integrin inhibition or therapy with TGF-β pathway inhibitors. The biomarker profiles disclosed herein provide individualized gene and protein profiles which will aid in treating diseases and disorders which are amenable to treatment with therapies designed against αvβ6-integrin and/or TGF-β pathway inhibitors.

公开(公告)号：US10035860B2

公开(公告)日：2018-07-31

申请号：US14772863

申请日：2014-03-14

Applicant: Biogen MA Inc.

Inventor： Shelia M. Violette ,  Paul H. Weinreb ,  Timothy David Jones ,  Francis Joseph Carr ,  Anja Sibylle Tessarz

IPC: A61K39/395 ,  C07K16/00 ,  C07K16/46 ,  C07K16/28 ,  G01N33/53

CPC classification number: C07K16/2839 ,  C07K2317/14 ,  C07K2317/24 ,  C07K2317/565 ,  G01N33/5308 ,  G01N2800/00

Abstract: Humanized antibodies and antibody fragments thereof that bind to αvβ6 are disclosed. Also disclosed are methods of using these antibodies and antibody fragments to diagnose, treat, and/or prevent αvβ6-mediated diseases such as acute tissue injury, fibrosis, and cancer.

公开(公告)号：US10035859B2

公开(公告)日：2018-07-31

申请号：US14772512

申请日：2014-03-14

Applicant: Biogen MA Inc.

Inventor： Shelia M. Violette ,  Paul H. Weinreb ,  Timothy David Jones ,  Francis Joseph Carr ,  Anja Sibylle Tessarz

IPC: A61K39/395 ,  C07K16/00 ,  C07K16/46 ,  C07K16/28

CPC classification number: C07K16/2839 ,  C07K16/2842 ,  C07K2317/24 ,  C07K2317/56 ,  C07K2317/565 ,  C07K2317/567 ,  C07K2317/76 ,  C07K2317/92

Abstract: Humanized antibodies and antibody fragments thereof that bind to αvβ6 are disclosed. Also disclosed are methods of using these antibodies and antibody fragments to treat or prevent αvβ6-mediated diseases such as fibrosis and cancer.

公开(公告)号：US09745376B2

公开(公告)日：2017-08-29

申请号：US14444701

申请日：2014-07-28

Applicant: Biogen MA Inc. ,  The Regents of the University of California

Inventor： Shelia M. Violette ,  Paul Henry Weinreb ,  Kenneth J. Simon ,  Dean Sheppard ,  Diane R. Leone

IPC: C07H21/04 ,  C12P21/06 ,  C12N15/87 ,  C12N15/74 ,  C12N1/20 ,  C07K16/28 ,  A61K47/48 ,  A61K51/10 ,  G01N33/574 ,  G01N33/68 ,  A61K39/00

CPC classification number: C07K16/2839 ,  A61K47/48507 ,  A61K47/48561 ,  A61K47/48623 ,  A61K47/68 ,  A61K47/6835 ,  A61K47/6849 ,  A61K47/6851 ,  A61K47/6865 ,  A61K51/1027 ,  A61K51/1066 ,  A61K2039/505 ,  C07K2317/24 ,  C07K2317/56 ,  C07K2317/565 ,  C07K2317/73 ,  C07K2317/76 ,  C07K2317/77 ,  C07K2317/92 ,  G01N33/57492 ,  G01N33/6893 ,  G01N2333/70546 ,  G01N2800/085 ,  G01N2800/205

Abstract: Monoclonal antibodies that specifically bind to M.96. Also included are methods of using these antibodies to treat mammals having or at risk of having 006-mediated diseases, or to diagnose % Qmediated diseases.

公开(公告)号：US20160031992A1

公开(公告)日：2016-02-04

申请号：US14772512

申请日：2014-03-14

Applicant: Biogen MA Inc.

Inventor： Shelia M. Violette ,  Paul H. Weinreb ,  Timothy David Jones ,  Francis Joseph Carr ,  Anja Sibylle Tessarz

IPC: C07K16/28

CPC classification number: C07K16/2839 ,  C07K16/2842 ,  C07K2317/24 ,  C07K2317/56 ,  C07K2317/565 ,  C07K2317/567 ,  C07K2317/76 ,  C07K2317/92

Abstract: Humanized antibodies and antibody fragments thereof that bind to αvβ6 are disclosed. Also disclosed are methods of using these antibodies and antibody fragments to treat or prevent αvβ6-mediated diseases such as fibrosis and cancer.

Abstract translation: 公开了结合αv＆bgr6的人源化抗体及其抗体片段。 还公开了使用这些抗体和抗体片段来治疗或预防αvβb介导的疾病如纤维化和癌症的方法。