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1.发明申请Crystalline Azithromycin L-Malate Monohydrate and Pharmaceutical Composition Containing Same 审中-公开结晶阿奇霉素L-苹果酸一水合物和含有其的药物组合物公开(公告)号：US20090318375A1
公开(公告)日：2009-12-24
申请号：US11915929
申请日：2003-06-06
申请人： Bo Sung Kwon , Eun Sook Kim , Hee Cheol Kim , Sangmin Yun , Myoung-sil Ko , Tae Hun Song , Han Kyong Kim , Kwee Hyun Suh , Gwansun Lee
发明人： Bo Sung Kwon , Eun Sook Kim , Hee Cheol Kim , Sangmin Yun , Myoung-sil Ko , Tae Hun Song , Han Kyong Kim , Kwee Hyun Suh , Gwansun Lee
IPC分类号： A61K31/7048 , C07H17/08 , A61P31/00
CPC分类号： C07H17/08
摘要： This invention provides a crystalline azithromycin L-malate monohydrate for treating various microbial infections, which has high thermostability, solubility and non-hygroscopicity, a method for preparing same, and a pharmaceutical composition containing same.
摘要翻译： 本发明提供了一种用于治疗各种微生物感染的结晶阿奇霉素L-苹果酸盐一水合物，其具有高的热稳定性，溶解性和非吸湿性，其制备方法和含有它们的药物组合物。
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2.发明授权Crystalline monohydrate clopidogrel naphthalenedisulfonate and process of preparation 失效结晶一水合物氯吡格雷萘二磺酸盐及其制备方法公开(公告)号：US07470707B2
公开(公告)日：2008-12-30
申请号：US10971028
申请日：2004-10-25
申请人： Sangmin Yun , Eun Sook Kim , Hee Seock Kim , Bo Sung Kwon , Cheol Kyung Kim , Han Kyong Kim , Kwee-Hyun Suh , Gwan Sun Lee
发明人： Sangmin Yun , Eun Sook Kim , Hee Seock Kim , Bo Sung Kwon , Cheol Kyung Kim , Han Kyong Kim , Kwee-Hyun Suh , Gwan Sun Lee
IPC分类号： C07D495/04 , A61K31/4365
CPC分类号： C07D495/04
摘要： A crystalline clopidogrel naphthalenesulfonate or a hydrate thereof, a method for preparing same, and a pharmaceutical composition containing same are provided.
摘要翻译： 提供结晶氯吡格雷萘磺酸盐或其水合物，其制备方法和含有它们的药物组合物。
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公开(公告)号：US07652140B2
公开(公告)日：2010-01-26
申请号：US11917794
申请日：2005-11-28
申请人： Eun Sook Kim , Hee Cheol Kim , Bo Sung Kwon , Sangmin Yun , Mi Young Ko , Cheol Kyung Kim , Kwee Hyun Suh
发明人： Eun Sook Kim , Hee Cheol Kim , Bo Sung Kwon , Sangmin Yun , Mi Young Ko , Cheol Kyung Kim , Kwee Hyun Suh
IPC分类号： C07D495/04
CPC分类号： C07D495/04
摘要： Optically pure clopidogrel can be prepared in a high yield by optically resolving a racemic form of the compound of formula (II) using an optically active amine to form the optically active form of the compound of formula (III) or its acid-addition salt; and methylating the compound of formula (III) or its acid-addition salt.
摘要翻译： 光学纯氯吡格雷可以通过光学拆分式（II）化合物的外消旋形式，使用光学活性胺形成式（III）化合物或其酸加成盐的光学活性形式，以高产率制备; 并使式（III）化合物或其酸加成盐进行甲基化。
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公开(公告)号：US07763730B2
公开(公告)日：2010-07-27
申请号：US12549850
申请日：2009-08-28
申请人： Eun Sook Kim , Hee Cheol Kim , Bo Sung Kwon , Sangmin Yun , Mi Young Ko , Cheol Kyung Kim , Kwee Hyun Suh
发明人： Eun Sook Kim , Hee Cheol Kim , Bo Sung Kwon , Sangmin Yun , Mi Young Ko , Cheol Kyung Kim , Kwee Hyun Suh
IPC分类号： C07D495/04
CPC分类号： C07D495/04
摘要： Optically pure clopidogrel can be prepared in a high yield by optically resolving a racemic form of the compound of formula (II) using an optically active amine to form the optically active form of the compound of formula (III) or its acid-addition salt; and methylating the compound of formula (III) or its acid-addition salt.
摘要翻译： 光学纯氯吡格雷可以通过光学拆分式（II）化合物的外消旋形式，使用光学活性胺形成式（III）化合物或其酸加成盐的光学活性形式，以高产率制备; 并使式（III）化合物或其酸加成盐进行甲基化。
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5.发明申请公开(公告)号：US20100120888A1
公开(公告)日：2010-05-13
申请号：US12524807
申请日：2008-01-21
申请人： Eun Sook Kim , Sun Young Jang , Bo Sung Kwon , Sangmin Yun , Kwee Hyun Suh , Gwan Sun Lee
发明人： Eun Sook Kim , Sun Young Jang , Bo Sung Kwon , Sangmin Yun , Kwee Hyun Suh , Gwan Sun Lee
IPC分类号： A61K31/40 , C07D207/323 , A61P3/06 , A61P3/00
CPC分类号： C07D207/416
摘要： This invention provides atorvastatin strontium salt or its hydrates or polymorphs having improved water solubility, which is useful for the prevention or treatment of hyperlipidemia and hypercholesterolemia, and a pharmaceutical composition comprising same.
摘要翻译： 本发明提供了可用于预防或治疗高脂血症和高胆固醇血症的具有改善的水溶性的阿托伐他汀锶盐或其水合物或多晶型物，以及包含其的药物组合物。
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公开(公告)号：US20080214821A1
公开(公告)日：2008-09-04
申请号：US11917794
申请日：2005-11-28
申请人： Eun Sook Kim , Hee Cheol , Bo Sung Kwon , Sangmin Yun , Mi Young Ko , Cheol Kyung Kim , Kwee Hyun Suh
发明人： Eun Sook Kim , Hee Cheol , Bo Sung Kwon , Sangmin Yun , Mi Young Ko , Cheol Kyung Kim , Kwee Hyun Suh
IPC分类号： C07D495/04
CPC分类号： C07D495/04
摘要： Optically pure clopidogrel can be prepared in a high yield by optically resolving a racemic form of the compound of formula (II) using an optically active amine to form the optically active form of the compound of formula (III) or its acid-addition salt; and methylating the compound of formula (III) or its acid-addition salt.
摘要翻译： 光学纯氯吡格雷可以通过光学拆分式（II）化合物的外消旋形式，使用光学活性胺形成式（III）化合物或其酸加成盐的光学活性形式，以高产率制备; 并使式（III）化合物或其酸加成盐进行甲基化。
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![Method of preparing thieno[3,2-c]pyridine derivatives and intermediates used therein](/abs-image/US/2008/11/11/US07449580B2/abs.jpg.150x150.jpg)
7.发明授权Method of preparing thieno[3,2-c]pyridine derivatives and intermediates used therein 失效噻吩并[3,2-c]吡啶衍生物及其中使用的方法公开(公告)号：US07449580B2
公开(公告)日：2008-11-11
申请号：US10598790
申请日：2005-03-03
申请人： Sangmin Yun , Eun Sook Kim , Hee Seock Kim , Tae Hee Ha , Kwee-Hyun Suh , Gwan Sun Lee
发明人： Sangmin Yun , Eun Sook Kim , Hee Seock Kim , Tae Hee Ha , Kwee-Hyun Suh , Gwan Sun Lee
IPC分类号： C07D495/04
CPC分类号： C07D333/38 , C07D333/12 , C07D333/16 , C07D333/18 , C07D495/04
摘要： Ticlopidine and clopidogrel having high blood platelet aggregation inhibitory and anti-thrombotic activities are simply prepared by reacting a substituted thiophene derivative with a 2-chlorobenzylamine derivative.
摘要翻译： 通过使取代的噻吩衍生物与2-氯苄胺衍生物反应，简单地制备具有高血小板聚集抑制和抗血栓形成活性的噻氯匹定和氯吡格雷。
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8.发明申请METHOD FOR PREPARING CLOPIDOGREL 1,5-NAPHTHALENEDISULFONATE OR HYDRATE THEREOF 失效制备氯硝酸盐的方法1,5-萘硫代磺酸盐或其水合物公开(公告)号：US20090036683A1
公开(公告)日：2009-02-05
申请号：US12293959
申请日：2007-03-16
申请人： Kwee Hyun Suh , Sang Min Yun , Eun Sook Kim , Gwan Sun Lee
发明人： Kwee Hyun Suh , Sang Min Yun , Eun Sook Kim , Gwan Sun Lee
IPC分类号： C07D495/04
CPC分类号： C07D495/04
摘要： The present invention relates to a method for preparing clopidogrel 1,5-naphthalenedisulfonate or a hydrate thereof, which comprises reacting a clopidogrel-acid addition salt with disodium 1,5-naphthalenedisulfonate or its hydrate in water, or a mixture of water and an organic solvent. High quality clopidogrel 1,5-naphthalenedisulfonate can be prepared by the inventive method by way of using non-corrosive disodium 1,5-naphthalenedisulfonate.
摘要翻译： 本发明涉及一种氯吡格雷1,5-萘二磺酸盐或其水合物的制备方法，该方法包括使氯吡格雷酸加成盐与1,5-萘二磺酸二钠或其水合物在水中或水与有机物的混合物 溶剂。 通过本发明方法可以通过使用1,5-萘二磺酸非腐蚀性二钠制备高质量的氯萘吡格雷1,5-萘二磺酸盐。
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9.发明授权Method for preparing clopidogrel 1,5-naphthalenedisulfonate or hydrate thereof 失效制备1,5-萘二磺酸氯吡格雷或其水合物的方法公开(公告)号：US07612207B2
公开(公告)日：2009-11-03
申请号：US12293959
申请日：2007-03-16
申请人： Kwee Hyun Suh , Sang Min Yun , Eun Sook Kim , Gwan Sun Lee
发明人： Kwee Hyun Suh , Sang Min Yun , Eun Sook Kim , Gwan Sun Lee
IPC分类号： C07D495/04
CPC分类号： C07D495/04
摘要： The present invention relates to a method for preparing clopidogrel 1,5-naphthalenedisulfonate or a hydrate thereof, which comprises reacting a clopidogrel-acid addition salt with disodium 1,5-naphthalenedisulfonate or its hydrate in water, or a mixture of water and an organic solvent. High quality clopidogrel 1,5-naphthalenedisulfonate can be prepared by the inventive method by way of using non-corrosive disodium 1,5-naphthalenedisulfonate.
摘要翻译： 本发明涉及一种氯吡格雷1,5-萘二磺酸盐或其水合物的制备方法，该方法包括使氯吡格雷酸加成盐与1,5-萘二磺酸二钠或其水合物在水中或水与有机物的混合物 溶剂。 通过本发明方法可以通过使用1,5-萘二磺酸非腐蚀性二钠制备高质量的氯萘吡格雷1,5-萘二磺酸盐。
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公开(公告)号：US20170275800A1
公开(公告)日：2017-09-28
申请号：US15506891
申请日：2015-08-20
申请人： Eun Sook Kim
发明人： Eun Sook Kim
IPC分类号： D06B21/00 , D06M15/277 , D06B3/10 , D04B1/14
CPC分类号： D06B21/00 , D02G3/04 , D04B1/14 , D06B3/08 , D06B3/10 , D06B5/20 , D06L1/18 , D06M15/277 , D06M23/06 , D06M2101/12 , D06M2101/26 , D06M2101/34 , D06M2200/12 , D10B2401/021
摘要： Disclosed is a method of preparing a knitting yarn having a water-repellent function, including providing a knitting yarn in the form of a skein or a cone, washing the provided yarn to remove impurities and oil therefrom, coating the washed yarn with a water-repellent agent by spraying a water repellent solution containing the water-repellent agent at a predetermined pressure, dehydrating and drying the coated yarn, and fixing the water-repellent agent to the yarn by applying heat to the dried yarn.
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