摘要:
The present invention provides an efficient method for mass-producing 2-hydroxy-5-(substituted)phenylalkylamino benzoic acid derivatives represented by specific Chemical formulas or their salts, particularly 2-hydroxy-5-[2-(4-trifluoromethylphenyl)ethylamino]benzoic acid or its salt.
摘要:
A circular saw includes a housing, a motor having a rotating axis and a center of gravity on the rotating axis, a handle, a circular blade, a fixed guard, and a base plate having a width supporting the housing. The motor and the circular blade are parallel or coplanar with respect to each other and the circular saw does not extend beyond the width of the base plate in the width direction.
摘要:
A hydrophobic binding pocket on ubiquitin-protein ligase E3 is described, and used in designing the inhibitors disrupting ubiquitin conjugating enzyme E2 and E3 interaction. Four types of inhibitors designed by using the binding pocket are provided, which can be used for cancer treatment.
摘要:
The subject invention concerns methods and compounds that have utility in the treatment of a condition associated with cyclooxygenase-2 mediated disorders. Compounds of particular interest are benzopyrans and their analogs defined by formula 1 Wherein Z, X, R1, R2, R3, and R4 are as described in the specification.
摘要:
An electrical connection and a method of electrically coupling are disclosed. In one embodiment, a circuit substrate with a first set of circuitry has a bonding pad mounted to a surface of the circuit board. The bonding pad is electrically coupled to the first set of circuitry. A flexible circuit substrate with a second set of circuitry has a connecting pad mounted to a surface of the flexible circuit substrate facing the surface of the circuit board. The connecting pad is electrically coupled to the second set of circuitry. A ball of conductive material is mounted on the bonding pad. A clamping device presses the connecting pad to the ball of conductive material.
摘要:
A computer implemented software method enables the prediction of the pKa of an arbitrary molecule based upon a knowledge of the molecular structure of that molecule and a statistical analysis of the molecular structures of a group of molecules (training set) for which the pKa is known. Hierarchical atom connectivity trees are constructed for the training set and the various atoms types identified in each molecule are associated in a bit string for that molecule and also associated with the experimentally determined pKa for that molecule. PLS analysis of the training set data yields coefficients associated with each atom type represented in the bit strings. A hierarchical atom connectivity tree may then be constructed for the molecule of interest. The predicted pKa is determined by multiplying the number of occurrences of each atom type in the molecule of interest by the PLS coefficient determined for that atom type and summing the resulting multiplications.
摘要翻译:基于对该分子的分子结构的了解和一组分子的分子结构的统计分析(训练集合),计算机实现的软件方法能够预测任意分子的pK a a ),已知pK SUB>。 为训练集合构建分层原子连接性树,并且在每个分子中鉴定的各种原子类型与该分子的位串相关联,并且还与该分子的实验确定的pK SUB>相关联。 训练集数据的PLS分析产生与位串中表示的每个原子类型相关联的系数。 然后可以为感兴趣的分子构建分层的原子连接性树。 通过将感兴趣分子中每个原子类型的出现次数乘以为该原子类型确定的PLS系数并将所得到的乘法相加来确定预测的pK 。
摘要:
The subject invention concerns methods and compounds that have utility in the treatment of a condition associated with cyclooxygenase-2 mediated disorders. Compounds of particular interest are benzopyrans and their analogs defined by formula 1 Wherein Z, X, R1, R2, R3, and R4 are as described in the specification.
摘要:
A guiding mechanism for an electric tool includes at least two guiding elements at least one of which has a first end portion having at least one protruding portion extending outwards therefrom and the other of which has a second end portion having at least one groove therein which may be engaged with the protruding portion. The groove has a cut-out and the protruding portion has an elastic clamping portion which may be engaged with the cut-out.