METHOD FOR PREPARING CLOPIDOGREL 1,5-NAPHTHALENEDISULFONATE OR HYDRATE THEREOF
    6.
    发明申请
    METHOD FOR PREPARING CLOPIDOGREL 1,5-NAPHTHALENEDISULFONATE OR HYDRATE THEREOF 失效
    制备氯硝酸盐的方法1,5-萘硫代磺酸盐或其水合物

    公开(公告)号:US20090036683A1

    公开(公告)日:2009-02-05

    申请号:US12293959

    申请日:2007-03-16

    IPC分类号: C07D495/04

    CPC分类号: C07D495/04

    摘要: The present invention relates to a method for preparing clopidogrel 1,5-naphthalenedisulfonate or a hydrate thereof, which comprises reacting a clopidogrel-acid addition salt with disodium 1,5-naphthalenedisulfonate or its hydrate in water, or a mixture of water and an organic solvent. High quality clopidogrel 1,5-naphthalenedisulfonate can be prepared by the inventive method by way of using non-corrosive disodium 1,5-naphthalenedisulfonate.

    摘要翻译: 本发明涉及一种氯吡格雷1,5-萘二磺酸盐或其水合物的制备方法,该方法包括使氯吡格雷酸加成盐与1,5-萘二磺酸二钠或其水合物在水中或水与有机物的混合物 溶剂。 通过本发明方法可以通过使用1,5-萘二磺酸非腐蚀性二钠制备高质量的氯萘吡格雷1,5-萘二磺酸盐。

    Method for preparing clopidogrel 1,5-naphthalenedisulfonate or hydrate thereof
    7.
    发明授权
    Method for preparing clopidogrel 1,5-naphthalenedisulfonate or hydrate thereof 失效
    制备1,5-萘二磺酸氯吡格雷或其水合物的方法

    公开(公告)号:US07612207B2

    公开(公告)日:2009-11-03

    申请号:US12293959

    申请日:2007-03-16

    IPC分类号: C07D495/04

    CPC分类号: C07D495/04

    摘要: The present invention relates to a method for preparing clopidogrel 1,5-naphthalenedisulfonate or a hydrate thereof, which comprises reacting a clopidogrel-acid addition salt with disodium 1,5-naphthalenedisulfonate or its hydrate in water, or a mixture of water and an organic solvent. High quality clopidogrel 1,5-naphthalenedisulfonate can be prepared by the inventive method by way of using non-corrosive disodium 1,5-naphthalenedisulfonate.

    摘要翻译: 本发明涉及一种氯吡格雷1,5-萘二磺酸盐或其水合物的制备方法,该方法包括使氯吡格雷酸加成盐与1,5-萘二磺酸二钠或其水合物在水中或水与有机物的混合物 溶剂。 通过本发明方法可以通过使用1,5-萘二磺酸非腐蚀性二钠制备高质量的氯萘吡格雷1,5-萘二磺酸盐。