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    Compounds, compositions and methods for preventing neurodegeneration in acute and chronic injuries in the central nervous system
    2.
    发明授权
    Compounds, compositions and methods for preventing neurodegeneration in acute and chronic injuries in the central nervous system 有权
    用于预防中枢神经系统急性和慢性损伤神经变性的化合物，组合物和方法

    公开(公告)号：US08211877B2

    公开(公告)日：2012-07-03

    申请号：US12786226

    申请日：2010-05-24

    申请人： Byoung Joo Gwag ,  Young Ae Lee ,  Bo Rum Ryu ,  Sung Hwa Yoon ,  Ho Sang Moon

    发明人： Byoung Joo Gwag ,  Young Ae Lee ,  Bo Rum Ryu ,  Sung Hwa Yoon ,  Ho Sang Moon

    IPC分类号： A61K31/60 ,  C07C229/00 ,  C07C205/00 ,  A01N37/36

    CPC分类号： C07C229/64 ,  A61K31/195 ,  A61K31/24

    摘要： The present invention provides compositions and methods for prevention and prophylaxis of neurological diseases accompanied by neuronal death. The invention includes synthesis of 5-benzylamino salicylic acid (BAS) and its derivatives. BAS and its derivatives protect cortical neurons from toxic insults by N-methyl-D-aspartate, Zn2+, and reactive oxygen species. Thus, the present invention provides compositions and methods for treating stroke, traumatic brain and spinal cord injury, epilepsy, and neurodegenerative diseases that are accompanied by severe neuronal loss via excitotoxicity, Zn2+ neurotoxicity, and free radical neurotoxicity.

    摘要翻译： 本发明提供了预防和预防伴有神经元死亡的神经疾病的组合物和方法。 本发明包括5-苄基氨基水杨酸（BAS）及其衍生物的合成。 BAS及其衍生物保护皮质神经元免受N-甲基-D-天冬氨酸，Zn 2+和活性氧的毒性损伤。 因此，本发明提供了用于治疗中风，创伤性脑和脊髓损伤，癫痫和神经变性疾病的组合物和方法，其伴随着经由兴奋毒性，Zn2 +神经毒性和自由基神经毒性的严重神经元损失。

    Compounds, compositions and methods for preventing neurodegeneration in acute and chronic injuries in the central nervous system
    3.
    发明授权
    Compounds, compositions and methods for preventing neurodegeneration in acute and chronic injuries in the central nervous system 有权
    用于预防中枢神经系统急性和慢性损伤神经变性的化合物，组合物和方法

    公开(公告)号：US06964982B2

    公开(公告)日：2005-11-15

    申请号：US10206765

    申请日：2002-07-29

    申请人： Byoung Joo Gwag ,  Young Ae Lee ,  Bo Rum Ryu ,  Sung Hwa Yoon ,  Ho Sang Moon

    发明人： Byoung Joo Gwag ,  Young Ae Lee ,  Bo Rum Ryu ,  Sung Hwa Yoon ,  Ho Sang Moon

    IPC分类号： A61K31/195 ,  A61K31/24

    CPC分类号： C07C229/64 ,  A61K31/195 ,  A61K31/24

    摘要： The present invention provides compositions and methods for prevention and prophylaxis of neurological diseases accompanied by neuronal death. The invention includes synthesis of 5-benzylamino salicylic acid (BAS) and its derivatives. BAS and its derivatives protect cortical neurons from toxic insults by N-methyl-D-aspartate, Zn2+, and reactive oxygen species. Thus, the present invention provides compositions and methods for treating stroke, traumatic brain and spinal cord injury, epilepsy, and neurodegenerative diseases that are accompanied by severe neuronal loss via excitotoxicity, Zn2+ neurotoxicity, and free radical neurotoxicity.

    摘要翻译： 本发明提供了预防和预防伴有神经元死亡的神经疾病的组合物和方法。 本发明包括5-苄基氨基水杨酸（BAS）及其衍生物的合成。 BAS及其衍生物保护皮质神经元免受N-甲基-D-天冬氨酸，Zn 2+和活性氧的毒性损伤。 因此，本发明提供了用于治疗中风，创伤性脑和脊髓损伤，癫痫和神经变性疾病的组合物和方法，其伴随着经由兴奋毒性，Zn 2+和/或自由基的严重神经元损失 神经毒性。

    Compounds, compositions and methods for preventing neurodegeneration in acute and chronic injuries in the central nervous system
    4.
    发明授权
    Compounds, compositions and methods for preventing neurodegeneration in acute and chronic injuries in the central nervous system 有权
    用于预防中枢神经系统急性和慢性损伤神经变性的化合物，组合物和方法

    公开(公告)号：US07750045B2

    公开(公告)日：2010-07-06

    申请号：US11205313

    申请日：2005-08-17

    申请人： Byoung Joo Gwag ,  Young Ae Lee ,  Bo Rum Ryu ,  Sung Hwa Yoon ,  Ho Sang Moon

    发明人： Byoung Joo Gwag ,  Young Ae Lee ,  Bo Rum Ryu ,  Sung Hwa Yoon ,  Ho Sang Moon

    IPC分类号： A01N37/12 ,  A01N37/44 ,  A61K31/24 ,  A61K31/245 ,  A61K31/60

    CPC分类号： C07C229/64 ,  A61K31/195 ,  A61K31/24

    摘要： The present invention provides compositions and methods for prevention and prophylaxis of neurological diseases accompanied by neuronal death. The invention includes synthesis of 5-benzylamino salicylic acid (BAS) and its derivatives. BAS and its derivatives protect cortical neurons from toxic insults by N-methyl-D-aspartate, Zn2+, and reactive oxygen species. Thus, the present invention provides compositions and methods for treating stroke, traumatic brain and spinal cord injury, epilepsy, and neurodegenerative diseases that are accompanied by severe neuronal loss via excitotoxicity, Zn2+ neurotoxicity, and free radical neurotoxicity.

    摘要翻译： 本发明提供了预防和预防伴有神经元死亡的神经疾病的组合物和方法。 本发明包括5-苄基氨基水杨酸（BAS）及其衍生物的合成。 BAS及其衍生物保护皮质神经元免受N-甲基-D-天冬氨酸，Zn 2+和活性氧的毒性损伤。 因此，本发明提供了用于治疗中风，创伤性脑和脊髓损伤，癫痫和神经变性疾病的组合物和方法，其伴随着经由兴奋毒性，Zn2 +神经毒性和自由基神经毒性的严重神经元损失。

    Compositions for inhibition of necrosis induced by a neurotrophin
    7.
    发明授权
    Compositions for inhibition of necrosis induced by a neurotrophin 有权
    用于抑制由神经营养因子诱导的坏死的组合物

    公开(公告)号：US07608585B2

    公开(公告)日：2009-10-27

    申请号：US10542936

    申请日：2004-01-20

    申请人： Byoung Joo Gwag ,  Sung-Hwa Yoon ,  Sun-Hee Kim ,  Seok-Joon Won

    发明人： Byoung Joo Gwag ,  Sung-Hwa Yoon ,  Sun-Hee Kim ,  Seok-Joon Won

    IPC分类号： A61K38/18 ,  C07C229/68 ,  C07K14/475

    CPC分类号： A61K31/355 ,  A61K31/00 ,  A61K31/60 ,  A61K31/606 ,  A61K38/185 ,  A61K45/06 ,  A61K2300/00

    摘要： Disclosed is a method for inhibition of necrosis induced by neurotrophin, and more specifically a method for inhibition of necrosis by administrating oxidative stress inhibitor and a method for simultaneous inhibition of necrosis and apoptosis by administrating oxidative stress inhibitor and neurotrophin. The oxidative stress inhibitor of the present invention can inhibit nerve cell necrosis induced by neurotrophin. Moreover, it can be used for protecting nerve cell damage connected with alzheimer disease, parkinson's disease, degenerating cerebropathia and promoting regeneration of the nerve cells by administrating oxidative stress inhibitor and neurotrophin.

    摘要翻译： 本发明公开了抑制神经营养因子诱导的坏死的方法，更具体地，是通过施用氧化应激抑制剂来抑制坏死的方法，以及通过施用氧化应激抑制剂和神经营养因子同时抑制坏死和凋亡的方法。 本发明的氧化应激抑制剂可以抑制神经营养蛋白诱导的神经细胞坏死。 此外，它可用于保护与阿尔茨海默病，帕金森病，退行性脑病有关的神经细胞损伤，并通过施用氧化应激抑制剂和神经营养因子促进神经细胞的再生。